{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:10:10Z","timestamp":1790374210472,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier","isbn-type":[{"value":"9780443429255","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.mie.2025.08.023","type":"book-chapter","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:19:38Z","timestamp":1759205978000},"page":"35-60","source":"Crossref","is-referenced-by-count":1,"title":["The ARTS toolset: Resistance-based genome mining for systematic prioritization of bioactive gene clusters"],"prefix":"10.1016","author":[{"given":"Martina","family":"Adamek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgut Mesut","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semih","family":"Erdogmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Ziemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"May","key":"10.1016\/bs.mie.2025.08.023_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/nar\/gkx360","article-title":"The antibiotic resistant target seeker ( ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery","volume":"45","author":"Alanjary","year":"2017","journal-title":"Nucleic Acids Research"},{"issue":"6885","key":"10.1016\/bs.mie.2025.08.023_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/417141a","article-title":"Complete genome sequence of the model actinomycete streptomyces coelicolor A3(2)","volume":"417","author":"Bentley","year":"2002","journal-title":"Nature"},{"issue":"D1","key":"10.1016\/bs.mie.2025.08.023_bib3","doi-asserted-by":"crossref","first-page":"D586","DOI":"10.1093\/nar\/gkad984","article-title":"The antiSMASH database version 4: Additional genomes and BGCs, new sequence-based searches and more","volume":"52","author":"Blin","year":"2024","journal-title":"Nucleic Acids Research"},{"issue":"W1","key":"10.1016\/bs.mie.2025.08.023_bib4","doi-asserted-by":"crossref","first-page":"W81","DOI":"10.1093\/nar\/gkz310","article-title":"antiSMASH 5.0: Updates to the secondary metabolite genome mining pipeline","volume":"47","author":"Blin","year":"2019","journal-title":"Nucleic Acids Research"},{"issue":"3","key":"10.1016\/bs.mie.2025.08.023_bib5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00253-011-3557-z","article-title":"Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives","volume":"92","author":"Collin","year":"2011","journal-title":"Applied Microbiology and Biotechnology"},{"issue":"5","key":"10.1016\/bs.mie.2025.08.023_bib6","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41564-022-01110-2","article-title":"Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes","volume":"7","author":"Gavriilidou","year":"2022","journal-title":"Nature Microbiology"},{"key":"10.1016\/bs.mie.2025.08.023_bib7","article-title":"Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology","author":"Gibson","year":"2014","journal-title":"The ISME Journal Advance Online Publication"},{"issue":"7","key":"10.1016\/bs.mie.2025.08.023_bib8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nchembio0709-450","article-title":"Hidden biosynthetic treasures brought to light","volume":"5","author":"Hertweck","year":"2009","journal-title":"Nature Chemical Biology"},{"issue":"6","key":"10.1016\/bs.mie.2025.08.023_bib9","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1021\/acs.chemrev.0c01214","article-title":"The antibiotic resistome: A guide for the discovery of natural products as antimicrobial agents","volume":"121","author":"Hobson","year":"2021","journal-title":"Chemical Reviews"},{"issue":"11","key":"10.1016\/bs.mie.2025.08.023_bib10","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.7164\/antibiotics.31.1203","article-title":"Mechanism of action of globomycin","volume":"31","author":"Inukai","year":"1978","journal-title":"The Journal of Antibiotics"},{"issue":"27\u201328","key":"10.1016\/bs.mie.2025.08.023_bib11","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1016\/j.tet.2014.03.009","article-title":"Discovery of the lomaiviticin biosynthetic gene cluster in salinispora pacifica","volume":"70","author":"Janso","year":"2014","journal-title":"Tetrahedron"},{"issue":"11","key":"10.1016\/bs.mie.2025.08.023_bib12","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1021\/cb2002544","article-title":"Bacterial self-resistance to the natural proteasome inhibitor salinosporamide a","volume":"6","author":"Kale","year":"2011","journal-title":"ACS Chemical Biology"},{"issue":"D1","key":"10.1016\/bs.mie.2025.08.023_bib13","doi-asserted-by":"crossref","first-page":"D490","DOI":"10.1093\/nar\/gkaa812","article-title":"BiG-FAM: The biosynthetic gene cluster families database","volume":"49","author":"Kautsar","year":"2021","journal-title":"Nucleic Acids Research"},{"issue":"14","key":"10.1016\/bs.mie.2025.08.023_bib14","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/S0960-894X(03)00432-3","article-title":"Synthesis and antimicrobial activity of novel globomycin analogues","volume":"13","author":"Kiho","year":"2003","journal-title":"Bioorganic and Medicinal Chemistry Letters"},{"issue":"D1","key":"10.1016\/bs.mie.2025.08.023_bib15","doi-asserted-by":"crossref","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","article-title":"DrugBank 6.0: The DrugBank knowledgebase for 2024","volume":"52","author":"Knox","year":"2024","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"10.1016\/bs.mie.2025.08.023_bib16","first-page":"371","article-title":"Platforms for antibiotic discovery","volume":"12","author":"Lewis","year":"2013","journal-title":"Nature Publishing Group"},{"issue":"16","key":"10.1016\/bs.mie.2025.08.023_bib17","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1021\/jacs.1c01516","article-title":"Targeted genome mining reveals the biosynthetic gene clusters of natural product CYP51 inhibitors","volume":"143","author":"Liu","year":"2021","journal-title":"Journal of the American Chemical Society"},{"issue":"10","key":"10.1016\/bs.mie.2025.08.023_bib18","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41570-021-00313-1","article-title":"Towards the sustainable discovery and development of new antibiotics","volume":"5","author":"Miethke","year":"2021","journal-title":"Nature Reviews Chemistry"},{"issue":"12","key":"10.1016\/bs.mie.2025.08.023_bib19","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1021\/acschembio.5b00658","article-title":"Identification of thiotetronic acid antibiotic biosynthetic pathways by target-directed genome mining","volume":"10","author":"Moore","year":"2015","journal-title":"ACS Chemical Biology"},{"issue":"W1","key":"10.1016\/bs.mie.2025.08.023_bib20","doi-asserted-by":"crossref","first-page":"W546","DOI":"10.1093\/nar\/gkaa374","article-title":"ARTS 2.0: Feature updates and expansion of the antibiotic resistant target seeker for comparative genome mining","volume":"48","author":"Mungan","year":"2020","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"10.1016\/bs.mie.2025.08.023_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab940","article-title":"ARTS-DB: A database for antibiotic resistant targets","volume":"50","author":"Mungan","year":"2022","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"10.1016\/bs.mie.2025.08.023_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41589-019-0400-9","article-title":"A computational framework to explore large-scale biosynthetic diversity","volume":"16","author":"Navarro-Mu\u00f1oz","year":"2020","journal-title":"Nature Chemical Biology"},{"issue":"4","key":"10.1016\/bs.mie.2025.08.023_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41587-020-0718-6","article-title":"A genomic catalog of earth\u2019s microbiomes","volume":"39","author":"Nayfach","year":"2021","journal-title":"Nature Biotechnology"},{"issue":"3","key":"10.1016\/bs.mie.2025.08.023_bib24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"Journal of Natural Products"},{"issue":"1","key":"10.1016\/bs.mie.2025.08.023_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13724-y","article-title":"Structures of lipoprotein signal peptidase II from staphylococcus aureus complexed with antibiotics globomycin and myxovirescin","volume":"11","author":"Olatunji","year":"2020","journal-title":"Nature Communications"},{"issue":"2","key":"10.1016\/bs.mie.2025.08.023_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.synbio.2023.02.001","article-title":"Identification and heterologous expression of the globomycin biosynthetic gene cluster","volume":"8","author":"Oves-Costales","year":"2023","journal-title":"Synthetic and Systems Biotechnology"},{"issue":"21","key":"10.1016\/bs.mie.2025.08.023_bib27","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1039\/C8SC01325J","article-title":"Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria","volume":"9","author":"Panter","year":"2018","journal-title":"Chemical Science"},{"key":"10.1016\/bs.mie.2025.08.023_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf397","article-title":"AutoMLST2: A web server for phylogeny and microbial taxonomy","author":"Pourmohsenin","year":"2025","journal-title":"Nucleic Acids Research"},{"issue":"40","key":"10.1016\/bs.mie.2025.08.023_bib29","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1016\/S0040-4020(01)82396-6","article-title":"Fellutamides A and B, cytotoxic peptides from a marine fish-possessing fungus penicillium fellutanum","volume":"47","author":"Shigemori","year":"1991","journal-title":"Tetrahedron"},{"issue":"7714","key":"10.1016\/bs.mie.2025.08.023_bib30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-018-0319-4","article-title":"Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action","volume":"559","author":"Yan","year":"2018","journal-title":"Nature"},{"issue":"8","key":"10.1016\/bs.mie.2025.08.023_bib31","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1021\/acschembio.6b00213","article-title":"Resistance gene-guided genome mining: Serial promoter exchanges in aspergillus nidulans reveal the biosynthetic pathway for fellutamide B, A proteasome inhibitor","volume":"11","author":"Yeh","year":"2016","journal-title":"ACS Chemical Biology"},{"issue":"1 W","key":"10.1016\/bs.mie.2025.08.023_bib32","article-title":"FunARTS, the fungal bioactive compound resistant target seeker, an exploration engine for target-directed genome mining in fungi","volume":"51","author":"Yllmaz","year":"2023","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"10.1016\/bs.mie.2025.08.023_bib33","doi-asserted-by":"crossref","first-page":"D678","DOI":"10.1093\/nar\/gkae1115","article-title":"MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration","volume":"53","author":"Zdouc","year":"2025","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/bs.mie.2025.08.023_bib34","first-page":"1","article-title":"Natural product reports the evolution of genome mining in microbes \u2013 a review","volume":"00","author":"Ziemert","year":"2016","journal-title":"Natural Product Reports"}],"container-title":["Methods in Enzymology","Computational Approaches to Natural Products Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687925003398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687925003398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:28:56Z","timestamp":1779456536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0076687925003398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443429255"],"references-count":34,"URL":"https:\/\/doi.org\/10.1016\/bs.mie.2025.08.023","relation":{},"ISSN":["0076-6879"],"issn-type":[{"value":"0076-6879","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}