{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:46:03Z","timestamp":1782409563959,"version":"3.54.5"},"reference-count":81,"publisher":"Elsevier","isbn-type":[{"value":"9780443432248","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006785","name":"Google","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.mie.2026.05.006","type":"book-chapter","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T19:46:09Z","timestamp":1780170369000},"page":"427-461","source":"Crossref","is-referenced-by-count":0,"title":["Pyrone and pyranthione scaffolds for click-to-release and biological gas delivery"],"prefix":"10.1016","author":[{"given":"Kangqiao","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evans","family":"Kusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Laughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.mie.2026.05.006_bib1","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1002\/anie.201500088","article-title":"Self-immolative spacers: Kinetic aspects, structure\u2013property relationships, and applications","volume":"54","author":"Alouane","year":"2015","journal-title":"Angewandte Chemie International Edition"},{"key":"10.1016\/bs.mie.2026.05.006_bib2","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1016\/j.bmcl.2006.03.073","article-title":"A new drug-release method using the staudinger ligation","volume":"16","author":"Azoulay","year":"2006","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/bs.mie.2026.05.006_bib3","doi-asserted-by":"crossref","first-page":"13518","DOI":"10.1021\/ja8053805","article-title":"Tetrazine ligation: Fast bioconjugation based on inverse-electron-demand Diels\u2212Alder reactivity","volume":"130","author":"Blackman","year":"2008","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib4","doi-asserted-by":"crossref","first-page":"12293","DOI":"10.1002\/anie.202003115","article-title":"The huisgen reaction: Milestones of the 1,3-dipolar cycloaddition","volume":"59","author":"Breugst","year":"2020","journal-title":"Angewandte Chemie - International Edition"},{"key":"10.1016\/bs.mie.2026.05.006_bib5","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1002\/anie.201301100","article-title":"BODIPY\u2013tetrazine derivatives as superbright bioorthogonal turn-on probes","volume":"52","author":"Carlson","year":"2013","journal-title":"Angewandte Chemie International Edition"},{"key":"10.1016\/bs.mie.2026.05.006_bib6","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1021\/jacs.7b11217","article-title":"Unraveling tetrazine-triggered bioorthogonal elimination enables chemical tools for ultrafast release and universal cleavage","volume":"140","author":"Carlson","year":"2018","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib7","article-title":"Design and development of a bioorthogonal, visualizable and mitochondria-targeted hydrogen sulfide (H2 S) delivery system","volume":"61","author":"Chen","year":"2022","journal-title":"Angewandte Chemie (International Ed. in English)"},{"key":"10.1016\/bs.mie.2026.05.006_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiological Reviews"},{"key":"10.1016\/bs.mie.2026.05.006_bib9","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.1021\/acs.orglett.2c02819","article-title":"Controllable cycloadditions between 2H-(Thio)pyran-2-(thi)ones and strained alkynes: A click-and-release strategy for COS\/H2S generation","volume":"24","author":"Cui","year":"2022","journal-title":"Organic Letters"},{"key":"10.1016\/bs.mie.2026.05.006_bib10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/asia.201801184","article-title":"Alkene\u2013Azide 1,3-dipolar cycloaddition as a trigger for ultrashort peptide hydrogel dissolution","volume":"14","author":"Dadhwal","year":"2019","journal-title":"Chemistry, an Asian Journal"},{"key":"10.1016\/bs.mie.2026.05.006_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ab.2011.10.016","article-title":"Passive loss of hydrogen sulfide in biological experiments","volume":"421","author":"Deleon","year":"2012","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1055\/s-0037-1611693","article-title":"Self-immolative prodrugs: Effective tools for the controlled release of sulfur signaling species","volume":"30","author":"Dillon","year":"2019","journal-title":"Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202402353","article-title":"An expanded palette of fluorescent COS\/H2S-releasing donors for H2S delivery, detection, and in vivo application","volume":"63","author":"Fosnacht","year":"2024","journal-title":"Angewandte Chemie International Edition"},{"key":"10.1016\/bs.mie.2026.05.006_bib14","doi-asserted-by":"crossref","first-page":"17651","DOI":"10.1021\/jacs.2c07225","article-title":"Subcellular delivery of hydrogen sulfide using small molecule donors impacts organelle stress","volume":"144","author":"Gilbert","year":"2022","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib15","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1002\/anie.200704847","article-title":"A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation","volume":"47","author":"Hangauer","year":"2008","journal-title":"Angewandte Chemie (International Ed. in English)"},{"issue":"1","key":"10.1016\/bs.mie.2026.05.006_bib16","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1038\/s41467-024-47188-6","article-title":"An all-in-one tetrazine reagent for cysteine-selective labeling and bioorthogonal activable prodrug construction","volume":"15","author":"He","year":"2024","journal-title":"Nature Communications 2024"},{"key":"10.1016\/bs.mie.2026.05.006_bib17","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1021\/acs.chemrev.1c00014","article-title":"Bioorthogonal reactions of triarylphosphines and related analogues","volume":"121","author":"Heiss","year":"2021","journal-title":"Chemical Reviews"},{"key":"10.1016\/bs.mie.2026.05.006_bib18","doi-asserted-by":"crossref","first-page":"11537","DOI":"10.1002\/chem.201601807","article-title":"A photo-triggered traceless Staudinger\u2013Bertozzi ligation reaction","volume":"22","author":"Hu","year":"2016","journal-title":"Chemistry - A European Journal"},{"key":"10.1016\/bs.mie.2026.05.006_bib19","doi-asserted-by":"crossref","first-page":"12998","DOI":"10.1021\/acs.joc.8b01370","article-title":"Development of a visible light triggerable traceless Staudinger ligation reagent","volume":"83","author":"Hu","year":"2018","journal-title":"The Journal of Organic Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.chembiol.2023.09.010","article-title":"Cell-selective bioorthogonal labeling","volume":"31","author":"Huang","year":"2024","journal-title":"Cell Chemical Biology"},{"key":"10.1016\/bs.mie.2026.05.006_bib21","article-title":"Pyranthiones\/pyrones: \u201cClick and Release\u201d donors for subcellular hydrogen sulfide delivery and labeling**","volume":"30","author":"Huang","year":"2024","journal-title":"Chemistry - A European Journal"},{"key":"10.1016\/bs.mie.2026.05.006_bib22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1201\/9781003403333-8","article-title":"Click chemistry for cell labeling: A review of pro-fluorescent tetrazines for live cell imaging","author":"Huang","year":"2024","journal-title":"Click Chemistry: Volume 2: Emerging Applications and Challenges"},{"key":"10.1016\/bs.mie.2026.05.006_bib23","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1039\/D4OB01263A","article-title":"Unveiling the reactivity of 2H-(thio)pyran-2-(thi)ones in cycloaddition reactions with strained alkynes through density functional theory studies","volume":"22","author":"Huang","year":"2024","journal-title":"Organic & Biomolecular Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib24","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1021\/acs.joc.4c02336","article-title":"Evaluation of pyrones in bioorthogonal reactions: Correlation between structure, reactivity, and bioorthogonality","volume":"90","author":"Huang","year":"2025","journal-title":"The Journal of Organic Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1039\/C8CS00395E","article-title":"Click and release: Bioorthogonal approaches to \u2018on-demand\u2019 activation of prodrugs","volume":"48","author":"Ji","year":"2019","journal-title":"Chemical Society Reviews"},{"key":"10.1016\/bs.mie.2026.05.006_bib26","first-page":"1","article-title":"Enzyme- or light-triggered cyclopropenes for bioorthogonal ligation","volume":"641","author":"Jiang","year":"2020","journal-title":"Methods in Enzymology"},{"key":"10.1016\/bs.mie.2026.05.006_bib27","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1021\/ja01620a032","article-title":"Preparation and cyclization of diethyl \u03b1,\u03b1-diethoxy-\u03b1\u2019-ethoxalylglutarate and diethyl \u03b1,\u03b1-diethoxy-\u03b1\u2019-formylglutarate","volume":"77","author":"Jones","year":"1955","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib28","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1039\/D2CC00911K","article-title":"Green light enabled Staudinger\u2013Bertozzi ligation","volume":"58","author":"Kalayci","year":"2022","journal-title":"Chemical Communications"},{"key":"10.1016\/bs.mie.2026.05.006_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202400304","article-title":"Redox\u2010activated substrates for enhancing activatable cyclopropene bioorthogonal reactions","volume":"25","author":"Kao","year":"2024","journal-title":"Chembiochem: a European Journal of Chemical Biology"},{"key":"10.1016\/bs.mie.2026.05.006_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s41061-025-00492-1","article-title":"Click-triggered bioorthogonal bond-cleavage reactions","volume":"383","author":"Keppel","year":"2025","journal-title":"Topics in Current Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib31","doi-asserted-by":"crossref","DOI":"10.1021\/jacs.5c23084","article-title":"Tetrazine-mediated bioorthogonally activated therapeutic (TBAT) platforms","author":"Kim","year":"2026","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib32","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1021\/acs.bioconjchem.8b00061","article-title":"Bioorthogonally applicable fluorogenic cyanine-tetrazines for no-wash super-resolution imaging","volume":"29","author":"Knorr","year":"2018","journal-title":"Bioconjugate Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/bs.mie.2019.02.007","article-title":"Modular activatable bioorthogonal reagents","volume":"622","author":"Kumar","year":"2019","journal-title":"Methods in Enzymology"},{"key":"10.1016\/bs.mie.2026.05.006_bib34","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1021\/ja029013y","article-title":"A fluorogenic dye activated by the staudinger ligation","volume":"125","author":"Lemieux","year":"2003","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ejoc.201901427","article-title":"Pyrone synthesis from renewable sources: Easy preparation of 3-acetoxy-2-oxo-2H-pyran-6-carboxylic salts and their derivatives as 3-hydroxy-2h-pyran-2-one from c6 aldaric acids","volume":"2020","author":"Leonardi","year":"2020","journal-title":"European Journal of Organic Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nchembio.2024","article-title":"Development and application of bond cleavage reactions in bioorthogonal chemistry","volume":"12","author":"Li","year":"2016","journal-title":"Nature Chemical Biology"},{"key":"10.1016\/bs.mie.2026.05.006_bib37","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1021\/ja044461m","article-title":"Mechanistic investigation of the staudinger ligation","volume":"127","author":"Lin","year":"2005","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib38","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/jhet.1698","article-title":"Synthesis of polysubstituted \u03b1-pyrones using zinc-catalyzed addition-cyclization reactions","volume":"51","author":"Liu","year":"2014","journal-title":"Journal of Heterocyclic Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib39","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nchem.2573","article-title":"Small-molecule control of protein function through Staudinger reduction","volume":"8","author":"Luo","year":"2016","journal-title":"Nat. Chem"},{"key":"10.1016\/bs.mie.2026.05.006_bib40","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1016\/S0040-4020(01)97184-4","article-title":"Convenient approaches to heterocycles via copper-catalysed additions of organic polyhalides to activated olefins","volume":"41","author":"Martin","year":"1985","journal-title":"Tetrahedron"},{"key":"10.1016\/bs.mie.2026.05.006_bib41","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1039\/C4SC02574A","article-title":"Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition","volume":"6","author":"Matikonda","year":"2015","journal-title":"Chemical Science"},{"key":"10.1016\/bs.mie.2026.05.006_bib42","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1002\/anie.201403890","article-title":"Ultrafluorogenic coumarin-tetrazine probes for real-time biological imaging","volume":"53","author":"Meimetis","year":"2014","journal-title":"Angewandte Chemie International Edition"},{"key":"10.1016\/bs.mie.2026.05.006_bib43","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1021\/jo00078a023","article-title":"Hydration of alkynes in anhydrous medium with formic acid as water donor","volume":"58","author":"Menashe","year":"2002","journal-title":"Journal of Organic Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib44","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1039\/D3MD00137G","article-title":"Bioorthogonal activation of prodrugs, for the potential treatment of breast cancer, using the Staudinger reaction","volume":"14","author":"Mitry","year":"2023","journal-title":"RSC Medicinal Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib45","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1111\/bph.12368","article-title":"Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II\u00a0Pathophysiological and therapeutic aspects","volume":"171","author":"M\u00f3dis","year":"2014","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/bs.mie.2026.05.006_bib46","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"Motterlini","year":"2010","journal-title":"Nature Reviews. Drug Discovery"},{"key":"10.1016\/bs.mie.2026.05.006_bib47","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1039\/C8SC02610F","article-title":"Tetrazine-mediated bioorthogonal prodrug\u2013prodrug activation","volume":"9","author":"Neumann","year":"2018","journal-title":"Chemical Science"},{"key":"10.1016\/bs.mie.2026.05.006_bib48","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1039\/C7CS00184C","article-title":"Inverse electron demand Diels\u2013Alder reactions in chemical biology","volume":"46","author":"Oliveira","year":"2017","journal-title":"Chemical Society Reviews"},{"key":"10.1016\/bs.mie.2026.05.006_bib49","article-title":"The therapeutic potential of hydrogen sulfide: separating hype from hope","volume":"301","author":"Olson","year":"2011","journal-title":"American Journal of"},{"key":"10.1016\/bs.mie.2026.05.006_bib50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cbpa.2015.07.006","article-title":"Orthogonal bioorthogonal chemistries","volume":"28","author":"Patterson","year":"2015","journal-title":"Current Opinion in Chemical Biology"},{"key":"10.1016\/bs.mie.2026.05.006_bib51","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H\u2082S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/bs.mie.2026.05.006_bib52","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/bs.mie.2026.05.006_bib53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nchembio0605-13","article-title":"Chemistry in living systems","volume":"1","author":"Prescher","year":"2005","journal-title":"Nature Chemical Biology"},{"key":"10.1016\/bs.mie.2026.05.006_bib54","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1039\/D0SC00532K","article-title":"Dynamic pH responsivity of triazole-based self-immolative linkers","volume":"11","author":"Roberts","year":"2020","journal-title":"Chemical Science"},{"key":"10.1016\/bs.mie.2026.05.006_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03880-y","article-title":"Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice","volume":"9","author":"Rossin","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/bs.mie.2026.05.006_bib56","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1021\/acs.bioconjchem.6b00231","article-title":"Triggered drug release from an Antibody\u2013Drug conjugate using fast \u201cClick-to-Release\u201d chemistry in mice","volume":"27","author":"Rossin","year":"2016","journal-title":"Bioconjugate Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib57","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1002\/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4","article-title":"A stepwise huisgen cycloaddition process: Copper(I)-catalyzed regioselective \u2018ligation\u2019 of azides and terminal alkynes","volume":"41","author":"Rostovtsev","year":"2002","journal-title":"Angewandte Chemie (International Ed. in English)"},{"key":"10.1016\/bs.mie.2026.05.006_bib58","first-page":"2007","article-title":"Cell surface engineering by a modified Staudinger reaction","volume":"287","author":"Saxon","year":"2000","journal-title":"Science (1979)"},{"key":"10.1016\/bs.mie.2026.05.006_bib59","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1021\/jacs.4c15986","article-title":"Not so bioorthogonal chemistry","volume":"147","author":"Schauenburg","year":"2025","journal-title":"Journal of the American Chemical Society"},{"issue":"1 1","key":"10.1016\/bs.mie.2026.05.006_bib60","first-page":"1","article-title":"Bioorthogonal chemistry","volume":"1","author":"Scinto","year":"2021","journal-title":"Nature Reviews Methods Primers"},{"key":"10.1016\/bs.mie.2026.05.006_bib61","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1039\/C8GC01797B","article-title":"Thermal azide\u2013alkene cycloaddition reactions: Straightforward multi-gram access to \u03942-1,2,3-triazolines in deep eutectic solvents","volume":"20","author":"Sebest","year":"2018","journal-title":"Green Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib62","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1021\/jacs.5b13401","article-title":"Light-Activated Staudinger\u2013Bertozzi Ligation within living animals","volume":"138","author":"Shah","year":"2016","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib63","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1002\/anie.200900942","article-title":"Bioorthogonal chemistry: Fishing for selectivity in a sea of functionality","volume":"48","author":"Sletten","year":"2009","journal-title":"Angewandte Chemie (International Ed. in English)"},{"key":"10.1016\/bs.mie.2026.05.006_bib64","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/hlca.19190020164","article-title":"\u00dcber neue organische phosphorverbindungen III. Phosphinmethylenderivate und Phosphinimine","volume":"2","author":"Staudinger","year":"1919","journal-title":"Helvetica Chimica Acta"},{"key":"10.1016\/bs.mie.2026.05.006_bib65","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1111\/bph.12369","article-title":"Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms","volume":"171","author":"Szabo","year":"2014","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/bs.mie.2026.05.006_bib66","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrd.2015.1","article-title":"Gasotransmitters in cancer: From pathophysiology to experimental therapy","volume":"15","author":"Szabo","year":"2016","journal-title":"Nature Reviews. Drug Discovery"},{"key":"10.1016\/bs.mie.2026.05.006_bib67","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1073\/pnas.98.1.355","article-title":"The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O2","volume":"98","author":"Thomas","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/bs.mie.2026.05.006_bib68","doi-asserted-by":"crossref","first-page":"15631","DOI":"10.1021\/acs.analchem.4c02677","article-title":"Development of a bioorthogonal click-to-release reaction for hydrogen polysulfide (H2Sn) detection","volume":"96","author":"Tong","year":"2024","journal-title":"Analytical Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib69","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/jo011148j","article-title":"Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides","volume":"67","author":"Tornoe","year":"2002","journal-title":"The Journal of Organic Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib70","doi-asserted-by":"crossref","first-page":"8410","DOI":"10.1021\/jacs.8b05093","article-title":"Bioorthogonal removal of 3-isocyanopropyl groups enables the controlled release of fluorophores and drugs in vivo","volume":"140","author":"Tu","year":"2018","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib71","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1021\/jacs.0c00531","article-title":"Bioorthogonal tetrazine carbamate cleavage by highly reactive trans-cyclooctene","volume":"142","author":"Van Onzen","year":"2020","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/bs.mie.2026.05.006_bib72","doi-asserted-by":"crossref","first-page":"10494","DOI":"10.1002\/anie.201800402","article-title":"Click-to-release from trans-cyclooctenes: Mechanistic insights and expansion of scope from established carbamate to remarkable ether cleavage","volume":"57","author":"Versteegen","year":"2018","journal-title":"Angewandte Chemie (International Ed. in English)"},{"key":"10.1016\/bs.mie.2026.05.006_bib73","doi-asserted-by":"crossref","first-page":"14112","DOI":"10.1002\/anie.201305969","article-title":"Click to release: Instantaneous doxorubicin elimination upon tetrazine ligation","volume":"52","author":"Versteegen","year":"2013","journal-title":"Angewandte Chemie - International Edition"},{"key":"10.1016\/bs.mie.2026.05.006_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2025.1643663","article-title":"Activity evaluation of multifunctional H2S donors for anti-inflammatory, cardioprotective, and hepatoprotective applications","volume":"13","author":"Wang","year":"2025","journal-title":"Frontiers in Chemistry"},{"key":"10.1016\/bs.mie.2026.05.006_bib75","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1021\/acscentsci.1c00124","article-title":"Unleashing the power of bond cleavage chemistry in living systems","volume":"7","author":"Wang","year":"2021","journal-title":"ACS Central Science"},{"key":"10.1016\/bs.mie.2026.05.006_bib76","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/cr000040l","article-title":"Nitric oxide donors: Chemical activities and biological applications","volume":"102","author":"Wang","year":"2002","journal-title":"Chemical Reviews"},{"key":"10.1016\/bs.mie.2026.05.006_bib77","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiological Reviews"},{"issue":"1","key":"10.1016\/bs.mie.2026.05.006_bib78","first-page":"15","article-title":"Sydnthiones are versatile bioorthogonal hydrogen sulfide donors","volume":"15","author":"Xu","year":"2024","journal-title":"Nature Communications 2024"},{"key":"10.1016\/bs.mie.2026.05.006_bib79","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1002\/anie.201202122","article-title":"Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions","volume":"51","author":"Yang","year":"2012","journal-title":"Angewandte Chemie (International Ed. in English)"},{"key":"10.1016\/bs.mie.2026.05.006_bib80","doi-asserted-by":"crossref","first-page":"14638","DOI":"10.1002\/anie.201608052","article-title":"Hydrogen sulfide donors activated by reactive oxygen species","volume":"55","author":"Zhao","year":"2016","journal-title":"Angewandte Chemie - International Edition"},{"key":"10.1016\/bs.mie.2026.05.006_bib81","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/med.22095","article-title":"Advances in the delivery, activation and therapeutics applications of bioorthogonal prodrugs","volume":"45","author":"Zhou","year":"2025","journal-title":"Medicinal Research Reviews"}],"container-title":["Methods in Enzymology","Bioorthogonal Labeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687926001217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687926001217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:51:47Z","timestamp":1782406307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0076687926001217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443432248"],"references-count":81,"URL":"https:\/\/doi.org\/10.1016\/bs.mie.2026.05.006","relation":{},"ISSN":["0076-6879"],"issn-type":[{"value":"0076-6879","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}