{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:08:52Z","timestamp":1788876532062,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier","isbn-type":[{"value":"9780443520167","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.pbr.2026.07.009","type":"book-chapter","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:54:29Z","timestamp":1786049669000},"page":"93-127","source":"Crossref","is-referenced-by-count":0,"title":["REM sleep behavior disorder and synucleinopathies"],"prefix":"10.1016","author":[{"given":"Nazia","family":"Uzma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Wajdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasea","family":"Alhashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashar","family":"Qatanany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Sharafkhaneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagannatha Rao","family":"Kosagisharaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Nami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/bs.pbr.2026.07.009_bib1","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1007\/s10072-024-07659-6","article-title":"Efficacy of cognitive behavioral therapy for anxiety and depression in Parkinson\u2019s disease patients: an updated systematic review and meta-analysis","volume":"45","author":"Alnajjar","year":"2024","journal-title":"Neurological Sci."},{"key":"10.1016\/bs.pbr.2026.07.009_bib2","series-title":"International classification of sleep disorders","year":"2023"},{"issue":"4","key":"10.1016\/bs.pbr.2026.07.009_bib3","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/ene.14664","article-title":"Rapid eye movement sleep behavior disorder: a proof\u2010of\u2010concept neuroprotection study for prodromal synucleinopathies","volume":"28","author":"Arnaldi","year":"2021","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/bs.pbr.2026.07.009_bib4","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/ana.26902","article-title":"Presynaptic dopaminergic imaging characterizes patients with REM sleep behavior disorder due to synucleinopathy","volume":"95","author":"Arnaldi","year":"2024","journal-title":"Ann. Neurol."},{"issue":"8","key":"10.1016\/bs.pbr.2026.07.009_bib5","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx071","article-title":"Prodromal Parkinsonism and neurodegenerative risk stratification in REM sleep behavior disorder","volume":"40","author":"Barber","year":"2017","journal-title":"Sleep"},{"issue":"12","key":"10.1016\/bs.pbr.2026.07.009_bib6","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S1474-4422(24)00442-3","article-title":"REM sleep behaviour disorder and alpha-synuclein","volume":"23","author":"Boeve","year":"2024","journal-title":"Lancet Neurol."},{"issue":"9","key":"10.1016\/bs.pbr.2026.07.009_bib7","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1007\/s00415-022-11213-9","article-title":"Isolated REM sleep behaviour disorder: current diagnostic procedures and emerging new technologies","volume":"269","author":"Bramich","year":"2022","journal-title":"J. Neurol."},{"key":"10.1016\/bs.pbr.2026.07.009_bib8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00401-020-02202-1","article-title":"Genetics of synucleins in neurodegenerative diseases","volume":"141","author":"Bras","year":"2020","journal-title":"Acta. Neuropathologica"},{"key":"10.1016\/bs.pbr.2026.07.009_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2025.1515922","article-title":"Enhancing sleep quality in synucleinopathies through physical exercise","volume":"19","author":"Canonichesi","year":"2025","journal-title":"Front. Cell. Neurosci."},{"issue":"5","key":"10.1016\/bs.pbr.2026.07.009_bib10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3390\/brainsci13050797","article-title":"Melatonin as a chronobiotic\/cytoprotective agent in REM sleep behavior disorder","volume":"13","author":"Cardinali","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/bs.pbr.2026.07.009_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1727683","article-title":"Circadian and sleep\u2013wake rhythm alterations in isolated REM sleep behavior disorder: biomarkers of prodromal alpha-synucleinopathy","volume":"19","author":"Carpi","year":"2025","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/bs.pbr.2026.07.009_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.70109","article-title":"Isolated REM sleep behaviour disorder\u2014Is screening possible?","volume":"34","author":"Cesari","year":"2025","journal-title":"J. Sleep. Res."},{"issue":"1","key":"10.1016\/bs.pbr.2026.07.009_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14802\/jmd.23216","article-title":"Fighting against the clock: circadian disruption and parkinson\u2019s disease","volume":"17","author":"Chen","year":"2024","journal-title":"J. Mov. Disord."},{"issue":"2","key":"10.1016\/bs.pbr.2026.07.009_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.5664\/jcsm.10888","article-title":"A case of prazosin in treatment of rapid eye movement sleep behavior disorder","volume":"20","author":"Cho","year":"2024","journal-title":"J. Clin. Sleep. Med."},{"issue":"10","key":"10.1016\/bs.pbr.2026.07.009_bib15","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/mds.29898","article-title":"Understanding REM sleep behavior disorder through functional MRI: a systematic review","volume":"39","author":"Churchill","year":"2024","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/bs.pbr.2026.07.009_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsaa294","article-title":"Prevalence of idiopathic REM behavior disorder: a systematic review and meta-analysis","volume":"44","author":"Cicero","year":"2021","journal-title":"SLEEP"},{"issue":"1","key":"10.1016\/bs.pbr.2026.07.009_bib17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41531-025-01032-w","article-title":"Novel technologies for REM sleep behavior disorder detection for home screening in Parkinson\u2019s disease and related alpha-synucleinopathies","volume":"11","author":"Colman","year":"2025","journal-title":"Npj Parkinson S Dis."},{"issue":"3","key":"10.1016\/bs.pbr.2026.07.009_bib18","first-page":"129","article-title":"Detailed genetic link between REM sleep behaviour disorder and synucleinopathies","volume":"16","author":"Fyfe","year":"2020","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/bs.pbr.2026.07.009_bib19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00415-020-10353-0","article-title":"A critical review of the pharmacological treatment of REM sleep behavior disorder in adults: time for more and larger randomized placebo-controlled trials","volume":"269","author":"Gilat","year":"2022","journal-title":"J. Neurol."},{"issue":"4","key":"10.1016\/bs.pbr.2026.07.009_bib20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.5664\/jcsm.10424","article-title":"Management of REM sleep behavior disorder: an American academy of sleep medicine clinical practice guideline","volume":"19","author":"Howell","year":"2023","journal-title":"J. Clin. Sleep. Med."},{"key":"10.1016\/bs.pbr.2026.07.009_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104996","article-title":"REM sleep behavior disorder (RBD)","volume":"143","author":"Hu","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/bs.pbr.2026.07.009_bib22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3928\/19404921-20240911-03","article-title":"Severe sleep disturbances in persons with dementia with REM sleep behavior disorder and family caregivers: a mixed methods study","volume":"17","author":"Ju","year":"2024","journal-title":"Res. Gerontol.\u00a0Nurs."},{"issue":"11","key":"10.1016\/bs.pbr.2026.07.009_bib23","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1136\/jnnp-2020-323475","article-title":"REM sleep behaviour disorder in patients without synucleinopathy","volume":"91","author":"Keir","year":"2020","journal-title":"J. Neurol., Neurosurg. & Psychiatry"},{"issue":"1","key":"10.1016\/bs.pbr.2026.07.009_bib24","first-page":"1","article-title":"REM sleep behavior disorder as a key predictor of cognitive decline: insights from a narrative review","volume":"19","author":"Khorshidian","year":"2026","journal-title":"Sleep. Sci."},{"issue":"1","key":"10.1016\/bs.pbr.2026.07.009_bib25","doi-asserted-by":"crossref","first-page":"7496","DOI":"10.1038\/s41467-022-34732-5","article-title":"Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects","volume":"13","author":"Krohn","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/bs.pbr.2026.07.009_bib26","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/ana.25687","article-title":"Fine\u2010mapping of SNCA in rapid eye movement sleep behavior disorder and overt synucleinopathies","volume":"87","author":"Krohn","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/bs.pbr.2026.07.009_bib27","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.3390\/ijms22115795","article-title":"Physical exercise-induced Myokines in neurodegenerative diseases","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/bs.pbr.2026.07.009_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s13311-020-00983-7","article-title":"Current concepts and controversies in the management of REM sleep behavior disorder","volume":"18","author":"Matar","year":"2021","journal-title":"Neurotherapeutics: J. Am. Soc. Exp. NeuroTher."},{"issue":"8","key":"10.1016\/bs.pbr.2026.07.009_bib29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S1474-4422(21)00176-9","article-title":"Biomarkers of conversion to \u03b1-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder","volume":"20","author":"Miglis","year":"2021","journal-title":"Lancet. Neurol."},{"issue":"9","key":"10.1016\/bs.pbr.2026.07.009_bib30","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1007\/s00415-022-11120-z","article-title":"REM sleep behavior disorder and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau and phosphorylated tau in Parkinson\u2019s disease: a cross-sectional and longitudinal study","volume":"269","author":"Nabizadeh","year":"2022","journal-title":"J. Neurol."},{"issue":"1","key":"10.1016\/bs.pbr.2026.07.009_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11910-025-01452-4","article-title":"REM sleep behavior disorder as a prodromal synucleinopathy: updates on clinical and laboratory biomarkers, and implications for neuroprotective trials","volume":"25","author":"Neilson","year":"2025","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"8","key":"10.1016\/bs.pbr.2026.07.009_bib32","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3390\/brainsci13081146","article-title":"The genetic basis of probable REM sleep behavior disorder in Parkinson\u2019s disease","volume":"13","author":"Perez-Lloret","year":"2023","journal-title":"Brain Sci."},{"issue":"3","key":"10.1016\/bs.pbr.2026.07.009_bib33","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/brain\/awz030","article-title":"Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study","volume":"142","author":"Postuma","year":"2019","journal-title":"Brain: a J. Neurol."},{"issue":"3","key":"10.1016\/bs.pbr.2026.07.009_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/clinpract15030065","article-title":"A narrative review on biochemical markers and emerging treatments in prodromal synucleinopathies","volume":"15","author":"Rissardo","year":"2025","journal-title":"Clin. Pract."},{"key":"10.1016\/bs.pbr.2026.07.009_bib35","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3389\/fneur.2020.00610","article-title":"A neurologist\u2019s guide to rem sleep behavior disorder","volume":"11","author":"Roguski","year":"2020","journal-title":"Front. Neurol."},{"issue":"3","key":"10.1016\/bs.pbr.2026.07.009_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/ctn7030019","article-title":"Update on rapid-eye-movement sleep behavior disorder (RBD): focus on its strong association with alpha-synucleinopathies","volume":"7","author":"Schenck","year":"2023","journal-title":"Clin. Transl. Neurosci."},{"issue":"8","key":"10.1016\/bs.pbr.2026.07.009_bib37","article-title":"The correlation between Parkinson\u2019s disease and rapid eye movement sleep behavior disorder: a systematic review","volume":"13","author":"Shrestha","year":"2021","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/bs.pbr.2026.07.009_bib38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41531-025-01078-w","article-title":"Genome-wide association study of REM sleep behavior disorder in Parkinson\u2019s disease","volume":"11","author":"Sosero","year":"2025","journal-title":"Npj Parkinson S Dis."},{"key":"10.1016\/bs.pbr.2026.07.009_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-025-00809-0","article-title":"From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease","volume":"20","author":"Stefani","year":"2025","journal-title":"Mol. Neurodegeneration"},{"issue":"7","key":"10.1016\/bs.pbr.2026.07.009_bib40","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/15459683211011238","article-title":"Motor dysfunction in REM sleep behavior disorder: a rehabilitation framework for prodromal synucleinopathy","volume":"35","author":"Summers","year":"2021","journal-title":"Neurorehabilitation Neural Repair."},{"issue":"7","key":"10.1016\/bs.pbr.2026.07.009_bib41","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/jnnp-2020-322875","article-title":"Clinical trials in REM sleep behavioural disorder: challenges and opportunities","volume":"91","author":"Videnovic","year":"2020","journal-title":"J. Neurol. Neurosurg. & Psychiatry"},{"issue":"11","key":"10.1016\/bs.pbr.2026.07.009_bib42","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1136\/jnnp-2022-330922","article-title":"Familial alpha-synucleinopathy spectrum features in patients with psychiatric REM sleep behaviour disorder","volume":"94","author":"Wang","year":"2023","journal-title":"J. Neurol., Neurosurg. & Psychiatry"},{"key":"10.1016\/bs.pbr.2026.07.009_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1440850","article-title":"Cognitive behavioral therapy for anxiety and depression symptoms in people of Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"17","author":"Yu","year":"2025","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/bs.pbr.2026.07.009_bib44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.14336\/AD.2019.0324","article-title":"Rapid eye movement sleep behavior disorder and neurodegenerative diseases: an update","volume":"11","author":"Zhang","year":"2020","journal-title":"Aging Dis."},{"issue":"9","key":"10.1016\/bs.pbr.2026.07.009_bib45","doi-asserted-by":"crossref","first-page":"166","DOI":"10.31083\/j.jin2309166","article-title":"Research progress on the relationship between Parkinson\u2019s disease and REM sleep behavior disorder","volume":"23","author":"Zhou","year":"2024","journal-title":"J. Integr. Neurosci."}],"container-title":["Progress in Brain Research","Neuroscience for Sleep Medicine - Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612326000099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079612326000099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:26:36Z","timestamp":1788873996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612326000099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443520167"],"references-count":45,"URL":"https:\/\/doi.org\/10.1016\/bs.pbr.2026.07.009","relation":{},"ISSN":["0079-6123"],"issn-type":[{"value":"0079-6123","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}