{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T02:59:55Z","timestamp":1771729195153,"version":"3.50.1"},"reference-count":75,"publisher":"Elsevier","isbn-type":[{"value":"9780443432408","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009229","name":"American University in Cairo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.podrm.2025.12.001","type":"book-chapter","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:12:14Z","timestamp":1767442334000},"page":"211-252","source":"Crossref","is-referenced-by-count":0,"title":["Perindopril: A comprehensive profile"],"prefix":"10.1016","author":[{"given":"Jude Majed","family":"Lababidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Fawzy","family":"Kabil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan Mohamed El-Said","family":"Azzazy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/bs.podrm.2025.12.001_bib1","unstructured":"European Commission. Commission decision of 9 July 2014 relating to a proceeding under Articles 101 and 102 of the Treaty on the Functioning of the European Union (Case AT.39612 \u2013 Perindopril (Servier)). Brussels: European Commission; 2014. Available from: https:\/\/ec.europa.eu\/competition\/antitrust\/cases\/dec_docs\/39612\/39612_12422_3.pdf."},{"key":"10.1016\/bs.podrm.2025.12.001_bib2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.20959\/wjpr20174-8268","article-title":"Analytical methods of perindopril","volume":"6","author":"Housheh","year":"2017","journal-title":"Review World J. Pharm. Res."},{"key":"10.1016\/bs.podrm.2025.12.001_bib3","unstructured":"Damien G, Lefoulon F, Marchand B. Salt of perindopril and pharmaceutical compositions containing it. United States patent US 6,696,481 B2. 2004 Feb 24. Available from: https:\/\/patents.google.com\/patent\/US6696481B2\/en."},{"key":"10.1016\/bs.podrm.2025.12.001_bib4","unstructured":"Australian Government Department of Health and Ageing, Therapeutic Goods Administration (TGA). Australian public assessment report for perindopril arginine\/amlodipine (as besylate) (Coveram). Canberra (AU): Therapeutic Goods Administration; 2009. Available from: https:\/\/www.tga.gov.au\/sites\/default\/files\/auspar-coveram.pdf."},{"key":"10.1016\/bs.podrm.2025.12.001_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s40256-015-0144-1","article-title":"Perindopril\/amlodipine (Prestalia\u00ae): a review in hypertension","volume":"15","author":"Shirley","year":"2015","journal-title":"Am. J. Of. Cardiovascular Drugs"},{"issue":"4","key":"10.1016\/bs.podrm.2025.12.001_bib6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10557-021-07248-1","article-title":"The combination of beta-blockers and ACE inhibitors across the spectrum of cardiovascular diseases","volume":"37","author":"Strauss","year":"2023","journal-title":"Cardiovascular Drugs Ther"},{"issue":"11","key":"10.1016\/bs.podrm.2025.12.001_bib7","doi-asserted-by":"crossref","first-page":"o443","DOI":"10.1107\/S0108270112041583","article-title":"Perindoprilat monohydrate","volume":"68","author":"Bojarska","year":"2012","journal-title":"Acta Crystallogr. Sect. C: Cryst. Structure Commun"},{"key":"10.1016\/bs.podrm.2025.12.001_bib8","unstructured":"D. Bank, Perindopril. 2023 28 November 2023 [cited 2023; Available from: https:\/\/go.drugbank.com\/drugs\/DB00790."},{"key":"10.1016\/bs.podrm.2025.12.001_bib9","unstructured":"(NCBI), N.Cf.B.I., Perindopril erbumine - PubChem. (n.d.). https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Perindopril-Erbumine#section=2D-Structure."},{"issue":"5","key":"10.1016\/bs.podrm.2025.12.001_bib10","first-page":"700","article-title":"Increased bradykinin levels accompany the hemodynamic response to acute inhibition of angiotensin-converting enzyme in dogs with heart failure","volume":"34","author":"Su","year":"1999","journal-title":"J. Cardiovasc\u00a0Pharmacol"},{"issue":"5","key":"10.1016\/bs.podrm.2025.12.001_bib11","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1185\/030079907X182158","article-title":"Perindopril arginine: benefits of a new salt of the ACE inhibitor perindopril","volume":"23","author":"Telejko","year":"2007","journal-title":"Curr. Med. Res. Opin"},{"key":"10.1016\/bs.podrm.2025.12.001_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2165\/00003495-199142010-00006","article-title":"Perindopril: a review of its pharmacological properties and therapeutic use in cardiovascular disorders","volume":"42","author":"Todd","year":"1991","journal-title":"Drugs"},{"issue":"2","key":"10.1016\/bs.podrm.2025.12.001_bib13","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/hy0202.103417","article-title":"Perindopril alters vascular angiotensin-converting enzyme, AT1 receptor, and nitric oxide synthase expression in patients with coronary heart disease","volume":"39","author":"Zhuo","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/bs.podrm.2025.12.001_bib14","article-title":"Process for the preparation of the L-arginine salt of perindopril","author":"Linol","year":"2014","journal-title":"Google Pat."},{"key":"10.1016\/bs.podrm.2025.12.001_bib15","unstructured":"P. Langlois, H. Turbe, Method for synthesis of perindopril and its pharmaceutically acceptable salts. United States patent US 6,835,843 B2. 2004 Dec 28. Available from: https:\/\/patents.google.com\/patent\/US6835843B2\/en."},{"issue":"6","key":"10.1016\/bs.podrm.2025.12.001_bib16","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3109\/10837450.2014.915568","article-title":"Development and in vitro\/in vivo evaluation of immediate release perindopril tablets","volume":"20","author":"\u00d6l\u00e7er","year":"2015","journal-title":"Pharm. Dev. Technol"},{"key":"10.1016\/bs.podrm.2025.12.001_bib17","unstructured":"E.P.\u00a0Office,\u00a0Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules, E.P.O. (EP3842035A1), Editor. 2019. https:\/\/patents.google.com\/patent\/EP3842035A1\/en."},{"key":"10.1016\/bs.podrm.2025.12.001_bib18","unstructured":"R.R. Jetti, C.K. Raval, A.R. Bommareddy, D. Datta, Polymorphic forms of perindopril (L)-arginine and process for the preparation thereof. United States patent US 9,725,412 B2. 2017 Aug 8. Available from: https:\/\/patents.google.com\/patent\/US9725412B2\/en."},{"key":"10.1016\/bs.podrm.2025.12.001_bib19","unstructured":"J. Linol, S. Laurent, A. Grenier, S. Mathieu, Delta crystalline form of the arginine salt of perindopril, a process for its preparation, and pharmaceutical compositions containing it. United States patent application US 2013\/0178464 A1. 2013 Jul 11. Available from: https:\/\/patents.google.com\/patent\/US20130178464A1\/en."},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib20","first-page":"43393","article-title":"Quantitative determination of perindopril tablets available in the Malaysian outlets by UV spectroscopy and fourier transform infrared spectroscopy (FTIR), evaluation for structural characterization and disintegration analysis","volume":"52","author":"Khan","year":"2023","journal-title":"Biomed. J. Sci. & Technical Res."},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13065-023-00964-9","article-title":"Three techniques for the determination of perindopril through derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole","volume":"17","author":"Askar","year":"2023","journal-title":"BMC Chem"},{"issue":"8","key":"10.1016\/bs.podrm.2025.12.001_bib22","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0731-7085(97)00254-9","article-title":"Utility of certain \u03c0-acceptors for the spectrophotometric determination of perindopril","volume":"17","author":"Abdellatef","year":"1998","journal-title":"J. Pharm. Biomed. Anal"},{"key":"10.1016\/bs.podrm.2025.12.001_bib23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.saa.2015.07.099","article-title":"Novel ratio difference at coabsorptive point spectrophotometric method for determination of components with wide variation in their absorptivities","volume":"152","author":"Saad","year":"2016","journal-title":"Spectrochimica Acta Part. A: Mol. Biomolecular Spectrosc"},{"issue":"6","key":"10.1016\/bs.podrm.2025.12.001_bib24","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1080\/22297928.2016.1250673","article-title":"Validated spectrophotometric methods for determination of weakly UV absorbed perindopril arginine in bulk and combined dosage form","volume":"6","author":"El-Bagary","year":"2016","journal-title":"Anal. Chem. Lett"},{"key":"10.1016\/bs.podrm.2025.12.001_bib25","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.saa.2015.05.096","article-title":"Conventional univariate versus multivariate spectrophotometric assisted techniques for simultaneous determination of perindopril arginin and amlodipine besylate in presence of their degradation products","volume":"150","author":"Hegazy","year":"2015","journal-title":"Spectrochimica Acta Part. A: Mol. Biomolecular Spectrosc"},{"issue":"5","key":"10.1016\/bs.podrm.2025.12.001_bib26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.36468\/pharmaceutical-sciences.713","article-title":"Development and validation of a novel UV spectrophotometric method for simultaneous analysis of amlodipine, indapamide and perindopril","volume":"82","author":"Alves","year":"2020","journal-title":"Indian. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0731-7085(01)00388-0","article-title":"Comparison of spectrophotometric and an LC method for the determination perindopril and indapamide in pharmaceutical formulations","volume":"26","author":"Erk","year":"2001","journal-title":"J. Pharm. Biomed. Anal"},{"issue":"6","key":"10.1016\/bs.podrm.2025.12.001_bib28","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0731-7085(98)00113-7","article-title":"Spectrophotometric and atomic absorption spectrometric determination of ramipril and perindopril through ternary complex formation with eosin and Cu(II)","volume":"18","author":"Abdellatef","year":"1999","journal-title":"J. Pharm. Biomed. Anal"},{"key":"10.1016\/bs.podrm.2025.12.001_bib29","doi-asserted-by":"crossref","first-page":"S831","DOI":"10.1016\/j.arabjc.2012.12.017","article-title":"Kinetic spectrophotometric method for the determination of perindopril erbumine in pure and commercial dosage forms","volume":"10","author":"Rahman","year":"2017","journal-title":"Arab. J. Chem"},{"issue":"2","key":"10.1016\/bs.podrm.2025.12.001_bib30","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.4067\/S0717-97072012000200002","article-title":"Development of spectrophotometric method for the determination of perindopril erbumine in pharmaceutical formulations using 2, 4 dinitrofluorobenzene","volume":"57","author":"Rahman","year":"2012","journal-title":"J. Chil. Chem. Soc."},{"key":"10.1016\/bs.podrm.2025.12.001_bib31","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902022e20012","article-title":"Determination of perindopril erbumine by oxidative coupling reaction using 2, 6-dichloroquinone-4-chlorimide","volume":"58","author":"Thuttagunta","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"issue":"6","key":"10.1016\/bs.podrm.2025.12.001_bib32","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.52711\/0974-360X.2021.00570","article-title":"Direct spectrophotometric determination of perindopril erbumine and enalapril maleate in pure and pharmaceutical dosage forms using bromocresol green","volume":"14","author":"Sakur","year":"2021","journal-title":"Res. J. Pharm. Technol"},{"issue":"10","key":"10.1016\/bs.podrm.2025.12.001_bib33","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1080\/10826076.2012.686141","article-title":"High performance liquid chromatography, tlc-densitometry, and first-derivative spectrophotometry for simultaneous determination of amlodipine and perindopril in bulk powder and its tablets","volume":"36","author":"Gizawy","year":"2013","journal-title":"J. Liq. Chromatogr. & Relat. Technol"},{"issue":"6","key":"10.1016\/bs.podrm.2025.12.001_bib34","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s10895-015-1666-2","article-title":"Novel spectrofluorimetric method for the determination of perindopril erbumine based on fluorescence quenching of rhodamine B","volume":"25","author":"Fael","year":"2015","journal-title":"J. Fluorescence"},{"key":"10.1016\/bs.podrm.2025.12.001_bib35","article-title":"Novel spectrofluorimetric method for the determination of perindopril erbumine based on charge transfer reaction with 7-hydroxycoumarin","author":"Fael","year":"2015","journal-title":"J. Fluorescence"},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40543-015-0045-6","article-title":"Selective spectrofluorimetric method for the determination of perindopril erbumine in bulk and tablets through derivatization with dansyl chloride","volume":"6","author":"Sakur","year":"2015","journal-title":"J. Anal. Sci. Technol"},{"issue":"9","key":"10.1016\/bs.podrm.2025.12.001_bib37","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/bio.4540","article-title":"Utilization of erythrosine B in spectrofluorimetric quenching analysis of amlodipine and perindopril in pharmaceutical and biological matrices","volume":"38","author":"Badr El\u2010Din","year":"2023","journal-title":"Luminescence"},{"issue":"5","key":"10.1016\/bs.podrm.2025.12.001_bib38","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1007\/s11696-023-02668-9","article-title":"Spectrofluorimetric assay of amlodipine and perindopril in their raw materials, pharmaceutical formulations and spiked human plasma through the formation of complexes with Eosin Y","volume":"77","author":"Salem","year":"2023","journal-title":"Chem. Pap."},{"issue":"2","key":"10.1016\/bs.podrm.2025.12.001_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/1573412916666200327152049","article-title":"Analytical techniques for the estimation of perindopril erbumine: a review","volume":"17","author":"Pathak","year":"2021","journal-title":"Curr. Pharm. Anal"},{"issue":"4","key":"10.1016\/bs.podrm.2025.12.001_bib40","doi-asserted-by":"crossref","first-page":"992","DOI":"10.5740\/jaoacint.16-0279","article-title":"A validated HPLC method for simultaneous determination of perindopril arginine, amlodipine, and indapamide: application in bulk and in different pharmaceutical dosage forms","volume":"100","author":"El-Bagary","year":"2017","journal-title":"J. AOAC Int."},{"key":"10.1016\/bs.podrm.2025.12.001_bib41","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s10337-014-2724-7","article-title":"The development and validation of a stability-indicating UHPLC-DAD method for determination of perindopril l-arginine in bulk substance and pharmaceutical dosage form","volume":"77","author":"Paczkowska","year":"2014","journal-title":"Chromatographia"},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/scipharm86010007","article-title":"UHPLC-UV method for simultaneous determination of perindopril arginine and indapamide hemihydrate in combined dosage form: a stability-indicating assay method","volume":"86","author":"Al-Tannak","year":"2018","journal-title":"Sci. Pharmaceutica"},{"key":"10.1016\/bs.podrm.2025.12.001_bib43","first-page":"qsad077","article-title":"Chromatographic techniques for assessment of bisoprolol fumarate and perindopril arginine in solid formulations under various stress conditions and application to six sigma, content uniformity, and comparative dissolution approaches","author":"Mahmoud","year":"2023","journal-title":"J. AOAC Int."},{"issue":"4","key":"10.1016\/bs.podrm.2025.12.001_bib44","article-title":"Simultaneous determination of indapamide, amlodipine besylate and perindopril arginine combined in tablet dosage form using high performance liquid chromatography","volume":"13","author":"Metwally","year":"2020","journal-title":"Jordan. J. Pharm. Sci."},{"issue":"8","key":"10.1016\/bs.podrm.2025.12.001_bib45","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/chromsci\/bmaa031","article-title":"Stability-indicating RP-HPLC and CE methods for simultaneous determination of bisoprolol and perindopril in pharmaceutical formulation: a comparative study","volume":"58","author":"Hassan","year":"2020","journal-title":"J. Chromatographic Sci."},{"issue":"5","key":"10.1016\/bs.podrm.2025.12.001_bib46","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.32383\/appdr\/82922","article-title":"Impact of hydrochlorothiazide on the stability of two perindopril salts. Evaluation of the interaction with HPLC and ESI LC\/MS methods","volume":"75","author":"Juszczak","year":"2018","journal-title":"Acta Poloniae Pharmaceutica-Drug Res."},{"key":"10.1016\/bs.podrm.2025.12.001_bib47","first-page":"6267","article-title":"Estimation of perindopril arginine, i ndapamide, and amlodipine in bulk and fixed dose combinantion using stability indicating reverse phase high-pressure liquid chromatography","author":"Chaudhary","year":"2020","journal-title":"IJPSR"},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib48","first-page":"1","article-title":"Development of new stability indicating UPLC-UV method for the extraction and quantification of perindopril and indapamide from human plasma","volume":"7","author":"Palakeeti","year":"2021","journal-title":"Future J. Pharm. Sci."},{"issue":"4","key":"10.1016\/bs.podrm.2025.12.001_bib49","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/1735-5362.212048","article-title":"Method development and validation of HPLC tandem\/mass spectrometry for quantification of perindopril arginine and amlodipine besylate combination in bulk and pharmaceutical formulations","volume":"12","author":"Duraisamy","year":"2017","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/bs.podrm.2025.12.001_bib50","first-page":"1567","article-title":"Bioanalytical method validation for perindopril and amlodipine in human plasma using UPLC\/ESI-MS\/MS","volume":"7","author":"Kalaiyarasi","year":"2018","journal-title":"World J. Pharma. Res."},{"key":"10.1016\/bs.podrm.2025.12.001_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.122585","article-title":"Simultaneous determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma using UPLC-MS\/MS method","volume":"1169","author":"Zheng","year":"2021","journal-title":"J. Chromatogr. B"},{"issue":"5","key":"10.1016\/bs.podrm.2025.12.001_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5048","article-title":"Determination of amlodipine, indapamide and perindopril in human plasma by a novel LC\u2013MS\/MS method: application to a bioequivalence study","volume":"35","author":"Rezk","year":"2021","journal-title":"Biomed. Chromatogr"},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2298\/CICEQ110628042J","article-title":"Validation of a dissolution method with RP-HPLC analysis for perindopril erbumine and indapamide combination tablet","volume":"18","author":"Jain","year":"2012","journal-title":"Chem. Ind. Chem. Eng. Q."},{"key":"10.1016\/bs.podrm.2025.12.001_bib54","first-page":"575","article-title":"A validated RP-HPLC method for the determination of perindopril erbumine in pharmaceutical formulations","volume":"1","author":"Rani","year":"2009","journal-title":"Int. J. Pharm. Tech. Res."},{"key":"10.1016\/bs.podrm.2025.12.001_bib55","article-title":"Method development and validation for simultaneous estimation of perindopril erbumine and indapamide by RP-HPLC in pharmaceutical dosage forms","author":"Joseph","year":"2011","journal-title":"Int. J. Pharm. Pharm. Sci"},{"issue":"4","key":"10.1016\/bs.podrm.2025.12.001_bib56","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/chromsci\/bmt031","article-title":"Stability-indicating RP-HPLC method for the quantitative analysis of perindopril erbumine in tablet dosage form","volume":"52","author":"Dugga","year":"2014","journal-title":"J. Chromatographic Sci."},{"issue":"4","key":"10.1016\/bs.podrm.2025.12.001_bib57","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1515\/amma-2015-0073","article-title":"Analytical performance of an HPLC and CZE methods for the analysis and separation of perindopril erbumine and indapamide","volume":"61","author":"Valentin","year":"2015","journal-title":"Acta Marisiensis-Seria Medica"},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib58","first-page":"22","article-title":"Quantitative determination of captopril, perindopril erbumine, moexipril hydrochloride, and ramipril in bulk and pharmaceutical preparations by high performance liquid chromatography","volume":"1","author":"Elgawish","year":"2017","journal-title":"Rec. Pharm. Biomed. Sci."},{"issue":"12","key":"10.1016\/bs.podrm.2025.12.001_bib59","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.5958\/0974-360X.2020.01033.1","article-title":"A novel HPLC cleaning validation and assay method for the simultaneous estimation of perindopril and amlodipine","volume":"13","author":"Naik","year":"2020","journal-title":"Res. J. Pharm. Technol"},{"issue":"3","key":"10.1016\/bs.podrm.2025.12.001_bib60","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/chromsci\/bmu223","article-title":"Simultaneous quantification of related substances of perindopril tert-butylamine using a novel stability indicating liquid chromatographic method","volume":"53","author":"Szab\u00f3","year":"2015","journal-title":"J. Chromatographic Sci."},{"issue":"3","key":"10.1016\/bs.podrm.2025.12.001_bib61","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/chromsci\/bmac044","article-title":"Analysis of fixed-dose combination of three antihypertensive drugs by a green and quality by design approach","volume":"61","author":"Mandi\u0107-Kova\u010devi\u0107","year":"2022","journal-title":"J. Chromatographic Sci."},{"issue":"2","key":"10.1016\/bs.podrm.2025.12.001_bib62","first-page":"124","article-title":"Validated chromatographic methods for concurrent determination of atorvastatin and perindopril","volume":"16","author":"Patel","year":"2022","journal-title":"J. Chem. Metrology"},{"issue":"3","key":"10.1016\/bs.podrm.2025.12.001_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e14209","article-title":"Method development for simultaneous estimation of amlodipine besylate and perindopril tertbutyl amine in fixed-dose","volume":"9","author":"Khan","year":"2023","journal-title":"Heliyon"},{"issue":"11","key":"10.1016\/bs.podrm.2025.12.001_bib64","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s11094-011-0531-0","article-title":"Analysis of the angiotensin-converting enzyme inhibitors perindopril, lisinopril, and quinapril by HPLC","volume":"44","author":"Khomushku","year":"2011","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/bs.podrm.2025.12.001_bib65","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/jaoac\/94.3.723","article-title":"Validation of an oil-in-water microemulsion liquid chromatography method for analysis of perindopril tert-butylamine and its impurities","volume":"94","author":"Maskovi\u0107","year":"2011","journal-title":"J. AOAC Int."},{"issue":"26","key":"10.1016\/bs.podrm.2025.12.001_bib66","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1007\/s00216-017-0552-y","article-title":"A new LC-MS\/MS bioanalytical method for perindopril and perindoprilat in human plasma and milk","volume":"409","author":"Lwin","year":"2017","journal-title":"Anal. Bioanal. Chem"},{"issue":"12","key":"10.1016\/bs.podrm.2025.12.001_bib67","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/rcm.2529","article-title":"High\u2010throughput quantification of perindopril in human plasma by liquid chromatography\/tandem mass spectrometry: application to a bioequivalence study","volume":"20","author":"Nirogi","year":"2006","journal-title":"Rapid Commun. Mass Spectrom.: Int. J. Devoted to the Rapid Dissemination of Up\u2010to\u2010the\u2010Minute Res. Mass. Spectrom."},{"issue":"2","key":"10.1016\/bs.podrm.2025.12.001_bib68","first-page":"559","article-title":"A validated HPTLC method for simultaneous determination of losartan and perindopril in tablets","volume":"3","author":"Lakshmi","year":"2010","journal-title":"Res. J. Pharm. Technol"},{"issue":"5","key":"10.1016\/bs.podrm.2025.12.001_bib69","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/sscp.202000010","article-title":"Simultaneous quantification of perindopril erbumine, indapamide and amlodipine besylate in newer combination of anti\u2010hypertensive drugs in pharmaceutical dosage form by thin layer chromatography method","volume":"3","author":"Patel","year":"2020","journal-title":"Sep. Sci. Plus"},{"issue":"10","key":"10.1016\/bs.podrm.2025.12.001_bib70","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1080\/00032719608001521","article-title":"Derivatization-GAS chromatographic determination of perindopril","volume":"29","author":"Lin","year":"1996","journal-title":"Anal. Lett"},{"key":"10.1016\/bs.podrm.2025.12.001_bib71","article-title":"Novel microfabricated solid-contact potentiometric sensors doped with multiwall carbon-nanotubes for simultaneous determination of bisoprolol and perindopril in spiked human plasma","volume":"178","author":"Hassan","year":"2022","journal-title":"Microchem.\u00a0J."},{"issue":"7","key":"10.1016\/bs.podrm.2025.12.001_bib72","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1134\/S1061934822070036","article-title":"A novel magnetic polyethylene glycol nanocomposite based on graphite reinforcement carbon paste electrode for voltammetric determination of perindopril L-arginine","volume":"77","author":"Rahim","year":"2022","journal-title":"J. Anal. Chem"},{"issue":"3","key":"10.1016\/bs.podrm.2025.12.001_bib73","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0925-4005(99)00114-8","article-title":"Determination of S-perindopril using a flow injection system with an amperometric biosensor","volume":"54","author":"Stefan","year":"1999","journal-title":"Sens. Actuators B: Chem"},{"issue":"1","key":"10.1016\/bs.podrm.2025.12.001_bib74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0003-2670(02)00089-2","article-title":"On-line simultaneous determination of S- and R-perindopril using amperometric biosensors as detectors in flow systems","volume":"467","author":"Stefan","year":"2002","journal-title":"Analytica Chim. Acta"},{"issue":"7","key":"10.1016\/bs.podrm.2025.12.001_bib75","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0731-7085(91)80172-6","article-title":"A new radioimmunoassay for the determination of the angiotensin-converting enzyme inhibitor perindopril and its active metabolite in plasma and urine: advantages of a lysine derivative as immunogen to improve the assay specificity","volume":"9","author":"Van Den Berg","year":"1991","journal-title":"J. Pharm. Biomed. Anal"}],"container-title":["Profiles of Drug Substances, Excipients and Related Methodology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871512525000135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871512525000135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T02:10:06Z","timestamp":1771726206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871512525000135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443432408"],"references-count":75,"URL":"https:\/\/doi.org\/10.1016\/bs.podrm.2025.12.001","relation":{},"ISSN":["1871-5125"],"issn-type":[{"value":"1871-5125","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}