{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:57:45Z","timestamp":1754161065867,"version":"3.41.2"},"reference-count":41,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780128239247"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL126524","HL132389","HL134764"],"award-info":[{"award-number":["HL126524","HL132389","HL134764"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/bs.mie.2021.03.008","type":"book-chapter","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T08:06:07Z","timestamp":1617955567000},"page":"407-434","source":"Crossref","is-referenced-by-count":2,"title":["In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy"],"prefix":"10.1016","member":"78","reference":[{"issue":"1","key":"10.1016\/bs.mie.2021.03.008_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00001573-200101000-00001","article-title":"Basic mechanisms of reentrant arrhythmias","volume":"16","author":"Antzelevitch","year":"2001","journal-title":"Current Opinion in Cardiology"},{"issue":"5","key":"10.1016\/bs.mie.2021.03.008_bb0015","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.cell.2016.02.001","article-title":"Unfolding of a temperature-sensitive domain controls voltage-gated channel activation","volume":"164","author":"Arrigoni","year":"2016","journal-title":"Cell"},{"issue":"9","key":"10.1016\/bs.mie.2021.03.008_bb0020","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1016\/j.bpj.2009.02.019","article-title":"Novel micropatterned cardiac cell cultures with realistic ventricular microstructure","volume":"96","author":"Badie","year":"2009","journal-title":"Biophysical Journal"},{"issue":"12","key":"10.1016\/bs.mie.2021.03.008_bb0025","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1007\/s10439-009-9815-x","article-title":"A method to replicate the microstructure of heart tissue in vitro using DTMRI-based cell micropatterning","volume":"37","author":"Badie","year":"2009","journal-title":"Annals of Biomedical Engineering"},{"issue":"2","key":"10.1016\/bs.mie.2021.03.008_bb0030","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/cvr\/cvr209","article-title":"Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model","volume":"92","author":"Bikou","year":"2011","journal-title":"Cardiovascular Research"},{"issue":"10","key":"10.1016\/bs.mie.2021.03.008_bb0035","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1529\/biophysj.106.090464","article-title":"Acidic residues on the voltage-sensor domain determine the activation of the NaChBac sodium channel","volume":"92","author":"Blanchet","year":"2007","journal-title":"Biophysical Journal"},{"issue":"3","key":"10.1016\/bs.mie.2021.03.008_bb0040","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1152\/physrev.1999.79.3.917","article-title":"Cardiac ionic currents and acute ischemia: From channels to arrhythmias","volume":"79","author":"Carmeliet","year":"1999","journal-title":"Physiological Reviews"},{"issue":"1","key":"10.1016\/bs.mie.2021.03.008_bb0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00232-004-0701-z","article-title":"Role of arginine residues on the S4 segment of the Bacillus halodurans Na+ channel in voltage-sensing","volume":"201","author":"Chahine","year":"2004","journal-title":"The Journal of Membrane Biology"},{"issue":"28","key":"10.1016\/bs.mie.2021.03.008_bb0050","doi-asserted-by":"crossref","first-page":"11331","DOI":"10.1073\/pnas.1309452110","article-title":"Catalysis of Na+ permeation in the bacterial sodium channel Na(V)Ab","volume":"110","author":"Chakrabarti","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"32","key":"10.1016\/bs.mie.2021.03.008_bb0055","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1021\/bi200942y","article-title":"NaChBac: The long lost sodium channel ancestor","volume":"50","author":"Charalambous","year":"2011","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/bs.mie.2021.03.008_bb0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12013-015-0626-4","article-title":"Cardiac arrhythmias: Diagnosis, symptoms, and treatments","volume":"73","author":"Fu","year":"2015","journal-title":"Cell Biochemistry and Biophysics"},{"issue":"3","key":"10.1016\/bs.mie.2021.03.008_bb0065","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.acvd.2016.09.009","article-title":"Brugada syndrome: Diagnosis, risk stratification and management","volume":"110","author":"Gourraud","year":"2017","journal-title":"Archives of Cardiovascular Diseases"},{"issue":"12","key":"10.1016\/bs.mie.2021.03.008_bb0070","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jacc.2012.04.042","article-title":"Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction","volume":"60","author":"Greener","year":"2012","journal-title":"Journal of the American College of Cardiology"},{"issue":"10","key":"10.1016\/bs.mie.2021.03.008_bb0075","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1177\/1535370218777972","article-title":"Dysfunctional Nav1.5 channels due to SCN5A mutations","volume":"243","author":"Han","year":"2018","journal-title":"Experimental Biology and Medicine (Maywood, N.J.)"},{"issue":"18","key":"10.1016\/bs.mie.2021.03.008_bb0080","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/j.jacc.2019.02.045","article-title":"Arrhythmia-induced cardiomyopathy: JACC state-of-the-art review","volume":"73","author":"Huizar","year":"2019","journal-title":"Journal of the American College of Cardiology"},{"issue":"2","key":"10.1016\/bs.mie.2021.03.008_bb0085","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCULATIONAHA.111.053272","article-title":"Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation","volume":"125","author":"Igarashi","year":"2012","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/bs.mie.2021.03.008_bb0090","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1074\/jbc.M109.057455","article-title":"Comparative study of the gating motif and C-type inactivation in prokaryotic voltage-gated sodium channels","volume":"285","author":"Irie","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.mie.2021.03.008_bb0095","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.biomaterials.2016.09.024","article-title":"Dynamic culture yields engineered myocardium with near-adult functional output","volume":"111","author":"Jackman","year":"2016","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/bs.mie.2021.03.008_bb0100","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1152\/physrev.1989.69.4.1049","article-title":"Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction","volume":"69","author":"Janse","year":"1989","journal-title":"Physiological Reviews"},{"issue":"1\u20132","key":"10.1016\/bs.mie.2021.03.008_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1023\/A:1019907104763","article-title":"Endogenous Kv channels in human embryonic kidney (HEK-293) cells","volume":"238","author":"Jiang","year":"2002","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"7","key":"10.1016\/bs.mie.2021.03.008_bb0110","doi-asserted-by":"crossref","first-page":"e006273","DOI":"10.1161\/CIRCEP.118.006273","article-title":"Frequency of cardiac rhythm abnormalities in a half million adults","volume":"11","author":"Khurshid","year":"2018","journal-title":"Circulation. Arrhythmia and Electrophysiology"},{"key":"10.1016\/bs.mie.2021.03.008_bb0115","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ncomms1302","article-title":"Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies","volume":"2","author":"Kirkton","year":"2011","journal-title":"Nature Communications"},{"issue":"2","key":"10.1016\/bs.mie.2021.03.008_bb0120","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1152\/physrev.00025.2003","article-title":"Basic mechanisms of cardiac impulse propagation and associated arrhythmias","volume":"84","author":"Kleber","year":"2004","journal-title":"Physiological Reviews"},{"issue":"4","key":"10.1016\/bs.mie.2021.03.008_bb0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cpcardiol.2015.01.002","article-title":"Sudden cardiac death","volume":"40","author":"Kuriachan","year":"2015","journal-title":"Current Problems in Cardiology"},{"issue":"4","key":"10.1016\/bs.mie.2021.03.008_bb0130","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neuron.2013.05.036","article-title":"Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation","volume":"79","author":"Lacroix","year":"2013","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/bs.mie.2021.03.008_bb0135","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nrcardio.2014.85","article-title":"Cardiac sodium channel mutations: Why so many phenotypes?","volume":"11","author":"Liu","year":"2014","journal-title":"Nature Reviews. Cardiology"},{"issue":"5","key":"10.1016\/bs.mie.2021.03.008_bb0140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcm.2018.09.014","article-title":"Treatment of ventricular arrhythmias: What's new?","volume":"29","author":"Markman","year":"2019","journal-title":"Trends in Cardiovascular Medicine"},{"key":"10.1016\/bs.mie.2021.03.008_bb0145","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ncomms2077","article-title":"Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing","volume":"3","author":"McCusker","year":"2012","journal-title":"Nature Communications"},{"issue":"3","key":"10.1016\/bs.mie.2021.03.008_bb0150","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.hrthm.2008.11.009","article-title":"Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies","volume":"6","author":"Meregalli","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/bs.mie.2021.03.008_bb0155","doi-asserted-by":"crossref","first-page":"13132","DOI":"10.1038\/ncomms13132","article-title":"Engineering prokaryotic channels for control of mammalian tissue excitability","volume":"7","author":"Nguyen","year":"2016","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/bs.mie.2021.03.008_bb0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/gt.2010.105","article-title":"Robust cardiomyocyte-specific gene expression following systemic injection of AAV: In vivo gene delivery follows a Poisson distribution","volume":"18","author":"Prasad","year":"2011","journal-title":"Gene Therapy"},{"key":"10.1016\/bs.mie.2021.03.008_bb0165","doi-asserted-by":"crossref","first-page":"1.29.21","DOI":"10.1002\/0471250953.bi0129s53","article-title":"UniProt tools","volume":"53","author":"Pundir","year":"2016","journal-title":"Current Protocols in Bioinformatics"},{"issue":"5550","key":"10.1016\/bs.mie.2021.03.008_bb0170","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1126\/science.1065635","article-title":"A prokaryotic voltage-gated sodium channel","volume":"294","author":"Ren","year":"2001","journal-title":"Science"},{"issue":"12","key":"10.1016\/bs.mie.2021.03.008_bb0175","doi-asserted-by":"crossref","first-page":"e007622","DOI":"10.1161\/JAHA.117.007622","article-title":"Sodium channel remodeling in subcellular microdomains of murine failing cardiomyocytes","volume":"6","author":"Rivaud","year":"2017","journal-title":"Journal of the American Heart Association"},{"issue":"2","key":"10.1016\/bs.mie.2021.03.008_bb0180","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.mt.6300027","article-title":"Design of tissue-specific regulatory cassettes for high-level rAAV-mediated expression in skeletal and cardiac muscle","volume":"15","author":"Salva","year":"2007","journal-title":"Molecular Therapy"},{"issue":"5","key":"10.1016\/bs.mie.2021.03.008_bb0185","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s10439-011-0478-z","article-title":"Single-detector simultaneous optical mapping of V(m) and [Ca(2+)](i) in cardiac monolayers","volume":"40","author":"Scull","year":"2012","journal-title":"Annals of Biomedical Engineering"},{"issue":"2","key":"10.1016\/bs.mie.2021.03.008_bb0190","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jmb.2013.10.010","article-title":"Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels","volume":"426","author":"Shaya","year":"2014","journal-title":"Journal of Molecular Biology"},{"issue":"9","key":"10.1016\/bs.mie.2021.03.008_bb0195","doi-asserted-by":"crossref","first-page":"7409","DOI":"10.1074\/jbc.M110.186510","article-title":"Arrangement and mobility of the voltage sensor domain in prokaryotic voltage-gated sodium channels","volume":"286","author":"Shimomura","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"issue":"1\u20133","key":"10.1016\/bs.mie.2021.03.008_bb0200","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pbiomolbio.2005.05.002","article-title":"Endogenous channels in HEK cells and potential roles in HCN ionic current measurements","volume":"90","author":"Varghese","year":"2006","journal-title":"Progress in Biophysics and Molecular Biology"},{"issue":"8","key":"10.1016\/bs.mie.2021.03.008_bb0205","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics\u20142020 update: A report from the American Heart Association","volume":"143","author":"Virani","year":"2020","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/bs.mie.2021.03.008_bb0210","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1085\/jgp.20028699","article-title":"The cation selectivity filter of the bacterial sodium channel, NaChBac","volume":"120","author":"Yue","year":"2002","journal-title":"The Journal of General Physiology"}],"container-title":["Methods in Enzymology","Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S007668792100121X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S007668792100121X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:05:27Z","timestamp":1753707927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S007668792100121X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9780128239247"],"references-count":41,"URL":"https:\/\/doi.org\/10.1016\/bs.mie.2021.03.008","relation":{},"ISSN":["0076-6879"],"issn-type":[{"type":"print","value":"0076-6879"}],"subject":[],"published":{"date-parts":[[2021]]}}}