{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:15:33Z","timestamp":1790615733079,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier","isbn-type":[{"value":"9780443521607","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.mie.2026.07.033","type":"book-chapter","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:21:32Z","timestamp":1787224892000},"page":"217-252","source":"Crossref","is-referenced-by-count":0,"title":["YerE-like enzymes for the synthesis of tertiary alcohols"],"prefix":"10.1016","author":[{"given":"Lucrezia","family":"Lanza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Bjarnesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.mie.2026.07.033_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202500200","article-title":"Diversity of ThDP-dependent enzymes forming chiral tertiary alcohols","volume":"26","author":"Bjarnesen","year":"2025","journal-title":"Chembiochem: a European Journal of Chemical Biology"},{"key":"10.1016\/bs.mie.2026.07.033_bib2","article-title":"Chai-1: Decoding the molecular interactions of life","author":"Boitreaud","year":"2024","journal-title":"BioRxiv. Advance online publication"},{"issue":"45","key":"10.1016\/bs.mie.2026.07.033_bib3","doi-asserted-by":"crossref","first-page":"11796","DOI":"10.1021\/ja983071v","article-title":"Biosynthesis of Yersiniose: Attachment of the two-carbon branched-chain is catalyzed by a thiamine pyrophosphate-dependent flavoprotein","volume":"120","author":"Chen","year":"1998","journal-title":"Journal of the American Chemical Society"},{"issue":"9","key":"10.1016\/bs.mie.2026.07.033_bib4","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/glycob\/cwr010","article-title":"Genetic analysis of the O-antigen gene clusters of Yersinia pseudotuberculosis O:6 and O:7","volume":"21","author":"Cunneen","year":"2011","journal-title":"Glycobiology"},{"issue":"W1","key":"10.1016\/bs.mie.2026.07.033_bib5","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkae410","article-title":"The Galaxy platform for accessible, reproducible, and collaborative data analyses: 2024 update","volume":"52","year":"2024","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/bs.mie.2026.07.033_bib6","series-title":"The proteomics protocols handbook","first-page":"571","article-title":"Protein identification and analysis tools on the expasy server","author":"Gasteiger","year":"2005"},{"issue":"1","key":"10.1016\/bs.mie.2026.07.033_bib7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12934-016-0452-4","article-title":"New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis","volume":"15","author":"Gonz\u00e1lez","year":"2016","journal-title":"Microbial Cell Factories"},{"issue":"2","key":"10.1016\/bs.mie.2026.07.033_bib8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0008-6215(84)85389-6","article-title":"Yersiniose, a new branched-chain sugar","volume":"126","author":"Gorshkova","year":"1984","journal-title":"Carbohydrate Research"},{"issue":"21","key":"10.1016\/bs.mie.2026.07.033_bib9","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/cbic.201800325","article-title":"Structural and mutagenesis studies of the thiamine-dependent, ketone-accepting YerE from Pseudomonas protegens","volume":"19","author":"Hampel","year":"2018","journal-title":"Chembiochem: a European Journal of Chemical Biology"},{"key":"10.1016\/bs.mie.2026.07.033_bib10","unstructured":"Krug, L. (2022). ThDP-dependent branching and related modifications in keto sugars of natural products. Dissertation. Albert-Ludwigs Universit\u00e4t Freiburg."},{"issue":"42","key":"10.1016\/bs.mie.2026.07.033_bib11","article-title":"Identification of kibdelomycin and related biosynthetic gene clusters and characterization of the c-branching of amycolose","volume":"63","author":"Krug","year":"2024","journal-title":"Angewandte Chemie International Edition"},{"key":"10.1016\/bs.mie.2026.07.033_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202500890","article-title":"Engineering of the thiamine diphosphate-dependent JanthE for the synthesis of tertiary alcohols","volume":"31","author":"Lanza","year":"2025","journal-title":"Chemistry-a European Journal"},{"issue":"34","key":"10.1016\/bs.mie.2026.07.033_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202404045","article-title":"Identification and characterization of thiamine diphosphate-dependent lyases with an unusual CDG motif","volume":"63","author":"Lanza","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/bs.mie.2026.07.033_bib14","unstructured":"Lehwald, P. (2009). Biokatalytische Synthese terti\u00e4rer Alkohole mittels asymmetrischer Carboligationsreaktion unter Verwendung eines Thiamindiphosphat-abh\u00e4ngigen Enzyms. Dissertation. Albert-Ludwigs Universit\u00e4t Freiburg."},{"issue":"13","key":"10.1016\/bs.mie.2026.07.033_bib15","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/anie.200906181","article-title":"Enantioselective intermolecular aldehyde-ketone cross-coupling through an enzymatic carboligation reaction","volume":"49","author":"Lehwald","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/bs.mie.2026.07.033_bib16","unstructured":"Loschonsky, S. (2014). Untersuchungen zur C-C-Bindungskn\u00fcpfungs- und C-C-Bindungsspaltungs-Aktivit\u00e4t des Thiamindiphosphat-abh\u00e4ngigen Enzyms Cyclohexan-1,2-dion Hydrolase. Dissertation. Albert-Ludwigs Universit\u00e4t Freiburg."},{"issue":"11","key":"10.1016\/bs.mie.2026.07.033_bib17","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Research"},{"key":"10.1016\/bs.mie.2026.07.033_bib18","unstructured":"Steitz, J.\u2011P. (2019). Characterisation of ThDP-dependent enzymes from the biosynthesis of longer-branched sugars. Dissertation. Albert-Ludwigs Universit\u00e4t Freiburg."},{"issue":"12","key":"10.1016\/bs.mie.2026.07.033_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202113405","article-title":"Unifying scheme for the biosynthesis of acyl-branched sugars: Extended substrate scope of thiamine-dependent enzymes","volume":"61","author":"Steitz","year":"2022","journal-title":"Angewandte Chemie International Edition"},{"issue":"1","key":"10.1016\/bs.mie.2026.07.033_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pep.2005.01.016","article-title":"Protein production by auto-induction in high density shaking cultures","volume":"41","author":"Studier","year":"2005","journal-title":"Protein Expression and Purification"},{"issue":"51","key":"10.1016\/bs.mie.2026.07.033_bib21","doi-asserted-by":"crossref","first-page":"9814","DOI":"10.1002\/anie.200801204","article-title":"Natural-product sugar biosynthesis and enzymatic glycodiversification","volume":"47","author":"Thibodeaux","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"issue":"5","key":"10.1016\/bs.mie.2026.07.033_bib22","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/acssynbio.3c00055","article-title":"Biosynthesis and engineered overproduction of everninomicins with promising activity against multidrug-resistant bacteria","volume":"12","author":"Zhu","year":"2023","journal-title":"ACS Synthetic Biology"}],"container-title":["Methods in Enzymology","Thiamine Pyrophosphate (TPP)-Dependent Enzymes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687926002752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687926002752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:28:09Z","timestamp":1790612889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0076687926002752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443521607"],"references-count":22,"URL":"https:\/\/doi.org\/10.1016\/bs.mie.2026.07.033","relation":{},"ISSN":["0076-6879"],"issn-type":[{"value":"0076-6879","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}