{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:42:50Z","timestamp":1778884970371,"version":"3.51.4"},"reference-count":143,"publisher":"Elsevier","isbn-type":[{"value":"9780323853019","type":"print"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","award":["2019-3396"],"award-info":[{"award-number":["2019-3396"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2018-12367290"],"award-info":[{"award-number":["GR-2018-12367290"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"publisher","award":["PRA_2018_68"],"award-info":[{"award-number":["PRA_2018_68"]}],"id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["26565"],"award-info":[{"award-number":["26565"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/bs.pmbts.2020.12.006","type":"book-chapter","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T01:07:34Z","timestamp":1611968854000},"page":"403-438","source":"Crossref","is-referenced-by-count":6,"title":["Genome editing in stem cells for genetic neurodisorders"],"prefix":"10.1016","author":[{"given":"Claudia","family":"Dell' Amico","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Tata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Pellegrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Onorati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/bs.pmbts.2020.12.006_bb0010","first-page":"8096","article-title":"Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease","volume":"14","author":"Rouet","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0015","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev-biochem-060713-035418","article-title":"Genome engineering with targetable nucleases","volume":"83","author":"Carroll","year":"2014","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.dnarep.2015.03.007","article-title":"Cell cycle regulation of human DNA repair and chromatin remodeling genes","volume":"30","author":"Mjelle","year":"2015","journal-title":"DNA Repair (Amst)"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0025","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1073\/pnas.93.3.1156","article-title":"Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain","volume":"93","author":"Kim","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5007","key":"10.1016\/bs.pmbts.2020.12.006_bb0030","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.2028256","article-title":"Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A","volume":"252","author":"Pavletich","year":"1991","journal-title":"Science"},{"issue":"17","key":"10.1016\/bs.pmbts.2020.12.006_bb0035","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1093\/nar\/28.17.3361","article-title":"Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains","volume":"28","author":"Smith","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"10.1016\/bs.pmbts.2020.12.006_bb0040","doi-asserted-by":"crossref","first-page":"10570","DOI":"10.1073\/pnas.95.18.10570","article-title":"Foki dimerization is required for DNA cleavage","volume":"95","author":"Bitinaite","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3486","article-title":"TALENs: a widely applicable technology for targeted genome editing","volume":"14","author":"Joung","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nbt.1755","article-title":"A TALE nuclease architecture for efficient genome editing","volume":"29","author":"Miller","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"6213","key":"10.1016\/bs.pmbts.2020.12.006_bb0055","doi-asserted-by":"crossref","DOI":"10.1126\/science.1258096","article-title":"Genome editing. The new frontier of genome engineering with CRISPR-Cas9","volume":"346","author":"Doudna","year":"2014","journal-title":"Science"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0060","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2015.09.038","article-title":"Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system","volume":"163","author":"Zetsche","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0065","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cell.2015.12.041","article-title":"The heroes of CRISPR","volume":"164","author":"Lander","year":"2016","journal-title":"Cell"},{"issue":"5819","key":"10.1016\/bs.pmbts.2020.12.006_bb0070","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/292154a0","article-title":"Establishment in culture of pluripotential cells from mouse embryos","volume":"292","author":"Evans","year":"1981","journal-title":"Nature"},{"issue":"12 II","key":"10.1016\/bs.pmbts.2020.12.006_bb0075","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.1073\/pnas.78.12.7634","article-title":"Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells","volume":"78","author":"Martin","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrm.2015.27","article-title":"Pluripotent stem cells in disease modelling and drug discovery","volume":"17","author":"Avior","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5965","key":"10.1016\/bs.pmbts.2020.12.006_bb0085","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/309255a0","article-title":"Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines","volume":"309","author":"Bradley","year":"1984","journal-title":"Nature"},{"issue":"6","key":"10.1016\/bs.pmbts.2020.12.006_bb0090","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrg1619","article-title":"Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century","volume":"6","author":"Capecchi","year":"2005","journal-title":"Nat Rev Genet"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0095","doi-asserted-by":"crossref","first-page":"P583","DOI":"10.1016\/j.cell.2008.02.007","article-title":"Mechanisms of asymmetric stem cell division","volume":"132","author":"Knoblich","year":"2008","journal-title":"Cell"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0100","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0012-1606(62)90043-X","article-title":"Adult frogs derived from the nuclei of single somatic cells","volume":"4","author":"Gurdon","year":"1962","journal-title":"Dev Biol"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0105","series-title":"The Strategy of the Genes: A Discussion of Some Aspects of Theoretical Biology","author":"Waddington","year":"2014"},{"issue":"7151","key":"10.1016\/bs.pmbts.2020.12.006_bb0110","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"issue":"6087","key":"10.1016\/bs.pmbts.2020.12.006_bb0115","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/323445a0","article-title":"Germ-Line transmission of genes introduced into cultured pluripotential cells by retroviral vector","volume":"323","author":"Robertson","year":"1986","journal-title":"Nature"},{"issue":"7351","key":"10.1016\/bs.pmbts.2020.12.006_bb0120","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10163","article-title":"A conditional knockout resource for the genome-wide study of mouse gene function","volume":"474","author":"Skarnes","year":"2011","journal-title":"Nature"},{"issue":"5","key":"10.1016\/bs.pmbts.2020.12.006_bb0125","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"4","key":"10.1016\/bs.pmbts.2020.12.006_bb0130","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0135","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.clp.2009.06.008","article-title":"The molecular and genetic mechanisms of neocortex development","volume":"36","author":"Diaz","year":"2009","journal-title":"Clin Perinatol"},{"issue":"4862","key":"10.1016\/bs.pmbts.2020.12.006_bb0140","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1126\/science.3291116","article-title":"Specification of cerebral cortical areas","volume":"241","author":"Rakic","year":"1988","journal-title":"Science"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0145","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neuron.2015.12.008","article-title":"The cellular and molecular landscapes of the developing human central nervous system","volume":"89","author":"Silbereis","year":"2016","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0150","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cell.2017.06.036","article-title":"Evolution of the human nervous system function, structure, and development","volume":"170","author":"Sousa","year":"2017","journal-title":"Cell"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0155","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu Rev Neurosci"},{"issue":"4","key":"10.1016\/bs.pmbts.2020.12.006_bb0160","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.neuron.2011.05.005","article-title":"Neural stem cells: historical perspective and future prospects","volume":"70","author":"Breunig","year":"2011","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/bs.pmbts.2020.12.006_bb0165","first-page":"1","article-title":"Human neural stem cell systems to explore pathogen-related neurodevelopmental and neurodegenerative disorders","volume":"9","author":"Baggiani","year":"2020","journal-title":"Cell"},{"issue":"6","key":"10.1016\/bs.pmbts.2020.12.006_bb0170","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nn.2553","article-title":"OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling","volume":"13","author":"Fietz","year":"2010","journal-title":"Nat Neurosci"},{"issue":"7288","key":"10.1016\/bs.pmbts.2020.12.006_bb0175","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature08845","article-title":"Neurogenic radial glia in the outer subventricular zone of human neocortex","volume":"464","author":"Hansen","year":"2010","journal-title":"Nature"},{"issue":"9","key":"10.1016\/bs.pmbts.2020.12.006_bb0180","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1093\/cercor\/bhr284","article-title":"Germinal zones in the developing cerebral cortex of ferret: ontogeny, cell cycle kinetics, and diversity of progenitors","volume":"22","author":"Reillo","year":"2012","journal-title":"Cereb Cortex"},{"issue":"6","key":"10.1016\/bs.pmbts.2020.12.006_bb0185","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1517\/17460441.2015.1037737","article-title":"Human pluripotent stem cells as tools for neurodegenerative and neurodevelopmental disease modeling and drug discovery","volume":"10","author":"Corti","year":"2015","journal-title":"Expert Opin Drug Discovery"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0190","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","article-title":"Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling","volume":"27","author":"Chambers","year":"2009","journal-title":"Nat Biotechnol"},{"issue":"12","key":"10.1016\/bs.pmbts.2020.12.006_bb0195","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1038\/nn.3860","article-title":"Molecular and functional definition of the developing human striatum","volume":"17","author":"Onorati","year":"2014","journal-title":"Nat Neurosci"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0200","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1242\/dev.084608","article-title":"Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons","volume":"140","author":"Delli Carri","year":"2013","journal-title":"Development"},{"issue":"7","key":"10.1016\/bs.pmbts.2020.12.006_bb0205","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1242\/dev.117093","article-title":"Activin a directs striatal projection neuron differentiation of human pluripotent stem cells","volume":"142","author":"Arber","year":"2015","journal-title":"Development"},{"issue":"6","key":"10.1016\/bs.pmbts.2020.12.006_bb0210","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3390\/cells9061489","article-title":"Development and differentiation of midbrain dopaminergic neuron: from bench to bedside","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0215","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3389\/fncel.2019.00369","article-title":"Restoring motor neurons in spinal cord injury with induced pluripotent stem cells","volume":"13","author":"Trawczynski","year":"2019","journal-title":"Front Cell Neurosci"},{"issue":"5052","key":"10.1016\/bs.pmbts.2020.12.006_bb0220","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science"},{"issue":"9","key":"10.1016\/bs.pmbts.2020.12.006_bb0225","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1371\/journal.pbio.0030283","article-title":"Niche-independent symmetrical self-renewal of a mammalian tissue stem cell","volume":"3","author":"Conti","year":"2005","journal-title":"PLoS Biol"},{"issue":"SUPPL. 1","key":"10.1016\/bs.pmbts.2020.12.006_bb0230","doi-asserted-by":"crossref","first-page":"i112","DOI":"10.1093\/cercor\/bhj167","article-title":"Adherent neural stem (NS) cells from fetal and adult forebrain","volume":"16","author":"Pollard","year":"2006","journal-title":"Cereb Cortex"},{"issue":"12","key":"10.1016\/bs.pmbts.2020.12.006_bb0235","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1038\/cdd.2008.118","article-title":"Setting the conditions for efficient, robust and reproducible generation of functionally active neurons from adult subventricular zone-derived neural stem cells","volume":"15","author":"Goffredo","year":"2008","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0240","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jbiotec.2010.07.027","article-title":"A DNA transposon-based approach to functional screening in neural stem cells","volume":"150","author":"Albieri","year":"2010","journal-title":"J Biotechnol"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0245","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.mcn.2009.12.002","article-title":"Neuropotent self-renewing neural stem (NS) cells derived from mouse induced pluripotent stem (iPS) cells","volume":"43","author":"Onorati","year":"2010","journal-title":"Mol Cell Neurosci"},{"issue":"10","key":"10.1016\/bs.pmbts.2020.12.006_bb0250","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00018-010-0548-7","article-title":"Preservation of positional identity in fetus-derived neural stem (NS) cells from different mouse central nervous system compartments","volume":"68","author":"Onorati","year":"2011","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0255","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mcn.2008.02.014","article-title":"Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture","volume":"38","author":"Sun","year":"2008","journal-title":"Mol Cell Neurosci"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0260","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.neuint.2011.06.024","article-title":"Non-immortalized human neural stem (NS) cells as a scalable platform for cellular assays","volume":"59","author":"Hook","year":"2011","journal-title":"Neurochem Int"},{"issue":"10","key":"10.1016\/bs.pmbts.2020.12.006_bb0265","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.celrep.2016.08.038","article-title":"Zika virus disrupts phospho-TBK1 localization and mitosis in human neuroepithelial stem cells and radial glia","volume":"16","author":"Onorati","year":"2016","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0270","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1038\/s41467-018-05844-8","article-title":"Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit","volume":"9","author":"Dell\u2019Anno","year":"2018","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0275","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nrn2761","article-title":"Neural stem cell systems: physiological players or in vitro entities?","volume":"11","author":"Conti","year":"2010","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"10.1016\/bs.pmbts.2020.12.006_bb0280","first-page":"1257","article-title":"Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage","volume":"22","author":"Elkabetz","year":"2008","journal-title":"Genes Dev"},{"issue":"9","key":"10.1016\/bs.pmbts.2020.12.006_bb0285","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1073\/pnas.0808387106","article-title":"A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration","volume":"106","author":"Koch","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"10.1016\/bs.pmbts.2020.12.006_bb0290","doi-asserted-by":"crossref","first-page":"8299","DOI":"10.1073\/pnas.1014041108","article-title":"Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors","volume":"108","author":"Li","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0295","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1038\/ncomms7500","article-title":"Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors","volume":"6","author":"Edri","year":"2015","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0300","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/mi10030165","article-title":"Engineering microfluidic organoid-on-a-chip platforms","volume":"10","author":"Yu","year":"2019","journal-title":"Micromachines"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0305","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3389\/fcell.2020.00328","article-title":"In vitro models of neurodegenerative diseases","volume":"8","author":"Slanzi","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"6500","key":"10.1016\/bs.pmbts.2020.12.006_bb0310","doi-asserted-by":"crossref","first-page":"eaaz5626","DOI":"10.1126\/science.aaz5626","article-title":"Human CNS barrier-forming organoids with cerebrospinal fluid production","volume":"369","author":"Pellegrini","year":"2020","journal-title":"Science"},{"issue":"4","key":"10.1016\/bs.pmbts.2020.12.006_bb0315","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1602\/neurorx.1.4.379","article-title":"Cell replacement therapy: helping the brain to repair itself","volume":"1","author":"Lindvall","year":"2004","journal-title":"NeuroRx"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0320","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.stemcr.2014.01.013","article-title":"Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation","volume":"2","author":"Doi","year":"2014","journal-title":"Stem Cell Rep"},{"issue":"11","key":"10.1016\/bs.pmbts.2020.12.006_bb0325","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0166-2236(97)01121-1","article-title":"Neurulation: coming to closure","volume":"20","author":"Smith","year":"1997","journal-title":"Trends Neurosci"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0330","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(79)90349-4","article-title":"Synaptic density in human frontal cortex\u2014developmental changes and effects of aging","volume":"163","author":"Huttenlocher","year":"1979","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0335","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J Morphol"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0340","series-title":"Development of the Nervous System","author":"Sanes","year":"2019"},{"issue":"11","key":"10.1016\/bs.pmbts.2020.12.006_bb0345","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/s41587-020-0525-0","article-title":"Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient","volume":"38","author":"Rifes","year":"2020","journal-title":"Nat Biotechnol"},{"issue":"7467","key":"10.1016\/bs.pmbts.2020.12.006_bb0350","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"issue":"5","key":"10.1016\/bs.pmbts.2020.12.006_bb0355","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1086\/429930","article-title":"Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings","volume":"76","author":"Woods","year":"2005","journal-title":"Am J Hum Genet"},{"issue":"11","key":"10.1016\/bs.pmbts.2020.12.006_bb0360","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2471\/BLT.16.170639","article-title":"Microcephaly in north-east Brazil: a retrospective study on neonates born between 2012 and 2015","volume":"94","author":"De Ara\u00fajo","year":"2016","journal-title":"Bull World Health Organ"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0365","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clp.2014.11.001","article-title":"TORCH infections","volume":"42","author":"Neu","year":"2015","journal-title":"Clin Perinatol"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0370","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/S0016672318000046","article-title":"Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH)","volume":"100","author":"Naveed","year":"2018","journal-title":"Genet Res (Camb)"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0375","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41398-018-0122-x","article-title":"Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids","volume":"8","author":"Srikanth","year":"2018","journal-title":"Transl Psychiatry"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0380","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/s41467-019-10497-2","article-title":"Modeling microcephaly with cerebral organoids reveals a WDR62\u2013CEP170\u2013KIF2A pathway promoting cilium disassembly in neural progenitors","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat Commun"},{"issue":"21","key":"10.1016\/bs.pmbts.2020.12.006_bb0385","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1242\/jcs.203703","article-title":"Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2","volume":"130","author":"Tungadi","year":"2017","journal-title":"J Cell Sci"},{"issue":"7","key":"10.1016\/bs.pmbts.2020.12.006_bb0390","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s10803-014-2033-x","article-title":"Autism spectrum disorder as early neurodevelopmental disorder: evidence from the brain imaging abnormalities in 2-3 years old toddlers","volume":"44","author":"Xiao","year":"2014","journal-title":"J Autism Dev Disord"},{"issue":"4","key":"10.1016\/bs.pmbts.2020.12.006_bb0395","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1017\/S1355617797003032","article-title":"Neuropsychologic functioning in autism: profile of a complex information processing disorder","volume":"3","author":"Minshew","year":"1997","journal-title":"J Int Neuropsychol Soc"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0400","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/aur.239","article-title":"Global prevalence of autism and other pervasive developmental disorders","volume":"5","author":"Elsabbagh","year":"2012","journal-title":"Autism Res"},{"issue":"June","key":"10.1016\/bs.pmbts.2020.12.006_bb0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnsyn.2018.00001","article-title":"Modeling neurological diseases with human brain organoids","volume":"10","author":"Wang","year":"2018","journal-title":"Front Synaptic Neurosci"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0410","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2015.06.034","article-title":"FOXG1-dependent dysregulation of GABA\/glutamate neuron differentiation in autism spectrum disorders","volume":"162","author":"Mariani","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0415","series-title":"Signs and Symptoms of Genetic Conditions\u2014A Handbook","volume":"vol. 03","author":"Bodurtha","year":"2015"},{"issue":"6","key":"10.1016\/bs.pmbts.2020.12.006_bb0420","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/mp.2016.95","article-title":"Altered proliferation and networks in neural cells derived from idiopathic autistic individuals","volume":"22","author":"Marchetto","year":"2017","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-017-0124-1","article-title":"CRISPR\/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells","volume":"8","author":"Wang","year":"2017","journal-title":"Mol Autism"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0430","author":"U.S. Department of Health and Human Services, National Institutes of Health NI of MH"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0435","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/1566524015666150303003028","article-title":"Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders","volume":"15","author":"Gao","year":"2015","journal-title":"Curr Mol Med"},{"issue":"7510","key":"10.1016\/bs.pmbts.2020.12.006_bb0440","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Ripke","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0445","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/schbul\/sbn187","article-title":"The neurodevelopmental hypothesis of Schizophrenia, revisited","volume":"35","author":"Fatemi","year":"2009","journal-title":"Schizophr Bull"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0450","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/schbul\/sbr100","article-title":"How genes and environmental factors determine the different neurodevelopmental trajectories of schizophrenia and bipolar disorder","volume":"38","author":"Demjaha","year":"2012","journal-title":"Schizophr Bull"},{"issue":"8706","key":"10.1016\/bs.pmbts.2020.12.006_bb0455","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0140-6736(90)91520-K","article-title":"Association within a family of a balanced autosomal translocation with major mental illness","volume":"336","author":"St Clair","year":"1990","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0460","first-page":"478","article-title":"Schizophrenia-associated chromosome 11q21 translocation: identification of flanking markers and development of chromosome 11q fragment hybrids as cloning and mapping resources","volume":"52","author":"Fletcher","year":"1993","journal-title":"Am J Hum Genet"},{"issue":"9","key":"10.1016\/bs.pmbts.2020.12.006_bb0465","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/hmg\/9.9.1415","article-title":"Disruption of two novel genes by a translocation co-segregating with schizophrenia","volume":"9","author":"Millar","year":"2000","journal-title":"Hum Mol Genet"},{"issue":"9","key":"10.1016\/bs.pmbts.2020.12.006_bb0470","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.celrep.2015.07.061","article-title":"Genomic DISC1 disruption in hiPSCs alters Wnt signaling and neural cell fate","volume":"12","author":"Srikanth","year":"2015","journal-title":"Cell Rep"},{"issue":"7527","key":"10.1016\/bs.pmbts.2020.12.006_bb0475","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nature13716","article-title":"Synaptic dysregulation in a human iPS cell model of mental disorders","volume":"515","author":"Wen","year":"2014","journal-title":"Nature"},{"issue":"7381","key":"10.1016\/bs.pmbts.2020.12.006_bb0480","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature10761","article-title":"The promise of induced pluripotent stem cells in research and therapy","volume":"481","author":"Robinton","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0485","doi-asserted-by":"crossref","DOI":"10.1038\/srep37540","article-title":"Rapid and efficient CRISPR\/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming","volume":"6","author":"Rubio","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0490","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ymeth.2019.06.016","article-title":"Improving homology-directed repair efficiency in human stem cells","volume":"164\u2013165","author":"Skarnes","year":"2019","journal-title":"Methods"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0495","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbt.2017.05.009","article-title":"Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: possibilities and challenges","volume":"39","author":"Poon","year":"2017","journal-title":"N Biotechnol"},{"issue":"4","key":"10.1016\/bs.pmbts.2020.12.006_bb0500","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/WCO.0b013e3283550c97","article-title":"Huntington's disease","volume":"25","author":"Ha","year":"2012","journal-title":"Curr Opin Neurol"},{"issue":"5","key":"10.1016\/bs.pmbts.2020.12.006_bb0505","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The biology of Huntingtin","volume":"89","author":"Saudou","year":"2016","journal-title":"Neuron"},{"issue":"OCT","key":"10.1016\/bs.pmbts.2020.12.006_bb0510","first-page":"1","article-title":"Characterization of human Huntington's disease cell model from induced pluripotent stem cells","volume":"2","author":"Zhang","year":"2010","journal-title":"PLoS Curr"},{"issue":"11","key":"10.1016\/bs.pmbts.2020.12.006_bb0515","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1002\/stem.1245","article-title":"Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells","volume":"30","author":"Jeon","year":"2012","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0520","doi-asserted-by":"crossref","first-page":"43","DOI":"10.15283\/ijsc.2014.7.1.43","article-title":"In vivo roles of a patient-derived induced pluripotent stem cell line (HD72-iPSC) in the YAC128 model of huntington's disease","volume":"7","author":"Jeon","year":"2014","journal-title":"Int J Stem Cells"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0525","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.stem.2012.04.027","article-title":"Induced pluripotent stem cells from patients with huntington's disease show CAG repeat expansion associated phenotypes","volume":"11","author":"Mattis","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0530","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.stem.2012.04.026","article-title":"Genetic correction of huntington's disease phenotypes in induced pluripotent stem cells","volume":"11","author":"An","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/bs.pmbts.2020.12.006_bb0535","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuron.2012.05.009","article-title":"Sustained therapeutic reversal of Huntington's disease by transient repression of Huntingtin synthesis","volume":"74","author":"Kordasiewicz","year":"2012","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/bs.pmbts.2020.12.006_bb0540","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/hum.2013.200","article-title":"Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's Disease","volume":"25","author":"Stanek","year":"2014","journal-title":"Hum Gene Ther"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0545","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/JHD-199003","article-title":"Huntington's Disease Clinical Trials Corner: June 2019","volume":"8","author":"Rodrigues","year":"2019","journal-title":"J Huntingtons Dis"},{"issue":"4","key":"10.1016\/bs.pmbts.2020.12.006_bb0550","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/brain\/awr333","article-title":"Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum","volume":"135","author":"Grondin","year":"2012","journal-title":"Brain"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0555","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington's disease","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol Rev"},{"issue":"5222","key":"10.1016\/bs.pmbts.2020.12.006_bb0560","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.7618107","article-title":"Inactivation of the mouse huntington's disease gene homolog Hdh","volume":"269","author":"Duyao","year":"1995","journal-title":"Science"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0565","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/81593","article-title":"Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice","volume":"26","author":"Dragatsis","year":"2000","journal-title":"Nat Genet"},{"issue":"7","key":"10.1016\/bs.pmbts.2020.12.006_bb0570","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41591-019-0478-3","article-title":"Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease","volume":"25","author":"Zeitler","year":"2019","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0575","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.molmed.2012.11.002","article-title":"Spinal muscular atrophy: going beyond the motor neuron","volume":"19","author":"Hamilton","year":"2013","journal-title":"Trends Mol Med"},{"issue":"4","key":"10.1016\/bs.pmbts.2020.12.006_bb0580","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bbadis.2014.07.024","article-title":"Molecular mechanisms and animal models of spinal muscular atrophy","volume":"1852","author":"Edens","year":"2015","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"issue":"7227","key":"10.1016\/bs.pmbts.2020.12.006_bb0585","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","author":"Ebert","year":"2009","journal-title":"Nature"},{"issue":"12","key":"10.1016\/bs.pmbts.2020.12.006_bb0590","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/stem.749","article-title":"Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient","volume":"29","author":"Chang","year":"2011","journal-title":"Stem Cells"},{"issue":"165","key":"10.1016\/bs.pmbts.2020.12.006_bb0595","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004108","article-title":"Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy","volume":"4","author":"Corti","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0600","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pediatrneurol.2019.06.007","article-title":"From clinical trials to clinical practice: practical considerations for gene replacement therapy in SMA type 1","volume":"100","author":"Al-Zaidy","year":"2019","journal-title":"Pediatr Neurol"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0605","series-title":"Parkinson's Disease: Pathogenesis and Clinical Aspects","first-page":"129","article-title":"Pharmacological treatment of Parkinson's disease","author":"Zahoor","year":"2018"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0610","first-page":"67","article-title":"Genetic basis of Parkinson's disease: inheritance, penetrance, and expression","volume":"4","author":"Schulte","year":"2011","journal-title":"Appl Clin Genet"},{"issue":"SUPPL. 1","key":"10.1016\/bs.pmbts.2020.12.006_bb0615","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S1353-8020(11)70005-0","article-title":"Autosomal dominant Parkinson's disease","volume":"18","author":"Sundal","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"issue":"7","key":"10.1016\/bs.pmbts.2020.12.006_bb0620","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.cell.2009.06.017","article-title":"Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors","volume":"137","author":"Soldner","year":"2009","journal-title":"Cell"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0625","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.stem.2011.01.013","article-title":"LRRK2 mutant iPSC-derived da neurons demonstrate increased susceptibility to oxidative stress","volume":"8","author":"Nguyen","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/bs.pmbts.2020.12.006_bb0630","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/emmm.201200215","article-title":"Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease","volume":"4","author":"S\u00e1nchez-Dan\u00e9s","year":"2012","journal-title":"EMBO Mol Med"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0635","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1756-6606-5-35","article-title":"Mitochondrial dysfunction associated with increased oxidative stress and \u03b1-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue","volume":"5","author":"Imaizumi","year":"2012","journal-title":"Mol Brain"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0640","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ncomms1453","article-title":"Parkinson's disease induced pluripotent stem cells with triplication of the \u03b1-synuclein locus","volume":"2","author":"Devine","year":"2011","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0645","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2011.06.019","article-title":"Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations","volume":"146","author":"Soldner","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0650","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1038\/ncomms5028","article-title":"IPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis","volume":"5","author":"Sch\u00f6ndorf","year":"2014","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/bs.pmbts.2020.12.006_bb0655","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jalz.2010.01.009","article-title":"2010 Alzheimer's disease facts and figures","volume":"6","author":"Alzahimer's Association","year":"2010","journal-title":"Alzheimers Dement"},{"issue":"SUPPL. 3","key":"10.1016\/bs.pmbts.2020.12.006_bb0660","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/JAD-2006-9S338","article-title":"Segregation of a missense mutation in the amyloid \u03b2-protein precursor gene with familial Alzheimer's disease","volume":"9","author":"Goate","year":"2006","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0665","first-page":"619","article-title":"Chromosome 14 and late-onset familial Alzheimer disease (FAD)","volume":"53","author":"Schellenberg","year":"1993","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0670","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer's disease risk genes and mechanisms of disease pathogenesis","volume":"77","author":"Karch","year":"2015","journal-title":"Biol Psychiatry"},{"issue":"8","key":"10.1016\/bs.pmbts.2020.12.006_bb0675","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2174\/15672050113109990155","article-title":"Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors","volume":"10","author":"Jiang","year":"2013","journal-title":"Curr Alzheimer Res"},{"issue":"23","key":"10.1016\/bs.pmbts.2020.12.006_bb0680","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1093\/hmg\/ddr394","article-title":"Modeling familial Alzheimer's disease with induced pluripotent stem cells","volume":"20","author":"Yagi","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"7384","key":"10.1016\/bs.pmbts.2020.12.006_bb0685","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10821","article-title":"Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells","volume":"482","author":"Israel","year":"2012","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2020.12.006_bb0690","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuint.2017.07.007","article-title":"Application of the gene editing tool, CRISPR-Cas9, for treating neurodegenerative diseases","volume":"112","author":"Kolli","year":"2018","journal-title":"Neurochem Int"},{"issue":"3","key":"10.1016\/bs.pmbts.2020.12.006_bb0695","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1055\/s-0037-1601448","article-title":"Autosomal recessive primary microcephaly (MCPH): an update","volume":"48","author":"Zaqout","year":"2017","journal-title":"Neuropediatrics"},{"issue":"6","key":"10.1016\/bs.pmbts.2020.12.006_bb0700","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1073\/pnas.1525518113","article-title":"Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos","volume":"113","author":"Cohen","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/bs.pmbts.2020.12.006_bb0705","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/s41591-019-0507-2","article-title":"Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease","volume":"25","author":"Barker","year":"2019","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/bs.pmbts.2020.12.006_bb0710","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.stemcr.2017.11.005","article-title":"Human neural stem cell transplantation rescues functional deficits in R6\/2 and Q140 Huntington's disease mice","volume":"10","author":"Reidling","year":"2018","journal-title":"Stem Cell Rep"},{"issue":"PB","key":"10.1016\/bs.pmbts.2020.12.006_bb0715","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2013.10.043","article-title":"Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells","volume":"557","author":"Fujiwara","year":"2013","journal-title":"Neurosci Lett"},{"issue":"15","key":"10.1016\/bs.pmbts.2020.12.006_bb0720","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1073\/pnas.0801677105","article-title":"Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease","volume":"105","author":"Wernig","year":"2008","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Progress in Molecular Biology and Translational Science","Curing Genetic Diseases Through Genome Reprogramming"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877117320301769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877117320301769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:50:06Z","timestamp":1724395806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877117320301769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9780323853019"],"references-count":143,"URL":"https:\/\/doi.org\/10.1016\/bs.pmbts.2020.12.006","relation":{},"ISSN":["1877-1173"],"issn-type":[{"value":"1877-1173","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]}}}