{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:40:58Z","timestamp":1791945658498,"version":"4.3.4"},"reference-count":90,"publisher":"Elsevier","isbn-type":[{"value":"9780323957786","type":"print"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H00184"],"award-info":[{"award-number":["21H00184"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02846"],"award-info":[{"award-number":["21H02846"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H05612"],"award-info":[{"award-number":["21H05612"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/bs.pbr.2023.01.003","type":"book-chapter","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T15:24:21Z","timestamp":1677770661000},"page":"61-77","source":"Crossref","is-referenced-by-count":50,"title":["Neuroinflammation through the vagus nerve-dependent gut\u2013microbiota\u2013brain axis in treatment-resistant depression"],"prefix":"10.1016","member":"78","reference":[{"issue":"6","key":"10.1016\/bs.pbr.2023.01.003_bb0010","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/nmo.12792","article-title":"Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study","volume":"28","author":"Bonaz","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnins.2018.00049","article-title":"The vagus nerve at the interface of the microbiota-gut-brain axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"issue":"8","key":"10.1016\/bs.pbr.2023.01.003_bb0020","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034199","article-title":"Vagus nerve stimulation at the interface of brain-gut interactions","volume":"9","author":"Bonaz","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"6785","key":"10.1016\/bs.pbr.2023.01.003_bb0025","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"issue":"10","key":"10.1016\/bs.pbr.2023.01.003_bb0030","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1017\/S1041610219000115","article-title":"Fecal microbiota transplantation in an elderly patient with mental depression","volume":"31","author":"Cai","year":"2019","journal-title":"Int. Psychogeriatr."},{"issue":"3","key":"10.1016\/bs.pbr.2023.01.003_bb0035","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s13311-017-0537-8","article-title":"Vagal nerve stimulation for treatment-resistant depression","volume":"14","author":"Carreno","year":"2017","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0040","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41398-020-00874-7","article-title":"Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study","volume":"10","author":"Cattaneo","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainresbull.2022.02.004","article-title":"Brain-gut-microbiota axis in depression: a historical overview and future directions","volume":"182","author":"Chang","year":"2022","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/bs.pbr.2023.01.003_bb0050","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105746","article-title":"The gut microbiome and adult hippocampal neurogenesis: a new focal point for epilepsy?","volume":"170","author":"Dohm-Hansen","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0060","article-title":"Fecal microbiota transplantation (FMT) as an adjunctive therapy for depression-case report","volume":"13","author":"Doll","year":"2022","journal-title":"Front. Psych."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.813075","article-title":"Gut microbiome: a potential indicator for predicting treatment outcomes in major depressive disorder","volume":"16","author":"Dong","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0070","article-title":"Inflammation, lifestyle factors, and the microbiome-gut-brain axis: relevance to depression and antidepressant action","author":"Donoso","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"issue":"7","key":"10.1016\/bs.pbr.2023.01.003_bb0075","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41380-018-0256-5","article-title":"Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)","volume":"25","author":"Fava","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"6","key":"10.1016\/bs.pbr.2023.01.003_bb0080","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/s41380-018-0096-3","article-title":"What does plasma CRP tell us about peripheral and central inflammation in depression?","volume":"25","author":"Felger","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"9","key":"10.1016\/bs.pbr.2023.01.003_bb0085","first-page":"311","article-title":"Exploring the role of gut microbiota in major depressive disorder and in treatment resistance to antidepressants","volume":"8","author":"Fontana","year":"2020","journal-title":"Biomedicine"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173954","article-title":"Dextran sulfate sodium-induced inflammation and colitis in mice are ameliorated by (R)-ketamine, but not (S)-ketamine: a role of TrkB signaling","volume":"897","author":"Fujita","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0095","first-page":"36","article-title":"Inflammatory biomarker and response to antidepressant in major depressive disorder: a systematic review and meta-analysis","volume":"52","author":"Gasparini","year":"2022","journal-title":"Psychopharmacol. Bull."},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/BPL-220141","article-title":"Microbiota-gut-brain axis regulation of adult hippocampal neurogenesis","volume":"8","author":"Guzzetta","year":"2022","journal-title":"Brain Plast."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.psyneuen.2018.05.026","article-title":"Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder","volume":"95","author":"Haroon","year":"2018","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/bs.pbr.2023.01.003_bb0110","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.3390\/ijms16047796","article-title":"Inflammatory biomarkers as differential predictors of antidepressant response","volume":"16","author":"Hashimoto","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/bs.pbr.2023.01.003_bb0115","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/pcn.12902","article-title":"Rapid-acting antidepressant ketamine, its metabolites and other candidates: a historical overview and future perspective","volume":"73","author":"Hashimoto","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113935","article-title":"Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine","volume":"177","author":"Hashimoto","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/bs.pbr.2023.01.003_bb0125","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1038\/s41380-022-01587-7","article-title":"Ketamine: anesthetic, psychotomimetic, antidepressant, or anthelmintic?","volume":"27","author":"Hashimoto","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0130","doi-asserted-by":"crossref","DOI":"10.1007\/s00406-023-01570-5","article-title":"Arketamine for cognitive impairment in psychiatric disorders","author":"Hashimoto","year":"2023","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainresbull.2022.05.014","article-title":"Special issue on \u201cbrain\u2013body communication in health and diseases\u201d","volume":"186","author":"Hashimoto","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109272","article-title":"Depression and antidepressant effects of ketamine and its metabolites: the pivotal role of gut microbiota","volume":"220","author":"Hua","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0145","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pbb.2018.12.001","article-title":"Role of Actinobacteria and Coriobacteriia in the antidepressant effects of ketamine in an inflammation model of depression","volume":"176","author":"Huang","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.114972","article-title":"Comparison on the clinical features in patients with or without treatment-resistant depression: a national survey on symptomatology of depression report","volume":"319","author":"Huang","year":"2023","journal-title":"Psychiatry Res."},{"key":"10.1016\/bs.pbr.2023.01.003_bb456","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroscience.2022.04.026","article-title":"Gut feelings: Vagus stimulation reduces emotional biases","volume":"494","author":"Johnson","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2022.120171","article-title":"Vagus nerve stimulation: an update on a novel treatment for treatment-resistant depression","volume":"434","author":"Kamel","year":"2022","journal-title":"J. Neurol. Sci."},{"issue":"29","key":"10.1016\/bs.pbr.2023.01.003_bb0160","doi-asserted-by":"crossref","first-page":"8284","DOI":"10.1073\/pnas.1605635113","article-title":"Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis","volume":"113","author":"Koopman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109318","article-title":"Are neuromodulation interventions associated with changes in the gut microbiota? A systematic review","volume":"223","author":"Korenblik","year":"2023","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/bs.pbr.2023.01.003_bb0170","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00406-020-01110-5","article-title":"Intravenous arketamine for treatment-resistant depression: open-label pilot study","volume":"271","author":"Leal","year":"2021","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"2","key":"10.1016\/bs.pbr.2023.01.003_bb0175","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41380-019-0474-5","article-title":"Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"15","key":"10.1016\/bs.pbr.2023.01.003_bb0180","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.3390\/ijms22157931","article-title":"The mechanism of secretion and metabolism of gut-derived 5-hydroxytryptamine","volume":"22","author":"Liu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/bs.pbr.2023.01.003_bb0185","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.neuron.2022.05.027","article-title":"The role of hippocampal KCNQ2 channel in antidepressant actions of ketamine","volume":"110","author":"Ma","year":"2022","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0190","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41398-022-01803-6","article-title":"Nuclear factor of activated T cells 4 in the prefrontal cortex is required for prophylactic actions of (R)-ketamine","volume":"12","author":"Ma","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109250","article-title":"A role of microRNA-149 in the prefrontal cortex for prophylactic actions of (R)-ketamine in inflammation model","volume":"219","author":"Ma","year":"2022","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/bs.pbr.2023.01.003_bb0200","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1038\/s41380-020-00867-4","article-title":"The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression","volume":"26","author":"Mac Giollabhui","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0205","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jad.2020.09.007","article-title":"A systematic review and meta-analysis of the efficacy of intravenous ketamine infusion for treatment resistant depression: January 2009 - January 2019","volume":"277","author":"Marcantoni","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"8","key":"10.1016\/bs.pbr.2023.01.003_bb0210","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","article-title":"Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets","volume":"10","author":"Mawe","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0215","doi-asserted-by":"crossref","first-page":"14290","DOI":"10.1038\/s41598-019-50807-8","article-title":"Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling","volume":"9","author":"McVey Neufeld","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/bs.pbr.2023.01.003_bb0220","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/WNF.0000000000000299","article-title":"Clostridium butyricum MIYAIRI 588 as adjunctive therapy for treatment-resistant major depressive disorder: a prospective open-label trial","volume":"41","author":"Miyaoka","year":"2018","journal-title":"Clin. Neuropharmacol."},{"issue":"8","key":"10.1016\/bs.pbr.2023.01.003_bb0225","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1176\/appi.ps.201300059","article-title":"A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013","volume":"65","author":"Mrazek","year":"2014","journal-title":"Psychiatr. Serv."},{"issue":"12","key":"10.1016\/bs.pbr.2023.01.003_bb0230","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1001\/jamapsychiatry.2021.2573","article-title":"Perturbations in gut microbiota composition in psychiatric disorders: a review and meta-analysis","volume":"78","author":"Nikolova","year":"2021","journal-title":"JAMA Psychiat."},{"issue":"5","key":"10.1016\/bs.pbr.2023.01.003_bb0235","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tim.2019.12.009","article-title":"Improving risk-benefit in faecal transplantation through microbiome screening","volume":"28","author":"Papanicolas","year":"2020","journal-title":"Trends Microbiol."},{"issue":"21","key":"10.1016\/bs.pbr.2023.01.003_bb0240","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1016\/j.neuron.2022.09.003","article-title":"Bioelectronic medicine: preclinical insights and clinical advances","volume":"110","author":"Pavlov","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0245","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbi.2020.12.032","article-title":"A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes","volume":"94","author":"Pu","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0250","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41398-022-01993-z","article-title":"Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation","volume":"12","author":"Pu","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0255","doi-asserted-by":"crossref","first-page":"15725","DOI":"10.1038\/s41598-017-16060-7","article-title":"Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model","volume":"7","author":"Qu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173500","article-title":"Rapid antidepressant-like effect of non-hallucinogenic psychedelic analog lisuride, but not hallucinogenic psychedelic DOI, in lipopolysaccharide-treated mice","volume":"222","author":"Qu","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.115020","article-title":"Repeated use of 3,4-methylenedioxymethamphetamine is associated with the resilience in mice after chronic social defeat stress: a role of gut\u2013microbiota\u2013brain axis","volume":"320","author":"Qu","year":"2023","journal-title":"Psychiatry Res."},{"issue":"15","key":"10.1016\/bs.pbr.2023.01.003_bb0270","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.147700","article-title":"Age-associated gut microbiota impair hippocampus-dependent memory in a vagus-dependent manner","volume":"7","author":"Rei","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0275","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neubiorev.2020.03.034","article-title":"Vagus nerve stimulation and neurotrophins: a biological psychiatric perspective","volume":"113","author":"Rosso","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2020.01.102","article-title":"Gut microbiota and major depressive disorder: a systematic review and meta-analysis","volume":"266","author":"Sanada","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/bs.pbr.2023.01.003_bb0285","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/cells11030382","article-title":"The influence of gut microbiota on neurogenesis: evidence and hopes","volume":"11","author":"Sarubbo","year":"2022","journal-title":"Cell"},{"issue":"9","key":"10.1016\/bs.pbr.2023.01.003_bb0290","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1093\/brain\/awac256","article-title":"Understanding the effects of serotonin in the brain through its role in the gastrointestinal tract","volume":"145","author":"Shine","year":"2022","journal-title":"Brain"},{"issue":"6","key":"10.1016\/bs.pbr.2023.01.003_bb0295","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1176\/appi.ps.201900398","article-title":"Incremental health care burden of treatment-resistant depression among commercial, medicaid, and medicare payers","volume":"71","author":"Shrestha","year":"2020","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0300","doi-asserted-by":"crossref","first-page":"1015175","DOI":"10.3389\/fneur.2022.1015175","article-title":"Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis","volume":"13","author":"Tan","year":"2022","journal-title":"Front. Neurol."},{"issue":"12","key":"10.1016\/bs.pbr.2023.01.003_bb0305","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S2215-0366(19)30394-3","article-title":"Esketamine for treatment-resistant depression: seven concerns about efficacy and FDA approval","volume":"6","author":"Turner","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109139","article-title":"Effects of (R)-ketamine on reduced bone mineral density in ovariectomized mice: a role of gut microbiota","volume":"213","author":"Wan","year":"2022","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0315","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12974-020-01916-z","article-title":"Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0320","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jad.2021.06.006","article-title":"Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: a role of brain-gut-microbiota axis via the subdiaphragmatic vagus nerve","volume":"292","author":"Wang","year":"2021","journal-title":"J. Affect. Disord."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173226","article-title":"Gut microbiota is involved in the antidepressant-like effect of (S)-norketamine in an inflammation model of depression","volume":"207","author":"Wang","year":"2021","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105635","article-title":"(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: a role of gut-microbiota-brain axis","volume":"165","author":"Wang","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104762","article-title":"(R)-ketamine as prophylactic and therapeutic drug for neurological disorders: beyond depression","volume":"139","author":"Wang","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105951","article-title":"Key role of the gut-microbiota-brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain","volume":"176","author":"Wang","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0345","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41380-021-01121-1","article-title":"Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor","volume":"27","author":"Wei","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0350","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainresbull.2022.02.008","article-title":"Brain-spleen axis in health and diseases: a review and future perspective","volume":"182","author":"Wei","year":"2022","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0355","doi-asserted-by":"crossref","first-page":"21130","DOI":"10.1038\/s41598-021-00615-w","article-title":"Identification of SSRI-evoked antidepressant sensory signals by decoding vagus nerve activity","volume":"11","author":"West","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0360","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.693362","article-title":"Gut microbiota in depression: a focus on ketamine","volume":"15","author":"Wilkowska","year":"2021","journal-title":"Front. Behav. Neurosci."},{"issue":"6","key":"10.1016\/bs.pbr.2023.01.003_bb0365","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s41380-019-0471-8","article-title":"Effects of immunomodulatory drugs on depressive symptoms: a mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders","volume":"25","author":"Wittenberg","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0370","author":"World Health Organization"},{"issue":"9","key":"10.1016\/bs.pbr.2023.01.003_bb0375","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.136","article-title":"R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects","volume":"5","author":"Yang","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"12","key":"10.1016\/bs.pbr.2023.01.003_bb0380","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/s41398-017-0031-4","article-title":"Possible role of the gut microbiota-brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model","volume":"7","author":"Yang","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0385","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biopsych.2017.05.016","article-title":"Mechanistic target of rapamycin-independent antidepressant effects of (R)-ketamine in a social defeat stress model","volume":"83","author":"Yang","year":"2018","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0390","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41398-019-0624-1","article-title":"Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites","volume":"9","author":"Yang","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110652","article-title":"A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice","volume":"120","author":"Yang","year":"2023","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"3","key":"10.1016\/bs.pbr.2023.01.003_bb0400","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/s41380-021-01377-7","article-title":"Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine","volume":"27","author":"Yao","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"8","key":"10.1016\/bs.pbr.2023.01.003_bb0405","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0410","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pbb.2013.11.033","article-title":"R (\u2212)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine","volume":"116","author":"Zhang","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"7","key":"10.1016\/bs.pbr.2023.01.003_bb0415","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/1570159X14666160119094646","article-title":"Brain-derived neurotrophic factor (BDNF)-TrkB signaling in inflammation-related depression and potential therapeutic targets","volume":"14","author":"Zhang","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/bs.pbr.2023.01.003_bb0420","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41398-020-00878-3","article-title":"A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration","volume":"10","author":"Zhang","year":"2020","journal-title":"Transl. Psychiatry"},{"issue":"10","key":"10.1016\/bs.pbr.2023.01.003_bb0425","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1007\/s00213-021-05889-6","article-title":"(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation","volume":"238","author":"Zhang","year":"2021","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119882","article-title":"(R)-Ketamine ameliorates lethal inflammatory responses and multi-organ injury in mice induced by cecum ligation and puncture","volume":"284","author":"Zhang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109219","article-title":"Arketamine, a new rapid-acting antidepressant: a historical review and future directions","volume":"218","author":"Zhang","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/bs.pbr.2023.01.003_bb0440","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbi.2022.02.007","article-title":"Bacteroides species differentially modulate depression-like behavior via gut-brain metabolic signaling","volume":"102","author":"Zhang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/bs.pbr.2023.01.003_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109305","article-title":"Ketamine and its metabolites: potential as novel treatments for depression","volume":"222","author":"Zhang","year":"2023","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/bs.pbr.2023.01.003_bb0450","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatry"}],"container-title":["Progress in Brain Research","Treatment-Resistant Depression Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612323000031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612323000031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T20:58:48Z","timestamp":1754427528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612323000031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780323957786"],"references-count":90,"URL":"https:\/\/doi.org\/10.1016\/bs.pbr.2023.01.003","relation":{},"ISSN":["0079-6123"],"issn-type":[{"value":"0079-6123","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}