{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:49:29Z","timestamp":1789537769611,"version":"build-2803163510"},"reference-count":135,"publisher":"Elsevier","isbn-type":[{"value":"9780443344671","type":"print"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.pbr.2024.06.005","type":"book-chapter","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T23:10:13Z","timestamp":1720048213000},"page":"123-150","source":"Crossref","is-referenced-by-count":17,"title":["Coffee, antioxidants, and brain inflammation"],"prefix":"10.1016","author":[{"given":"Swayam Prabha","family":"Rai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atifa Haseeb","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durgesh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sippy","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.pbr.2024.06.005_bb0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-4899-2626-5_4","article-title":"Synthesis and availability of niacin in roasted coffee","volume":"289","author":"Adrian","year":"1991","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0015","article-title":"Integration of genomic variants and bioinformatic-based approach to drive drug repurposing for multiple sclerosis","volume":"32","author":"Afief","year":"2022","journal-title":"Biochem. Biophys. Rep."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0020","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3945\/jn.115.224774","article-title":"Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial","volume":"146","author":"Agudelo-Ochoa","year":"2016","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.005_bb0025","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.neuroscience.2006.07.021","article-title":"Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain \u03b2-amyloid production","volume":"142","author":"Arendash","year":"2006","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0030","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3233\/JAD-2009-1087","article-title":"Caffeine reverses cognitive impairment and decreases brain amyloid-\u03b2 levels in aged Alzheimer's disease mice","volume":"17","author":"Arendash","year":"2009","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0035","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ana.1052","article-title":"Prospective study of caffeine consumption and risk of Parkinson's disease in men and women","volume":"50","author":"Ascherio","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120861","article-title":"Alzheimer's disease failed clinical trials","volume":"306","author":"Asher","year":"2022","journal-title":"Life Sci."},{"issue":"11","key":"10.1016\/bs.pbr.2024.06.005_bb0045","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1101\/gad.3.11.1689","article-title":"A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB","volume":"3","author":"Baeuerle","year":"1989","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0050","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3233\/JPD-191882","article-title":"Associations of lower caffeine intake and plasma urate levels with idiopathic Parkinson's disease in the Harvard Biomarkers Study","volume":"10","author":"Bakshi","year":"2020","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfoodeng.2016.11.014","article-title":"Optimization of autohydrolysis conditions to extract antioxidant phenolic compounds from spent coffee grounds","volume":"199","author":"Ballesteros","year":"2017","journal-title":"J. Food Eng."},{"issue":"17","key":"10.1016\/bs.pbr.2024.06.005_bb0060","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1523\/JNEUROSCI.21-17-06480.2001","article-title":"Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity","volume":"21","author":"Bal-Price","year":"2001","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0065","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0006-8993(92)91004-X","article-title":"Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death","volume":"587","author":"Boje","year":"1992","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.phrs.2007.01.006","article-title":"Coffee and cardiovascular disease: in vitro, cellular, animal, and human studies","volume":"55","author":"Bonita","year":"2007","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.005_bb0075","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/10408390903586412","article-title":"Coffee and its consumption: benefits and risks","volume":"51","author":"Butt","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"47","key":"10.1016\/bs.pbr.2024.06.005_bb0080","doi-asserted-by":"crossref","first-page":"14741","DOI":"10.1523\/JNEUROSCI.3728-09.2009","article-title":"Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by \u03b2-amyloid peptides via p38 mitogen-activated protein kinase pathway","volume":"29","author":"Canas","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0085","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2165\/00003088-200039020-00004","article-title":"Clinically significant pharmacokinetic interactions between dietary caffeine and medications","volume":"39","author":"Carrillo","year":"2000","journal-title":"Clin. Pharmacokinet."},{"issue":"8","key":"10.1016\/bs.pbr.2024.06.005_bb0090","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0278-6915(02)00029-7","article-title":"Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity","volume":"40","author":"Cavin","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00394-009-0083-1","article-title":"Chlorogenic acid attenuates adhesion molecules upregulation in IL-1\u03b2-treated endothelial cells","volume":"49","author":"Chang","year":"2010","journal-title":"Eur. J. Nutr."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0100","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.neuro.2012.07.004","article-title":"Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase","volume":"33","author":"Che","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2009.10.054","article-title":"Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats","volume":"1309","author":"Chen","year":"2010","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0110","first-page":"1340","article-title":"Administration of chlorogenic acid alleviates spinal cord injury via TLR4\/NF-\u03baB and p38 signaling pathway anti-inflammatory activity","volume":"17","author":"Chen","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0115","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jinorgbio.2018.11.001","article-title":"Chlorogenic acid protects against aluminum toxicity via MAPK\/Akt signaling pathway in murine RAW264. 7 macrophages","volume":"190","author":"Cheng","year":"2019","journal-title":"J. Inorg. Biochem."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0120","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1006\/bbrc.1998.9062","article-title":"Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters","volume":"248","author":"Chu","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/biom10010137","article-title":"Microglia mediated neuroinflammation: focus on PI3K modulation","volume":"10","author":"Cianciulli","year":"2020","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0130","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3390\/molecules27020341","article-title":"Inflammaging and brain: curcumin and its beneficial potential as regulator of microglia activation","volume":"27","author":"Cianciulli","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0135","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1097-0010(19990301)79:3<362::AID-JSFA256>3.0.CO;2-D","article-title":"Chlorogenic acids and other cinnamates\u2014nature, occurrence and dietary burden","volume":"79","author":"Clifford","year":"1999","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0140","article-title":"Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four \u03ba\u0392-like motifs and of constitutive and inducible forms of NF-\u03baB","author":"Collart","year":"1990","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/bs.pbr.2024.06.005_bb0145","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1093\/brain\/awx275","article-title":"Synaptic phosphorylated \u03b1-synuclein in dementia with Lewy bodies","volume":"140","author":"Colom-Cadena","year":"2017","journal-title":"Brain"},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.005_bb0150","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.neuroscience.2008.03.038","article-title":"Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tyrosine kinase receptor (TrkB) content in mice","volume":"153","author":"Costa","year":"2008","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"10.1016\/bs.pbr.2024.06.005_bb0155","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-5793(97)01377-X","article-title":"Involvement of NF-\u03baB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages","volume":"418","author":"D'Acquisto","year":"1997","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0160","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.expneurol.2006.08.008","article-title":"Caffeine and adenosine A2a receptor antagonists prevent \u03b2-amyloid (25\u201335)-induced cognitive deficits in mice","volume":"203","author":"Dall'Igna","year":"2007","journal-title":"Exp. Neurol."},{"issue":"24","key":"10.1016\/bs.pbr.2024.06.005_bb0165","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1039\/C7AY00721C","article-title":"Factorial design effects of plant density, pattern and light availability on the caffeine, chlorogenic acids, lipids, reducing sugars and ash contents of Coffea arabica L. beans and leaves","volume":"9","author":"Delaroza","year":"2017","journal-title":"Anal. Methods"},{"issue":"10","key":"10.1016\/bs.pbr.2024.06.005_bb0170","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.tem.2014.07.003","article-title":"Impact of caffeine and coffee on our health","volume":"25","author":"de Mejia","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.005_bb0175","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1468-1331.2011.03596.x","article-title":"Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis","volume":"19","author":"D\u2019hooghe","year":"2012","journal-title":"Eur. J. Neurol."},{"issue":"6642","key":"10.1016\/bs.pbr.2024.06.005_bb0180","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/41493","article-title":"A cytokine-responsive I\u03baB kinase that activates the transcription factor NF-\u03baB","volume":"388","author":"DiDonato","year":"1997","journal-title":"Nature"},{"issue":"7","key":"10.1016\/bs.pbr.2024.06.005_bb0185","first-page":"2303","volume":"9","author":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)","year":"2011","journal-title":"EFSA J."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.005_bb0190","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.2903\/j.efsa.2011.2054","volume":"9","author":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)","year":"2011","journal-title":"EFSA J."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0195","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.2903\/j.efsa.2015.4102","article-title":"Scientific Opinion on the safety of caffeine","volume":"13","author":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)","year":"2015","journal-title":"EFSA J."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.7861\/clinmedicine.18-2-155","article-title":"Acute encephalitis\u2014diagnosis and management","volume":"18","author":"Ellul","year":"2018","journal-title":"Clin. Med."},{"issue":"Suppl. 1","key":"10.1016\/bs.pbr.2024.06.005_bb0205","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.3233\/JAD-2010-1404","article-title":"Caffeine as a protective factor in dementia and Alzheimer's disease","volume":"20","author":"Eskelinen","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0210","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3233\/JAD-111982","article-title":"Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A 2A receptors upregulation in the hippocampus of a rat model of sporadic dementia","volume":"34","author":"Espinosa","year":"2013","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.005_bb0215","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2036.2003.01429.x","article-title":"Moderate coffee consumption increases plasma glutathione but not homocysteine in healthy subjects","volume":"17","author":"Esposito","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0220","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.maturitas.2021.02.006","article-title":"The twilight of the immune system: the impact of immunosenescence in aging","volume":"147","author":"Feehan","year":"2021","journal-title":"Maturitas"},{"issue":"11","key":"10.1016\/bs.pbr.2024.06.005_bb0225","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/nn.4648","article-title":"\u03b1-Synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B","volume":"20","author":"Ferreira","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0230","first-page":"718","article-title":"Adenosine A2A receptors modulate \u03b1-synuclein aggregation and toxicity","volume":"27","author":"Ferreira","year":"2017","journal-title":"Cereb. Cortex"},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090699","article-title":"Chlorogenic acid inhibits human platelet activation and thrombus formation","volume":"9","author":"Fuentes","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0240","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1038\/s41598-020-59380-x","article-title":"Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-\u03baB and activating Nrf2","volume":"10","author":"Funakoshi-Tago","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2022.104980","article-title":"Coffee ingredients, hydroquinone, pyrocatechol, and 4-ethylcatechol exhibit anti-inflammatory activity through inhibiting NF-\u03baB and activating Nrf2","volume":"90","author":"Funakoshi-Tago","year":"2022","journal-title":"J. Funct. Foods"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0250","author":"Global Hot Drinks Market Size, Share | Industry Trends Report, 2025"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0255","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10654-016-0202-2","article-title":"Coffee consumption and risk of all-cause, cardiovascular, and cancer mortality in smokers and non-smokers: a dose-response meta-analysis","volume":"31","author":"Grosso","year":"2016","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.752826","article-title":"Pharmacokinetics of caffeine: a systematic analysis of reported data for application in metabolic phenotyping and liver function testing","volume":"12","author":"Grzegorzewski","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"17","key":"10.1016\/bs.pbr.2024.06.005_bb0265","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.3390\/molecules24173205","article-title":"Effect of chlorogenic acid on the physicochemical and functional properties of Coregonus peled myofibrillar protein through hydroxyl radical oxidation","volume":"24","author":"Guo","year":"2019","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0270","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a source and target of cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0275","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jep.2011.02.033","article-title":"Effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus","volume":"135","author":"Hebeda","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0280","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fnut.2018.00133","article-title":"The impact of coffee and caffeine on multiple sclerosis compared to other neurodegenerative diseases","volume":"5","author":"Herden","year":"2018","journal-title":"Front. Nutr."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0285","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/10408390500400009","article-title":"Coffee and health: a review of recent human research","volume":"46","author":"Higdon","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0290","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.immuni.2015.03.011","article-title":"C-Myb (+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages","volume":"42","author":"Hoeffel","year":"2015","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/bs.pbr.2024.06.005_bb0295","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/mnfr.201000048","article-title":"Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules","volume":"54","author":"Hoelzl","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0300","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/oxygen1010004","article-title":"Comprehension of the relationship between autophagy and reactive oxygen species for superior cancer therapy with histone deacetylase inhibitors","volume":"1","author":"Ikeda","year":"2021","journal-title":"Oxygen"},{"issue":"9","key":"10.1016\/bs.pbr.2024.06.005_bb0305","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3390\/antiox9090902","article-title":"Antioxidant and neuroprotective effects of caffeine against Alzheimer's and Parkinson's disease: insight into the role of Nrf-2 and A2AR signaling","volume":"9","author":"Ikram","year":"2020","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/bs.pbr.2024.06.005_bb0310","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0315","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jneuroim.2019.03.012","article-title":"Toll-like receptors in the pathogenesis of neuroinflammation","volume":"332","author":"Kumar","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0320","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0325","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40120-021-00239-2","article-title":"Comprehensive approach to management of multiple sclerosis: addressing invisible symptoms\u2014a narrative review","volume":"10","author":"Lakin","year":"2021","journal-title":"Neurol. Ther."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0330","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple sclerosis pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0335","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1023\/A:1013911205494","article-title":"Effects of microenvironment on morphology and function of the microglial cell line BV-2","volume":"26","author":"Laurenzi","year":"2001","journal-title":"Neurochem. Res."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1423-0127-19-60","article-title":"Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma","volume":"19","author":"Lee","year":"2012","journal-title":"J. Biomed. Sci."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0345","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/mrm.29355","article-title":"Blood\u2013brain barrier permeability in response to caffeine challenge","volume":"88","author":"Lin","year":"2022","journal-title":"Magn. Reson. Med."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0350","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/aje\/kwf074","article-title":"Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging","volume":"156","author":"Lindsay","year":"2002","journal-title":"Am. J. Epidemiol."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0355","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/nu13020537","article-title":"Potential of caffeine in Alzheimer's disease\u2014a review of experimental studies","volume":"13","author":"Londzin","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0360","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bcp.2019.06.008","article-title":"The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors","volume":"166","author":"Lopes","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0365","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fnins.2018.00301","article-title":"Chronic caffeine treatment protects against \u03b1-synucleinopathy by reestablishing autophagy activity in the mouse striatum","volume":"12","author":"Luan","year":"2018","journal-title":"Front. Neurosci."},{"issue":"8","key":"10.1016\/bs.pbr.2024.06.005_bb0370","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1039\/C4FO00042K","article-title":"Coffee: biochemistry and potential impact on health","volume":"5","author":"Ludwig","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0375","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbr.2014.01.051","article-title":"Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions","volume":"264","author":"Machado-Filho","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0380","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.immuni.2019.12.003","article-title":"Microglia, lifestyle stress, and neurodegeneration","volume":"52","author":"Madore","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0385","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00735","article-title":"Phenylindanes in brewed coffee inhibit amyloid-beta and tau aggregation","volume":"12","author":"Mancini","year":"2018","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0390","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/eji.1830270508","article-title":"Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-kappa B and AP-1","volume":"27","author":"Martin","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0395","unstructured":"McAllister, C., 2022. Encephalitis Lethargica, viral illness and the binary structures of the modern British health system c. 1900\u20131975. Doctoral dissertation, University of Sheffield."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-017-0241-2","article-title":"Role of neuroinflammation in neurodegeneration: new insights","volume":"9","author":"McManus","year":"2017","journal-title":"Alzheimer's Res. Ther."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0405","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0192-0561(90)90076-Y","article-title":"Coffee and the immune system","volume":"12","author":"Melamed","year":"1990","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13063-017-2271-2","article-title":"The Pocket-4-Life project, bioavailability and beneficial properties of the bioactive compounds of espresso coffee and cocoa-based confectionery containing coffee: study protocol for a randomized cross-over trial","volume":"18","author":"Mena","year":"2017","journal-title":"Trials"},{"key":"10.1016\/bs.pbr.2024.06.005_bb681","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/bs.apha.2019.12.002","article-title":"Pharmacological action and potential targets of chlorogenic acid","volume":"87","author":"Miao","year":"2020","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0415","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6281454","article-title":"Foods with potential prooxidant and antioxidant effects involved in Parkinson's disease","volume":"2020","author":"Miranda-D\u00edaz","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1\u20132","key":"10.1016\/bs.pbr.2024.06.005_bb0420","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mrfmmm.2010.08.003","article-title":"Impact of paper filtered coffee on oxidative DNA-damage: results of a clinical trial","volume":"692","author":"Mi\u0161\u00edk","year":"2010","journal-title":"Mutat. Res."},{"issue":"10","key":"10.1016\/bs.pbr.2024.06.005_bb0425","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/glia.22993","article-title":"Glial cells as drug targets: what does it take?","volume":"64","author":"M\u00f6ller","year":"2016","journal-title":"Glia"},{"issue":"9","key":"10.1016\/bs.pbr.2024.06.005_bb0430","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1021\/jf1005148","article-title":"Formation of volatile chemicals from thermal degradation of less volatile coffee components: quinic acid, caffeic acid, and chlorogenic acid","volume":"58","author":"Moon","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"Suppl. 6","key":"10.1016\/bs.pbr.2024.06.005_bb0435","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/09637480903158893","article-title":"The increase in human plasma antioxidant capacity after acute coffee intake is not associated with endogenous non-enzymatic antioxidant components","volume":"60","author":"Moura-Nunes","year":"2009","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0440","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.742065","article-title":"Microglia in neuroinflammation and neurodegeneration: from understanding to therapy","volume":"15","author":"Muzio","year":"2021","journal-title":"Front. Neurosci."},{"issue":"21","key":"10.1016\/bs.pbr.2024.06.005_bb0445","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1021\/jf025768c","article-title":"Coffee drinking influences plasma antioxidant capacity in humans","volume":"50","author":"Natella","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0450","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"Chlorogenic acid (CGA): a pharmacological review and call for further research","volume":"97","author":"Naveed","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0265203021000007840","article-title":"Effects of caffeine on human health","volume":"20","author":"Nawrot","year":"2003","journal-title":"Food Addit. Contam."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0460","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jphs.2015.01.003","article-title":"Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects","volume":"127","author":"Noguchi","year":"2015","journal-title":"J. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0465","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/cid\/ciu772","article-title":"The role of antiviral therapy in immunocompromised patients with herpes simplex virus meningitis","volume":"60","author":"Noska","year":"2015","journal-title":"Clin. Infect. Dis."},{"issue":"6","key":"10.1016\/bs.pbr.2024.06.005_bb0470","doi-asserted-by":"crossref","first-page":"1600670","DOI":"10.1002\/mnfr.201600670","article-title":"Health benefits of methylxanthines in neurodegenerative diseases","volume":"61","author":"O\u00f1atibia-Astibia","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0475","article-title":"The role of lipopolysaccharide-induced cell signalling in chronic inflammation","volume":"6","author":"Page","year":"2022","journal-title":"Chronic Stress (Thousand Oaks)"},{"issue":"10","key":"10.1016\/bs.pbr.2024.06.005_bb0480","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/mds.25076","article-title":"Caffeine and risk of Parkinson's disease in a large cohort of men and women","volume":"27","author":"Palacios","year":"2012","journal-title":"Mov. Disord."},{"issue":"200","key":"10.1016\/bs.pbr.2024.06.005_bb0485","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/978-3-642-13443-2_12","article-title":"Methylxanthines and sleep","author":"Porkka-Heiskanen","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"issue":"17","key":"10.1016\/bs.pbr.2024.06.005_bb0490","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1212\/WNL.0000000000004568","article-title":"Caffeine as symptomatic treatment for Parkinson disease (Caf\u00e9-PD): a randomized trial","volume":"89","author":"Postuma","year":"2017","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.005_bb0495","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/1541-4337.12206","article-title":"A comprehensive overview of the risks and benefits of coffee consumption","volume":"15","author":"Pourshahidi","year":"2016","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0500","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1046\/j.1471-4159.2003.02245.x","article-title":"Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure","volume":"88","author":"Quarta","year":"2004","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0505","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s10719-022-10064-w","article-title":"Neuroinflammation and galectins: a key relationship in neurodegenerative diseases","volume":"39","author":"Ramirez Hernandez","year":"2022","journal-title":"Glycoconj. J."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0510","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13205-022-03123-4","article-title":"Hippocampus and its involvement in Alzheimer's disease: a review","volume":"12","author":"Rao","year":"2022","journal-title":"3 Biotech"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0515","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.602697","article-title":"Caffeine and Parkinson's disease: multiple benefits and emerging mechanisms","volume":"14","author":"Ren","year":"2020","journal-title":"Front. Neurosci."},{"issue":"9","key":"10.1016\/bs.pbr.2024.06.005_bb0520","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.3390\/nu13093088","article-title":"Caffeine as a factor influencing the functioning of the human body\u2014friend or foe?","volume":"13","author":"Rodak","year":"2021","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0525","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/jlb.65.3.291","article-title":"Stimulus-specific regulation of chemokine expression involves differential activation of the redox-responsive transcription factors AP-1 and NF-\u03baB","volume":"65","author":"Roebuck","year":"1999","journal-title":"J. Leukoc. Biol."},{"issue":"20","key":"10.1016\/bs.pbr.2024.06.005_bb0530","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1001\/jama.283.20.2674","article-title":"Association of coffee and caffeine intake with the risk of Parkinson disease","volume":"283","author":"Ross","year":"2000","journal-title":"JAMA"},{"issue":"6301","key":"10.1016\/bs.pbr.2024.06.005_bb0535","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1126\/science.aaf6260","article-title":"Inflammatory neuroprotection following traumatic brain injury","volume":"353","author":"Russo","year":"2016","journal-title":"Science"},{"issue":"11","key":"10.1016\/bs.pbr.2024.06.005_bb0540","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nri3086","article-title":"Microglial cell origin and phenotypes in health and disease","volume":"11","author":"Saijo","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0545","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1172\/JCI117185","article-title":"Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation","volume":"93","author":"Salvemini","year":"1994","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0550","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-8993(89)90078-4","article-title":"Production of tumor necrosis factor-alpha by microglia and astrocytes in culture","volume":"491","author":"Sawada","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0555","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","volume":"476","author":"Sawcer","year":"2011","journal-title":"Nature"},{"issue":"13","key":"10.1016\/bs.pbr.2024.06.005_bb0560","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.3390\/ijms21134766","article-title":"Caffeine: an overview of its beneficial effects in experimental models and clinical trials of Parkinson's disease","volume":"21","author":"Schepici","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0565","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/life12030330","article-title":"Impact of caffeine on Alzheimer's disease pathogenesis\u2014protective or risk factor?","volume":"12","author":"Schreiner","year":"2022","journal-title":"Life"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0570","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.foodchem.2016.07.176","article-title":"Elemental composition of green coffee and its contribution to dietary intake","volume":"215","author":"\u015eemen","year":"2017","journal-title":"Food Chem."},{"issue":"82","key":"10.1016\/bs.pbr.2024.06.005_bb0575","doi-asserted-by":"crossref","first-page":"78548","DOI":"10.1039\/C6RA17602J","article-title":"The role of caffeine as an inhibitor in the aggregation of amyloid forming peptides: a unified molecular dynamics simulation and experimental study","volume":"6","author":"Sharma","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0580","series-title":"National Institute of Neurological Disorders and Stroke","author":"Sheet","year":"2022"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0585","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fncel.2018.00072","article-title":"An inflammation-centric view of neurological disease: beyond the neuron","volume":"12","author":"Skaper","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0590","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.expneurol.2012.01.022","article-title":"Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease","volume":"234","author":"Sonsalla","year":"2012","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0595","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1021\/jf011234k","article-title":"Alkylpyridiniums. 1. Formation in model systems via thermal degradation of trigonelline","volume":"50","author":"Stadler","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0600","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/BF01193443","article-title":"Trigonellin in Bohnenkaffee. II. Gehalte in Rohkaffee, R\u00f6stkaffee und Kaffee-Extrakt: II. Content of green, roasted and instant coffee","volume":"199","author":"Stennert","year":"1994","journal-title":"Z. Lebensm. Unters. Forsch."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0605","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0028-3908(99)00156-2","article-title":"Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats","volume":"39","author":"Strong","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0610","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00394-017-1379-1","article-title":"The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature","volume":"56","author":"Tajik","year":"2017","journal-title":"Eur. J. Nutr."},{"issue":"11","key":"10.1016\/bs.pbr.2024.06.005_bb0615","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1177\/014107689608901107","article-title":"The cholesterol-raising factor from coffee beans","volume":"89","author":"Urgert","year":"1996","journal-title":"J. R. Soc. Med."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.005_bb0620","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/biology9050103","article-title":"Clinical features of Parkinson's disease: the evolution of critical symptoms","volume":"9","author":"V\u00e1radi","year":"2020","journal-title":"Biology"},{"issue":"10053","key":"10.1016\/bs.pbr.2024.06.005_bb0625","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Vos","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0630","unstructured":"Wallace, J.T., 2017. An analysis of the acid profile of coffee brews: caffeine and chlorogenic acid concentrations in different forms of coffee brew. SMBHC Thesis Repository."},{"issue":"10053","key":"10.1016\/bs.pbr.2024.06.005_bb0635","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Wang","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0640","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12031-021-01894-8","article-title":"Caffeine inhibits activation of the NLRP3 inflammasome via autophagy to attenuate microglia-mediated neuroinflammation in experimental autoimmune encephalomyelitis","volume":"72","author":"Wang","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/bs.pbr.2024.06.005_bb0645","series-title":"The World of Caffeine: The Science and Culture of the World's Most Popular Drug","author":"Weinberg","year":"2001"},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0650","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/oxygen2030022","article-title":"Roles of reactive oxygen species and autophagy in the pathogenesis of cisplatin-induced acute kidney injury","volume":"2","author":"Yoshikawa","year":"2022","journal-title":"Oxygen"},{"key":"10.1016\/bs.pbr.2024.06.005_bb0655","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5568011","article-title":"The neuroprotective effects of moderate and regular caffeine consumption in Alzheimer's disease","volume":"2021","author":"Zhou","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/bs.pbr.2024.06.005_bb0660","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3390\/cells8080911","article-title":"The therapeutic implications of tea polyphenols against dopamine (DA) neuron degeneration in Parkinson's disease (PD)","volume":"8","author":"Zhou","year":"2019","journal-title":"Cells"},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.005_bb0665","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ana.22630","article-title":"Adenosine A2A receptor gene disruption protects in an \u03b1-synuclein model of Parkinson's disease","volume":"71","author":"Kachroo","year":"2012","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.005_bb0675","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3390\/cells10030598","article-title":"The nigral coup in Parkinson's disease by \u03b1-synuclein and its associated rebels","volume":"10","author":"Sian-Hulsmann","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.005_bb0680","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/ijms22010107","article-title":"Neuroprotective effects of coffee bioactive compounds: a review","volume":"22","author":"Soca\u0142a","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Progress in Brain Research","Neuroscience of Coffee Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612324000906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612324000906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T16:17:46Z","timestamp":1724084266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612324000906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443344671"],"references-count":135,"URL":"https:\/\/doi.org\/10.1016\/bs.pbr.2024.06.005","relation":{},"ISSN":["0079-6123"],"issn-type":[{"value":"0079-6123","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}