{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:10:07Z","timestamp":1747368607973,"version":"3.40.5"},"reference-count":102,"publisher":"Elsevier","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/bs.pbr.2025.04.009","type":"book-chapter","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T19:50:42Z","timestamp":1747338642000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring heart-brain axis alterations in Parkinson\u2019s disease"],"prefix":"10.1016","author":[{"given":"Youssef","family":"Razouqi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanane","family":"El Fatimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marouane","family":"Mergaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loubna","family":"Khalki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/mds.29315","article-title":"In situ global structural proteome analysis identifies potential biomarkers for Parkinson\u2019s disease","volume":"38","author":"Abdelhafeez","year":"2023","journal-title":"Mov. Disord."},{"issue":"18","key":"10.1016\/bs.pbr.2025.04.009_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186513","article-title":"Non-coding RNAs in the brain-heart axis: the case of Parkinson\u2019s disease","volume":"21","author":"Acharya","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/bs.pbr.2025.04.009_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.31887\/DCNS.2004.6.3\/galexander","article-title":"Biology of Parkinson\u2019s disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder","volume":"6","author":"Alexander","year":"2004","journal-title":"Dialogues Clin. Neurosci."},{"issue":"7","key":"10.1016\/bs.pbr.2025.04.009_bib4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/jnnp.2006.102343","article-title":"Autonomic dysfunction in dementia","volume":"78","author":"Allan","year":"2007","journal-title":"J. Neurology, Neurosurgery, Psychiatry"},{"issue":"5","key":"10.1016\/bs.pbr.2025.04.009_bib5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/ana.24393","article-title":"Heart rate variability and the risk of Parkinson disease: the atherosclerosis risk in communities study","volume":"77","author":"Alonso","year":"2015","journal-title":"Ann. Neurol"},{"key":"10.1016\/bs.pbr.2025.04.009_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.crphys.2024.100123","article-title":"Autonomic brain functioning and age-related health concerns","volume":"7","author":"Alrosan","year":"2024","journal-title":"Curr. Res. Physiol."},{"issue":"3","key":"10.1016\/bs.pbr.2025.04.009_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci6030033","article-title":"Effects of deep brain stimulation on autonomic function","volume":"6","author":"Basiago","year":"2016","journal-title":"Brain Sci."},{"key":"10.1016\/bs.pbr.2025.04.009_bib8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fneur.2015.00182","article-title":"Potential interactions between the autonomic nervous system and higher level functions in neurological and neuropsychiatric conditions","volume":"6","author":"Bassi","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/bs.pbr.2025.04.009_bib9","article-title":"Onset of postural instability in Parkinson\u2019s disease depends on age rather than disease duration","volume":"2022","author":"Becker","year":"2022","journal-title":"Parkinson\u2019s Dis."},{"issue":"4","key":"10.1016\/bs.pbr.2025.04.009_bib10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.parkreldis.2009.11.006","article-title":"The description of all four cardinal signs of Parkinson\u2019s disease in a Hungarian medical text published in 1690","volume":"16","author":"Bereczki","year":"2010","journal-title":"Parkinsonism & Relat. Disord."},{"issue":"23","key":"10.1016\/bs.pbr.2025.04.009_bib11","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.jacc.2019.10.027","article-title":"Blood pressure management in afferent baroreflex failure: JACC review topic of the week","volume":"74","author":"Biaggioni","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib12","article-title":"Understanding mental health challenges in cardiovascular care","volume":"16","author":"Borkowski","year":"2024","journal-title":"Cureus"},{"issue":"11","key":"10.1016\/bs.pbr.2025.04.009_bib13","article-title":"Telehealth and COVID-19 pandemic: an overview of the telehealth use, advantages, challenges, and opportunities during COVID-19 pandemic","volume":"10","author":"Bouabida","year":"2022","journal-title":"Healthc. (Basel, Switz.)"},{"issue":"3","key":"10.1016\/bs.pbr.2025.04.009_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1590\/2175-8239-jbn-2018-0155","article-title":"Hypertension in patients on dialysis: diagnosis, mechanisms, and management","volume":"41","author":"Bucharles","year":"2019","journal-title":"J. Brasileiro de. Nefrologia"},{"issue":"11","key":"10.1016\/bs.pbr.2025.04.009_bib15","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6579\/acead2","article-title":"The 2023 wearable photoplethysmography roadmap","volume":"44","author":"Charlton","year":"2023","journal-title":"Physiological Meas"},{"key":"10.1016\/bs.pbr.2025.04.009_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jad.2024.03.098","article-title":"The brain-heart axis: integrative analysis of the shared genetic etiology between neuropsychiatric disorders and cardiovascular disease","volume":"355","author":"Chen","year":"2024","journal-title":"J. Affect. Disord"},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10286-019-00598-9","article-title":"Autonomic uprising: the tilt table test in autonomic medicine","volume":"29","author":"Cheshire","year":"2019","journal-title":"Clin. Autonomic Res.: Off. J. Clin. Autonomic Research Soc."},{"issue":"3","key":"10.1016\/bs.pbr.2025.04.009_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s13139-023-00790-w","article-title":"Optimal protocol and clinical usefulness of (123)I-MIBG cardiac scintigraphy for differentiation of Parkinson\u2019s disease and dementia with Lewy body from non-Parkinson\u2019s diseases","volume":"57","author":"Chun","year":"2023","journal-title":"Nucl. Med. Mol. Imaging"},{"issue":"9","key":"10.1016\/bs.pbr.2025.04.009_bib19","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1016\/j.numecd.2022.06.017","article-title":"Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: a 8-year follow-up","volume":"32","author":"Cicero","year":"2022","journal-title":"Nutrition, Metab. Cardiovasc. Dis."},{"key":"10.1016\/bs.pbr.2025.04.009_bib20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00401-008-0345-7","article-title":"Evidence that incidental LEwy body disease is pre-symptomatic Parkinson\u2019s disease","volume":"115","author":"Dickson","year":"2008","journal-title":"Acta Neuropathol."},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1469-1809.2009.00560.x","article-title":"Genome-Wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for parkinson disease","volume":"74","author":"Edwards","year":"2010","journal-title":"Ann. Hum. Genet"},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19485565.2014.929488","article-title":"Gender differences in hypertension and hypertension awareness among young adults","volume":"61","author":"Everett","year":"2015","journal-title":"Biodemography Soc. Biol."},{"issue":"7","key":"10.1016\/bs.pbr.2025.04.009_bib23","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1093\/brain\/awac022","article-title":"Establishing gene regulatory networks from Parkinson\u2019s disease risk loci","volume":"145","author":"Farrow","year":"2022","journal-title":"Brain: A J. Neurol."},{"issue":"8","key":"10.1016\/bs.pbr.2025.04.009_bib24","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/mds.21989","article-title":"Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson\u2019s disease","volume":"23","author":"Fujishiro","year":"2008","journal-title":"Mov. Disorders: Off. J. Mov. Disord. Soc."},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41531-023-00515-y","article-title":"Shared molecular genetic factors influence subcortical brain morphometry and Parkinson\u2019s disease risk","volume":"9","author":"Garc\u00eda-Mar\u00edn","year":"2023","journal-title":"Npj Parkinson\u2019s Dis."},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00335-022-09974-9","article-title":"A rationale for considering heart\/brain axis control in neuropsychiatric disease","volume":"34","author":"Garrett","year":"2023","journal-title":"Mammalian Genome"},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0735-1097(01)01319-5","article-title":"Time course of cardiac structural, functional and electrical changes in asymptomatic patients after myocardial infarction: their inter-relation and prognostic impact","volume":"38","author":"Gaudron","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/bs.pbr.2025.04.009_bib28","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/mds.25776","article-title":"Multiple organ involvement by alpha\u2010synuclein pathology in Lewy body disorders","volume":"29","author":"Gelpi","year":"2014","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","article-title":"100 years of Lewy pathology","volume":"9","author":"Goedert","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/bs.pbr.2025.04.009_bib30","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/WCO.0000000000000112","article-title":"Premotor and nonmotor features of Parkinson\u2019s disease","volume":"27","author":"Goldman","year":"2014","journal-title":"Curr. Opin. Neurol."},{"issue":"11","key":"10.1016\/bs.pbr.2025.04.009_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1474-4422(03)00555-6","article-title":"Dysautonomia in Parkinson\u2019s disease: neurocardiological abnormalities","volume":"2","author":"Goldstein","year":"2003","journal-title":"Lancet Neurol."},{"issue":"11","key":"10.1016\/bs.pbr.2025.04.009_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115999","article-title":"The catecholaldehyde hypothesis for the pathogenesis of catecholaminergic neurodegeneration: what we know and what we do not know","volume":"22","author":"Goldstein","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/bs.pbr.2025.04.009_bib33","doi-asserted-by":"crossref","first-page":"338","DOI":"10.7326\/0003-4819-133-5-200009050-00009","article-title":"Cardiac sympathetic denervation in Parkinson disease","volume":"133","author":"Goldstein","year":"2000","journal-title":"Ann. Intern. Med."},{"issue":"16","key":"10.1016\/bs.pbr.2025.04.009_bib34","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1212\/01.wnl.0000268696.57912.64","article-title":"Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation","volume":"69","author":"Goldstein","year":"2007","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/bs.pbr.2025.04.009_bib35","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.7326\/0003-4819-135-11-200112040-00026","article-title":"Sympathetic neurocirculatory failure in Parkinson disease: evidence for an etiologic role of \u03b1-synuclein","volume":"135","author":"Goldstein","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/bs.pbr.2025.04.009_bib36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2017.09.033","article-title":"The heart of PD: Lewy body diseases as neurocardiologic disorders","volume":"1702","author":"Goldstein","year":"2019","journal-title":"Brain Res."},{"issue":"11","key":"10.1016\/bs.pbr.2025.04.009_bib37","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1002\/mds.28197","article-title":"The Parkinson\u2019s disease genome-wide association study locus browser","volume":"35","author":"Grenn","year":"2020","journal-title":"Mov. Disorders: Off. J. Mov. Disord. Soc."},{"issue":"9","key":"10.1016\/bs.pbr.2025.04.009_bib38","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s40263-016-0355-2","article-title":"Pharmacologic neuroprotection for functional outcomes after traumatic brain injury: a systematic review of the clinical literature","volume":"30","author":"Gruenbaum","year":"2016","journal-title":"CNS Drugs"},{"key":"10.1016\/bs.pbr.2025.04.009_bib39","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3389\/fneur.2018.00628","article-title":"Impact of tremor on patients with early stage Parkinson\u2019s disease","volume":"9","author":"Heusinkveld","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/bs.pbr.2025.04.009_bib40","article-title":"Machine learning identifies six genetic variants and alterations in the heart atrial appendage as key contributors to PD risk predictivity","volume":"12","author":"Ho","year":"2021","journal-title":"Front. Genet."},{"issue":"10","key":"10.1016\/bs.pbr.2025.04.009_bib41","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1093\/brain\/awaa238","article-title":"Brain-first versus body-first Parkinson\u2019s disease: amultimodal imaging case-control study","volume":"143","author":"Horsager","year":"2020","journal-title":"Brain"},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41531-022-00323-w","article-title":"Heart-brain synchronization breakdown in Parkinson\u2019s disease","volume":"8","author":"Iniguez","year":"2022","journal-title":"NPJ Parkinson\u2019s Dis."},{"issue":"6","key":"10.1016\/bs.pbr.2025.04.009_bib43","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1212\/WNL.52.6.1269","article-title":"Lewy body\u2013type degeneration in cardiac plexus in Parkinson\u2019s and incidental Lewy body diseases","volume":"52","author":"Iwanaga","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2025.04.009_bib44","first-page":"535","article-title":"Sleep disorders in Parkinson\u2019s disease","volume":"5","author":"Jahan","year":"2009","journal-title":"Neuropsychiatric Dis. Treat"},{"issue":"3","key":"10.1016\/bs.pbr.2025.04.009_bib45","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.nbd.2011.10.025","article-title":"Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis","volume":"46","author":"Jain","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"7 1","key":"10.1016\/bs.pbr.2025.04.009_bib46","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1212\/WNL.0000000000200787","article-title":"Lifestyle interventions for the prevention of Parkinson disease: a recipe for action","volume":"99","author":"Janssen Daalen","year":"2022","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/bs.pbr.2025.04.009_bib47","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000314573","article-title":"Importance of 123I-metaiodobenzylguanidine scintigraphy\/single photon emission computed tomography for diagnosis and differential diagnostics of Parkinson syndromes","volume":"7","author":"Jost","year":"2010","journal-title":"Neurodegenerative Dis."},{"key":"10.1016\/bs.pbr.2025.04.009_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.907293","article-title":"Alpha-Synuclein strain variability in body-first and brain-first synucleinopathies","volume":"14","author":"Just","year":"2022","journal-title":"Front. aging Neurosci."},{"key":"10.1016\/bs.pbr.2025.04.009_bib49","article-title":"Nonpharmacological modulation of chronic inflammation in Parkinson\u2019s disease: role of diet interventions","volume":"2019","author":"Kalampokini","year":"2019","journal-title":"Parkinson\u2019s Dis."},{"issue":"7","key":"10.1016\/bs.pbr.2025.04.009_bib50","first-page":"1099","article-title":"Reduced cardiac uptake and enhanced washout of 123I-MIBG in pure autonomic failure occurs conjointly with Parkinson\u2019s disease and dementia with Lewy bodies","volume":"47","author":"Kashihara","year":"2006","journal-title":"J. Nucl. Med."},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/HCR.0000000000000423","article-title":"Exercise testing and exercise rehabilitation for patients with atrial fibrillation","volume":"39","author":"Keteyian","year":"2019","journal-title":"J. Cardiopulm. Rehabilitation Prev"},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/CRD.0000000000000280","article-title":"Cardiovascular disorders mediated by autonomic nervous system dysfunction","volume":"28","author":"Khemani","year":"2020","journal-title":"Cardiology Rev."},{"issue":"5","key":"10.1016\/bs.pbr.2025.04.009_bib53","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1212\/CPJ.0000000000200068","article-title":"Orthostatic hypotension in Parkinson disease: what is new?","volume":"12","author":"Lamotte","year":"2022","journal-title":"Neurol. Clin. Pract."},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/JPD-130333","article-title":"Peripheral autonomic nervous system involvement in Gaucher-related parkinsonism","volume":"4","author":"Lebouvier","year":"2014","journal-title":"J. Parkinson\u2019s Dis."},{"issue":"4\u20135","key":"10.1016\/bs.pbr.2025.04.009_bib55","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0161-813X(02)00066-9","article-title":"Conformational behavior of human \u03b1-synuclein is modulated by familial Parkinson\u2019s disease point mutations A30P and A53T","volume":"23","author":"Li","year":"2002","journal-title":"Neurotoxicology"},{"key":"10.1016\/bs.pbr.2025.04.009_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1274595","article-title":"Cardiovascular disease and depression: a narrative review","volume":"10","author":"Li","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/bs.pbr.2025.04.009_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1038945","article-title":"The autonomic nervous system: a potential link to the efficacy of acupuncture","volume":"16","author":"Li","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/bs.pbr.2025.04.009_bib58","doi-asserted-by":"crossref","DOI":"10.1177\/10742484241233872","article-title":"Association between use of sodium-glucose cotransporter-2 inhibitors or angiotensin receptor-neprilysin inhibitor and the risk of atherosclerotic cardiovascular disease with coexisting diabetes and heart failure","volume":"29","author":"Lin","year":"2024","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/bs.pbr.2025.04.009_bib59","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/mdc3.12454","article-title":"Autonomic dysfunction in early Parkinson\u2019s disease: results from the United Kingdom tracking Parkinson\u2019s study","volume":"4","author":"Malek","year":"2017","journal-title":"Mov. Disord. Clin. Pract"},{"issue":"1\u20132","key":"10.1016\/bs.pbr.2025.04.009_bib60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jns.2010.08.056","article-title":"Relationship between orthostatic hypotension and cognitive impairment in the elderly","volume":"299","author":"Mehrabian","year":"2010","journal-title":"J. Neurol. Sci."},{"issue":"6","key":"10.1016\/bs.pbr.2025.04.009_bib61","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1097\/CCM.0b013e318246b9ad","article-title":"Improved cerebral perfusion pressures and 24-hr neurological survival in a porcine model of cardiac arrest with active compression-decompression cardiopulmonary resuscitation and augmentation of negative intrathoracic pressure","volume":"40","author":"Metzger","year":"2012","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/bs.pbr.2025.04.009_bib62","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10048-017-0514-8","article-title":"Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson\u2019s disease on chromosome 7p15.3","volume":"18","author":"Murthy","year":"2017","journal-title":"Neurogenetics"},{"issue":"5","key":"10.1016\/bs.pbr.2025.04.009_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15051503","article-title":"The management of Parkinson\u2019s disease: an overview of the current advancements in drug delivery systems","volume":"15","author":"Nakmode","year":"2023","journal-title":"Pharmaceutics"},{"issue":"11","key":"10.1016\/bs.pbr.2025.04.009_bib64","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/HJH.0000000000003825","article-title":"White-coat effect and masked hypertension in patients with high-normal office blood pressure: results of the Hungarian ABPM registry","volume":"42","author":"Nemcsik","year":"2024","journal-title":"J. Hypertension"},{"issue":"6","key":"10.1016\/bs.pbr.2025.04.009_bib65","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/jch.14653","article-title":"Comprehensive effects of lifestyle reform, adherence, and related factors on hypertension control: a review","volume":"25","author":"Ojangba","year":"2023","journal-title":"J. Clin. Hypertension (Greenwich, Conn.)"},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib66","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3390\/neurolint15020042","article-title":"Exploring the utility of autonomic nervous system evaluation for stroke prognosis","volume":"15","author":"Orgianelis","year":"2023","journal-title":"Neurol. Int."},{"key":"10.1016\/bs.pbr.2025.04.009_bib67","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00401-005-0995-7","article-title":"Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease","volume":"109","author":"Orimo","year":"2005","journal-title":"Acta Neuropathol."},{"issue":"10","key":"10.1016\/bs.pbr.2025.04.009_bib68","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/mds.20594","article-title":"Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2","volume":"20","author":"Orimo","year":"2005","journal-title":"Mov. Disorders: Off. J. Mov. Disord. Soc."},{"key":"10.1016\/bs.pbr.2025.04.009_bib69","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00401-008-0428-5","article-title":"Cardiac sympathetic denervation in Parkinson\u2019s disease linked to SNCA duplication","volume":"116","author":"Orimo","year":"2008","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/bs.pbr.2025.04.009_bib70","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/brain\/awm302","article-title":"Axonal \u03b1-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson\u2019s disease","volume":"131","author":"Orimo","year":"2008","journal-title":"Brain"},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib71","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cger.2019.09.002","article-title":"Orthostatic hypotension in Parkinson disease","volume":"36","author":"Palma","year":"2020","journal-title":"Clin. Geriatric Med."},{"key":"10.1016\/bs.pbr.2025.04.009_bib72","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/j.parkreldis.2015.09.004","article-title":"Non-motor symptoms in Parkinson\u2019s disease","volume":"22","author":"Pfeiffer","year":"2016","journal-title":"Parkinsonism & Relat. Disord"},{"issue":"4","key":"10.1016\/bs.pbr.2025.04.009_bib73","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1007\/s13311-020-00897-4","article-title":"Autonomic dysfunction in Parkinson\u2019s disease","volume":"17","author":"Pfeiffer","year":"2020","journal-title":"Neurotherapeutics: J. Am. Soc. Exp. NeuroTherapeutics"},{"issue":"5321","key":"10.1016\/bs.pbr.2025.04.009_bib74","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-62786-6","article-title":"Tango and physiotherapy interventions in Parkinson\u2019s disease: a pilot study on efficacy outcomes on motor and cognitive skills","volume":"14","author":"Rabini","year":"2024","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/bs.pbr.2025.04.009_bib76","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3934\/Neuroscience.2023017","article-title":"Depletion of dopamine in Parkinson\u2019s disease and relevant therapeutic options: a review of the literature","volume":"10","author":"Ramesh","year":"2023","journal-title":"AIMS Neurosci."},{"issue":"4","key":"10.1016\/bs.pbr.2025.04.009_bib77","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1152\/jn.00548.2020","article-title":"Baroreflex dysfunction in Parkinson\u2019s disease: integration of central and peripheral mechanisms","volume":"125","author":"Sabino-Carvalho","year":"2021","journal-title":"J. Neurophysiol."},{"issue":"12","key":"10.1016\/bs.pbr.2025.04.009_bib78","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11883-020-00889-x","article-title":"Digital health innovations to improve cardiovascular disease care","volume":"22","author":"Santo","year":"2020","journal-title":"Curr. Atherosclerosis Rep."},{"issue":"12","key":"10.1016\/bs.pbr.2025.04.009_bib79","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/ng.485","article-title":"Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson\u2019s disease","volume":"41","author":"Satake","year":"2009","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib80","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41531-024-00791-2","article-title":"MicroRNAs regulation in Parkinson\u2019s disease, and their potential role as diagnostic and therapeutic targets","volume":"10","author":"Shaheen","year":"2024","journal-title":"NPJ Parkinson\u2019s Dis."},{"key":"10.1016\/bs.pbr.2025.04.009_bib81","article-title":"Heart brain axis in health and disease: role of innate and adaptive immunity","author":"Simats","year":"2024","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/bs.pbr.2025.04.009_bib82","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/brain\/awh081","article-title":"Association between cardiac denervation and parkinsonism caused by \u03b1\u2010synuclein gene triplication","volume":"127","author":"Singleton","year":"2004","journal-title":"Brain"},{"key":"10.1016\/bs.pbr.2025.04.009_bib83","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.2147\/NDT.S304567","article-title":"Current perspectives on the assessment and management of gait disorders in Parkinson\u2019s disease","volume":"17","author":"Smith","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat"},{"issue":"6645","key":"10.1016\/bs.pbr.2025.04.009_bib84","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"issue":"6","key":"10.1016\/bs.pbr.2025.04.009_bib85","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1590\/0004-282x-anp-2021-0153","article-title":"Does length of time since diagnosis in Parkinson\u2019s disease influence heart rate variability? A cross-sectional study","volume":"80","author":"Stoco-Oliveira","year":"2022","journal-title":"Arquivos de. Neuro-Psiquiatria"},{"issue":"11","key":"10.1016\/bs.pbr.2025.04.009_bib86","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1177\/1535370215576313","article-title":"Parkinson\u2019s disease and enhanced inflammatory response","volume":"240","author":"Stojkovska","year":"2015","journal-title":"Exp. Biol. Med. (Maywood, N. J.)"},{"issue":"1\u20132","key":"10.1016\/bs.pbr.2025.04.009_bib87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jns.2005.08.011","article-title":"Impaired myocardial 123I-metaiodobenzylguanidine uptake in Lewy body disease: comparison between dementia with Lewy bodies and Parkinson\u2019s disease","volume":"240","author":"Suzuki","year":"2006","journal-title":"J. Neurol. Sci."},{"issue":"9","key":"10.1016\/bs.pbr.2025.04.009_bib88","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/jnnp-2015-310686","article-title":"Quantitative correlation between cardiac MIBG uptake and remaining axons in the cardiac sympathetic nerve in Lewy body disease","volume":"86","author":"Takahashi","year":"2015","journal-title":"J. Neurol. Neurosurg. & Psychiatry"},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib89","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.parkreldis.2012.08.001","article-title":"Cardiac sympathetic denervation in symptomatic and asymptomatic carriers of the E46K mutation in the \u03b1 synuclein gene","volume":"19","author":"Tijero","year":"2013","journal-title":"Parkinsonism & Relat. Disord"},{"key":"10.1016\/bs.pbr.2025.04.009_bib90","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10286-010-0068-4","article-title":"Cardiac sympathetic denervation precedes nigrostriatal loss in the E46K mutation of the \u03b1-synuclein gene (SNCA)","volume":"20","author":"Tijero","year":"2010","journal-title":"Clin. Autonomic Res."},{"key":"10.1016\/bs.pbr.2025.04.009_bib91","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10286-011-0135-5","article-title":"MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis","volume":"22","author":"Treglia","year":"2012","journal-title":"Clin. Autonomic Res."},{"issue":"14","key":"10.1016\/bs.pbr.2025.04.009_bib92","doi-asserted-by":"crossref","first-page":"e1434","DOI":"10.1212\/WNL.0000000000207725","article-title":"High-throughput CSF proteomics and machine learning to identify proteomic signatures for Parkinson disease development and progression","volume":"101","author":"Tsukita","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/bs.pbr.2025.04.009_bib93","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/971453","article-title":"Emerging risk biomarkers in cardiovascular diseases and disorders","volume":"2015","author":"Upadhyay","year":"2015","journal-title":"J. Lipids"},{"issue":"7","key":"10.1016\/bs.pbr.2025.04.009_bib94","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1055\/s-0042-1755225","article-title":"Autonomic and cardiorespiratory responses to the active tilt test in individuals with Parkinson disease: cross-sectional study","volume":"80","author":"Valente","year":"2022","journal-title":"Arquivos de. Neuro-Psiquiatria"},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib95","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10286-024-01030-7","article-title":"Hypotensive episodes at 24-h ambulatory blood pressure monitoring predict adverse outcomes in Parkinson\u2019s disease","volume":"34","author":"Vallelonga","year":"2024","journal-title":"Clin. Autonomic Res.: Off. J. Clin. Autonomic Research Soc."},{"key":"10.1016\/bs.pbr.2025.04.009_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105599","article-title":"Animal models of brain-first and body-first Parkinson\u2019s disease","volume":"163","author":"Van Den Berge","year":"2022","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib97","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s40620-019-00633-y","article-title":"Factors associated with systolic hypertension in peritoneal dialysis patients","volume":"33","author":"Vongsanim","year":"2020","journal-title":"J. Nephrol."},{"issue":"8","key":"10.1016\/bs.pbr.2025.04.009_bib98","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1474-4422(22)00169-7","article-title":"Diagnosis and treatment of orthostatic hypotension","volume":"21","author":"Wieling","year":"2022","journal-title":"Lancet. Neurol."},{"issue":"1","key":"10.1016\/bs.pbr.2025.04.009_bib99","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac343","article-title":"Identification of a possible proteomic biomarker in Parkinson\u2019s disease: discovery and replication in blood, brain and cerebrospinal fluid","volume":"5","author":"Winchester","year":"2023","journal-title":"Brain Commun."},{"key":"10.1016\/bs.pbr.2025.04.009_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpc.2023.100528","article-title":"Associations between diet quality and NT-proBNP in U.S. adults, NHANES 1999-2004","volume":"16","author":"Yang","year":"2023","journal-title":"Am. J. Preventive Cardiol."},{"issue":"2","key":"10.1016\/bs.pbr.2025.04.009_bib101","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/2249-4863.154630","article-title":"Resistant hypertension: an approach to management in primary care","volume":"4","author":"Yaxley","year":"2015","journal-title":"J. Family Med. Prim. Care"},{"issue":"4","key":"10.1016\/bs.pbr.2025.04.009_bib102","article-title":"The role of heart rate variability (HRV) in different hypertensive syndromes","volume":"13","author":"Yugar","year":"2023","journal-title":"Diagnostics (Basel, Switz.)"}],"container-title":["Progress in Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S007961232500055X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S007961232500055X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T19:50:57Z","timestamp":1747338657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S007961232500055X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":102,"URL":"https:\/\/doi.org\/10.1016\/bs.pbr.2025.04.009","relation":{},"ISSN":["0079-6123"],"issn-type":[{"value":"0079-6123","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}