{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:55:46Z","timestamp":1791388546179,"version":"4.3.3"},"reference-count":155,"publisher":"Elsevier","isbn-type":[{"value":"9780443431906","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JP25gm1810012"],"award-info":[{"award-number":["JP25gm1810012"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR215W"],"award-info":[{"award-number":["JPMJFR215W"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21H050430"],"award-info":[{"award-number":["JP21H050430"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP223fa627002"],"award-info":[{"award-number":["JP223fa627002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21gm1010004"],"award-info":[{"award-number":["21gm1010004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22gm6210016"],"award-info":[{"award-number":["22gm6210016"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.pmbts.2026.01.021","type":"book-chapter","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T20:51:59Z","timestamp":1770411119000},"page":"339-359","source":"Crossref","is-referenced-by-count":1,"title":["Microbiota-derived metabolites in intestinal immune disorders"],"prefix":"10.1016","author":[{"given":"Hisako","family":"Kayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.pmbts.2026.01.021_bib1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0966-842X(96)10057-3","article-title":"The indigenous gastrointestinal microflora","volume":"4","author":"Berg","year":"1996","journal-title":"Trends Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nri3684","article-title":"The mycobiota: interactions between commensal fungi and the host immune system","volume":"14","author":"Underhill","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nri.2017.55","article-title":"Fungal dysbiosis: immunity and interactions at mucosal barriers","volume":"17","author":"Iliev","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cell.2015.01.002","article-title":"Disease-specific alterations in the enteric virome in inflammatory bowel disease","volume":"160","author":"Norman","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cell.2014.02.032","article-title":"The virome in mammalian physiology and disease","volume":"157","author":"Virgin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib6","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.4049\/jimmunol.1800631","article-title":"The Intestinal Virome and Immunity","volume":"201","author":"Neil","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.immuni.2015.05.003","article-title":"The virome in host health and disease","volume":"42","author":"Cadwell","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-immunol-070119-115104","article-title":"Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine","volume":"38","author":"Kayama","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev-pharmtox-011613-140007","article-title":"Understanding and modulating mammalian-microbial communication for improved human health","volume":"54","author":"Mani","year":"2014","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal interactions of the intestinal microbiota and immune system","volume":"489","author":"Maynard","year":"2012","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41579-025-01163-0","article-title":"Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities","volume":"23","author":"Iliev","year":"2025","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib13","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1124\/dmd.115.065276","article-title":"Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice","volume":"43","author":"Selwyn","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/msb.2008.56","article-title":"Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes","volume":"4","author":"Claus","year":"2008","journal-title":"Mol Syst Biol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.0105-2896.2005.00291.x","article-title":"Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota","volume":"206","author":"Elson","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-019-0268-7","article-title":"Host-microbiota interactions in inflammatory bowel disease","volume":"20","author":"Caruso","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/gutjnl-2016-313235","article-title":"A microbial signature for Crohn\u2019s disease","volume":"66","author":"Pascal","year":"2017","journal-title":"Gut"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41575-022-00581-2","article-title":"Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders","volume":"19","author":"Metwaly","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aap8914","article-title":"Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome","volume":"10","author":"Vich Vila","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ni.3489","article-title":"Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis","volume":"17","author":"Klose","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.it.2014.04.003","article-title":"Intestinal macrophages and dendritic cells: what\u2019s the difference?","volume":"35","author":"Cerovic","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib23","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/mi.2017.22","article-title":"Diversity and functions of intestinal mononuclear phagocytes","volume":"10","author":"Joeris","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nri2778","article-title":"Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria","volume":"10","author":"Varol","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib26","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","article-title":"Mechanisms of foxp3+ T regulatory cell-mediated suppression","volume":"30","author":"Shevach","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib27","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.chom.2022.08.009","article-title":"Human gut microbiota stimulate defined innate immune responses that vary from phylum to strain","volume":"30","author":"Spindler","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41586-019-0884-1","article-title":"GPR31-dependent dendrite protrusion of intestinal CX3CR1(+) cells by bacterial metabolites","volume":"566","author":"Morita","year":"2019","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature11809","article-title":"Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells","volume":"494","author":"Diehl","year":"2013","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.aao1503","article-title":"CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi","volume":"359","author":"Leonardi","year":"2018","journal-title":"Science"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib31","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41586-022-04502-w","article-title":"Immune regulation by fungal strain diversity in inflammatory bowel disease","volume":"603","author":"Li","year":"2022","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib32","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1038\/s41591-023-02556-5","article-title":"Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T(H)1 cell responses in Crohn\u2019s disease","volume":"29","author":"Martini","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.chom.2021.01.002","article-title":"Adherent-invasive E. coli metabolism of propanediol in Crohn\u2019s disease regulates phagocytes to drive intestinal inflammation","volume":"29","author":"Viladomiu","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib34","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases","volume":"569","author":"Lloyd-Price","year":"2019","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1084\/jem.20181639","article-title":"Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification","volume":"216","author":"Sorbara","year":"2019","journal-title":"J Exp Med"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib36","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.tim.2024.04.004","article-title":"Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis","volume":"32","author":"McCrory","year":"2024","journal-title":"Trends Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib37","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1053\/j.gastro.2014.02.009","article-title":"The microbiome in inflammatory bowel disease: current status and the future ahead","volume":"146","author":"Kostic","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/nmicrobiol.2017.4","article-title":"Dynamics of the human gut microbiome in inflammatory bowel disease","volume":"2","author":"Halfvarson","year":"2017","journal-title":"Nat Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00060-18","article-title":"Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease","volume":"32","author":"Mirsepasi-Lauridsen","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib40","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1136\/gutjnl-2017-314903","article-title":"Adherent-invasive Escherichia coli in inflammatory bowel disease","volume":"67","author":"Palmela","year":"2018","journal-title":"Gut"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib41","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.ygeno.2019.10.013","article-title":"Comparative genomics of a subset of Adherent\/Invasive Escherichia coli strains isolated from individuals without inflammatory bowel disease","volume":"112","author":"Barrios-Villa","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib43","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2005.05.007","article-title":"An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system","volume":"122","author":"Mazmanian","year":"2005","journal-title":"Cell"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib45","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1084\/jem.20062008","article-title":"A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2","volume":"203","author":"Wang","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib46","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.chom.2014.03.006","article-title":"Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms","volume":"15","author":"Dasgupta","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib47","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1073\/pnas.0909122107","article-title":"Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota","volume":"107","author":"Round","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib48","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1206095","article-title":"The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota","volume":"332","author":"Round","year":"2011","journal-title":"Science"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib49","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1126\/science.aad9948","article-title":"Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease","volume":"352","author":"Chu","year":"2016","journal-title":"Science"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2025.05.016","article-title":"Structure of gut microbial glycolipid modulates host inflammatory response","author":"Cho","year":"2025","journal-title":"Cell"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib51","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pharmthera.2005.04.013","article-title":"Adenosine 5\u2032-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation","volume":"112","author":"Bours","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib52","doi-asserted-by":"crossref","first-page":"8267","DOI":"10.1073\/pnas.87.21.8267","article-title":"Extracellular ATP in T-lymphocyte activation: possible role in effector functions","volume":"87","author":"Filippini","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib53","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1126\/science.1132559","article-title":"ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors","volume":"314","author":"Chen","year":"2006","journal-title":"Science"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib54","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbalip.2005.10.001","article-title":"ATP-induced apoptosis of thymocytes is mediated by activation of P2\u00d77 receptor and involves de novo ceramide synthesis and mitochondria","volume":"1761","author":"Lepine","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib55","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.immuni.2014.10.010","article-title":"ATP-gated ionotropic P2\u00d77 receptor controls follicular T helper cell numbers in Peyer\u2019s patches to promote host-microbiota mutualism","volume":"41","author":"Proietti","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1083\/jcb.112.2.279","article-title":"Extracellular ATP as a trigger for apoptosis or programmed cell death","volume":"112","author":"Zheng","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib57","first-page":"F962","article-title":"Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z\/P2\u00d77 receptors","volume":"275","author":"Schulze-Lohoff","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib58","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/1471-2180-13-301","article-title":"Release of extracellular ATP by bacteria during growth","volume":"13","author":"Mempin","year":"2013","journal-title":"BMC Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib59","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1128\/JCM.01941-09","article-title":"Isolation and identification of ATP-secreting bacteria from mice and humans","volume":"48","author":"Iwase","year":"2010","journal-title":"J Clin Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib60","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1128\/AEM.03871-12","article-title":"Glucose triggers ATP secretion from bacteria in a growth-phase-dependent manner","volume":"79","author":"Hironaka","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib61","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41467-018-08156-z","article-title":"ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens","volume":"10","author":"Proietti","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib62","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1016\/j.celrep.2017.02.061","article-title":"T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP","volume":"18","author":"Perruzza","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib63","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature07240","article-title":"ATP drives lamina propria T(H)17 cell differentiation","volume":"455","author":"Atarashi","year":"2008","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib64","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11302-005-5303-4","article-title":"Modulation of purinergic signaling by NPP-type ectophosphodiesterases","volume":"2","author":"Stefan","year":"2006","journal-title":"Purinergic Signal"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib65","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.tibs.2005.08.005","article-title":"NPP-type ectophosphodiesterases: unity in diversity","volume":"30","author":"Stefan","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172509","article-title":"E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine","volume":"12","author":"Furuta","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib67","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2015.01.015","article-title":"The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells","volume":"42","author":"Tsai","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib68","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/ncomms2023","article-title":"Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2\u00d77 purinoceptors","volume":"3","author":"Kurashima","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib69","doi-asserted-by":"crossref","first-page":"774","DOI":"10.4049\/jimmunol.1103067","article-title":"Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine","volume":"190","author":"Kusu","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib70","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100594118","article-title":"The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2\u00d74 receptor-dependent metabolism in myeloid cells","volume":"118","author":"Tani","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib71","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib72","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41586-019-1605-5","article-title":"Cyclic GMP-AMP signalling protects bacteria against viral infection","volume":"574","author":"Cohen","year":"2019","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib73","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.immuni.2021.05.008","article-title":"Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells","volume":"54","author":"Shmuel-Galia","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib74","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1016\/j.celrep.2017.11.101","article-title":"STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis","volume":"21","author":"Ahn","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50656-5","article-title":"Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice","volume":"9","author":"Martin","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib76","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41392-020-0198-7","article-title":"The interactions between cGAS-STING pathway and pathogens","volume":"5","author":"Cheng","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib77","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.immuni.2025.05.016","article-title":"ILC3s sense gut microbiota through STING to initiate immune tolerance","volume":"58","author":"Zhou","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib78","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.immuni.2023.11.001","article-title":"Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis","volume":"56","author":"Zhang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib79","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41419-021-04101-z","article-title":"Extracellular vesicles package dsDNA to aggravate Crohn\u2019s disease by activating the STING pathway","volume":"12","author":"Zhao","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2025.103434","article-title":"Microbial dysbiosis fuels STING-driven autoinflammation through cyclic dinucleotides","volume":"154","author":"Shibahara","year":"2025","journal-title":"J Autoimmun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib81","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1097\/MIB.0b013e3182802ab6","article-title":"Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians","volume":"19","author":"Yang","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib82","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng.275","article-title":"Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study","volume":"41","author":"Silverberg","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib83","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib84","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/ng.549","article-title":"Genome-wide association identifies multiple ulcerative colitis susceptibility loci","volume":"42","author":"McGovern","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib85","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adm6843","article-title":"OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation","volume":"10","author":"Li","year":"2025","journal-title":"Sci Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib86","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.chom.2019.04.002","article-title":"Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis","volume":"25","author":"Brown","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2019.115664","article-title":"Lipidomes in health and disease: Analytical strategies and considerations","volume":"120","author":"Wei","year":"2019","journal-title":"Trac-Trends in Analytical Chemistry"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib88","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","volume":"17","author":"Sayin","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib89","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/jssc.201500899","article-title":"Recent advances in lipidomics for disease research","volume":"39","author":"Yang","year":"2016","journal-title":"J Sep Sci"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12040333","article-title":"Lipidomics in Understanding Pathophysiology and Pharmacologic Effects in Inflammatory Diseases: Considerations for Drug Development","volume":"12","author":"Ahluwalia","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib91","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrm.2017.138","article-title":"Understanding the diversity of membrane lipid composition","volume":"19","author":"Harayama","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib92","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adc9317","article-title":"Brain lipidomics: From functional landscape to clinical significance","volume":"8","author":"Yoon","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib93","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1007\/s00018-020-03715-4","article-title":"Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases","volume":"78","author":"Tabassum","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib94","doi-asserted-by":"crossref","first-page":"33429","DOI":"10.18632\/oncotarget.7960","article-title":"Lipidome in colorectal cancer","volume":"7","author":"Yan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib95","doi-asserted-by":"crossref","first-page":"5864","DOI":"10.1038\/ncomms6864","article-title":"Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation","volume":"5","author":"Progatzky","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib96","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.chom.2020.05.013","article-title":"Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level","volume":"28","author":"Kenny","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib97","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2013.03.013","article-title":"Pleiotropic roles of bile acids in metabolism","volume":"17","author":"de Aguiar Vallim","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib98","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib99","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.1038\/s41467-023-42788-0","article-title":"Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts","volume":"14","author":"Ning","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib100","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/gutjnl-2012-302578","article-title":"Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases","volume":"62","author":"Duboc","year":"2013","journal-title":"Gut"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib101","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.chom.2020.07.020","article-title":"Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease","volume":"28","author":"Bushman","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib102","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11306-014-0677-3","article-title":"Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn\u2019s disease and healthy individuals","volume":"11","author":"Bjerrum","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib103","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1038\/s41467-020-17956-1","article-title":"Integrated microbiota and metabolite profiles link Crohn\u2019s disease to sulfur metabolism","volume":"11","author":"Metwaly","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib104","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10\u2013\/\u2013 mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib105","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.immuni.2017.11.012","article-title":"The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids","volume":"47","author":"Cao","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib106","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1084\/jem.20130301","article-title":"Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids","volume":"211","author":"Ramesh","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib107","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41586-021-03421-6","article-title":"CAR directs T cell adaptation to bile acids in the small intestine","volume":"593","author":"Chen","year":"2021","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib108","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-021-03832-5","article-title":"Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians","volume":"599","author":"Sato","year":"2021","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib109","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature13828","article-title":"Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile","volume":"517","author":"Buffie","year":"2015","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.829525","article-title":"The Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease","volume":"13","author":"Thomas","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib111","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.celrep.2018.12.028","article-title":"Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib112","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.chom.2018.07.019","article-title":"Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration","volume":"24","author":"Jain","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-020-2193-0","article-title":"Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells","author":"Campbell","year":"2020","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib114","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.immuni.2016.09.008","article-title":"Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome","volume":"45","author":"Guo","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib115","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-019-1865-0","article-title":"Microbial bile acid metabolites modulate gut RORgamma(+) regulatory T cell homeostasis","volume":"577","author":"Song","year":"2020","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib116","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.chom.2021.07.013","article-title":"A bacterial bile acid metabolite modulates T(reg) activity through the nuclear hormone receptor NR4A1","volume":"29","author":"Li","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib117","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-019-1785-z","article-title":"Bile acid metabolites control T(H)17 and T(reg) cell differentiation","volume":"576","author":"Hang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib118","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41586-022-04480-z","article-title":"Human gut bacteria produce Tau(Eta)17-modulating bile acid metabolites","volume":"603","author":"Paik","year":"2022","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib119","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.chom.2020.01.021","article-title":"Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation","volume":"27","author":"Sinha","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2020.101068","article-title":"Emerging roles of lysophospholipids in health and disease","volume":"80","author":"Tan","year":"2020","journal-title":"Prog Lipid Res"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib121","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1099\/mic.0.28609-0","article-title":"Phospholipase A in Gram-negative bacteria and its role in pathogenesis","volume":"152","author":"Istivan","year":"2006","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib122","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nchembio.1721","article-title":"Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay","volume":"11","author":"Kamat","year":"2015","journal-title":"Nat Chem Biol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib123","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/humu.22437","article-title":"Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects","volume":"34","author":"Chen","year":"2013","journal-title":"Hum Mutat"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib124","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211291","article-title":"Lysophosphatidylserines derived from microbiota in Crohn\u2019s disease elicit pathological Th1 response","volume":"219","author":"Otake-Kasamoto","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib125","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s11306-018-1439-4","article-title":"Italian cohort of patients affected by inflammatory bowel disease is characterised by variation in glycerophospholipid, free fatty acids and amino acid levels","volume":"14","author":"Murgia","year":"2018","journal-title":"Metabolomics"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib126","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/jgh.15067","article-title":"Novel mass spectrometry-based comprehensive lipidomic analysis of plasma from patients with inflammatory bowel disease","volume":"35","author":"Iwatani","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9120291","article-title":"Mucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitis","volume":"9","author":"Diab","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib128","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nmeth.2172","article-title":"TGFalpha shedding assay: an accurate and versatile method for detecting GPCR activation","volume":"9","author":"Inoue","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib129","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1111\/bph.12678","article-title":"Lysophospholipid receptor nomenclature review: IUPHAR Review 8","volume":"171","author":"Kihara","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib130","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bbrc.2006.01.069","article-title":"Identification of a lysophosphatidylserine receptor on mast cells","volume":"341","author":"Sugo","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib131","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.immuni.2021.05.007","article-title":"GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair","volume":"54","author":"Wang","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib132","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1038\/s41467-024-48763-7","article-title":"Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease","volume":"15","author":"Salihovic","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib133","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/ibd\/izy402","article-title":"Untargeted Metabolomics and Inflammatory Markers Profiling in Children With Crohn\u2019s Disease and Ulcerative Colitis-A Preliminary Study","volume":"25","author":"Daniluk","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib134","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jcmgh.2020.11.006","article-title":"Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in Mice","volume":"11","author":"Kennelly","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib135","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2096994","article-title":"Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent gammadelta T cells","volume":"14","author":"Li","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib136","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12929-021-00711-z","article-title":"Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency","volume":"28","author":"Tang","year":"2021","journal-title":"J Biomed Sci"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib137","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib138","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1128\/MMBR.00082-15","article-title":"Bacterial Sphingomyelinases and Phospholipases as Virulence Factors","volume":"80","author":"Flores-Diaz","year":"2016","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib139","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41575-021-00574-7","article-title":"Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease","volume":"19","author":"Verstockt","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib140","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/mi.2016.35","article-title":"Sphingosine-1-phosphate receptor-1 (S1P(1)) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease","volume":"10","author":"Karuppuchamy","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib141","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.4049\/jimmunol.171.7.3500","article-title":"Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor","volume":"171","author":"Dorsam","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib142","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature02284","article-title":"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1","volume":"427","author":"Matloubian","year":"2004","journal-title":"Nature"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib143","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1096\/fj.01-0625fje","article-title":"Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses","volume":"16","author":"Idzko","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib144","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/eji.200425556","article-title":"The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells","volume":"35","author":"Muller","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib145","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1084\/jem.20030680","article-title":"Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis","volume":"199","author":"Jolly","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib146","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/jb\/mvh081","article-title":"Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells","volume":"135","author":"Yokoo","year":"2004","journal-title":"J Biochem"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib147","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ni.2730","article-title":"Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation","volume":"14","author":"Garris","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib148","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000902","article-title":"Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa","volume":"6","author":"Bergstrom","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib149","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1038\/s41467-025-60234-1","article-title":"Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans","volume":"16","author":"Peters","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001610","article-title":"Production of alpha-galactosylceramide by a prominent member of the human gut microbiota","volume":"11","author":"Wieland Brown","year":"2013","journal-title":"PLoS Biol"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib151","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2013.11.042","article-title":"Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells","volume":"156","author":"An","year":"2014","journal-title":"Cell"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib152","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/s41467-020-16274-w","article-title":"Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels","volume":"11","author":"Johnson","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib153","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s44324-025-00066-1","article-title":"Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes","volume":"3","author":"Jyoti","year":"2025","journal-title":"NPJ Metab Health Dis"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib154","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41591-023-02217-7","article-title":"Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease","volume":"29","author":"Mehta","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/bs.pmbts.2026.01.021_bib155","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.chom.2021.06.019","article-title":"Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease","volume":"29","author":"Lee","year":"2021","journal-title":"Cell Host Microbe"}],"container-title":["Progress in Molecular Biology and Translational Science","Live Biotherapeutics: Advancing Microbial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877117326000219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877117326000219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:31:20Z","timestamp":1791387080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877117326000219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443431906"],"references-count":155,"URL":"https:\/\/doi.org\/10.1016\/bs.pmbts.2026.01.021","relation":{},"ISSN":["1877-1173"],"issn-type":[{"value":"1877-1173","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}