{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:14:00Z","timestamp":1789071240101,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier","isbn-type":[{"value":"9780443474804","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.mie.2026.06.016","type":"book-chapter","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:21:51Z","timestamp":1784114511000},"page":"217-234","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of lysine modified peptides and their cell penetrating peptide conjugates with sirtuin activity inhibition properties and intracellular delivery"],"prefix":"10.1016","author":[{"given":"Kamal D.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Aricthota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayan Heruka","family":"De Zoysa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalekshmi","family":"Sarojini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devyani","family":"Haldar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"26","key":"10.1016\/bs.mie.2026.06.016_bib1","doi-asserted-by":"crossref","first-page":"15113","DOI":"10.1073\/pnas.261574398","article-title":"Identification of a small molecule inhibitor of Sir2p","volume":"98","author":"Bedalov","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.mie.2026.06.016_bib2","article-title":"Quantitation of apoptosis and necrosis by annexin V binding, propidium iodide uptake, and flow cytometry","author":"Crowley","year":"2016","journal-title":"Cold Spring Harb Protocol Cold Spring Harbor Protocols"},{"issue":"1","key":"10.1016\/bs.mie.2026.06.016_bib3","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1080\/10717544.2017.1321060","article-title":"Cell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancer","volume":"24","author":"Duan","year":"2017","journal-title":"Drug Delivery"},{"issue":"14","key":"10.1016\/bs.mie.2026.06.016_bib4","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1016\/j.bmcl.2006.04.075","article-title":"Nepsilon-thioacetyl-lysine: A multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation","volume":"16","author":"Fatkins","year":"2006","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"1","key":"10.1016\/bs.mie.2026.06.016_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms9010001","article-title":"Substituting N-epsilon-thioacetyl-lysine for N-epsilon-acetyl-lysine in peptide substrates as a general approach to inhibiting human NAD(+)-dependent protein deacetylases","volume":"9","author":"Fatkins","year":"2008","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/bs.mie.2026.06.016_bib6","article-title":"A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition","volume":"6","author":"Gill","year":"2016","journal-title":"Scientific Reports"},{"issue":"42","key":"10.1016\/bs.mie.2026.06.016_bib7","doi-asserted-by":"crossref","first-page":"38837","DOI":"10.1074\/jbc.M106779200","article-title":"Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening","volume":"276","author":"Grozinger","year":"2001","journal-title":"Journal of Biological Chemistry"},{"issue":"8","key":"10.1016\/bs.mie.2026.06.016_bib8","doi-asserted-by":"crossref","first-page":"945","DOI":"10.4155\/fmc.14.44","article-title":"Sirtuin inhibitors as anticancer agents","volume":"6","author":"Hu","year":"2014","journal-title":"Future Medicinal Chemistry"},{"issue":"15","key":"10.1016\/bs.mie.2026.06.016_bib9","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1016\/j.bmc.2010.06.035","article-title":"N-epsilon-modified lysine containing inhibitors for SIRT1 and SIRT2","volume":"18","author":"Huhtiniemi","year":"2010","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10.1016\/bs.mie.2026.06.016_bib10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.biopha.2017.03.056","article-title":"The role of SIRT1 in diabetic cardiomyopathy","volume":"90","author":"Karbasforooshan","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"7","key":"10.1016\/bs.mie.2026.06.016_bib11","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1021\/jm801401k","article-title":"N-epsilon-thioacetyl-lysine-containing Tri-, Tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors","volume":"52","author":"Kiviranta","year":"2009","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/bs.mie.2026.06.016_bib12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fnagi.2019.00372","article-title":"Emerging role of sirtuin 2 in parkinson\u2019s disease","volume":"11","author":"Liu","year":"2020","journal-title":"Frontiers in\u00a0Aging Neuroscience"},{"issue":"12","key":"10.1016\/bs.mie.2026.06.016_bib13","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1349-7006.1999.tb00722.x","article-title":"Cisplatin-resistant HeLa cells are resistant to apoptosis via p53-dependent and -independent pathways","volume":"90","author":"Minagawa","year":"1999","journal-title":"Japanese Journal of Cancer Research"},{"issue":"18","key":"10.1016\/bs.mie.2026.06.016_bib14","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.1158\/1078-0432.CCR-05-0450","article-title":"Enhancement of cisplatin sensitivity of cisplatin-resistant human cervical carcinoma cells by bryostatin 1","volume":"11","author":"Mohanty","year":"2005","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/bs.mie.2026.06.016_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2012.00016","article-title":"Structures, substrates, and regulators of mammalian Sirtuins - opportunities and challenges for drug development","volume":"3","author":"Moniot","year":"2012","journal-title":"Frontiers in Pharmacology"},{"issue":"14","key":"10.1016\/bs.mie.2026.06.016_bib16","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1002\/anie.201108118","article-title":"Discovery of macrocyclic peptides armed with a mechanism-based warhead: Isoform-selective inhibition of human deacetylase SIRT2","volume":"51","author":"Morimoto","year":"2012","journal-title":"Angewandte Chemie (International Ed. in English)"},{"issue":"6","key":"10.1016\/bs.mie.2026.06.016_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01894-17","article-title":"Ancient regulatory role of lysine acetylation in central metabolism","volume":"8","author":"Nakayasu","year":"2017","journal-title":"Mbio"},{"key":"10.1016\/bs.mie.2026.06.016_bib18","doi-asserted-by":"crossref","first-page":"6268","DOI":"10.1039\/c3cc42840k","article-title":"AlCl3-mediated hydroarylation-heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest","volume":"49","author":"Nakhi","year":"2013","journal-title":"Chemical Communications (Cambridge, England)"},{"issue":"2","key":"10.1016\/bs.mie.2026.06.016_bib19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1097-2765(03)00038-8","article-title":"The human Sir2 ortholog, SIRT2, is an NAD(+)-dependent tubulin deacetylase","volume":"11","author":"North","year":"2003","journal-title":"Molecular Cell"},{"issue":"1","key":"10.1016\/bs.mie.2026.06.016_bib20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1021\/acs.jmedchem.9b01694","article-title":"Novel cell-penetrating peptide conjugated proteasome inhibitors: anticancer and antifungal investigations","volume":"63","author":"Patel","year":"2020","journal-title":"Journal of Medicinal Chemistry"},{"issue":"5","key":"10.1016\/bs.mie.2026.06.016_bib21","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.bmcl.2012.12.089","article-title":"Spiro heterocycles as potential inhibitors of SIRT1: Pd\/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2 \u2019-quinazolines","volume":"23","author":"Rambabu","year":"2013","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/bs.mie.2026.06.016_bib22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/abr.abr_142_19","article-title":"Histone deacetylases and histone deacetylase inhibitors: Molecular mechanisms of action in various cancers","volume":"8","author":"Sanaei","year":"2019","journal-title":"Advanced Biomedical Research"},{"issue":"4","key":"10.1016\/bs.mie.2026.06.016_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: The histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"15","key":"10.1016\/bs.mie.2026.06.016_bib24","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1242\/jcs.187518","article-title":"SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6","volume":"129","author":"Skoge","year":"2016","journal-title":"Journal of Cell Science"},{"issue":"3","key":"10.1016\/bs.mie.2026.06.016_bib25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1023\/B:PHAM.0000019289.61978.f5","article-title":"Cell penetrating peptides in drug delivery","volume":"21","author":"Snyder","year":"2004","journal-title":"Pharmaceutical Research"},{"issue":"6","key":"10.1016\/bs.mie.2026.06.016_bib26","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.cell.2014.03.061","article-title":"Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase","volume":"157","author":"Szyk","year":"2014","journal-title":"Cell"},{"issue":"7","key":"10.1016\/bs.mie.2026.06.016_bib27","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1021\/cb300709g","article-title":"Cell-penetrating bisubstrate-based protein kinase C inhibitors","volume":"8","author":"van Wandelen","year":"2013","journal-title":"ACS Chemical Biology"},{"issue":"2","key":"10.1016\/bs.mie.2026.06.016_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.str.2013.12.001","article-title":"Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change","volume":"22","author":"Yamagata","year":"2014","journal-title":"Structure (London, England: 1993)"},{"key":"10.1016\/bs.mie.2026.06.016_bib29","first-page":"650","article-title":"Cellular uptake and anti-tumor activity of gemcitabine conjugated with new amphiphilic cell penetrating peptides","volume":"16","author":"Zakeri-Milani","year":"2017","journal-title":"Excli Journal"},{"key":"10.1016\/bs.mie.2026.06.016_bib30","first-page":"135","article-title":"Lysine post-translational modifications and the cytoskeleton","volume":"52","author":"Zencheck","year":"2012","journal-title":"Lysine-Based Post-Translational Modification of Proteins"},{"key":"10.1016\/bs.mie.2026.06.016_fur1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-62703-383-1_7","article-title":"Analysis of cell death by electron microscopy","volume":"1004","author":"Burattini","year":"2013","journal-title":"Methods in Molecular Biology"},{"issue":"4","key":"10.1016\/bs.mie.2026.06.016_fur2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicologic Pathology"},{"issue":"2","key":"10.1016\/bs.mie.2026.06.016_fur3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1369-5274(00)00064-3","article-title":"The Sir proteins of Saccharomyces cerevisiae: Mediators of transcriptional silencing and much more","volume":"3","author":"Gartenberg","year":"2000","journal-title":"Current Opinion in Microbiology"},{"issue":"8","key":"10.1016\/bs.mie.2026.06.016_fur4","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1074\/jbc.M113.487736","article-title":"A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer","volume":"289","author":"Hoffmann","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.mie.2026.06.016_fur5","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-018-4710-1","article-title":"Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines","volume":"18","author":"Kozako","year":"2018","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/bs.mie.2026.06.016_fur6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1371\/journal.pgen.0020040","article-title":"Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation","volume":"2","author":"Pruitt","year":"2006","journal-title":"PLoS Genetics"}],"container-title":["Methods in Enzymology","Histone Deacetylases in Neurodegenerative Disease - Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687926002302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687926002302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:05:37Z","timestamp":1789070737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0076687926002302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443474804"],"references-count":36,"URL":"https:\/\/doi.org\/10.1016\/bs.mie.2026.06.016","relation":{},"ISSN":["0076-6879"],"issn-type":[{"value":"0076-6879","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}