{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:19:10Z","timestamp":1792876750632,"version":"4.5.0"},"reference-count":185,"publisher":"Elsevier","isbn-type":[{"value":"9780443346057","type":"print"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/bs.pbr.2025.05.007","type":"book-chapter","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:43:58Z","timestamp":1747755838000},"page":"189-227","source":"Crossref","is-referenced-by-count":9,"title":["Hormetic pathways in environmental enrichment in animal models and humans"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.pbr.2025.05.007_bib1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81453","article-title":"A prebiotic diet modulates microglial states and motor deficits in \u03b1-synuclein overexpressing mice","volume":"11","author":"Abdel-Haq","year":"2022","journal-title":"Elife"},{"issue":"1744","key":"10.1016\/bs.pbr.2025.05.007_bib2","doi-asserted-by":"crossref","first-page":"20170161","DOI":"10.1098\/rstb.2017.0161","article-title":"The functional highly sensitive brain: a review of the brain circuits underlying sensory processing sensitivity and seemingly related disorders","volume":"373","author":"Acevedo","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"17","key":"10.1016\/bs.pbr.2025.05.007_bib3","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1523\/JNEUROSCI.0496-05.2005","article-title":"Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer\u2019s disease","volume":"25","author":"Adlard","year":"2005","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3934\/Neuroscience.2023021","article-title":"Effect of postnatal environmental enrichment on LTP induction in the CA1 area of hippocampus of prenatally traffic noise-stressed female rats","volume":"10","author":"Aghighi","year":"2023","journal-title":"AIMS Neurosci."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0091-3057(81)90211-2","article-title":"Effect of early and later colony housing on oral ingestion of morphine in rats","volume":"15","author":"Alexander","year":"1981","journal-title":"Pharmacol. Biochem. Behav"},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0091-3057(81)90211-2","article-title":"Effect of early and later colony housing on oral ingestion of morphine in rats","volume":"15","author":"Alexander","year":"1981","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00426903","article-title":"The effect of housing and gender on morphine self-administration in rats","volume":"58","author":"Alexander","year":"1978","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"8","key":"10.1016\/bs.pbr.2025.05.007_bib8","first-page":"2388","article-title":"Long-term environmental enrichment affects microglial morphology in middle age mice","volume":"11","author":"Ali","year":"2019","journal-title":"Aging (Albany NY."},{"key":"10.1016\/bs.pbr.2025.05.007_bib9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fnsys.2014.00156","article-title":"Environmental enrichment and the sensory brain: the role of enrichment in remediating brain injury","volume":"8","author":"Alwis","year":"2014","journal-title":"Front. Syst. Neurosci."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib10","first-page":"241","article-title":"Understanding stress: characteristics and caveats","volume":"23","author":"Anisman","year":"1999","journal-title":"Alcohol. Res. Health"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1460-9568.2005.04552.x","article-title":"Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichment","volume":"23","author":"Artola","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib12","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.psyneuen.2013.02.004","article-title":"Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity","volume":"38","author":"Aschbacher","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13062-021-00297-4","article-title":"Lifestyle-dependent microglial plasticity: training the brain guardians","volume":"16","author":"Augusto-Oliveira","year":"2021","journal-title":"Biol. Direct"},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1017\/S2040174418000144","article-title":"Amygdala - and serum - neurotrophic factor levels depend on rearing condition in male rats","volume":"9","author":"Babri","year":"2018","journal-title":"J. Dev. Orig. Health Dis."},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.77","article-title":"Opposing actions of environmental enrichment and Alzheimer\u2019s disease on the expression of hippocampal microRNAs in mouse models","volume":"3","author":"Barak","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12383","article-title":"Paper or plastic? Exploring the effects of natural enrichment on behavioural and neuroendocrine responses in long-evans rats","volume":"28","author":"Bardi","year":"2016","journal-title":"J. Neuroendocrinol."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1192\/S2056474000002051","article-title":"The importance of greenspace for mental health","volume":"14","author":"Barton","year":"2017","journal-title":"BJPsych Int."},{"issue":"6","key":"10.1016\/bs.pbr.2025.05.007_bib18","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-derived neurotrophic factor and its clinical implications","volume":"11","author":"Bathina","year":"2015","journal-title":"Arch. Med. Sci."},{"issue":"12","key":"10.1016\/bs.pbr.2025.05.007_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029405","article-title":"Circulating and brain BDNF levels in stroke rats. Relevance to clinical studies","volume":"6","author":"B\u00e9jot","year":"2011","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib20","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.nbd.2011.04.022","article-title":"Beneficial effects of exercise in a transgenic mouse model of Alzheimer\u2019s disease-like Tau pathology","volume":"43","author":"Belarbi","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/bs.pbr.2025.05.007_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2024.105538","article-title":"Effects of the combination of chronic unpredictable stress and environmental enrichment on anxiety-like behavior assessed using the elevated plus maze in Swiss male mice: hypothalamus-pituitary-adrenal axis-mediated mechanisms","volume":"162","author":"Belo-Silva","year":"2024","journal-title":"Horm. Behav."},{"issue":"6","key":"10.1016\/bs.pbr.2025.05.007_bib22","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1037\/a0017376","article-title":"Beyond diathesis stress: differential susceptibility to environmental influences","volume":"135","author":"Belsky","year":"2009","journal-title":"Psychol. Bull"},{"issue":"3644","key":"10.1016\/bs.pbr.2025.05.007_bib23","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1126\/science.146.3644.610","article-title":"Chemical and anatomical plasticity brain","volume":"146","author":"Bennett","year":"1964","journal-title":"Science"},{"key":"10.1016\/bs.pbr.2025.05.007_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.nlm.2005.09.003","article-title":"Long-term continuous, but not daily, environmental enrichment reduces spatial memory decline in aged male mice","volume":"85","author":"Bennett","year":"2006","journal-title":"Neurobiol. Learn. Mem."},{"issue":"40","key":"10.1016\/bs.pbr.2025.05.007_bib25","doi-asserted-by":"crossref","first-page":"15570","DOI":"10.1073\/pnas.0803702105","article-title":"Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior","volume":"105","author":"Bergami","year":"2008","journal-title":"Proc. Natl Acad. Sci. U S A"},{"key":"10.1016\/bs.pbr.2025.05.007_bib26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bbi.2021.05.005","article-title":"Environmental activation of a hypothalamic BDNF-adipocyte IL-15 axis regulates adipose-natural killer cells","volume":"95","author":"Bergin","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib27","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1037\/amp0000583","article-title":"Environmental neuroscience","volume":"74","author":"Berman","year":"2019","journal-title":"Am. Psychologist"},{"issue":"35","key":"10.1016\/bs.pbr.2025.05.007_bib28","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.1523\/JNEUROSCI.23-35-10999.2003","article-title":"Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors","volume":"23","author":"Bezard","year":"2003","journal-title":"J. Neurosci."},{"issue":"Pt A","key":"10.1016\/bs.pbr.2025.05.007_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuropharm.2018.03.042","article-title":"Lifelong environmental enrichment in the absence of exercise protects the brain from age-related cognitive decline","volume":"145","author":"Birch","year":"2019","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/bs.pbr.2025.05.007_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/hipo.22103","article-title":"Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner","volume":"23","author":"Birch","year":"2013","journal-title":"Hippocampus"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jagp.2018.10.013","article-title":"The effects of yoga on patients with mild cognitive impairment and dementia: a scoping review","volume":"27","author":"Brenes","year":"2019","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/bs.pbr.2025.05.007_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13041-020-00567-8","article-title":"Donald O. Hebb and the organization of behavior: 17\u2009years in the writing","volume":"13","author":"Brown","year":"2020","journal-title":"Molecular Brain"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7326\/0003-4819-146-1-200701020-00007","article-title":"Narrative. review: reversible cerebral vasoconstriction syndromes","volume":"146","author":"Calabrese","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/bs.pbr.2025.05.007_bib34","article-title":"Hormesis, resilience and mental health: enhancing public health and therapeutic options","volume":"12","author":"Calabrese","year":"2020"},{"key":"10.1016\/bs.pbr.2025.05.007_bib35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/bs.irn.2024.08.003","article-title":"Environmental enrichment and complementary clinical interventions as therapeutic approaches for alcohol use disorder in animal models and humans","volume":"178","author":"Camarini","year":"2024","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/bs.pbr.2025.05.007_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2019.112638","article-title":"Environmental enrichment reduces the propensity to relapse following punishment-imposed abstinence of alcohol seeking","volume":"210","author":"Campbell","year":"2019","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.05.029","article-title":"Environmental and genetic activation of a brain-adipocyte BDNF\/leptin axis causes cancer remission and inhibition","volume":"142","author":"Cao","year":"2010","journal-title":"Cell"},{"issue":"1-2","key":"10.1016\/bs.pbr.2025.05.007_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.lfs.2012.05.013","article-title":"Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat","volume":"91","author":"Cechetti","year":"2012","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1021437905913","article-title":"Rearing environmental enrichment in two inbred strains of mice: 1. Effects on emotional reactivity","volume":"29","author":"Chapillon","year":"1999","journal-title":"Behav. Genet."},{"issue":"13","key":"10.1016\/bs.pbr.2025.05.007_bib40","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1038\/npp.2009.127","article-title":"Environmental enrichment reduces cocaine seeking and reinstatement induced by cues and stress but not by cocaine","volume":"34","author":"Chauvet","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"13","key":"10.1016\/bs.pbr.2025.05.007_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e34196","article-title":"Light and classical music therapies attenuate chronic unpredictable mild stress-induced depression via BDNF signaling pathway in mice","volume":"10","author":"Cheng","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/bs.pbr.2025.05.007_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2020.102421","article-title":"Impact of Yoga on cognition and mental health among elderly: a systematic review","volume":"52","author":"Chobe","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/bs.pbr.2025.05.007_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroscience.2012.06.016","article-title":"The impact of environmental enrichment on sex-specific neurochemical circuitries - effects on brain-derived neurotrophic factor and the serotonergic system","volume":"220","author":"Chourbaji","year":"2012","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.14283\/jpad.2023.5","article-title":"Environmental Enrichment in Murine Models and Its Translation to Human Factors Improving Conditions in Alzheimer Disease","volume":"10","author":"Colavitta","year":"2023","journal-title":"J Prev Alzheimers Dis"},{"issue":"7","key":"10.1016\/bs.pbr.2025.05.007_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.127","article-title":"Effects of chronic variable stress on cognition and Bace1 expression among wild-type mice","volume":"6","author":"Cordner","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/bs.pbr.2025.05.007_bib46","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuroscience.2023.07.001","article-title":"Environmental enrichment increased Bdnf transcripts in the prefrontal cortex: implications for an epigenetically controlled mechanism","volume":"526","author":"Costa","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/bs.pbr.2025.05.007_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neubiorev.2014.11.017","article-title":"Inoculation stress hypothesis of environmental enrichment","volume":"49","author":"Crofton","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/bs.pbr.2025.05.007_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.euroneuro.2020.08.010","article-title":"Sigma-1 (\u03c31) receptor activity is necessary for physiological brain plasticity in mice","volume":"39","author":"Crouzier","year":"2020","journal-title":"Eur. Neuropsychopharmacol"},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib49","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3233\/JAD-215193","article-title":"Environmental enrichment effects on the brain-derived neurotrophic factor expression in healthy condition, Alzheimer\u2019s disease, and other neurodegenerative disorders","volume":"85","author":"Cutuli","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/bs.pbr.2025.05.007_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijdevneu.2018.03.003","article-title":"Beneficial effects of environmental enrichment on behavior, stress reactivity and synaptophysin\/BDNF expression in hippocampus following early life stress","volume":"67","author":"Dandi","year":"2018","journal-title":"Int. J. Dev. Neurosci."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib51","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1111\/ejn.16089","article-title":"\u03a4he neuroprotective role of environmental enrichment against behavioral, morphological, neuroendocrine and molecular changes following chronic unpredictable mild stress: a systematic review","volume":"58","author":"Dandi","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/bs.pbr.2025.05.007_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2025.115462","article-title":"Environmental enrichment induces depressive- and anxiety-like behaviors in male Balb\/C mice","volume":"483","author":"De Brito","year":"2025","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib53","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10571-024-01506-0","article-title":"Can environmental enrichment modulate epigenetic processes in the central nervous system under adverse environmental conditions? A systematic review","volume":"44","author":"De Sousa Fernandes","year":"2024","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/bs.pbr.2025.05.007_bib54","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuroscience.2014.08.037","article-title":"Stress-induced neuroplasticity: (mal)adaptation to adverse life events in patients with PTSD--a critical overview","volume":"283","author":"Deppermann","year":"2014","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/bs.pbr.2025.05.007_bib55","doi-asserted-by":"crossref","first-page":"dmm048936","DOI":"10.1242\/dmm.048936","article-title":"An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation","volume":"15","author":"D\u00edaz de Le\u00f3n-Guerrero","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/bs.pbr.2025.05.007_bib56","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","article-title":"A molecular and cellular theory of depression","volume":"54","author":"Duman","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"issue":"6","key":"10.1016\/bs.pbr.2025.05.007_bib57","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1210\/en.2014-1905","article-title":"Adipose VEGF links the white-to-brown fat switch with environmental, genetic, and pharmacological stimuli in male mice","volume":"156","author":"During","year":"2015","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib58","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41398-021-01280-3","article-title":"The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation","volume":"11","author":"Eu","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/bs.pbr.2025.05.007_bib59","first-page":"50","article-title":"Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice","volume":"3","author":"Fabel","year":"2009","journal-title":"Front. Neurosci."},{"key":"10.1016\/bs.pbr.2025.05.007_bib60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neures.2021.04.007","article-title":"Environmental enrichment modulates HPA axis reprogramming in adult male rats exposed to early adolescent stress","volume":"172","author":"Fan","year":"2021","journal-title":"Neurosci. Res."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib61","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neures.2013.04.005","article-title":"Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats","volume":"76","author":"Fang","year":"2013","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib62","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2003.09.029","article-title":"Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo","volume":"124","author":"Farmer","year":"2004","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib63","first-page":"983","article-title":"Role of hypothalamic VGF in energy balance and metabolic adaption to environmental enrichment in mice","volume":"157","author":"Foglesong","year":"2016","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib64","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.celrep.2017.12.066","article-title":"Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer\u2019s disease not evident in mouse models","volume":"22","author":"Friedman","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/bs.pbr.2025.05.007_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2019.172829","article-title":"Therapeutic efficacy of environmental enrichment for substance use disorders","volume":"188","author":"Galaj","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"27","key":"10.1016\/bs.pbr.2025.05.007_bib66","doi-asserted-by":"crossref","first-page":"9240","DOI":"10.1523\/JNEUROSCI.23-27-09240.2003","article-title":"Brain structures differ between musicians and non-musicians","volume":"23","author":"Gaser","year":"2003","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib67","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/1545968310380926","article-title":"Enriched environment improves motor function and increases neurotrophins in hemicerebellar lesioned rats","volume":"25","author":"Gelfo","year":"2011","journal-title":"Neurorehabil Neural Repair"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/j.2040-4603.2013.tb00485.x","article-title":"The influence of exercise on cognitive abilities","volume":"3","author":"Gomez-Pinilla","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/bs.pbr.2025.05.007_bib69","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neubiorev.2019.01.009","article-title":"Sensory processing sensitivity in the context of environmental sensitivity: a critical review and development of research agenda","volume":"98","author":"Greven","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/bs.pbr.2025.05.007_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172874","article-title":"Environmental enrichment reduces food seeking and taking in rats: a review","volume":"190","author":"Grimm","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"12","key":"10.1016\/bs.pbr.2025.05.007_bib71","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fncel.2018.00224","article-title":"Environmental enrichment improves cognitive deficits, AD hallmarks and epigenetic alterations presented in 5xFAD mouse model","volume":"15","author":"Gri\u00f1\u00e1n-Ferr\u00e9","year":"2018","journal-title":"Front. Cell Neurosci."},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib72","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.21037\/tcr.2020.02.39","article-title":"Regulation of aging and cancer by enhanced environmental activation of a hypothalamic-sympathoneural-adipocyte axis","volume":"9","author":"Hassan","year":"2020","journal-title":"Transl. Cancer Res."},{"key":"10.1016\/bs.pbr.2025.05.007_bib73","first-page":"306","article-title":"The effects of early experience on problem-solving at maturity","volume":"2","author":"Hebb","year":"1947","journal-title":"Am. Psychologist"},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib74","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.neuropharm.2012.05.028","article-title":"Re-exposure and environmental enrichment reveal NPY-Y1 as a possible target for post-traumatic stress disorder","volume":"63","author":"Hendriksen","year":"2012","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib75","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neuron.2012.10.011","article-title":"Musical training as a framework for brain plasticity: behavior, function, and structure","volume":"76","author":"Herholz","year":"2012","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib76","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/j.2040-4603.2016.tb00694.x","article-title":"Regulation of the hypothalamic-pituitary-adrenocortical stress response","volume":"6","author":"Herman","year":"2016","journal-title":"Compr. Physiol."},{"issue":"8","key":"10.1016\/bs.pbr.2025.05.007_bib77","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.767","article-title":"Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice","volume":"7","author":"Holgate","year":"2017","journal-title":"Brain Behav."},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib78","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3390\/antiox13030312","article-title":"Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution","volume":"13","author":"Hong","year":"2024","journal-title":"Antioxid. (Basel)"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib79","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12929-018-0404-x","article-title":"Impact of social relationships on Alzheimer\u2019s memory impairment: mechanistic studies","volume":"25","author":"Hsiao","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/bs.pbr.2025.05.007_bib80","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neulet.2010.04.007","article-title":"Enriched environment increases spinophilin mRNA expression and spinophilin immunoreactive dendritic spines in hippocampus and cortex","volume":"476","author":"Hu","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/bs.pbr.2025.05.007_bib81","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn.2017.46","article-title":"The emerging field of epigenetics in neurodegeneration and neuroprotection","volume":"18","author":"Hwang","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"19","key":"10.1016\/bs.pbr.2025.05.007_bib82","doi-asserted-by":"crossref","first-page":"7489","DOI":"10.1523\/JNEUROSCI.20-19-07489.2000","article-title":"Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats","volume":"20","author":"Ito","year":"2000","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1806-9061-2019-1130","article-title":"Effect of environmental enrichment on the body weight in broiler chickens","volume":"22","author":"Jacob","year":"2020","journal-title":"Braz. J. Poult. Sci."},{"key":"10.1016\/bs.pbr.2025.05.007_bib84","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuroscience.2012.09.017","article-title":"Are BDNF and glucocorticoid activities calibrated?","volume":"239","author":"Jeanneteau","year":"2013","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib85","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neubiorev.2009.10.002","article-title":"Allostatic load biomarkers of chronic stress and impact on health and cognition","volume":"35","author":"Juster","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib86","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000446772","article-title":"Alteration of energy metabolism and antioxidative processing in the hippocampus of rats reared in long-term environmental enrichment","volume":"38","author":"Kang","year":"2016","journal-title":"Dev. Neurosci."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib87","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12974-024-03130-7","article-title":"Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging","volume":"21","author":"Kang","year":"2024","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib88","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1523\/JNEUROSCI.22-03-00635.2002","article-title":"Why new neurons? Possible functions for adult hippocampal neurogenesis","volume":"22","author":"Kempermann","year":"2002","journal-title":"J. neuroscience: Off. J. Soc. Neurosci"},{"issue":"6624","key":"10.1016\/bs.pbr.2025.05.007_bib89","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment","volume":"386","author":"Kempermann","year":"1997","journal-title":"Nature"},{"key":"10.1016\/bs.pbr.2025.05.007_bib90","first-page":"1","article-title":"Environmental enrichment attenuates behavioral abnormalities in a mouse model of neuropathic pain","volume":"84","author":"Kimura","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"8","key":"10.1016\/bs.pbr.2025.05.007_bib91","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1111\/bph.15584","article-title":"How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders","volume":"179","author":"Kimura","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/bs.pbr.2025.05.007_bib92","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S1461145710000738","article-title":"Blood BDNF concentrations reflect brain-tissue BDNF levels across species","volume":"14","author":"Klein","year":"2011","journal-title":"Int. J. Neuropsychopharmacol"},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib93","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1101\/lm.2283011","article-title":"Running is the neurogenic and neurotrophic stimulus in environmental enrichment","volume":"18","author":"Kobilo","year":"2011","journal-title":"Learn. Mem."},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib94","doi-asserted-by":"crossref","first-page":"e729","DOI":"10.1038\/tp.2015.217","article-title":"Short environmental enrichment in adulthood reverses anxiety and basolateral amygdala hypertrophy induced by maternal separation","volume":"6","author":"Koe","year":"2016","journal-title":"Transl Psychiatry"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euroneuro.2018.11.1107","article-title":"Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes","volume":"29","author":"Kokras","year":"2019","journal-title":"Eur. Neuropsychopharmacol"},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib96","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1037\/a0019165","article-title":"Conceptual distinctiveness supports detailed visual long-term memory for real-world objects","volume":"139","author":"Konkle","year":"2010","journal-title":"J. Exp. Psychol. Gen."},{"key":"10.1016\/bs.pbr.2025.05.007_bib97","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1037\/h0045402","article-title":"Effects of environmental complexity and training on brain chemistry","volume":"53","author":"Krech","year":"1960","journal-title":"J. Comp. Physiol. Psychol."},{"issue":"7","key":"10.1016\/bs.pbr.2025.05.007_bib98","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/NEN.0b013e318221bfab","article-title":"Moderate environmental enrichment mitigates tauopathy in a neurofibrillary tangle mouse model","volume":"70","author":"Lahiani-Cohen","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"12","key":"10.1016\/bs.pbr.2025.05.007_bib99","doi-asserted-by":"crossref","first-page":"7095","DOI":"10.1007\/s12035-022-03016-w","article-title":"The molecular effects of environmental enrichment on Alzheimer\u2019s disease","volume":"59","author":"Liew","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neurobiolaging.2004.03.002","article-title":"The impact of age, weight and gender on BDNF levels in human platelets and plasma","volume":"26","author":"Lommatzsch","year":"2005","journal-title":"Neurobiol Aging"},{"issue":"6","key":"10.1016\/bs.pbr.2025.05.007_bib101","doi-asserted-by":"crossref","first-page":"76","DOI":"10.15698\/cst2021.06.250","article-title":"The evolution of the concept of stress and the framework of the stress system","volume":"5","author":"Lu","year":"2021","journal-title":"Cell Stress"},{"issue":"17","key":"10.1016\/bs.pbr.2025.05.007_bib102","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.3390\/ijerph20176689","article-title":"Greenspace as workplace: benefits, challenges and essentialities in the physical environment","volume":"20","author":"Lygum","year":"2023","journal-title":"Int. J. Env. Res. Public. Health"},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib103","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3233\/JAD-180183","article-title":"The effects of music therapy on cognition, psychiatric symptoms, and activities of daily living in patients with Alzheimer\u2019s disease","volume":"64","author":"Lyu","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/bs.pbr.2025.05.007_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.113771","article-title":"Exposure to an enriched environment reduces alcohol self-administration in Sardinian alcohol-preferring rats","volume":"249","author":"Maccioni","year":"2022","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib105","doi-asserted-by":"crossref","DOI":"10.1111\/adb.13244","article-title":"Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice","volume":"28","author":"Ma\u00f1as-Padilla","year":"2023","journal-title":"Addict. Biol."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib106","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1037\/h0032547","article-title":"Interaction of environmental enrichment and genotype","volume":"79","author":"Manosevitz","year":"1972","journal-title":"J. Comp. Physiol. Psychol"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib107","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0018-506X(03)00002-3","article-title":"Effects of different forms of environmental enrichment on behavioral, endocrinological, and immunological parameters in male mice","volume":"43","author":"Marashi","year":"2003","journal-title":"Horm. Behav."},{"key":"10.1016\/bs.pbr.2025.05.007_bib108","first-page":"13","article-title":"The cognitive benefits of being bilingual","volume":"2012","author":"Marian","year":"2012","journal-title":"Cerebrum"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib109","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170317","article-title":"Environmental enrichment blunts ethanol consumption after restraint stress in C57BL\/6 mice","volume":"12","author":"Marianno","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/bs.pbr.2025.05.007_bib110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainres.2015.04.007","article-title":"Anti-oxidative effects produced by environmental enrichment in the hippocampus and cerebral cortex of male and female rats","volume":"1613","author":"M\u00e1rmol","year":"2015","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib111","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.celrep.2020.01.010","article-title":"Microglia heterogeneity in the single-cell era","volume":"30","author":"Masuda","year":"2020","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib112","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrn.2017.156","article-title":"Intermittent metabolic switching, neuroplasticity and brain health","volume":"19","author":"Mattson","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib113","doi-asserted-by":"crossref","first-page":"367","DOI":"10.31887\/DCNS.2006.8.4\/bmcewen","article-title":"Protective and damaging effects of stress mediators: central role of the brain","volume":"8","author":"McEwen","year":"2006","journal-title":"Dialogues Clin Neurosci"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib114","article-title":"Sleep deprivation as a neurobiologic and physiologic stressor: allostasis and allostatic load","volume":"S20-3","author":"McEwen","year":"2019","journal-title":"Metabolism. 55(10"},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib115","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/10253890.2011.623249","article-title":"Environmental enrichment in male CD-1 mice promotes aggressive behaviors and elevated corticosterone and brain norepinephrine activity in response to a mild stressor","volume":"15","author":"McQuaid","year":"2012","journal-title":"Stress"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib116","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/bjhp.12501","article-title":"What makes one feel eustress or distress in quarantine? An analysis from conservation of resources (COR) theory","volume":"26","author":"Merino","year":"2021","journal-title":"Br. J. Health Psychol."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib117","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/bs.3830300402","article-title":"A model of the eustress system for health\/illness","volume":"30","author":"Milsum","year":"1985","journal-title":"Behav. Sci."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib118","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib119","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s10072-020-04715-9","article-title":"Musical practice and BDNF plasma levels as a potential marker of synaptic plasticity: an instrument of rehabilitative processes","volume":"42","author":"Minutillo","year":"2021","journal-title":"Neurol. Sci."},{"key":"10.1016\/bs.pbr.2025.05.007_bib120","doi-asserted-by":"crossref","first-page":"1478656","DOI":"10.3389\/fnbeh.2024.1478656","article-title":"Environmental enrichment in middle age rats improves spatial and object memory discrimination deficits","volume":"18","author":"Miranda","year":"2024","journal-title":"Front. Behav. Neurosci."},{"issue":"6","key":"10.1016\/bs.pbr.2025.05.007_bib121","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1177\/0013916511404408","article-title":"Psychological and health outcomes of perceived information overload","volume":"44","author":"Misra","year":"2012","journal-title":"Environ. Behav."},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib122","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2826.2004.01173.x","article-title":"Effect of environmental enrichment on stress related systems in rats","volume":"16","author":"Moncek","year":"2004","journal-title":"J. Neuroendocrinol"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib123","first-page":"298","article-title":"Environmental enrichment reverses histone methylation changes in the aged hippocampus and restores age-related memory deficits","volume":"4","author":"Morse","year":"2015","journal-title":"Biol. (Basel)"},{"key":"10.1016\/bs.pbr.2025.05.007_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114544","article-title":"Efficacy of a music-based intervention in a preclinical model of traumatic brain injury: an initial foray into a novel and non-pharmacological rehabilitative therapy","volume":"369","author":"Moschonas","year":"2023","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib125","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.euroneuro.2019.03.009","article-title":"Effects of adult enriched environment on cognition, hippocampal-prefrontal plasticity and NMDAR subunit expression in MK-801-induced schizophrenia model","volume":"29","author":"Murueta-Goyena","year":"2019","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/bs.pbr.2025.05.007_bib126","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neuroscience.2012.06.007","article-title":"Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL\/6J mice","volume":"219","author":"Mustroph","year":"2012","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/bs.pbr.2025.05.007_bib127","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/npp.2012.2","article-title":"Loss of environmental enrichment increases vulnerability to cocaine addiction","volume":"37","author":"Nader","year":"2012","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/bs.pbr.2025.05.007_bib128","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/antiox11122345","article-title":"Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease","volume":"11","author":"Ngo","year":"2022","journal-title":"Antioxid. (Basel)"},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib129","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","volume":"7","author":"Nithianantharajah","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/bs.pbr.2025.05.007_bib130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neubiorev.2019.06.030","article-title":"\u201cAverage is good, extremes are bad\u201d - non-linear inverted U-shaped relationship between neural mechanisms and functionality of mental features","volume":"104","author":"Northoff","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"Pt A","key":"10.1016\/bs.pbr.2025.05.007_bib131","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.neuropharm.2016.10.026","article-title":"Environmental enrichment protects against stress-induced anxiety: role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala","volume":"113","author":"Novaes","year":"2017","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib132","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0169-328X(94)90246-1","article-title":"Glucocorticoid receptor and NGFI-A gene expression are induced in the hippocampus after environmental enrichment in adult rats","volume":"23","author":"Olsson","year":"1994","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/bs.pbr.2025.05.007_bib133","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.psych.59.103006.093656","article-title":"The adaptive brain: aging and neurocognitive scaffolding","volume":"60","author":"Park","year":"2009","journal-title":"Annu. Rev. Psychol."},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib134","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13606","article-title":"Transcriptional landscape of human microglia implicates age, sex, and APOE-related immunometabolic pathway perturbations","volume":"21","author":"Patel","year":"2022","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib135","doi-asserted-by":"crossref","first-page":"8574","DOI":"10.1038\/s41598-017-08795-0","article-title":"Effects of environmental enrichment upon ethanol-induced conditioned place preference and pre-frontal BDNF levels in adolescent and adult mice","volume":"7","author":"Pautassi","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib136","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbr.2006.07.007","article-title":"Environmental enrichment effects in social investigation in rats are gender dependent","volume":"174","author":"Pena","year":"2006","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib137","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.psyneuen.2009.04.019","article-title":"Enduring effects of environmental enrichment from weaning to adulthood on pituitary-adrenal function, pre-pulse inhibition and learning in male and female rats","volume":"34","author":"Pe\u00f1a","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib138","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0306-4522(99)00316-4","article-title":"Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year","volume":"94","author":"Pham","year":"1999","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib139","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0166-4328(99)00019-4","article-title":"Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats","volume":"103","author":"Pham","year":"1999","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib140","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1037\/0735-7044.120.4.787","article-title":"The role of voluntary exercise in enriched rearing: a behavioral analysis","volume":"120","author":"Pietropaolo","year":"2006","journal-title":"Behav. Neurosci."},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib141","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/cdep.12120","article-title":"Individual differences in environmental sensitivity","volume":"9","author":"Pluess","year":"2015","journal-title":"Child Dev. Perspect."},{"issue":"8","key":"10.1016\/bs.pbr.2025.05.007_bib142","first-page":"2452","article-title":"Temperament predicts the quality of social interactions in captive female rhesus macaques (macaca mulatta)","volume":"11","author":"Pomerantz","year":"2021","journal-title":"Anim. (Basel)"},{"key":"10.1016\/bs.pbr.2025.05.007_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.109971","article-title":"Environmental enrichment enhances ethanol preference over social reward in male swiss mice: involvement of oxytocin-dopamine interactions","volume":"253","author":"Rae","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/bs.pbr.2025.05.007_bib144","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuropharm.2018.06.013","article-title":"Environmental enrichment enhances conditioned place preference to ethanol via an oxytocinergic-dependent mechanism in male mice","volume":"138","author":"Rae","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/bs.pbr.2025.05.007_bib145","doi-asserted-by":"crossref","first-page":"1366747","DOI":"10.3389\/fnins.2024.1366747","article-title":"The impact of enriched environments on cerebral oxidative balance in rodents: a systematic review of environmental variability effects","volume":"18","author":"Ramos","year":"2024","journal-title":"Front. Neurosci."},{"issue":"22","key":"10.1016\/bs.pbr.2025.05.007_bib146","first-page":"3330","article-title":"Impact of growth rate on the welfare of broilers","volume":"14","author":"Riber","year":"2024","journal-title":"Anim. (Basel)"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib147","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1046\/j.0953-816x.2001.01858.x","article-title":"Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan","volume":"15","author":"Romanczyk","year":"2002","journal-title":"Eur. J. Neurosci."},{"issue":"7","key":"10.1016\/bs.pbr.2025.05.007_bib148","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1111\/j.1460-9568.2006.05059.x","article-title":"Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment","volume":"24","author":"Rossi","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib149","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1369-1600.2011.00408.x","article-title":"Environmental enrichment blocks ethanol-induced locomotor sensitization and decreases BDNF levels in the prefrontal cortex in mice","volume":"17","author":"Rueda","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/bs.pbr.2025.05.007_bib150","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neubiorev.2021.05.025","article-title":"Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: a systematic review and meta-analysis of randomized controlled trials","volume":"128","author":"Ruiz-Gonz\u00e1lez","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"10","key":"10.1016\/bs.pbr.2025.05.007_bib151","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2174\/1567205016666190725151614","article-title":"Dance for people with Alzheimer\u2019s disease: a systematic review","volume":"16","author":"Ruiz-Muelle","year":"2019","journal-title":"Curr. Alzheimer Res."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib152","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.00036.2012","article-title":"Environment and brain plasticity: towards an endogenous pharmacotherapy","volume":"94","author":"Sale","year":"2014","journal-title":"Physiol. Rev."},{"issue":"10","key":"10.1016\/bs.pbr.2025.05.007_bib153","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nn.4109","article-title":"Stress and the brain: individual variability and the inverted-U","volume":"18","author":"Sapolsky","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib154","first-page":"55","article-title":"How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions","volume":"21","author":"Sapolsky","year":"2000","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib155","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1192\/bjp.2020.73","article-title":"Extending the vulnerability-stress model of mental disorders: three-dimensional NPSR1 \u00d7 environment \u00d7 coping interaction study in anxiety","volume":"217","author":"Schiele","year":"2020","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/bs.pbr.2025.05.007_bib156","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.917527","article-title":"A brief overview on BDNF-Trk pathway in the nervous system: a potential biomarker or possible target in treatment of multiple sclerosis?","volume":"13","author":"Schir\u00f2","year":"2022","journal-title":"Front. Neurol."},{"issue":"10","key":"10.1016\/bs.pbr.2025.05.007_bib157","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3390\/antiox9100928","article-title":"Environmental enrichment attenuates oxidative stress and alters detoxifying enzymes in an A53T \u03b1-synuclein transgenic mouse model of Parkinson\u2019s disease","volume":"9","author":"Seo","year":"2020","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/bs.pbr.2025.05.007_bib158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2018.04.050","article-title":"Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1\/miR-134 signalling pathway regulates CREB\/BDNF expression in hippocampus in vivo and in vitro","volume":"349","author":"Shen","year":"2018","journal-title":"Behavioural Brain Res."},{"key":"10.1016\/bs.pbr.2025.05.007_bib159","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40035-018-0109-9","article-title":"Factors that influence adult neurogenesis as potential therapy","volume":"7","author":"Shohayeb","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/bs.pbr.2025.05.007_bib160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.111917","article-title":"The effects of short-term and long-term environmental enrichment on locomotion, mood-like behavior, cognition and hippocampal gene expression","volume":"368","author":"Singhal","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/bs.pbr.2025.05.007_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172993","article-title":"Differential impact of stress and environmental enrichment on corticolimbic circuits","volume":"197","author":"Smail","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib162","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/npp.2008.51","article-title":"Environmental enrichment during early stages of life reduces the behavioral, neurochemical, and molecular effects of cocaine","volume":"34","author":"Solinas","year":"2009","journal-title":"Neuropsychopharmacology: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib163","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00213-011-2448-4","article-title":"Environmental-induced differences in corticosterone and glucocorticoid receptor blockade of amphetamine self-administration in rats","volume":"218","author":"Stairs","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/bs.pbr.2025.05.007_bib164","doi-asserted-by":"crossref","first-page":"1265871","DOI":"10.3389\/fphys.2023.1265871","article-title":"The effects of environmental enrichment on voluntary physical activity and muscle mass gain in growing rats","volume":"14","author":"Sudo","year":"2023","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib165","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.physbeh.2010.11.005","article-title":"Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats","volume":"102","author":"Terry","year":"2011","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/bs.pbr.2025.05.007_bib166","first-page":"603","article-title":"Environmental enrichment reduces cocaine-seeking behavior and alters prefrontal cortex function in rats","volume":"202","author":"Thiel","year":"2009","journal-title":"Psychopharmacology"},{"issue":"4-5","key":"10.1016\/bs.pbr.2025.05.007_bib167","first-page":"117","article-title":"Strain specific behavioural response to environmental enrichment in the mouse","volume":"36","author":"Van de Weerd","year":"1994","journal-title":"J. Exp. Anim. Sci."},{"issue":"5","key":"10.1016\/bs.pbr.2025.05.007_bib168","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0031-9384(01)00425-5","article-title":"Modulation of aggression in male mice: influence of group size and cage size","volume":"72","author":"Van Loo","year":"2001","journal-title":"Physiol. & Behav."},{"issue":"23","key":"10.1016\/bs.pbr.2025.05.007_bib169","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"Van Praag","year":"1999","journal-title":"Proc. Natl Acad. Sci. U S A"},{"issue":"2","key":"10.1016\/bs.pbr.2025.05.007_bib170","first-page":"251","article-title":"Stress resilience and the dynamic regulation of glucocorticoids","volume":"59","author":"Vitousek","year":"2019","journal-title":"Integr. Comp. Biol."},{"issue":"1-2","key":"10.1016\/bs.pbr.2025.05.007_bib171","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0166-4328(00)00300-4","article-title":"Defeat followed by individual housing results in long-term impaired reward- and cognition-related behaviours in rats","volume":"117","author":"Von Frijtag","year":"2000","journal-title":"Behav. Brain Res."},{"issue":"8","key":"10.1016\/bs.pbr.2025.05.007_bib172","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.modgep.2006.03.009","article-title":"BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan","volume":"6","author":"Webster","year":"2006","journal-title":"Gene Expr. Patterns"},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib173","first-page":"1392","article-title":"The impact of environmental enrichment on the cortisol level of shelter cats","volume":"14","author":"Wojta\u015b","year":"2024","journal-title":"Anim. (Basel)"},{"key":"10.1016\/bs.pbr.2025.05.007_bib174","doi-asserted-by":"crossref","DOI":"10.1177\/11795735241301568","article-title":"Enriched environment may improve secondary brain injury after traumatic brain injury by regulating the TLR2\/NF-\u03baB signaling pathway","volume":"16","author":"Wu","year":"2024","journal-title":"J. Cent. Nerv. Syst. Dis."},{"issue":"7","key":"10.1016\/bs.pbr.2025.05.007_bib175","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.23690","article-title":"Lifestyle enrichment in later life and its association with dementia risk","volume":"6","author":"Wu","year":"2023","journal-title":"JAMA Netw. Open"},{"issue":"9","key":"10.1016\/bs.pbr.2025.05.007_bib176","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201808931","article-title":"Enriched environment enhances \u03b2-adrenergic signaling to prevent microglia inflammation by amyloid-\u03b2","volume":"10","author":"Xu","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"10.1016\/bs.pbr.2025.05.007_bib177","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12031-019-01428-3","article-title":"Changes in mitochondria-associated protein expression and mitochondrial function in response to 2 weeks of enriched environment training after cerebral ischaemia-reperfusion injury","volume":"70","author":"Yu","year":"2020","journal-title":"J. Mol. Neurosci."},{"issue":"10","key":"10.1016\/bs.pbr.2025.05.007_bib178","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1590\/0004-282x20200081","article-title":"Enriched environment alleviates post-stroke cognitive impairment through enhancing \u03b17-nAChR expression in rats","volume":"78","author":"Yuan","year":"2020","journal-title":"Arq. Neuropsiquiatr"},{"key":"10.1016\/bs.pbr.2025.05.007_bib179","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fnbeh.2015.00303","article-title":"Environmental enrichment increases glucocorticoid receptors and decreases GluA2 and protein kinase M zeta (PKM\u03b6) trafficking during chronic stress: a protective mechanism?","volume":"9","author":"Zanca","year":"2015","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib180","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41467-017-02748-x","article-title":"Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"issue":"439-66","key":"10.1016\/bs.pbr.2025.05.007_bib181","first-page":"C1","article-title":"Epigenetics and the environmental regulation of the genome and its function","volume":"61","author":"Zhang","year":"2010","journal-title":"Annu. Rev. Psychol."},{"issue":"8","key":"10.1016\/bs.pbr.2025.05.007_bib182","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1080\/21645515.2018.1463944","article-title":"The short-term improvements of enriched environment in behaviors and pathological changes of APP\/PS1 mice via regulating cytokines","volume":"14","author":"Zhang","year":"2018","journal-title":"Hum. Vaccin. Immunother"},{"issue":"7","key":"10.1016\/bs.pbr.2025.05.007_bib183","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/00207454.2020.1797722","article-title":"Enriched environment improves post-stroke cognitive impairment and inhibits neuroinflammation and oxidative stress by activating Nrf2-ARE pathway","volume":"131","author":"Zhang","year":"2021","journal-title":"Int. J. Neurosci."},{"issue":"1","key":"10.1016\/bs.pbr.2025.05.007_bib184","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1038\/s41467-021-23993-1","article-title":"Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus","volume":"12","author":"Zocher","year":"2021","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/bs.pbr.2025.05.007_bib185","doi-asserted-by":"crossref","first-page":"10657","DOI":"10.3390\/ijms221910657","article-title":"Environmental enrichment induces meningeal niche remodeling through TrkB-mediated signaling","volume":"22","author":"Zorzin","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Progress in Brain Research","Hormesis, Brain Aging and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612325000652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612325000652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T21:32:50Z","timestamp":1754429570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612325000652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9780443346057"],"references-count":185,"URL":"https:\/\/doi.org\/10.1016\/bs.pbr.2025.05.007","relation":{},"ISSN":["0079-6123"],"issn-type":[{"value":"0079-6123","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}