{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T22:40:23Z","timestamp":1758753623248,"version":"3.44.0"},"reference-count":350,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780444642608"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/bs.pbr.2020.01.002","type":"book-chapter","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T17:05:13Z","timestamp":1581354313000},"page":"217-270","source":"Crossref","is-referenced-by-count":6,"title":["Pathways of protein synthesis and degradation in PD pathogenesis"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.pbr.2020.01.002_bb0010","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1021\/bi501512m","article-title":"Extent of inhibition of \u03b1-synuclein aggregation in vitro by SUMOylation is conjugation site- and SUMO isoform-selective","volume":"54","author":"Abeywardana","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0015","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuron.2017.01.018","article-title":"The complicated relationship between Gaucher disease and parkinsonism: insights from a rare disease","volume":"93","author":"Aflaki","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0020","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/jamaneurol.2014.313","article-title":"Comparison of Parkinson risk in Ashkenazi Jewish patients with Gaucher disease and GBA heterozygotes","volume":"71","author":"Alcalay","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0025","doi-asserted-by":"crossref","first-page":"E4688","DOI":"10.1073\/pnas.1523597113","article-title":"Deubiquitinase Usp8 regulates \u03b1-synuclein clearance and modifies its toxicity in Lewy body disease","volume":"113","author":"Alexopoulou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0030","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/archneurol.2010.198","article-title":"Chaperone-mediated autophagy markers in Parkinson disease brains","volume":"67","author":"Alvarez-Erviti","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0035","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0304-3940(00)01049-1","article-title":"\u03b1-Synuclein and the Parkinson's disease-related mutant Ala53Thr-\u03b1-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells","volume":"285","author":"Ancolio","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0040","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.M600933200","article-title":"Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease","volume":"281","author":"Anderson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0045","first-page":"25","article-title":"Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease","volume":"12","author":"Anglade","year":"1997","journal-title":"Histol. Histopathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-017-0452-6","article-title":"Mechanisms underlying extensive Ser129-phosphorylation in \u03b1-synuclein aggregates","volume":"5","author":"Arawaka","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0055","doi-asserted-by":"crossref","first-page":"12842","DOI":"10.1074\/jbc.M608243200","article-title":"Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation","volume":"282","author":"Avraham","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0060","first-page":"879","article-title":"Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies","volume":"152","author":"Baba","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0065","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/nan.12260","article-title":"Unfolded protein response is activated in Lewy body dementias: UPR activation in Lewy body dementias","volume":"42","author":"Baek","year":"2016","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0070","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00005072-198901000-00007","article-title":"An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination","volume":"48","author":"Bancher","year":"1989","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.brainresbull.2016.12.004","article-title":"Parkin and PINK1 functions in oxidative stress and neurodegeneration","volume":"133","author":"Barodia","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.brainres.2015.06.002","article-title":"Post-translational modification of \u03b1-synuclein in Parkinson's disease","volume":"1628","author":"Barrett","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0085","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/ana.20939","article-title":"The proteasomal inhibition model of Parkinson's disease: \u201cBoon or bust\u201d?","volume":"60","author":"Beal","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0090","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1523\/JNEUROSCI.2218-08.2008","article-title":"Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies","volume":"28","author":"Bedford","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0095","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1073\/pnas.1318306111","article-title":"Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease","volume":"111","author":"Beilina","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0100","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/hmg\/ddr502","article-title":"The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant \u03b1-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins","volume":"21","author":"Belal","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0105","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1471-4159.2010.07143.x","article-title":"Induction of the unfolded protein response by \u03b1-synuclein in experimental models of Parkinson's disease: \u03b1-synuclein accumulation induces the UPR","volume":"116","author":"Bellucci","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0110","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.292.5521.1552","article-title":"Impairment of the ubiquitin-proteasome system by protein aggregation","volume":"292","author":"Bence","year":"2001","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0115","doi-asserted-by":"crossref","first-page":"33855","DOI":"10.1074\/jbc.274.48.33855","article-title":"Degradation of alpha-synuclein by proteasome","volume":"274","author":"Bennett","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0120","first-page":"31","article-title":"The proteasome inhibition model of Parkinson's disease","volume":"7","author":"Bentea","year":"2017","journal-title":"J. Park. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11803","article-title":"The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway","volume":"7","author":"Bento","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0130","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201744617","article-title":"Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation","volume":"19","author":"Betzer","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0135","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.biophys.28.1.295","article-title":"The proteasome","volume":"28","author":"Bochtler","year":"1999","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0140","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3389\/fneur.2018.01021","article-title":"A meta-analysis of \u03b1-synuclein multiplication in familial parkinsonism","volume":"9","author":"Book","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0145","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/cdd.2010.142","article-title":"Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress","volume":"18","author":"Bouman","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0150","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ana.20937","article-title":"Proteasome inhibition and Parkinson's disease modeling","volume":"60","author":"Bov\u00e9","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0155","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1126\/science.1101902","article-title":"A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress","volume":"307","author":"Boyce","year":"2005","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0160","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00018-012-1061-y","article-title":"The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK\/ERK pathway","volume":"70","author":"Bravo-San Pedro","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0165","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/416507a","article-title":"Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases","volume":"416","author":"Bucciantini","year":"2002","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0170","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.brainres.2010.02.045","article-title":"A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy","volume":"1326","author":"Bukhatwa","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0175","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.aam9080","article-title":"Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease","volume":"357","author":"Burbulla","year":"2017","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0180","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03522","article-title":"Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling","volume":"4","author":"Carrara","year":"2015","journal-title":"eLife"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0185","doi-asserted-by":"crossref","DOI":"10.1186\/s13062-017-0176-3","article-title":"Post translational modification of Parkin","volume":"12","author":"Chakraborty","year":"2017","journal-title":"Biol. Direct"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0190","doi-asserted-by":"crossref","first-page":"28733","DOI":"10.1074\/jbc.M404272200","article-title":"Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress","volume":"279","author":"Chan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0195","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/ng.3955","article-title":"A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci","volume":"49","author":"Chang","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0200","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","article-title":"Alpha-synuclein locus duplication as a cause of familial Parkinson's disease","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0205","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ajhg.2011.08.009","article-title":"Translation initiator EIF4G1 mutations in familial Parkinson disease","volume":"89","author":"Chartier-Harlin","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0210","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1038\/emboj.2011.204","article-title":"Autoregulation of Parkin activity through its ubiquitin-like domain","volume":"30","author":"Chaugule","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0215","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s00439-003-1002-9","article-title":"Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene","volume":"113","author":"Chiba-Falek","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0220","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/mds.21007","article-title":"Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients","volume":"21","author":"Chiba-Falek","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0225","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1093\/hmg\/dds070","article-title":"Regulation of parkin and PINK1 by neddylation","volume":"21","author":"Choo","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0230","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/01.jnen.0000229233.75253.be","article-title":"Autophagic stress in neuronal injury and disease","volume":"65","author":"Chu","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0235","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.nbd.2009.05.023","article-title":"Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions","volume":"35","author":"Chu","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0240","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.1093891","article-title":"S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function","volume":"304","author":"Chung","year":"2004","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0245","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.1245296","article-title":"Identification and rescue of \u03b1-synuclein toxicity in Parkinson patient-derived neurons","volume":"342","author":"Chung","year":"2013","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2012.10.010","article-title":"Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage","volume":"62","author":"Cleeter","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0255","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1523\/JNEUROSCI.5367-11.2012","article-title":"Endoplasmic reticulum stress is important for the manifestations of \u03b1-synucleinopathy in vivo","volume":"32","author":"Colla","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0260","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2004.07.026","article-title":"Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology","volume":"1022","author":"Conn","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0265","doi-asserted-by":"crossref","first-page":"a009415","DOI":"10.1101\/cshperspect.a009415","article-title":"Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways","volume":"2","author":"Cookson","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"year":"2000","series-title":"The Cell: A Molecular Approach","author":"Cooper","key":"10.1016\/bs.pbr.2020.01.002_bb0270"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0275","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1126\/science.1129462","article-title":"Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models","volume":"313","author":"Cooper","year":"2006","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0280","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/227561a0","article-title":"Central dogma of molecular biology","volume":"227","author":"Crick","year":"1970","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0285","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1093\/hmg\/ddp265","article-title":"Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain","volume":"18","author":"Cronin","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0290","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1126\/science.1101738","article-title":"Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy","volume":"305","author":"Cuervo","year":"2004","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0295","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1756-6606-2-5","article-title":"Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo","volume":"2","author":"Cullen","year":"2009","journal-title":"Mol. Brain"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0300","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/mds.21223","article-title":"The ups and downs of alpha-synuclein mRNA expression","volume":"22","author":"D\u00e4chsel","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0305","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.nbd.2013.12.011","article-title":"Enhanced ubiquitin-dependent degradation by Nedd4 protects against \u03b1-synuclein accumulation and toxicity in animal models of Parkinson's disease","volume":"64","author":"Davies","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0310","doi-asserted-by":"crossref","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from \u03b1-synuclein toxicity","volume":"110","author":"Decressac","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0315","doi-asserted-by":"crossref","first-page":"12535","DOI":"10.1523\/JNEUROSCI.1920-10.2010","article-title":"Pathogenic lysosomal depletion in Parkinson's disease","volume":"30","author":"Dehay","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0320","doi-asserted-by":"crossref","first-page":"9611","DOI":"10.1073\/pnas.1112368109","article-title":"Loss of P-type ATPase ATP13A2\/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration","volume":"109","author":"Dehay","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0325","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuron.2014.11.027","article-title":"Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on \u03b1-synuclein","volume":"85","author":"Dhungel","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0330","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1046\/j.1471-4159.2003.01885.x","article-title":"Characterization of chronic low-level proteasome inhibition on neural homeostasis","volume":"86","author":"Ding","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0335","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/hmg\/ddr573","article-title":"Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning","volume":"21","author":"Dodson","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0340","first-page":"1351","article-title":"Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo","volume":"7","author":"Dodson","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0345","first-page":"2124","article-title":"ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1","volume":"126","author":"Duplan","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0350","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201489729","article-title":"USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin","volume":"33","author":"Durcan","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0355","doi-asserted-by":"crossref","first-page":"14508","DOI":"10.1523\/JNEUROSCI.1560-11.2011","article-title":"Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of \u03b1-synuclein","volume":"31","author":"Ebrahimi-Fakhari","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0360","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1074\/jbc.M110.156430","article-title":"The endoplasmic reticulum stress sensor, ATF6\u03b1, protects against neurotoxin-induced dopaminergic neuronal death","volume":"286","author":"Egawa","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0365","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neurobiolaging.2008.07.008","article-title":"Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome","volume":"31","author":"Emmanouilidou","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0370","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1590\/0004-282x20170116","article-title":"Lafora and Tr\u00e9tiakoff: the naming of the inclusion bodies discovered by Lewy","volume":"75","author":"Engelhardt","year":"2017","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0375","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/hmg\/10.17.1847","article-title":"alpha-Synuclein gene haplotypes are associated with Parkinson's disease","volume":"10","author":"Farrer","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0380","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/ana.10846","article-title":"Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications","volume":"55","author":"Farrer","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0385","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0390","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/tra.12136","article-title":"The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer: Parkinson's disease causing mutation alters retromer's function","volume":"15","author":"Follett","year":"2014","journal-title":"Traffic"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0395","doi-asserted-by":"crossref","first-page":"8955","DOI":"10.1523\/JNEUROSCI.23-26-08955.2003","article-title":"Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition","volume":"23","author":"Fornai","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0400","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1073\/pnas.0409713102","article-title":"Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein","volume":"102","author":"Fornai","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0405","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-5793(97)00148-8","article-title":"Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein","volume":"405","author":"Friguet","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0410","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1212\/01.wnl.0000254458.17630.c5","article-title":"Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication","volume":"68","author":"Fuchs","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0415","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1096\/fj.07-9348com","article-title":"Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain","volume":"22","author":"Fuchs","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0420","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"alpha-Synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0425","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1212\/WNL.0b013e31828f180e","article-title":"The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease","volume":"80","author":"Gan-Or","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0430","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071634","article-title":"Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease","volume":"8","author":"Gardai","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0435","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1126\/science.1209126","article-title":"Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response","volume":"333","author":"Gardner","year":"2011","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0440","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ana.23614","article-title":"Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains","volume":"72","author":"Gegg","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0445","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature09191","article-title":"Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression","volume":"466","author":"Gehrke","year":"2010","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0450","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cmet.2014.12.007","article-title":"PINK1 and parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane","volume":"21","author":"Gehrke","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0455","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1046\/j.1471-4159.2000.0752221.x","article-title":"Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex","volume":"75","author":"Ghee","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0460","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.290.5493.985","article-title":"Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions","volume":"290","author":"Giasson","year":"2000","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0465","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","article-title":"eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation","volume":"68","author":"Gingras","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0470","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1073\/pnas.0710685105","article-title":"The Parkinson's disease protein-synuclein disrupts cellular Rab homeostasis","volume":"105","author":"Gitler","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0475","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/jmg.2004.024455","article-title":"Parkinsonism among Gaucher disease carriers","volume":"41","author":"Goker-Alpan","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0480","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/hmg\/ddr481","article-title":"Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP","volume":"21","author":"G\u00f3mez-Suaga","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0485","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s00702-004-0212-1","article-title":"Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion\/cellular matrix and vesicle trafficking genes","volume":"111","author":"Gr\u00fcnblatt","year":"2004","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0490","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/nar\/gkn084","article-title":"Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease","volume":"36","author":"Gr\u00fcndemann","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0495","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1074\/jbc.270.5.2344","article-title":"Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome","volume":"270","author":"Grune","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0500","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen. Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0505","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.nbd.2011.12.015","article-title":"ATP13A2 regulates mitochondrial bioenergetics through macroautophagy","volume":"45","author":"Gusdon","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0510","doi-asserted-by":"crossref","first-page":"17726","DOI":"10.1073\/pnas.1315654110","article-title":"Synthetic polyubiquitinated \u03b1-synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology","volume":"110","author":"Haj-Yahya","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0515","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bcmd.2006.02.004","article-title":"Increased incidence of Parkinson disease among relatives of patients with Gaucher disease","volume":"36","author":"Halperin","year":"2006","journal-title":"Blood Cells. Mol. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0520","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1247\/csf.28.49","article-title":"The early secretory pathway contributes to autophagy in yeast","volume":"28","author":"Hamasaki","year":"2003","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0525","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/35005107","article-title":"An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells","volume":"404","author":"Hammond","year":"2000","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0530","doi-asserted-by":"crossref","first-page":"702","DOI":"10.2174\/1389203717666160311121954","article-title":"The effects of variants in the parkin, PINK1, and DJ-1 genes along with evidence for their pathogenicity","volume":"18","author":"Hauser","year":"2017","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0535","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1021\/acschemneuro.8b00288","article-title":"Alpha-synuclein nitration and its implications in Parkinson's disease","volume":"10","author":"He","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0540","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.6610213","article-title":"Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice","volume":"224","author":"Heikkila","year":"1984","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0545","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ana.410440223","article-title":"Failure to replicate a protective effect of allele 2 of NACP\/alpha-synuclein polymorphism in Alzheimer's disease: an association study","volume":"44","author":"Hellman","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0550","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1093\/hmg\/ddx331","article-title":"Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons","volume":"26","author":"Heman-Ackah","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0555","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1073\/pnas.81.6.1619","article-title":"ATP-dependent degradation of ubiquitin-protein conjugates","volume":"81","author":"Hershko","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0560","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1046\/j.1471-4159.2003.01952.x","article-title":"Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease","volume":"86","author":"H\u00f6glinger","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0565","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1073\/pnas.0611671104","article-title":"The pRb\/E2F cell-cycle pathway mediates cell death in Parkinson's disease","volume":"104","author":"H\u00f6glinger","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0570","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nrm1618","article-title":"Translational control in stress and apoptosis","volume":"6","author":"Holcik","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0575","doi-asserted-by":"crossref","first-page":"19367","DOI":"10.1074\/jbc.M211821200","article-title":"Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons","volume":"278","author":"Holtz","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0580","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbrc.2007.01.043","article-title":"Activation of the unfolded protein response in Parkinson's disease","volume":"354","author":"Hoozemans","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0585","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1093\/hmg\/ddg269","article-title":"The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI","volume":"12","author":"Huynh","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0590","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0140-6736(04)17104-3","article-title":"Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease","volume":"364","author":"Ib\u00e1\u00f1ez","year":"2004","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0595","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00005072-199702000-00002","article-title":"Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly","volume":"56","author":"Ii","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0600","doi-asserted-by":"crossref","first-page":"35661","DOI":"10.1074\/jbc.C000447200","article-title":"Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity","volume":"275","author":"Imai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0605","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0092-8674(01)00407-X","article-title":"An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin","volume":"105","author":"Imai","year":"2001","journal-title":"Cell"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0610","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1038\/emboj.2008.163","article-title":"Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila","volume":"27","author":"Imai","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0615","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/hmg\/ddx179","article-title":"Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila","volume":"26","author":"Inoshita","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0620","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0140-6736(10)62345-8","article-title":"Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies","volume":"377","author":"IPDGC","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0625","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1016\/j.febslet.2007.08.067","article-title":"Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies","volume":"581","author":"Ishii","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0630","first-page":"1517","article-title":"Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease","volume":"148","author":"Iwatsubo","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0635","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0304-3940(01)01557-9","article-title":"Genetic studies in Parkinson's disease with an alpha-synuclein\/NACP gene polymorphism in Japan","volume":"300","author":"Izumi","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0640","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1074\/mcp.M600182-MCP200","article-title":"Identification of novel proteins associated with both \u03b1-synuclein and DJ-1","volume":"6","author":"Jin","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0645","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1212\/01.WNL.0000133401.09043.44","article-title":"SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies","volume":"63","author":"Johnson","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0650","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1083\/jcb.143.7.1883","article-title":"Aggresomes: a cellular response to misfolded proteins","volume":"143","author":"Johnston","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0655","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1212\/01.WNL.0000145710.25588.2F","article-title":"Heterozygous niemann-pick disease type C presenting with tremor","volume":"63","author":"Josephs","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0660","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1523\/JNEUROSCI.6119-09.2010","article-title":"Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients\u2019 brains","volume":"30","author":"Jowaed","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0665","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1042\/BCJ20170699","article-title":"P62\/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity","volume":"475","author":"Kalogeropulou","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0670","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1083\/jcb.201402104","article-title":"PINK1 phosphorylates ubiquitin to activate parkin E3 ubiquitin ligase activity","volume":"205","author":"Kane","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0675","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1101\/gad.13.10.1211","article-title":"Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls","volume":"13","author":"Kaufman","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0680","doi-asserted-by":"crossref","first-page":"939","DOI":"10.15252\/embr.201540352","article-title":"Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation","volume":"16","author":"Kazlauskaite","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0685","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0891-5849(00)00412-3","article-title":"Dopamine induces proteasome inhibition in neural PC12 cell line","volume":"29","author":"Keller","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0690","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1523\/JNEUROSCI.0632-14.2015","article-title":"\u03b1-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal parkinsonism protein Atp13a2","volume":"35","author":"Kett","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0695","doi-asserted-by":"crossref","DOI":"10.1038\/srep00090","article-title":"Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database","volume":"1","author":"Khoury","year":"2011","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0700","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120819","article-title":"Genetic and chemical activation of TFEB mediates clearance of aggregated \u03b1-synuclein","volume":"10","author":"Kilpatrick","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0705","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.bbrc.2008.10.104","article-title":"PINK1 controls mitochondrial localization of parkin through direct phosphorylation","volume":"377","author":"Kim","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0710","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jns.2011.04.015","article-title":"Proteasome inhibition induces \u03b1-synuclein SUMOylation and aggregate formation","volume":"307","author":"Kim","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0715","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/mds.10683","article-title":"Alteration in alpha-synuclein mRNA expression in Parkinson's disease","volume":"19","author":"Kingsbury","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0720","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0725","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008888","article-title":"Genetics of Parkinson's disease","volume":"2","author":"Klein","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0730","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jns.2013.08.033","article-title":"Parkinsonism syndrome in heterozygotes for Niemann\u2013Pick C1","volume":"335","author":"Kluenemann","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0735","doi-asserted-by":"crossref","first-page":"16691","DOI":"10.1073\/pnas.1006083107","article-title":"Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function","volume":"107","author":"Ko","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0740","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0745","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.120080","article-title":"PINK1 is activated by mitochondrial membrane potential depolarization and stimulates parkin E3 ligase activity by phosphorylating serine 65","volume":"2","author":"Kondapalli","year":"2012","journal-title":"Open Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0750","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/ana.20935","article-title":"Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys","volume":"60","author":"Kordower","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0755","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nature13392","article-title":"Ubiquitin is phosphorylated by PINK1 to activate parkin","volume":"510","author":"Koyano","year":"2014","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0760","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","article-title":"Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease","volume":"18","author":"Kr\u00fcger","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0765","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/1531-8249(199905)45:5<611::AID-ANA9>3.0.CO;2-X","article-title":"Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein\/apolipoprotein E genotype","volume":"45","author":"Kr\u00fcger","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0770","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1083\/jcb.201010117","article-title":"Sumoylation inhibits \u03b1-synuclein aggregation and toxicity","volume":"194","author":"Krumova","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0775","doi-asserted-by":"crossref","first-page":"6302","DOI":"10.1128\/JB.01077-10","article-title":"Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1","volume":"192","author":"Kthiri","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0780","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008730","article-title":"The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation","volume":"5","author":"Kumar","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0785","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF00687787","article-title":"Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study","volume":"75","author":"Kuzuhara","year":"1988","journal-title":"Acta Neuropathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0790","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0304-3940(91)90751-E","article-title":"Multicatalytic proteinase is present in Lewy bodies and neurofibrillary tangles in diffuse Lewy body disease brains","volume":"128","author":"Kwak","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0795","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00401-016-1590-9","article-title":"Epigenetic regulation in Parkinson's disease","volume":"132","author":"Labb\u00e9","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0800","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.tcb.2018.06.007","article-title":"Rab GTPase function in endosome and lysosome biogenesis","volume":"28","author":"Langemeyer","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0805","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1046\/j.1471-4159.2002.01253.x","article-title":"Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress: parkin in astrocytes during unfolded protein stress","volume":"83","author":"Ledesma","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0810","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1046\/j.1471-4159.2001.00149.x","article-title":"Effect of the overexpression of wild-type or mutant \u03b1-synuclein on cell susceptibility to insult: mutant \u03b1-synuclein, oxidative stress and cell apoptosis","volume":"76","author":"Lee","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0815","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.1471-4159.2001.00416.x","article-title":"Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production","volume":"78","author":"Lee","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0820","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1523\/JNEUROSCI.3809-03.2004","article-title":"Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway","volume":"24","author":"Lee","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0825","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1093\/hmg\/ddm363","article-title":"Ubiquitination of \u03b1-synuclein by Siah-1 promotes \u03b1-synuclein aggregation and apoptotic cell death","volume":"17","author":"Lee","year":"2007","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/bs.pbr.2020.01.002_bb0830","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/brain\/awz205","article-title":"Arylsulfatase A, a genetic modifier of Parkinson's disease, is an \u03b1-synuclein chaperone","volume":"142","author":"Lee","year":"2019","journal-title":"Brain J. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0835","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3389\/fnins.2019.00457","article-title":"Dysfunction of cellular proteostasis in Parkinson's disease","volume":"13","author":"Lehtonen","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0840","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/jnnp.52.1.67","article-title":"Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease","volume":"52","author":"Lennox","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0845","doi-asserted-by":"crossref","first-page":"2233.e1","DOI":"10.1016\/j.neurobiolaging.2012.05.006","article-title":"EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants?","volume":"33","author":"Lesage","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0850","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological functions of autophagy genes: a disease perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0855","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00018-011-0865-5","article-title":"Microautophagy: lesser-known self-eating","volume":"69","author":"Li","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0860","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.1146361","article-title":"IRE1 signaling affects cell fate during the unfolded protein response","volume":"318","author":"Lin","year":"2007","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0865","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.3390\/ijms20215312","article-title":"The overcrowded crossroads: mitochondria, alpha-synuclein, and the endo-lysosomal system interaction in Parkinson's disease","volume":"20","author":"Lin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0870","doi-asserted-by":"crossref","first-page":"12924","DOI":"10.1074\/jbc.M306390200","article-title":"Proteasomal inhibition by alpha-synuclein filaments and oligomers","volume":"279","author":"Lindersson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0875","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007480","article-title":"Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues","volume":"4","author":"Linnertz","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0880","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001237","article-title":"Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster","volume":"6","author":"Liu","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0885","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.1079293","article-title":"Endoproteolytic activity of the proteasome","volume":"299","author":"Liu","year":"2003","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0890","doi-asserted-by":"crossref","first-page":"12893","DOI":"10.1074\/jbc.272.20.12893","article-title":"p53-Dependent induction of apoptosis by proteasome inhibitors","volume":"272","author":"Lopes","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0895","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00005072-198807000-00001","article-title":"Alz-50, ubiquitin and tau immunoreactivity of neurofibrillary tangles, Pick bodies and Lewy bodies","volume":"47","author":"Love","year":"1988","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0900","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/path.1711550105","volume":"155","author":"Lowe","year":"1988","journal-title":"J. Pathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0905","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/path.1711610210","article-title":"Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases","volume":"161","author":"Lowe","year":"1990","journal-title":"J. Pathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0910","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1750-3639.1993.tb00726.x","article-title":"Ubiquitin in neurodegenerative diseases","volume":"3","author":"Lowe","year":"1993","journal-title":"Brain Pathol. Zurich Switz."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0915","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ymgme.2003.11.004","article-title":"Glucocerebrosidase mutations in subjects with parkinsonism","volume":"81","author":"Lwin","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0920","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/(SICI)1096-8652(199907)61:3<216::AID-AJH12>3.0.CO;2-B","article-title":"Parkinson's syndrome preceding clinical manifestation of Gaucher's disease","volume":"61","author":"Machaczka","year":"1999","journal-title":"Am. J. Hematol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0925","doi-asserted-by":"crossref","first-page":"40732","DOI":"10.1074\/jbc.M110.141952","article-title":"Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner","volume":"285","author":"Machiya","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0930","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neuron.2012.11.033","article-title":"RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk","volume":"77","author":"MacLeod","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0935","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ana.20938","article-title":"Lack of nigrostriatal pathology in a rat model of proteasome inhibition","volume":"60","author":"Manning-Bo\u011f","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0940","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.neuro.2009.06.009","article-title":"Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism","volume":"30","author":"Manning-Bo\u011f","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0945","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1001\/jama.296.6.661","article-title":"Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease","volume":"296","author":"Maraganore","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0950","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tcb.2003.12.002","article-title":"Autophagy: in sickness and in health","volume":"14","author":"Maria Cuervo","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0955","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cell.2014.01.064","article-title":"Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease","volume":"157","author":"Martin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0960","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-017-0170-3","article-title":"Quantitative proteomic analysis of Parkin substrates in Drosophila neurons","volume":"12","author":"Martinez","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0965","first-page":"777","article-title":"Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy","volume":"118","author":"Martinez-Vicente","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0970","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.expneurol.2012.08.008","article-title":"Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?","volume":"238","author":"Martins-Branco","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0975","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015522","article-title":"CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease","volume":"5","author":"Matsumoto","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0980","first-page":"21","article-title":"The role of protein ubiquitination in neurodegenerative disease","volume":"42","author":"Mayer","year":"1991","journal-title":"Acta Biol. Hung."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0985","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-1-4613-0335-0_33","article-title":"Endosome-lysosomes, ubiquitin and neurodegeneration","volume":"389","author":"Mayer","year":"1996","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb0990","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and \u03b1-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.pbr.2020.01.002_bb0995","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1074\/jbc.M109.081950","article-title":"Phosphorylation of synucleins by members of the polo-like kinase family","volume":"285","author":"Mbefo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1000","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s00018-014-1781-2","article-title":"Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system","volume":"72","author":"McKeon","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0304-3940(00)01701-8","article-title":"Proteasomal function is impaired in substantia nigra in Parkinson's disease","volume":"297","author":"McNaught","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ana.20936","article-title":"Proteasome inhibitor-induced model of Parkinson's disease","volume":"60","author":"McNaught","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3940(02)00296-3","article-title":"Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease","volume":"326","author":"McNaught","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1020","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1097\/00001756-200208070-00018","article-title":"Proteasome inhibition causes nigral degeneration with inclusion bodies in rats","volume":"13","author":"McNaught","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1025","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1471-4159.2002.00821.x","article-title":"Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures","volume":"81","author":"McNaught","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/exnr.2002.8050","article-title":"Altered proteasomal function in sporadic Parkinson's disease","volume":"179","author":"McNaught","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ana.20186","article-title":"Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease","volume":"56","author":"McNaught","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1040","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/sj.mp.4000446","article-title":"Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease","volume":"3","author":"Mezey","year":"1998","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1045","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1212\/01.WNL.0000127517.33208.F4","article-title":"\u03b1-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication","volume":"62","author":"Miller","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1050","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1042\/BCJ20180248","article-title":"The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human","volume":"475","author":"Mir","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1055","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/archneurol.2009.72","article-title":"Mutations for Gaucher disease confer high susceptibility to Parkinson disease","volume":"66","author":"Mitsui","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2014.07.014","article-title":"VPS35 dysfunction impairs lysosomal degradation of \u03b1-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease","volume":"71","author":"Miura","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neulet.2005.01.024","article-title":"Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition","volume":"380","author":"Miwa","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1070","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/hmg\/ddl030","article-title":"Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease","volume":"15","author":"Mizuta","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1075","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7609","article-title":"The Parkinson\u2019s-associated protein DJ-1 regulates the 20S proteasome","volume":"6","author":"Moscovitz","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200763","article-title":"Ubiquitination of alpha-synuclein filaments by Nedd4 ligases","volume":"13","author":"Mund","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1085","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/brain\/awt367","article-title":"Reduced glucocerebrosidase is associated with increased \u03b1-synuclein in sporadic Parkinson's disease","volume":"137","author":"Murphy","year":"2014","journal-title":"Brain J. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1090","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/mds.26141","article-title":"Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease: early loss of LAMP2A protein in PD","volume":"30","author":"Murphy","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1095","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.nbd.2013.11.007","article-title":"Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease","volume":"63","author":"Mutez","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1100","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/ng.3043","article-title":"Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease","volume":"46","author":"Nalls","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02705243","article-title":"The ubiquitin-proteasome system","volume":"31","author":"Nandi","year":"2006","journal-title":"J. Biosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1110","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1242\/jcs.146365","article-title":"TFEB at a glance","volume":"129","author":"Napolitano","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1115","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/qjmed\/89.9.691","article-title":"Occurrence of Parkinson's syndrome in type I Gaucher disease","volume":"89","author":"Neudorfer","year":"1996","journal-title":"QJM Mon. J. Assoc. Physicians"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/1531-8257(199905)14:3<417::AID-MDS1005>3.0.CO;2-X","article-title":"Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease","volume":"14","author":"Neystat","year":"1999","journal-title":"Mov. Disord."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1125","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.201501002","article-title":"MiT\/TFE transcription factors are activated during mitophagy downstream of parkin and Atg5","volume":"210","author":"Nezich","year":"2015","journal-title":"J. Cell Biol."},{"issue":"2444","key":"10.1016\/bs.pbr.2020.01.002_bb1130","first-page":"e1","article-title":"EIF4G1 mutations do not cause Parkinson's disease","volume":"36","author":"Nichols","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1135","first-page":"S43","article-title":"The identification of alpha-synuclein as the first Parkinson disease gene","volume":"7","author":"Nussbaum","year":"2017","journal-title":"J. Park. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1140","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainres.2011.01.039","article-title":"Human polycomb protein 2 promotes \u03b1-synuclein aggregate formation through covalent SUMOylation","volume":"1381","author":"Oh","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1145","doi-asserted-by":"crossref","first-page":"23787","DOI":"10.1074\/jbc.274.34.23787","article-title":"4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules","volume":"274","author":"Okada","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4161\/auto.5172","article-title":"Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway","volume":"4","author":"Olzmann","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1155","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1083\/jcb.200611128","article-title":"Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6","volume":"178","author":"Olzmann","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1160","first-page":"39","article-title":"Implication of alpha-synuclein phosphorylation at S129 in synucleinopathies: what have we learned in the last decade?","volume":"6","author":"Oueslati","year":"2016","journal-title":"J. Park. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1165","doi-asserted-by":"crossref","first-page":"E3945","DOI":"10.1073\/pnas.1309991110","article-title":"Polo-like kinase 2 regulates selective autophagic \u03b1-synuclein clearance and suppresses its toxicity in vivo","volume":"110","author":"Oueslati","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1170","doi-asserted-by":"crossref","DOI":"10.1038\/srep02202","article-title":"S-nitrosylation regulates mitochondrial quality control via activation of parkin","volume":"3","author":"Ozawa","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1175","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ana.20268","article-title":"\u03b1-Synuclein promoter confers susceptibility to Parkinson's disease","volume":"56","author":"Pals","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1180","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nchembio.2045","article-title":"Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation","volume":"12","author":"Pao","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1185","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/mds.21466","article-title":"Expression of \u03b1-synuclein mRNA in Parkinson's disease","volume":"22","author":"Papapetropoulos","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1190","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/mds.26243","article-title":"The role of ATP13A2 in Parkinson's disease: clinical phenotypes and molecular mechanisms: ATP13A2 in Parkinson's disease","volume":"30","author":"Park","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1195","article-title":"Interplay between leucine-rich repeat kinase 2 (LRRK2) and p62\/SQSTM-1 in selective autophagy","volume":"11","author":"Park","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1200","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1212\/WNL.51.6.1757","article-title":"Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease","volume":"51","author":"Parsian","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1205","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.1523\/JNEUROSCI.21-20-08053.2001","article-title":"Induction of alpha-synuclein aggregation by intracellular nitrative insult","volume":"21","author":"Paxinou","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1210","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0896-6273(02)01125-X","article-title":"Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons","volume":"36","author":"Petrucelli","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1215","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cbpa.2004.09.009","article-title":"Polyubiquitin chains: polymeric protein signals","volume":"8","author":"Pickart","year":"2004","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1220","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1225","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/ana.25274","article-title":"A comprehensive analysis of SNCA-related genetic risk in sporadic Parkinson disease","volume":"84","author":"Pihlstr\u00f8m","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1230","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1235","doi-asserted-by":"crossref","first-page":"17897","DOI":"10.1074\/jbc.R900012200","article-title":"The RNA-induced silencing complex: a versatile gene-silencing machine","volume":"284","author":"Pratt","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1240","doi-asserted-by":"crossref","first-page":"26515","DOI":"10.1074\/jbc.M003542200","article-title":"Synucleins are a novel class of substrates for G protein-coupled receptor kinases","volume":"275","author":"Pronin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1245","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1523\/JNEUROSCI.20-01-00259.2000","article-title":"Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons","volume":"20","author":"Qiu","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1250","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ng1884","article-title":"Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase","volume":"38","author":"Ramirez","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1255","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/gim.2012.107","article-title":"Age-specific Parkinson disease risk in GBA mutation carriers: information for genetic counseling","volume":"15","author":"Rana","year":"2013","journal-title":"Genet. Med."},{"issue":"Pt. 3","key":"10.1016\/bs.pbr.2020.01.002_bb1260","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1042\/bj3350637","article-title":"Comparative resistance of the 20S and 26S proteasome to oxidative stress","volume":"335","author":"Reinheckel","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1265","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms2032","article-title":"Alternative \u03b1-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology","volume":"3","author":"Rhinn","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1270","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature03205","article-title":"Regulation of cap-dependent translation by eIF4E inhibitory proteins","volume":"433","author":"Richter","year":"2005","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1275","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/mcne.2002.1173","article-title":"Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination","volume":"21","author":"Rideout","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1280","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1046\/j.1471-4159.2001.00474.x","article-title":"Proteasomal inhibition leads to formation of ubiquitin\/alpha-synuclein-immunoreactive inclusions in PC12 cells","volume":"78","author":"Rideout","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1285","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1471-4159.2005.03124.x","article-title":"Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition","volume":"93","author":"Rideout","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1290","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.cell.2005.06.043","article-title":"Rab conversion as a mechanism of progression from early to late endosomes","volume":"122","author":"Rink","year":"2005","journal-title":"Cell"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1295","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1093\/brain\/awx285","article-title":"Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease","volume":"140","author":"Robak","year":"2017","journal-title":"Brain J. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1300","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/acn3.177","article-title":"Progressive decline of glucocerebrosidase in aging and Parkinson's disease","volume":"2","author":"Rocha","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1305","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0006-8993(01)02772-X","article-title":"Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease","volume":"914","author":"Rockenstein","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1310","first-page":"2645","article-title":"Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease","volume":"25","author":"Rockenstein","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1315","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-016-0140-1","article-title":"LRRK2 at the interface of autophagosomes, endosomes and lysosomes","volume":"11","author":"Roosen","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1320","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.21380","article-title":"Genomic investigation of alpha-synuclein multiplication and parkinsonism","volume":"63","author":"Ross","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1325","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1074\/jbc.M704809200","article-title":"Monoubiquitylation of \u03b1-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells","volume":"283","author":"Rott","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1330","doi-asserted-by":"crossref","first-page":"18666","DOI":"10.1073\/pnas.1105725108","article-title":"\u03b1-Synuclein fate is determined by USP9X-regulated monoubiquitination","volume":"108","author":"Rott","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1335","doi-asserted-by":"crossref","first-page":"13176","DOI":"10.1073\/pnas.1704351114","article-title":"SUMOylation and ubiquitination reciprocally regulate \u03b1-synuclein degradation and pathological aggregation","volume":"114","author":"Rott","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1340","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1345","first-page":"809","article-title":"Combined kinase inhibition modulates parkin inactivation","volume":"18","author":"Rubio de la Torre","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1350","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.201312042","article-title":"ER-associated degradation: protein quality control and beyond","volume":"204","author":"Ruggiano","year":"2014","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/bs.pbr.2020.01.002_bb1355","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/WCO.0000000000000715","article-title":"GBA1-associated parkinsonism: new insights and therapeutic opportunities","author":"Ryan","year":"2019","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1360","doi-asserted-by":"crossref","first-page":"10690","DOI":"10.1523\/JNEUROSCI.22-24-10690.2002","article-title":"Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease","volume":"22","author":"Ryu","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1365","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2008.11.104","article-title":"Protective effect against Parkinson's disease-related insults through the activation of XBP1","volume":"1257","author":"Sado","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1370","doi-asserted-by":"crossref","DOI":"10.1038\/srep30793","article-title":"Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients","volume":"6","author":"Saito","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1375","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0002-9440(10)63633-4","article-title":"Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies","volume":"163","author":"Sampathu","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1380","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1073\/pnas.1220464110","article-title":"Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies","volume":"110","author":"Sardi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1385","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1073\/pnas.1616152114","article-title":"Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models","volume":"114","author":"Sardi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1390","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1093\/hmg\/ddu138","article-title":"Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy","volume":"23","author":"Schapansky","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1395","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ana.20934","article-title":"Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons","volume":"60","author":"Schapira","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1400","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)61113-3","article-title":"Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies","volume":"160","author":"Schlossmacher","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1405","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5028","article-title":"iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis","volume":"5","author":"Sch\u00f6ndorf","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1410","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10048-012-0334-9","article-title":"Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease","volume":"13","author":"Schulte","year":"2012","journal-title":"Neurogenetics"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1415","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jmb.2005.10.020","article-title":"The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway","volume":"354","author":"Schulze","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1420","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1172\/JCI61332","article-title":"Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT\/mTOR signaling","volume":"122","author":"Selvaraj","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1425","doi-asserted-by":"crossref","first-page":"9678","DOI":"10.1021\/bi800699v","article-title":"Cathepsin D is the main lysosomal enzyme involved in the degradation of \u03b1-synuclein and generation of its carboxy-terminally truncated species","volume":"47","author":"Sevlever","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1430","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/hmg\/ddp501","article-title":"Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling","volume":"19","author":"Sha","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1435","doi-asserted-by":"crossref","first-page":"31224","DOI":"10.1074\/jbc.M114.559237","article-title":"Interplay between sumoylation and phosphorylation for protection against \u03b1-synuclein inclusions","volume":"289","author":"Shahpasandzadeh","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1440","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jnr.10777","article-title":"An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells","volume":"74","author":"Shamoto-Nagai","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1445","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/jmedgenet-2012-101155","article-title":"A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants","volume":"49","author":"Sharma","year":"2012","journal-title":"J. Med. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1450","doi-asserted-by":"crossref","DOI":"10.1038\/srep01002","article-title":"PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy","volume":"2","author":"Shiba-Fukushima","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1455","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/77060","article-title":"Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase","volume":"25","author":"Shimura","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1460","doi-asserted-by":"crossref","first-page":"23727","DOI":"10.1074\/jbc.M503326200","article-title":"The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates \u03b1-synuclein degradation decisions between proteasomal and lysosomal pathways","volume":"280","author":"Shin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1465","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1470","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1471-4159.2005.03428.x","article-title":"CHOP\/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism","volume":"95","author":"Silva","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1475","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"alpha-Synuclein locus triplication causes Parkinson's disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1480","first-page":"333","article-title":"Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies","volume":"28","author":"Slodzinski","year":"2009","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1485","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1093\/hmg\/ddi396","article-title":"Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity","volume":"14","author":"Smith","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1490","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1126\/science.1209235","article-title":"Road to ruin: targeting proteins for degradation in the endoplasmic reticulum","volume":"334","author":"Smith","year":"2011","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1495","doi-asserted-by":"crossref","first-page":"11753","DOI":"10.1074\/jbc.M208641200","article-title":"Aggregated and monomeric alpha-synuclein bind to the S6\u2019 proteasomal protein and inhibit proteasomal function","volume":"278","author":"Snyder","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1500","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature17939","article-title":"Parkinson-associated risk variant in distal enhancer of \u03b1-synuclein modulates target gene expression","volume":"533","author":"Soldner","year":"2016","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1505","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1523\/JNEUROSCI.2569-15.2016","article-title":"Parkin modulates endosomal organization and function of the endo-lysosomal pathway","volume":"36","author":"Song","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1510","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1515","doi-asserted-by":"crossref","first-page":"9549","DOI":"10.1523\/JNEUROSCI.21-24-09549.2001","article-title":"Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death","volume":"21","author":"Stefanis","year":"2001","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/bs.pbr.2020.01.002_bb1520","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/jnc.14704","article-title":"How is alpha-synuclein cleared from the cell?","volume":"150","author":"Stefanis","year":"2019","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1525","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12813","article-title":"Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases","volume":"5","author":"Steger","year":"2016","journal-title":"eLife"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1530","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/(SICI)1097-4547(19990315)55:6<659::AID-JNR1>3.0.CO;2-C","article-title":"Cytotoxic and genotoxic potential of dopamine","volume":"55","author":"Stokes","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1535","doi-asserted-by":"crossref","first-page":"23179","DOI":"10.1074\/jbc.M802223200","article-title":"Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death","volume":"283","author":"Sugeno","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1540","doi-asserted-by":"crossref","first-page":"18137","DOI":"10.1074\/jbc.M113.529461","article-title":"Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized \u03b1-synuclein","volume":"289","author":"Sugeno","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1545","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1523\/JNEUROSCI.2292-12.2013","article-title":"ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin","volume":"33","author":"Sun","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1550","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1750-1326-8-29","article-title":"S-nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease","volume":"8","author":"Sunico","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1555","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nn.2372","article-title":"Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss","volume":"12","author":"Tain","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1560","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1212\/WNL.54.5.1195","article-title":"Polymorphism of NACP-Rep1 in Parkinson's disease: an etiologic link with essential tremor?","volume":"54","author":"Tan","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1565","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/hmg\/10.9.919","article-title":"Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis","volume":"10","author":"Tanaka","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1570","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1523\/JNEUROSCI.0042-15.2015","article-title":"VPS35 in dopamine neurons is required for endosome-to-golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for \u03b1-synuclein degradation and prevention of pathogenesis of Parkinson's disease","volume":"35","author":"Tang","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1575","doi-asserted-by":"crossref","first-page":"15194","DOI":"10.1074\/jbc.M113.457408","article-title":"Lewy body-like \u03b1-synuclein aggregates resist degradation and impair macroautophagy","volume":"288","author":"Tanik","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1580","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/mgme.2001.3201","article-title":"Gaucher disease and parkinsonism: a phenotypic and genotypic characterization","volume":"73","author":"Tayebi","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1585","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1096-7192(03)00071-4","article-title":"Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?","volume":"79","author":"Tayebi","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1590","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.molmed.2015.05.004","article-title":"Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis","volume":"21","author":"Taymans","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1595","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0014-5793(01)03115-5","article-title":"alpha-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome","volume":"509","author":"Tofaris","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1600","doi-asserted-by":"crossref","first-page":"44405","DOI":"10.1074\/jbc.M308041200","article-title":"Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function","volume":"278","author":"Tofaris","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1605","doi-asserted-by":"crossref","first-page":"17004","DOI":"10.1073\/pnas.1109356108","article-title":"Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway","volume":"108","author":"Tofaris","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1610","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1073\/pnas.1004676107","article-title":"Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of \u03b1-synuclein, and apoptotic cell death in aged mice","volume":"107","author":"Tong","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1615","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-7-2","article-title":"Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway","volume":"7","author":"Tong","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1620","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1101\/gr.165801","article-title":"Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element","volume":"11","author":"Touchman","year":"2001","journal-title":"Genome Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1625","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neulet.2012.04.033","article-title":"Study of the genetic variability in a Parkinson's disease gene: EIF4G1","volume":"518","author":"Tucci","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1630","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/jnr.22828","article-title":"Neddylation positively regulates the ubiquitin E3 ligase activity of parkin","volume":"90","author":"Um","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1635","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1093\/hmg\/dds206","article-title":"Identification of novel ATP13A2 interactors and their role in \u03b1-synuclein misfolding and toxicity","volume":"21","author":"Usenovic","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1640","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1523\/JNEUROSCI.5575-11.2012","article-title":"Deficiency of ATP13A2 leads to lysosomal dysfunction, \u03b1-synuclein accumulation, and neurotoxicity","volume":"32","author":"Usenovic","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1645","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1073\/pnas.1321845111","article-title":"Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1","volume":"111","author":"Vald\u00e9s","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1650","doi-asserted-by":"crossref","first-page":"10244","DOI":"10.1073\/pnas.0708518105","article-title":"RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways","volume":"105","author":"van der Brug","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1655","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms2623","article-title":"Sulfhydration mediates neuroprotective actions of parkin","volume":"4","author":"Vandiver","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1660","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ajhg.2011.06.001","article-title":"VPS35 mutations in Parkinson disease","volume":"89","author":"Vilari\u00f1o-G\u00fcell","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1665","doi-asserted-by":"crossref","first-page":"23542","DOI":"10.1074\/jbc.M801992200","article-title":"Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells","volume":"283","author":"Vogiatzi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1670","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1091\/mbc.e14-02-0741","article-title":"Formation of \u03b1-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes","volume":"25","author":"Volpicelli-Daley","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1675","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature17041","article-title":"Protein misfolding in the endoplasmic reticulum as a conduit to human disease","volume":"529","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2020.01.002_bb1680","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuint.2019.02.016","article-title":"Iron-induced oxidative stress contributes to \u03b1-synuclein phosphorylation and up-regulation via polo-like kinase 2 and casein kinase 2","volume":"125","author":"Wang","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1685","doi-asserted-by":"crossref","first-page":"25009","DOI":"10.1074\/jbc.M300227200","article-title":"Alpha-synuclein is degraded by both autophagy and the proteasome","volume":"278","author":"Webb","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1690","first-page":"219","article-title":"VPS35, the retromer complex and Parkinson's disease","volume":"7","author":"Williams","year":"2017","journal-title":"J. Park. Dis."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1695","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201003122","article-title":"\u03b1-synuclein impairs macroautophagy: implications for Parkinson's disease","volume":"190","author":"Winslow","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1700","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/ana.410400212","article-title":"Genetic studies in Alzheimer's disease with an NACP\/alpha-synuclein polymorphism","volume":"40","author":"Xia","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1705","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1710","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1074\/jbc.M407724200","article-title":"Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity","volume":"280","author":"Yamamoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1715","doi-asserted-by":"crossref","first-page":"10810","DOI":"10.1073\/pnas.0404161101","article-title":"Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity","volume":"101","author":"Yao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1720","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1471-4159.2007.04637.x","article-title":"A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132","volume":"102","author":"Zafar","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1725","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4828","article-title":"Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy","volume":"5","author":"Zavodszky","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1730","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ana.20932","article-title":"Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats","volume":"60","author":"Zeng","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1735","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1111\/j.1460-9568.2006.04718.x","article-title":"MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome","volume":"23","author":"Zeng","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1740","doi-asserted-by":"crossref","first-page":"20288","DOI":"10.1074\/jbc.M710560200","article-title":"alpha-synuclein protofibrils inhibit 26S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis","volume":"283","author":"Zhang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1745","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/10715760902801533","article-title":"Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones","volume":"43","author":"Zhou","year":"2009","journal-title":"Free Radic. Res."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1750","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ajhg.2011.06.008","article-title":"A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease","volume":"89","author":"Zimprich","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/bs.pbr.2020.01.002_bb1755","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184040","article-title":"Proteasome impairment by \u03b1-synuclein","volume":"12","author":"Zondler","year":"2017","journal-title":"PLoS One"}],"container-title":["Progress in Brain Research","Recent Advances in Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612320300029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612320300029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T22:05:47Z","timestamp":1758751547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612320300029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9780444642608"],"references-count":350,"URL":"https:\/\/doi.org\/10.1016\/bs.pbr.2020.01.002","relation":{},"ISSN":["0079-6123"],"issn-type":[{"type":"print","value":"0079-6123"}],"subject":[],"published":{"date-parts":[[2020]]}}}