{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:02:04Z","timestamp":1785182524954,"version":"3.55.0"},"reference-count":80,"publisher":"Elsevier","isbn-type":[{"value":"9780443316340","type":"print"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DST\/CURIE-PG\/2022\/10G"],"award-info":[{"award-number":["DST\/CURIE-PG\/2022\/10G"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.pbr.2024.06.012","type":"book-chapter","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T01:10:20Z","timestamp":1721869820000},"page":"35-58","source":"Crossref","is-referenced-by-count":12,"title":["Molecular targets of caffeine in the central nervous system"],"prefix":"10.1016","member":"78","reference":[{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0010","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jsps.2020.02.005","article-title":"Caffeine induces neurobehavioral effects through modulating neurotransmitters","volume":"28","author":"Alasmari","year":"2020","journal-title":"Saudi Pharm. J."},{"issue":"8","key":"10.1016\/bs.pbr.2024.06.012_bb0015","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1468-2982.2008.01814.x","article-title":"Migraine and the hypothalamus","volume":"29","author":"Alstadhaug","year":"2009","journal-title":"Cephalalgia"},{"key":"10.1016\/bs.pbr.2024.06.012_bb401","series-title":"Effect of plant-based diets on the brain","author":"Ansari","year":"2024"},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0020","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.neuroscience.2006.07.021","article-title":"Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain \u03b2-amyloid production","volume":"142","author":"Arendash","year":"2006","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/bs.pbr.2024.06.012_bb0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.pneurobio.2004.06.004","article-title":"Adenosine and sleep\u2013wake regulation","volume":"73","author":"Basheer","year":"2004","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/bs.pbr.2024.06.012_bb0030","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1526-4610.2005.05133.x","article-title":"Psychological, sleep, lifestyle, and comorbid associations with headache","volume":"45","author":"Boardman","year":"2005","journal-title":"Headache"},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.012_bb0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1523\/JNEUROSCI.4591-03.2004","article-title":"Input-specific modulation of neurotransmitter release in the lateral horn of the spinal cord via adenosine receptors","volume":"24","author":"Brooke","year":"2004","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/bs.pbr.2024.06.012_bb0040","first-page":"685","article-title":"Suicide by ingestion of caffeine","volume":"105","author":"Bryant","year":"1981","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0045","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/10408390903586412","article-title":"Coffee and its consumption: benefits and risks","volume":"51","author":"Butt","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"7","key":"10.1016\/bs.pbr.2024.06.012_bb0050","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1161\/01.STR.0000130989.17100.96","article-title":"Seizures and epilepsy after ischemic stroke","volume":"35","author":"Camilo","year":"2004","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.012_bb0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1570159X13666141210215655","article-title":"Caffeine: cognitive and physical performance enhancer or psychoactive drug?","volume":"13","author":"Cappelletti","year":"2015","journal-title":"Curr. Neuropharmacol."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0060","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5808\/GI.2013.11.4.282","article-title":"Molecular vibration-activity relationship in the agonism of adenosine receptors","volume":"11","author":"Chee","year":"2013","journal-title":"Genomics Inform."},{"issue":"s1","key":"10.1016\/bs.pbr.2024.06.012_bb0065","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.3233\/JAD-2010-1376","article-title":"Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases","volume":"20","author":"Chen","year":"2010","journal-title":"J. Alzheimer's Dis."},{"issue":"12","key":"10.1016\/bs.pbr.2024.06.012_bb0070","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1016\/0031-9422(91)83461-S","article-title":"Caffeine from green beans of Mascarocoffea","volume":"30","author":"Clifford","year":"1991","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0075","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1468-2982.1992.1202099.x","article-title":"Weekend attacks in migraine patients: caused by caffeine withdrawal?","volume":"12","author":"Couturier","year":"1992","journal-title":"Cephalalgia"},{"issue":"s1","key":"10.1016\/bs.pbr.2024.06.012_bb0080","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.3233\/JAD-2010-1408","article-title":"Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline","volume":"20","author":"Cunha","year":"2010","journal-title":"J. Alzheimer's Dis."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/beverages5020037","article-title":"Caffeine consumption through coffee: content in the beverage, metabolism, health benefits and risks","volume":"5","author":"dePaula","year":"2019","journal-title":"Beverages"},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.tins.2012.12.003","article-title":"Adenosine: setting the stage for plasticity","volume":"36","author":"Dias","year":"2013","journal-title":"Trends Neurosci."},{"issue":"6","key":"10.1016\/bs.pbr.2024.06.012_bb0095","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1079\/BJN20051370","article-title":"Is coffee a functional food?","volume":"93","author":"D\u00f3rea","year":"2005","journal-title":"Br. J. Nutr."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.012_bb0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00000542-200201000-00011","article-title":"Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans","volume":"96","author":"Eisenach","year":"2002","journal-title":"Anesthesiology"},{"issue":"9","key":"10.1016\/bs.pbr.2024.06.012_bb0105","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1523\/JNEUROSCI.5066-06.2007","article-title":"Sleep deprivation increases A(1) adenosine receptor binding in the human brain: a positron emission tomography study","volume":"27","author":"Elmenhorst","year":"2007","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/bs.pbr.2024.06.012_bb0110","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.2967\/jnumed.112.105114","article-title":"Caffeine occupancy of human cerebral A1 adenosine receptors: in vivo quantification with 18F-CPFPX and PET","volume":"53","author":"Elmenhorst","year":"2012","journal-title":"J. Nucl. Med."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0115","series-title":"StatPearls","author":"Evans","year":"2023"},{"issue":"s1","key":"10.1016\/bs.pbr.2024.06.012_bb0120","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.3233\/JAD-2010-1400","article-title":"Role of the central ascending neurotransmitter systems in the psychostimulant effects of caffeine","volume":"20","author":"Ferr\u00e9","year":"2010","journal-title":"J. Alzheimer's Dis."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.012_bb0125","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0306-4522(92)90291-9","article-title":"Adenosine-dopamine interactions in the brain","volume":"51","author":"Ferr\u00e9","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/bs.pbr.2024.06.012_bb0130","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroscience.2014.09.060","article-title":"Caffeine potentiates the release of GABA mediated by NMDA receptor activation: involvement of A1 adenosine receptors","volume":"281","author":"Ferreira","year":"2014","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.012_bb0135","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jada.2004.10.027","article-title":"Food sources and intakes of caffeine in the diets of persons in the United States","volume":"105","author":"Frary","year":"2005","journal-title":"J. Am. Diet. Assoc."},{"issue":"12","key":"10.1016\/bs.pbr.2024.06.012_bb0140","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/brainsci7030030","article-title":"The role of adenosine signaling in headache: a review","volume":"7","author":"Fried","year":"2017","journal-title":"Brain Sci."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.012_bb0145","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(96)00435-2","article-title":"The role of dopamine in the behavioral effects of caffeine in animals and humans","volume":"57","author":"Garrett","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0150","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.biocel.2014.07.009","article-title":"Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride","volume":"54","author":"Giunta","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0155","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/10408398.2017.1369391","article-title":"Coffee consumption and disease correlations","volume":"59","author":"G\u00f6kcen","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0160","doi-asserted-by":"crossref","first-page":"102","DOI":"10.13104\/imri.2017.21.2.102","article-title":"Immediate decrease in \u03b3-AminoButyric acid after caffeine intake in adolescents: a preliminary MRS study","volume":"21","author":"Hahn","year":"2017","journal-title":"Investig. Magn. Reson. Imaging"},{"issue":"17","key":"10.1016\/bs.pbr.2024.06.012_bb0165","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1200\/JCO.2009.25.1991","article-title":"Phase I dose-escalation study of recombinant human Apo2L\/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer","volume":"28","author":"Herbst","year":"2010","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.012_bb0170","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1046\/j.1468-2982.2003.00576.x","article-title":"Caffeine-induced headache in children and adolescents","volume":"23","author":"Hering-Hanit","year":"2003","journal-title":"Cephalalgia"},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0175","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1517\/14656566.4.4.485","article-title":"Chronic daily headaches in children","volume":"4","author":"Hershey","year":"2003","journal-title":"Expert Opin. Pharmacother."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/10408390500400009","article-title":"Coffee and health: a review of recent human research","volume":"46","author":"Higdon","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"10","key":"10.1016\/bs.pbr.2024.06.012_bb0185","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/0333102414541687","article-title":"Headache and sleep: shared patho physiological mechanisms","volume":"34","author":"Holland","year":"2014","journal-title":"Cephalalgia"},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.012_bb0190","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.pharmthera.2006.02.002","article-title":"Immunomodulatory effects of caffeine: friend or foe?","volume":"111","author":"Horrigan","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"7","key":"10.1016\/bs.pbr.2024.06.012_bb0195","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nn1491","article-title":"Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine","volume":"8","author":"Huang","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/1239629","article-title":"Caffeine-induced suppression of GABAergic inhibition and calcium-independent metaplasticity","volume":"2016","author":"Isokawa","year":"2016","journal-title":"Neural Plast."},{"issue":"16","key":"10.1016\/bs.pbr.2024.06.012_bb0205","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.1073\/pnas.161292398","article-title":"Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor","volume":"98","author":"Johansson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/bs.pbr.2024.06.012_bb0210","doi-asserted-by":"crossref","first-page":"R704","DOI":"10.1152\/ajpregu.00114.2014","article-title":"Caffeine promotes glutamate and histamine release in the posterior hypothalamus","volume":"307","author":"John","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0215","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/cns.12684","article-title":"The neuroprotective effects of caffeine in neurodegenerative diseases","volume":"23","author":"Kolahdouzan","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0220","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.48266","article-title":"Maternal caffeine consumption and its impact on the fetus: a review","author":"Lakin","year":"2023","journal-title":"Cureus"},{"issue":"27","key":"10.1016\/bs.pbr.2024.06.012_bb0225","doi-asserted-by":"crossref","first-page":"10067","DOI":"10.1523\/JNEUROSCI.6730-10.2011","article-title":"Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens","volume":"31","author":"Lazarus","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00740","article-title":"Gating and the need for sleep: dissociable effects of adenosine A1 and A2A receptors","volume":"13","author":"Lazarus","year":"2019","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.012_bb0235","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1124\/jpet.102.047951","article-title":"Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism","volume":"305","author":"Li","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/bs.pbr.2024.06.012_bb0240","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0922-4106(89)90028-X","article-title":"Interaction of caffeine with the GABAA receptor complex: alterations in receptor function but not ligand binding","volume":"172","author":"Lopez","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00526","article-title":"Caffeine and selective adenosine receptor antagonists as new therapeutic tools for the motivational symptoms of depression","volume":"9","author":"L\u00f3pez-Cruz","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0250","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00137","article-title":"Caffeine protects dopaminergic neurons from dopamine-induced neurodegeneration via synergistic adenosine-dopamine D2-like receptor interactions in transgenic Caenorhabditis elegans","volume":"12","author":"Manalo","year":"2018","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/bs.pbr.2024.06.012_bb0255","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.bjp.0704712","article-title":"Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes","volume":"136","author":"Marchi","year":"2002","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/bs.pbr.2024.06.012_bb0260","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/jat\/27.7.520","article-title":"Caffeine content of specialty coffees","volume":"27","author":"McCusker","year":"2003","journal-title":"J. Anal. Toxicol."},{"issue":"11","key":"10.1016\/bs.pbr.2024.06.012_bb0265","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1177\/0269881109106310","article-title":"Foetal response to maternal coffee intake: role of habitual versus non-habitual caffeine consumption","volume":"24","author":"Mulder","year":"2010","journal-title":"J. Psychopharmacol."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.012_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0265203021000007840","article-title":"Effects of caffeine on human health","volume":"20","author":"Nawrot","year":"2003","journal-title":"Food Addit. Contam."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0275","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000475895","article-title":"Caffeine and cannabis effects on vital neurotransmitters and enzymes in the brain tissue of juvenile experimental rats","volume":"24","author":"Owolabi","year":"2017","journal-title":"Ann. Neurosci."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0280","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.euroneuro.2012.04.011","article-title":"Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder","volume":"23","author":"Pandolfo","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0285","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.smrv.2010.06.005","article-title":"Adenosine, energy metabolism and sleep homeostasis","volume":"15","author":"Porkka-Heiskanen","year":"2011","journal-title":"Sleep Med. Rev."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.012_bb0290","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0026-895X(25)13347-6","article-title":"Chronic caffeine or theophylline exposure reduces gamma-aminobutyric acid\/benzodiazepine receptor site interactions","volume":"33","author":"Roca","year":"1988","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.012_bb0295","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0002-9378(89)90157-9","article-title":"Effects of regular and decaffeinated coffee on fetal breathing and heart rate","volume":"160","author":"Salvador","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0300","doi-asserted-by":"crossref","first-page":"H1633","DOI":"10.1152\/ajpheart.00575.2004","article-title":"Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease","volume":"288","author":"Sato","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"24","key":"10.1016\/bs.pbr.2024.06.012_bb0305","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.3390\/molecules26247634","article-title":"Relationship between the chemical composition and the biological functions of coffee","volume":"26","author":"Saud","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.012_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(97)01605-1","article-title":"Adenosine receptor activation and nociception","volume":"347","author":"Sawynok","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0315","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.pain.2010.10.011","article-title":"Caffeine and pain","volume":"152","author":"Sawynok","year":"2011","journal-title":"Pain"},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0320","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0306-4522(01)00383-9","article-title":"An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons","volume":"107","author":"Scammell","year":"2001","journal-title":"Neuroscience"},{"issue":"5246","key":"10.1016\/bs.pbr.2024.06.012_bb0325","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.271.5246.216","article-title":"Activation of ventrolateral preoptic neurons during sleep","volume":"271","author":"Sherin","year":"1996","journal-title":"Science (New York, N.Y.)"},{"issue":"9","key":"10.1016\/bs.pbr.2024.06.012_bb0330","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0278-6915(02)00096-0","article-title":"Effects of caffeine on human behavior","volume":"40","author":"Smith","year":"2002","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/bs.pbr.2024.06.012_bb0335","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/ijms22010107","article-title":"Neuroprotective effects of coffee bioactive compounds: a review","volume":"22","author":"Soca\u0142a","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/bs.pbr.2024.06.012_bb0340","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1523\/JNEUROSCI.22-15-06321.2002","article-title":"Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens","volume":"22","author":"Solinas","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0345","series-title":"Current Topics in Behavioral Neurosciences. Sleep, Neuronal Plasticity and Brain Function","first-page":"331","article-title":"Adenosine, caffeine, and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics","author":"Urry","year":"2014"},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0350","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/alcalc\/34.2.197","article-title":"A three-pathway psychobiological model of craving for alcohol","volume":"34","author":"Verheul","year":"1999","journal-title":"Alcohol Alcohol."},{"issue":"6","key":"10.1016\/bs.pbr.2024.06.012_bb0355","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/jcbfm.2013.40","article-title":"The effect of black tea and caffeine on regional cerebral blood flow measured with arterial spin labeling","volume":"33","author":"Vidyasagar","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0360","doi-asserted-by":"crossref","first-page":"e549","DOI":"10.1038\/tp.2015.46","article-title":"Caffeine increases striatal dopamine D2\/D3 receptor availability in the human brain","volume":"5","author":"Volkow","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"9","key":"10.1016\/bs.pbr.2024.06.012_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003155","article-title":"Fast inhibition of glutamate-activated currents by caffeine","volume":"3","author":"Vyleta","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/bs.pbr.2024.06.012_bb0370","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/nure.12146","article-title":"Legitimacy of concerns about caffeine and energy drink consumption","volume":"72","author":"Wesensten","year":"2014","journal-title":"Nutr. Rev."},{"issue":"110751","key":"10.1016\/bs.pbr.2024.06.012_bb0375","article-title":"Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague\u2013Dawley rats","volume":"133","author":"Xue","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/bs.pbr.2024.06.012_bb0380","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s11064-011-0682-0","article-title":"Role of secondary mediators in caffeine-mediated neuroprotection in maneb- and paraquat-induced Parkinson's disease phenotype in the mouse","volume":"37","author":"Yadav","year":"2012","journal-title":"Neurochem. Res."},{"issue":"5","key":"10.1016\/bs.pbr.2024.06.012_bb0385","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1523\/JNEUROSCI.2942-08.2009","article-title":"Control and function of the homeostatic sleep response by adenosine A(1) receptors","volume":"29","author":"Bjorness","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.pbr.2024.06.012_bb0390","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0074-7742(05)63007-3","article-title":"Adenosine and brain function","volume":"63","author":"Fredholm","year":"2005","journal-title":"Int. Rev. Neurobiol."},{"issue":"11","key":"10.1016\/bs.pbr.2024.06.012_bb0395","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1212\/01.WNL.0000145760.37852.ED","article-title":"Caffeine as a risk factor for chronic daily headache","volume":"63","author":"Scher","year":"2004","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/bs.pbr.2024.06.012_bb0400","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/sj.ejcn.1602495","article-title":"Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE study","volume":"61","author":"van Gelder","year":"2007","journal-title":"Eur. J. Clin. Nutr."}],"container-title":["Progress in Brain Research","Neuroscience of Coffee Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612324001080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612324001080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:27:11Z","timestamp":1762230431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612324001080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443316340"],"references-count":80,"URL":"https:\/\/doi.org\/10.1016\/bs.pbr.2024.06.012","relation":{},"ISSN":["0079-6123"],"issn-type":[{"value":"0079-6123","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}