{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:15:06Z","timestamp":1791875706329,"version":"4.3.4"},"reference-count":75,"publisher":"Elsevier","isbn-type":[{"value":"9780128177402","type":"print"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/bs.pmbts.2019.02.011","type":"book-chapter","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T17:30:40Z","timestamp":1554139840000},"page":"263-296","source":"Crossref","is-referenced-by-count":68,"title":["Molecular basis for Poria cocos mushroom polysaccharide used as an antitumor drug in China"],"prefix":"10.1016","author":[{"given":"Xiulian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.011_bb0010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jep.2013.03.027","article-title":"Mycology, cultivation, traditional uses, phytochemistry and pharmacology of Wolfiporia cocos (Schwein.) Ryvarden et Gilb.: a review","volume":"147","author":"Wang","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0015","first-page":"432","article-title":"T. P. Studied on pharmacology of Poria cocos polysaccharides and their modifications","volume":"25","author":"Wen","year":"2014","journal-title":"Lishizhen Med Mater Med Res."},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.011_bb0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcmm.13564","article-title":"Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China","volume":"23","author":"Li","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.011_bb0025","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.carres.2003.10.006","article-title":"Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of Poria cocos","volume":"339","author":"Wang","year":"2004","journal-title":"Carbohydr Res"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0030","first-page":"1","article-title":"Studies on the fractionation, structure analysis and bioactivities of Poria cocos acidic polysaccharides","volume":"23","author":"Lu","year":"2014","journal-title":"Food Res Dev."},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0035","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1142\/S0256767906001746","article-title":"Sulfation of pachyman with chlorosulfonic acid using the improved wolfrom method","volume":"24","author":"Jiao","year":"2006","journal-title":"Chin J Polym Sci."},{"issue":"14","key":"10.1016\/bs.pmbts.2019.02.011_bb0040","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0008-6215(03)00197-6","article-title":"Effect of culture media on the chemical and physical characteristics of polysaccharides isolated from Poria cocos mycelia","volume":"338","author":"Jin","year":"2003","journal-title":"Carbohydr Res"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0045","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tifs.2016.05.021","article-title":"Prospects of Poria cocos polysaccharides: isolation process, structural features and bioactivities","volume":"54","author":"Jia","year":"2016","journal-title":"Trends Food Sci Technol"},{"issue":"5236","key":"10.1016\/bs.pmbts.2019.02.011_bb0050","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/225943a0","article-title":"Antitumour polysaccharide derived chemically from natural glucan (Pachyman)","volume":"225","author":"Chihara","year":"1970","journal-title":"Nature"},{"issue":"5320","key":"10.1016\/bs.pmbts.2019.02.011_bb0055","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/233486a0","article-title":"Carboxymethylpachymaran, a new water soluble polysaccharide with marked antitumour activity","volume":"233","author":"Hamuro","year":"1971","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.011_bb0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/bip.20332","article-title":"Solution properties of (1\u21923)-alpha-d-glucan and its sulfated derivative from Poria cocos mycelia via fermentation tank","volume":"79","author":"Huang","year":"2005","journal-title":"Biopolymers"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.011_bb0065","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.ijbiomac.2012.08.022","article-title":"Effects of degree of carboxymethylation on physicochemical and biological properties of pachyman","volume":"51","author":"Yongjiang","year":"2012","journal-title":"Int J Biol Macromol"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.011_bb0070","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.intimp.2010.01.002","article-title":"Immunopotentiation and anti-tumor activity of carboxymethylated-sulfated beta-(1\u21923)-d-glucan from Poria cocos","volume":"10","author":"Chen","year":"2010","journal-title":"Int Immunopharmacol"},{"issue":"15","key":"10.1016\/bs.pmbts.2019.02.011_bb0075","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.carres.2004.08.003","article-title":"Correlation of structure to antitumor activities of five derivatives of a beta-glucan from Poria cocos sclerotium","volume":"339","author":"Wang","year":"2004","journal-title":"Carbohydr Res"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0080","first-page":"45","article-title":"Antitumor effects and pharmacological research of pachymaran","volume":"1","author":"Gao","year":"1996","journal-title":"Acta Chin Med Pharm."},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0085","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1039\/C7FO01886J","article-title":"Carboxymethyl pachyman (CMP) reduces intestinal mucositis and regulates the intestinal microflora in 5-fluorouracil-treated CT26 tumour-bearing mice","volume":"9","author":"Wang","year":"2018","journal-title":"Food Funct."},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.011_bb0090","first-page":"141","article-title":"Chinese FDA approved fungal glycan-based drugs: an overview of structures, mechanisms and clinical related studies","volume":"4","author":"Zhou","year":"2014","journal-title":"Translat Med."},{"issue":"127","key":"10.1016\/bs.pmbts.2019.02.011_bb0095","first-page":"207","article-title":"Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China","volume":"23","author":"Chang","year":"2017","journal-title":"Discov Med"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0100","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.biopha.2017.09.060","article-title":"Overview of Ganoderma sinense polysaccharide-an adjunctive drug used during concurrent chemo\/radiation therapy for cancer treatment in China","volume":"96","author":"Jiang","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"10.1016\/bs.pmbts.2019.02.011_bb0105","first-page":"1240","article-title":"Studies on the effective components of Poria cocos in antitumor activity","volume":"41","author":"Wang","year":"2014","journal-title":"Liaoning J Tradit Chin Med."},{"issue":"8","key":"10.1016\/bs.pmbts.2019.02.011_bb0110","first-page":"482","article-title":"The effects of botanical polysaccharides on the proliferation of S180 and K562 cells and the levels of sialic acid, phospholipid and cholesterol","volume":"14","author":"Tong","year":"1994","journal-title":"Chin J Integrated Tradit West Med"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.011_bb0115","first-page":"268","article-title":"Antitumor function and mechanism study of modified pachymaran","volume":"40","author":"Wang","year":"2009","journal-title":"Chin Tradit Herb Drug"},{"issue":"4","key":"10.1016\/bs.pmbts.2019.02.011_bb0120","first-page":"386","article-title":"The preparation and study on pharmacodynamics of antitumor of carboxymethy pachymaran","volume":"36","author":"Cheng","year":"2008","journal-title":"Chin Youjiang Med J."},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0125","series-title":"The preparation of water-soluble pachymaran and the study of its antitumor activities","first-page":"65","author":"Bian","year":"2006"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0130","series-title":"Studies on Antitumor Effects and Mechanisms of Chinese Medicine Polysaccharide in Signal Transduction Pathway","author":"Luo","year":"2005"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0135","series-title":"The Structure and Biological Activity of Poria cocos Sclerotium Polysaccharide and Its Derivatives","author":"Wang","year":"2004"},{"issue":"6","key":"10.1016\/bs.pmbts.2019.02.011_bb0140","first-page":"652","article-title":"Histological observation on antitumor effect of Poria cocos polysaccharide modified by chemical technology","volume":"25","author":"Tan","year":"2004","journal-title":"J Wuhan Univ"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0145","first-page":"38","article-title":"Antitumor experiments of carboxymethyl pachymaran","volume":"33","author":"Chen","year":"2002","journal-title":"Fujian J Tradit Chin Med"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0150","first-page":"39","article-title":"The antitumor activities and immune effects of carboxymethyl pachymaran","volume":"8","author":"Chen","year":"2001","journal-title":"Acta Edulis Fungi"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0155","first-page":"44","article-title":"Studies on immune function and antitumor effect of carboxymethyl pachymaran oral liquid","volume":"22","author":"Xu","year":"2000","journal-title":"Chin Tradit Patent Med"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0160","first-page":"267","article-title":"The effects of pachymaran on immune function in normal and tumor-burdened mice","volume":"10","author":"Lv","year":"1990","journal-title":"J First Mil Med Univ"},{"issue":"9","key":"10.1016\/bs.pmbts.2019.02.011_bb0165","first-page":"43","article-title":"The antitumor and related pharmacological effects of pachymaran","volume":"12","author":"Chen","year":"1987","journal-title":"China J Chin Mater Med"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.011_bb0170","first-page":"125","article-title":"The preparation and anti-tumor effect of sulfonyl pachymaran","volume":"13","author":"Zhao","year":"1996","journal-title":"J Shenyang Pharm Univ"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0175","first-page":"73","article-title":"The antitumor effects of pachymaran after chemotherapy","volume":"22","author":"Liu","year":"2006","journal-title":"Pharmacol Clin Chin Mater Med"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.011_bb0180","first-page":"599","article-title":"The antitumor and immune effects of compound fungal polysaccharides","volume":"24","author":"Tang","year":"2004","journal-title":"Basic Clin Med"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.011_bb0185","first-page":"67","article-title":"Histological observation on antitumor effect of Poria cocos polysaccharide modified by chemical technology","volume":"28","author":"Meng","year":"2007","journal-title":"J Wuhan Univ"},{"issue":"6","key":"10.1016\/bs.pmbts.2019.02.011_bb0190","first-page":"333","article-title":"The preparation and antitumor effect of carboxymethy pachymaran in vivo","volume":"15","author":"Ji","year":"2003","journal-title":"Chin J Microecol"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0195","first-page":"9","article-title":"The effects of carboxymethyl pachymaran on phagocytizing function of macrophages","volume":"15","author":"Chai","year":"1983","journal-title":"Beijing Med J"},{"issue":"12","key":"10.1016\/bs.pmbts.2019.02.011_bb0200","first-page":"638","article-title":"The effects of carboxymethyl pachymaran on increasing lymphocyte induce cytokines","volume":"21","author":"Miu","year":"1999","journal-title":"Chin Trad Patent Med"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.011_bb0205","first-page":"303","article-title":"Effects of two fungal polysaccharides on protein tyrosine phosphorylation of HL-60 cells","volume":"35","author":"Yang","year":"2000","journal-title":"Chin Pharm J"},{"issue":"6","key":"10.1016\/bs.pmbts.2019.02.011_bb0210","first-page":"41","article-title":"The application of carboxymethylpachymaran-inducers","volume":"3","author":"Chen","year":"1998","journal-title":"Acta Edulis Fungi"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.011_bb0215","first-page":"283","article-title":"The effects of Poria cocos on immune function of immune deficit mice","volume":"34","author":"Zhang","year":"2014","journal-title":"Chin J Vet Sci"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0220","first-page":"842","article-title":"Inhibition of pachymaran on spontaneous lung metastasis in Lewis lung cancer of mice and its mechanism","volume":"28","author":"Zhang","year":"2013","journal-title":"Drugs Clin"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0225","first-page":"1","article-title":"The preliminary research on the pharmacological effects of sulfation pachymaran","volume":"14","author":"Wei","year":"2009","journal-title":"Vet Pharm Feed Addit"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0230","first-page":"71","article-title":"The effects of carboxymethyl pachymaran on lymphocyte secreting cytokines in mice","volume":"22","author":"Liu","year":"2006","journal-title":"Pharmacol Clin Chin Mater Med"},{"issue":"11","key":"10.1016\/bs.pmbts.2019.02.011_bb0235","first-page":"1213","article-title":"The effects of pachymaran on the biosynthesis of IgA, IgG and IgM in serum in mice","volume":"29","author":"Zhang","year":"2013","journal-title":"Chin J Immunol"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.011_bb0240","first-page":"69","article-title":"The effects of pachymaran on humoral immunity function in immunosuppressive mice caused of cyclophosphamide","volume":"29","author":"Peng","year":"2013","journal-title":"Pharmacol Clin Chin Mater Med"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0245","first-page":"637","article-title":"Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: cell-cycle arrest and apoptosis induction","volume":"15","author":"Zhang","year":"2006","journal-title":"Oncol Rep"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.011_bb0250","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1615\/IntJMedMushr.v12.i2.10","article-title":"Immunomodulatory effect of the polysaccharide-rich fraction from sclerotium of medicinal mushroom Poria cocos F.A. Wolf (Aphyllophoromycetideae) on Balb\/c mice","volume":"12","author":"Ma","year":"2010","journal-title":"Int J Med Mushrooms"},{"issue":"9","key":"10.1016\/bs.pmbts.2019.02.011_bb0255","first-page":"3080","article-title":"\u03b2(1\u21923) glucan-mediated augmentation of alloreactive murine cytotoxic T-lymphocytes in vivo","volume":"38","author":"Hamuro","year":"1978","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.011_bb0260","first-page":"1237","article-title":"Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon \u03b3 levels in a mouse model of Kawasaki disease","volume":"5","author":"Chu","year":"2012","journal-title":"Mol Med Rep"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0265","first-page":"918","article-title":"The response surface method to optimize pachymaran extraction technology and research on its antioxidant activity","volume":"29","author":"Zheng","year":"2014","journal-title":"China J Tradit Chin Med Pharm"},{"issue":"11","key":"10.1016\/bs.pmbts.2019.02.011_bb0270","first-page":"148","article-title":"Studies on the antioxidative activities of pachymaran","volume":"30","author":"Cao","year":"2009","journal-title":"Food Res Dev"},{"issue":"8","key":"10.1016\/bs.pmbts.2019.02.011_bb0275","first-page":"1126","article-title":"Studies on the antioxidative activities of pachymaran","volume":"24","author":"Li","year":"2012","journal-title":"Nat Prod Res Dev"},{"issue":"9","key":"10.1016\/bs.pmbts.2019.02.011_bb0280","first-page":"1077","article-title":"Studies on the antioxidative activities of ferulic acid pachymaran","volume":"27","author":"Zhang","year":"2011","journal-title":"Mod Food Sci Technol"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0285","first-page":"1","article-title":"Studies on the antioxidative activities of carboxymethyl pachymaran","volume":"34","author":"Cheng","year":"2013","journal-title":"Food Res Dev"},{"issue":"22","key":"10.1016\/bs.pmbts.2019.02.011_bb0290","doi-asserted-by":"crossref","first-page":"10913","DOI":"10.1021\/jf902589m","article-title":"Carboxymethylated \u03b2-glucan derived from Poria cocos with biological activities","volume":"57","author":"Wang","year":"2009","journal-title":"J Agric Food Chem"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0295","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.carbpol.2011.03.052","article-title":"Oxidation of \u03b2-glucan extracted from Poria Cocos and its physiological activities","volume":"85","author":"Wang","year":"2011","journal-title":"Carbohydr Polym"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0300","first-page":"15","article-title":"Studies on the anti-inflammatory effects of pachymaran","volume":"19","author":"Hou","year":"2003","journal-title":"Pharmacol Clin Chin Mater Med"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0305","first-page":"10","article-title":"Studies on the anti-aging effects of pachymaran","volume":"20","author":"Hou","year":"2004","journal-title":"Pharmacol Clin Chin Mater Med"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0310","first-page":"290","article-title":"Studies on carboxymethyl pachymaran on the inpact of HBV transfection cells expressing function","volume":"19","author":"Duan","year":"2005","journal-title":"Chin Chin J Exp Clin Virol"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0315","first-page":"30","article-title":"The application of Chinese medicine effective component in interferon biotechnology experiment and clinical research","volume":"13","author":"Yang","year":"1993","journal-title":"China Biotechnol"},{"issue":"14","key":"10.1016\/bs.pmbts.2019.02.011_bb0320","first-page":"12","article-title":"Studies on the anti-diabetic effects of pachymaran","volume":"05","author":"Zheng","year":"2010","journal-title":"Natl Med Front China"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.011_bb0325","first-page":"94","article-title":"Studies on the anti-leukemia effects of pachymaran combined with selenium in mice","volume":"15","author":"Yang","year":"2006","journal-title":"J Lymphoma."},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.011_bb0330","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1254\/jjp.59.89","article-title":"Studies on antinephritic effects of plant components (3): effect of pachyman, a main component of Poria cocos Wolf on original-type anti-GBM nephritis in rats and its mechanisms","volume":"59","author":"Hattori","year":"1992","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0335","first-page":"215","article-title":"Synthesis and antihypertensive activity of pachyman sulfate","volume":"14","author":"Wang","year":"2016","journal-title":"Curr Top Nutraceutical Res"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.011_bb0340","first-page":"20","article-title":"The clinical trials of carboxymethyl pachymaran inducers","volume":"13","author":"Chen","year":"2003","journal-title":"Fujian J Tradit Chin Med"},{"issue":"1","key":"10.1016\/bs.pmbts.2019.02.011_bb0345","first-page":"51","article-title":"Experimental and clinical studies on carboxymethyl pachymaran on promoting the induction of IL-2","volume":"3","author":"Sheng","year":"1996","journal-title":"Chin J Cancer Biother"},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0350","first-page":"38","article-title":"The medical function of carboxymethyl pachymaran","volume":"3","author":"Chen","year":"1994","journal-title":"Acta Edulis Fungi"},{"issue":"2","key":"10.1016\/bs.pmbts.2019.02.011_bb0355","first-page":"109","article-title":"The observations of pachymaran on the cell immune function of patients with lung cancer and clinical curative effects","volume":"14","author":"Lv","year":"1994","journal-title":"Curr Immunol."},{"issue":"9","key":"10.1016\/bs.pmbts.2019.02.011_bb0360","first-page":"5","article-title":"The effects of pachymaran on immune function of tumor-burdened mice, the elderly and patients with tumor","volume":"1","author":"Lv","year":"1996","journal-title":"J Curr Physician"},{"issue":"3","key":"10.1016\/bs.pmbts.2019.02.011_bb0365","first-page":"27","article-title":"Carboxymethyl tuckahoe polysaccharide the safety of the experiment","volume":"34","author":"Chen","year":"2003","journal-title":"Fujian J Tradit Chin Med."},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0370","first-page":"29","article-title":"Toxicity studies on sodium carboxymethyl pachymaran","volume":"10","author":"Ye","year":"1988","journal-title":"Fujian Med J."},{"key":"10.1016\/bs.pmbts.2019.02.011_bb0375","first-page":"47","article-title":"Pharmacological effects and toxicity about carboxymethyl pachymaran","volume":"16","author":"Chai","year":"1984","journal-title":"Beijing Med J"},{"issue":"5","key":"10.1016\/bs.pmbts.2019.02.011_bb0380","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3390\/molecules22050756","article-title":"Hepatoprotective effect of carboxymethyl pachyman in fluorouracil-treated CT26-bearing mice","volume":"22","author":"Wang","year":"2017","journal-title":"Molecules"}],"container-title":["Progress in Molecular Biology and Translational Science","Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877117319300328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877117319300328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T11:34:17Z","timestamp":1556192057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877117319300328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9780128177402"],"references-count":75,"URL":"https:\/\/doi.org\/10.1016\/bs.pmbts.2019.02.011","relation":{},"ISSN":["1877-1173"],"issn-type":[{"value":"1877-1173","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}