{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:43:43Z","timestamp":1784346223606,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier","isbn-type":[{"value":"9780128177402","type":"print"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/bs.pmbts.2019.02.008","type":"book-chapter","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T03:15:51Z","timestamp":1553570151000},"page":"165-177","source":"Crossref","is-referenced-by-count":31,"title":["Ganoderma sinense polysaccharide: An adjunctive drug used for cancer treatment"],"prefix":"10.1016","author":[{"given":"Yiran","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.pmbts.2019.02.008_bb0010","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.3389\/fmicb.2018.01557","article-title":"Identifying the \u201cmushroom of immortality\u201d: assessing the Ganoderma species composition in commercial Reishi products","volume":"9","author":"Loyd","year":"2018","journal-title":"Front Microbiol"},{"issue":"7","key":"10.1016\/bs.pmbts.2019.02.008_bb0015","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1080\/01635581.2014.948215","article-title":"A comparative study on immunomodulatory activity of polysaccharides from two official species of Ganoderma (Lingzhi)","volume":"66","author":"Meng","year":"2014","journal-title":"Nutr Cancer"},{"issue":"04","key":"10.1016\/bs.pmbts.2019.02.008_bb0020","article-title":"Chinese FDA approved fungal glycan-based drugs: an overview of structures, mechanisms and clinical related studies","volume":"04","author":"Zhou","year":"2014","journal-title":"Transl Med"},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.chroma.2017.01.044","article-title":"Screening and analysis of potential anti-tumor components from the stipe of Ganoderma sinense using high-performance liquid chromatography\/time-of-flight mass spectrometry with multivariate statistical tool","volume":"1487","author":"Chan","year":"2017","journal-title":"J Chromatogr A"},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/bs.pmbts.2019.02.009","article-title":"Ganoderma lucidum polysaccharide used for treating physical frailty in China","volume":"163","author":"Zeng","year":"2019","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.008_bb0035","first-page":"792","article-title":"Ganoderma Lucidum (Reishi mushroom) and cancer","volume":"21","author":"Unlu","year":"2016","journal-title":"J B.U.ON. Off J Balkan Union Oncol."},{"issue":"6","key":"10.1016\/bs.pmbts.2019.02.008_bb0040","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317707437","article-title":"Ganoderma lucidum targeting lung cancer signaling: a review","volume":"39","author":"Gill","year":"2017","journal-title":"Tumour Biol J Int Soc Oncodev Biol Med"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.008_bb0045","first-page":"2126","article-title":"Ganoderma lucidum improves physical fitness in women with fibromyalgia","volume":"32","author":"Collado Mateo","year":"2015","journal-title":"Nutr Hosp"},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0050","series-title":"Study on Extraction, Purification, and the Primary Efficacy Activity of the Polysaccharides Isolated From Ganoderma Sinense","author":"Zhao","year":"2013"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.008_bb0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1615\/IntJMedMushrooms.v17.i2.40","article-title":"Antidiabetic and antioxidant activities of eight medicinal mushroom species from China","volume":"17","author":"Wu","year":"2015","journal-title":"Int J Med Mushrooms."},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0060","series-title":"Study on the Liquid Fermentation of Ganderma Lucidum and Antioxidant Activity of the Polysaccharide","author":"Nan","year":"2012"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.008_bb0065","first-page":"49","article-title":"Efficacy analysis of Ganoderma lucidum mushroom poisoning treatment","volume":"6","author":"He","year":"1999","journal-title":"Acta Edulis Fungi"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.008_bb0070","first-page":"105","article-title":"Purification and antioxidant activity in vitro of exopolysaccharides from fermentation liquid of Ganoderma Sinense","volume":"34","author":"Qi","year":"2013","journal-title":"Sci Technol Food Ind"},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0075","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.biopha.2017.09.060","article-title":"Overview of Ganoderma sinense polysaccharide-an adjunctive drug used during concurrent chemo\/radiation therapy for cancer treatment in China","volume":"96","author":"Jiang","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.008_bb0080","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.chroma.2003.07.015","article-title":"Fingerprint profiling of acid hydrolyzates of polysaccharides extracted from the fruiting bodies and spores of Lingzhi by high-performance thin-layer chromatography","volume":"1018","author":"Di","year":"2003","journal-title":"J Chromatogr A"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.008_bb0085","first-page":"59","article-title":"Molecular characterization of polysaccharides in hot-water extracts of Ganoderma lucidum fruiting bodies","volume":"12","author":"Chang","year":"2003","journal-title":"J Food Drug Anal"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.008_bb0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijbiomac.2010.10.015","article-title":"Purification and structural characterization of a new water-soluble neutral polysaccharide GLP-F1-1 from Ganoderma lucidum","volume":"48","author":"Huang","year":"2011","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.008_bb0095","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1038\/s41598-018-22885-7","article-title":"Comprehensive comparison of polysaccharides from Ganoderma lucidum and G sinense: chemical, antitumor, immunomodulating and gut-microbiota modulatory properties","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.008_bb0100","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3390\/molecules17010740","article-title":"Comparison of polysaccharides from two species of Ganoderma","volume":"17","author":"Xie","year":"2012","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.008_bb0105","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1128\/CMR.13.4.523","article-title":"Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function","volume":"13","author":"Tzianabos","year":"2000","journal-title":"Clin Microbiol Rev"},{"issue":"17","key":"10.1016\/bs.pmbts.2019.02.008_bb0110","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1021\/jf205056u","article-title":"Isolation, structure characterization, and immunomodulating activity of a hyperbranched polysaccharide from the fruiting bodies of Ganoderma sinense","volume":"60","author":"Han","year":"2012","journal-title":"J Agric Food Chem"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.008_bb0115","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1142\/S0192415X07005065","article-title":"Ganodermataceae: natural products and their related pharmacological functions","volume":"35","author":"Zhou","year":"2007","journal-title":"Am J Chin Med"},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5692852","article-title":"Reviews on mechanisms of in vitro antioxidant activity of polysaccharides","volume":"2016","author":"Wang","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.008_bb0125","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1039\/C6FO01315E","article-title":"Review on cell models to evaluate the potential antioxidant activity of polysaccharides","volume":"8","author":"Wang","year":"2017","journal-title":"Food Funct"},{"issue":"06","key":"10.1016\/bs.pmbts.2019.02.008_bb0130","first-page":"586","article-title":"Experimental study of ganoderma lucidum polysaccharide oral liquid's effects on immunologic function in mice","author":"Qiu","year":"2004","journal-title":"J Taishan Med Coll"},{"issue":"6","key":"10.1016\/bs.pmbts.2019.02.008_bb0135","first-page":"877","article-title":"Antitumor fraction from liquid submerged fermentation of Ganoderma Sinense","volume":"39","author":"Yang","year":"2008","journal-title":"Chin Tradit Herb Drug"},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0140","first-page":"108","article-title":"Extraction of crude polysaccharide from two Ganoderma lucidum and comparison of its antioxidant activity","volume":"6","author":"Cheng","year":"2018","journal-title":"Nong Cun Shi Yong Ke Ji Xin Xi"},{"issue":"7","key":"10.1016\/bs.pmbts.2019.02.008_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100380","article-title":"Structure elucidation and immunomodulatory activity of a Beta glucan from the fruiting bodies of Ganoderma sinense","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.008_bb0150","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ijbiomac.2012.06.029","article-title":"Structural characterization and immuno-modulating activities of a polysaccharide from Ganoderma sinense","volume":"51","author":"Han","year":"2012","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.008_bb0155","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/01635581.2013.788725","article-title":"Immunomodulatory activities of Ganoderma sinense polysaccharides in human immune cells","volume":"65","author":"Yue","year":"2013","journal-title":"Nutr Cancer"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.008_bb0160","first-page":"34","article-title":"Properties and in vitro immunological activities of polysaccharides from Ganoderma sinense fruit bodies","volume":"23","author":"Ying","year":"2016","journal-title":"Acta Edulis Fungi"},{"issue":"10","key":"10.1016\/bs.pmbts.2019.02.008_bb0165","first-page":"619","article-title":"Studies of anti-inflammatory and analgesic actions of artificial and fermentative Ganoderma sinense(AFGS)","author":"Wan","year":"1992","journal-title":"China J Chin Mater Med"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.008_bb0170","first-page":"9","article-title":"Influence of Ganoderma polysaccharide on hematopoietic cells in bone marrow on LACA mice and its radiation sensitivity","author":"Liu","year":"1983","journal-title":"J Jiangxi Med"},{"issue":"01","key":"10.1016\/bs.pmbts.2019.02.008_bb0175","first-page":"16","article-title":"Ganoderma polysaccharide on micronucleus in bone marrow nucleated cells of mice induced by radiation effect of protective effects","volume":"8","author":"Chu","year":"1988","journal-title":"J Radiat Prot"},{"issue":"09","key":"10.1016\/bs.pmbts.2019.02.008_bb0180","first-page":"75","article-title":"The Ganoderma Sinensis effect in the exhaustive rat of resistant sport fatigue and resisitant tissue damage","volume":"32","author":"Zhu","year":"2012","journal-title":"China Sport Sci"},{"issue":"05","key":"10.1016\/bs.pmbts.2019.02.008_bb0185","first-page":"968","article-title":"Identification and biological activity research of GS-A-1 polysaccharide from Ganoderma","volume":"34","author":"Niu","year":"2012","journal-title":"Chin Tradit Patent Med"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.008_bb0190","first-page":"284","article-title":"Some pharmacological actions of Ganoderma Lucidum and G.Japonicum (Fr) Llyod on mouse liver","volume":"14","author":"Liu","year":"1979","journal-title":"Acta Pharm Sin"},{"issue":"7","key":"10.1016\/bs.pmbts.2019.02.008_bb0195","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1615\/IntJMedMushrooms.v18.i7.60","article-title":"Comparison of the chemical profiles and antioxidant and antidiabetic activities of extracts from two Ganoderma species (Agaricomycetes)","volume":"18","author":"Xiaoqing","year":"2016","journal-title":"Int J Med Mushrooms"},{"issue":"08","key":"10.1016\/bs.pmbts.2019.02.008_bb0200","first-page":"1028","article-title":"Ganoderma decoction combined with hemodialysis in the treatment of 37 cases of mushroom poisoning","volume":"29","author":"Qiao","year":"2008","journal-title":"Shanxi J Tradit Chin Med"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.008_bb0205","first-page":"102","article-title":"Three kinds of poisonous mushroom poisoning clinical and treatment effect of Ganoderma. Information on epidemic prevention in Guangdong","author":"He","year":"1984","journal-title":"South China J Prev Med"},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0210","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1756-8722-2-25","article-title":"The effects of beta-glucan on human immune and cancer cells","volume":"2","author":"Chan","year":"2009","journal-title":"J Hematol Oncol"},{"issue":"6","key":"10.1016\/bs.pmbts.2019.02.008_bb0215","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.mycres.2007.02.011","article-title":"Medicinal importance of fungal \u03b2-(1\u21923), (1\u21926)-glucans","volume":"111","author":"Chen","year":"2007","journal-title":"Mycol Res"},{"key":"10.1016\/bs.pmbts.2019.02.008_bb0220","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-94-017-7555-7_2","article-title":"Biological response modifier in Cancer immunotherapy","volume":"909","author":"Liu","year":"2016","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.008_bb0225","first-page":"1","article-title":"Chinese FDA approved fungal glycan-based drugs: an overview of structures, mechanisms and clinical related studies","volume":"4","author":"Zhou","year":"2014","journal-title":"Translat Med."},{"issue":"7","key":"10.1016\/bs.pmbts.2019.02.008_bb0230","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1111\/jcmm.13613","article-title":"Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China","volume":"22","author":"Zeng","year":"2018","journal-title":"J Cell Mol Med"},{"issue":"138","key":"10.1016\/bs.pmbts.2019.02.008_bb0235","first-page":"159","article-title":"Grifola frondosa polysaccharide: a review of antitumor and other biological activity studies in China","volume":"25","author":"He","year":"2018","journal-title":"Discov Med"},{"issue":"11","key":"10.1016\/bs.pmbts.2019.02.008_bb0240","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s00432-018-2718-1","article-title":"Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China","volume":"144","author":"Zhang","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.008_bb0245","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcmm.13564","article-title":"Molecular basis for poria cocos mushroom polysaccharide used as an antitumour drug in China","volume":"23","author":"Li","year":"2019","journal-title":"J Cell Mol Med"}],"container-title":["Progress in Molecular Biology and Translational Science","Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877117319300298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877117319300298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T02:17:32Z","timestamp":1574389052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877117319300298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9780128177402"],"references-count":48,"URL":"https:\/\/doi.org\/10.1016\/bs.pmbts.2019.02.008","relation":{},"ISSN":["1877-1173"],"issn-type":[{"value":"1877-1173","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}