{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:01:25Z","timestamp":1789383685105,"version":"build-2803163510"},"reference-count":89,"publisher":"Elsevier","isbn-type":[{"value":"9780128048191","type":"print"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/bs.vh.2016.02.004","type":"book-chapter","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T19:00:53Z","timestamp":1458673253000},"page":"215-238","source":"Crossref","is-referenced-by-count":90,"title":["Klotho Is a Neuroprotective and Cognition-Enhancing Protein"],"prefix":"10.1016","author":[{"given":"C.R.","family":"Abraham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.C.","family":"Mullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tucker-Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.D.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Zeldich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/bs.vh.2016.02.004_bb0005","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.4155\/fmc.12.134","article-title":"Small-molecule Klotho enhancers as novel treatment of neurodegeneration","volume":"4","author":"Abraham","year":"2012","journal-title":"Future Medicinal Chemistry"},{"issue":"5","key":"10.1016\/bs.vh.2016.02.004_bb0010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00401-004-0971-7","article-title":"Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells","volume":"109","author":"Anamizu","year":"2005","journal-title":"Acta Neuropathologica"},{"key":"10.1016\/bs.vh.2016.02.004_bb0015","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0092-8674(00)81797-3","article-title":"Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons","volume":"87","author":"Arancio","year":"1996","journal-title":"Cell"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.004_bb7000","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1073\/pnas.022484299","article-title":"Association of human aging with a functional variant of klotho","volume":"99","author":"Arking","year":"2002","journal-title":"Proceedings of the National Academy of Science of the United States of America"},{"issue":"11\u201312","key":"10.1016\/bs.vh.2016.02.004_bb0020","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.bbadis.2006.03.008","article-title":"Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target","volume":"1762","author":"Barber","year":"2006","journal-title":"Biochimica et Biophysica Acta"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.004_bb0025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuron.2005.08.034","article-title":"NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII","volume":"48","author":"Barria","year":"2005","journal-title":"Neuron"},{"issue":"6407","key":"10.1016\/bs.vh.2016.02.004_bb0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: Long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"issue":"19","key":"10.1016\/bs.vh.2016.02.004_bb0035","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.febslet.2009.09.009","article-title":"Klotho is a substrate for alpha-, beta- and gamma-secretase","volume":"583","author":"Bloch","year":"2009","journal-title":"FEBS Letters"},{"key":"10.1016\/bs.vh.2016.02.004_bb0040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbr.2012.10.026","article-title":"Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor","volume":"238","author":"Brim","year":"2013","journal-title":"Behavioural Brain Research"},{"issue":"10","key":"10.1016\/bs.vh.2016.02.004_bb0045","doi-asserted-by":"crossref","first-page":"e0139914","DOI":"10.1371\/journal.pone.0139914","article-title":"Klotho protects dopaminergic neuron oxidant-induced degeneration by modulating ASK1 and p38 MAPK signaling pathways","volume":"10","author":"Brobey","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0050","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1124\/mol.109.055780","article-title":"Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho","volume":"76","author":"Cha","year":"2009","journal-title":"Molecular Pharmacology"},{"issue":"28","key":"10.1016\/bs.vh.2016.02.004_bb0055","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.1073\/pnas.0803223105","article-title":"Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1","volume":"105","author":"Cha","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5747","key":"10.1016\/bs.vh.2016.02.004_bb0060","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.1114245","article-title":"The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel","volume":"310","author":"Chang","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0065","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s12031-014-0336-1","article-title":"The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line","volume":"55","author":"Chen","year":"2015","journal-title":"Journal of Molecular Neuroscience"},{"issue":"50","key":"10.1016\/bs.vh.2016.02.004_bb0070","doi-asserted-by":"crossref","first-page":"19796","DOI":"10.1073\/pnas.0709805104","article-title":"Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17","volume":"104","author":"Chen","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/bs.vh.2016.02.004_bb0075","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1523\/JNEUROSCI.2080-12.2013","article-title":"The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS","volume":"33","author":"Chen","year":"2013","journal-title":"The Journal of Neuroscience"},{"issue":"34","key":"10.1016\/bs.vh.2016.02.004_bb0080","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1021\/bi500409n","article-title":"Identification of cleavage sites leading to the shed form of the anti-aging protein klotho","volume":"53","author":"Chen","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/bs.vh.2016.02.004_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.06.044","article-title":"Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood","volume":"1527","author":"Clinton","year":"2013","journal-title":"Brain Research"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0090","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1210\/en.2005-0998","article-title":"Estradiol replacement enhances working memory in middle-aged rats when initiated immediately after ovariectomy but not after a long-term period of ovarian hormone deprivation","volume":"147","author":"Daniel","year":"2006","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0095","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neulet.2004.12.005","article-title":"KLOTHO genotype and cognitive ability in childhood and old age in the same individuals","volume":"378","author":"Deary","year":"2005","journal-title":"Neuroscience Letters"},{"issue":"5","key":"10.1016\/bs.vh.2016.02.004_bb0100","doi-asserted-by":"crossref","first-page":"e0125271","DOI":"10.1371\/journal.pone.0125271","article-title":"Altered KLOTHO and NF-kappaB-TNF-alpha signaling are correlated with nephrectomy-induced cognitive impairment in rats","volume":"10","author":"Degaspari","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.004_bb0105","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.celrep.2014.03.076","article-title":"Life extension factor klotho enhances cognition","volume":"7","author":"Dubal","year":"2014","journal-title":"Cell Reports"},{"issue":"6","key":"10.1016\/bs.vh.2016.02.004_bb0110","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1523\/JNEUROSCI.5791-12.2015","article-title":"Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice","volume":"35","author":"Dubal","year":"2015","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.004_bb0115","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neurobiolaging.2005.03.027","article-title":"Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain","volume":"27","author":"Duce","year":"2006","journal-title":"Neurobiology of Aging"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0120","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/glia.20593","article-title":"Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey","volume":"56","author":"Duce","year":"2008","journal-title":"Glia"},{"key":"10.1016\/bs.vh.2016.02.004_bb0125","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jneuroim.2015.02.004","article-title":"Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis","volume":"281","author":"Emami Aleagha","year":"2015","journal-title":"Journal of Neuroimmunology"},{"issue":"6","key":"10.1016\/bs.vh.2016.02.004_bb0130","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/jnc.12353","article-title":"Retinitis pigmentosa: Over-expression of anti-ageing protein Klotho in degenerating photoreceptors","volume":"127","author":"Farinelli","year":"2013","journal-title":"Journal of Neurochemistry"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.004_bb0135","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1089\/ars.2009.2444","article-title":"Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis","volume":"11","author":"Foran","year":"2009","journal-title":"Antioxidants & Redox Signaling"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.004_bb0140","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1152\/jn.1999.81.2.925","article-title":"17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation","volume":"81","author":"Foy","year":"1999","journal-title":"Journal of Neurophysiology"},{"issue":"9","key":"10.1016\/bs.vh.2016.02.004_bb0145","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrn917","article-title":"Why does remyelination fail in multiple sclerosis?","volume":"3","author":"Franklin","year":"2002","journal-title":"Nature Reviews. Neuroscience"},{"issue":"14","key":"10.1016\/bs.vh.2016.02.004_bb0150","article-title":"White matter microstructural damage and cognitive impairment in Parkinson's disease","volume":"84","author":"Galantucci","year":"2015","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.004_bb0155","doi-asserted-by":"crossref","first-page":"1483.e1425","DOI":"10.1016\/j.neurobiolaging.2011.12.018","article-title":"Nuclear localization of Klotho in brain: An anti-aging protein","volume":"33","author":"German","year":"2012","journal-title":"Neurobiology of Aging"},{"issue":"15","key":"10.1016\/bs.vh.2016.02.004_bb0160","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1002\/cne.23101","article-title":"A stereological study of the numbers of neurons and glia in the primary visual cortex across the lifespan of male and female rhesus monkeys","volume":"520","author":"Giannaris","year":"2012","journal-title":"The Journal of Comparative Neurology"},{"issue":"12","key":"10.1016\/bs.vh.2016.02.004_bb0165","doi-asserted-by":"crossref","first-page":"10582","DOI":"10.1021\/nn403743b","article-title":"Custom cerium oxide nanoparticles protect against a free radical mediated autoimmune degenerative disease in the brain","volume":"7","author":"Heckman","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/bs.vh.2016.02.004_bb7010","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.13585","article-title":"Fibroblast growth factor 23 signaling in hippocampal cells: Impact on neuronal morphology and synaptic density","author":"Hensel","year":"2016","journal-title":"Journal of Neurochemistry"},{"issue":"12","key":"10.1016\/bs.vh.2016.02.004_bb0170","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s11064-007-9341-x","article-title":"What's behind the decline? The role of white matter in brain aging","volume":"32","author":"Hinman","year":"2007","journal-title":"Neurochemical Research"},{"issue":"2\u20133","key":"10.1016\/bs.vh.2016.02.004_bb0175","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1101\/lm.3.2-3.74","article-title":"Long-lasting forms of synaptic potentiation in the mammalian hippocampus","volume":"3","author":"Huang","year":"1996","journal-title":"Learning & Memory"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.004_bb0180","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0896-6273(00)80909-5","article-title":"Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons","volume":"25","author":"Huerta","year":"2000","journal-title":"Neuron"},{"issue":"1\u20133","key":"10.1016\/bs.vh.2016.02.004_bb0185","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.febslet.2004.03.090","article-title":"Secreted Klotho protein in sera and CSF: Implication for post-translational cleavage in release of Klotho protein from cell membrane","volume":"565","author":"Imura","year":"2004","journal-title":"FEBS Letters"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0190","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1042\/BJ20101909","article-title":"Identification of novel small molecules that elevate Klotho expression","volume":"441","author":"King","year":"2012","journal-title":"The Biochemical Journal"},{"issue":"6","key":"10.1016\/bs.vh.2016.02.004_bb0195","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s11357-011-9315-4","article-title":"Promoter methylation and age-related downregulation of Klotho in rhesus monkey","volume":"34","author":"King","year":"2012","journal-title":"Age"},{"key":"10.1016\/bs.vh.2016.02.004_bb7025","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ygcen.2013.04.024","volume":"188","author":"Kohler","year":"2013","journal-title":"General and Comparative Endocrinology"},{"issue":"41","key":"10.1016\/bs.vh.2016.02.004_bb0200","doi-asserted-by":"crossref","first-page":"16346","DOI":"10.1523\/JNEUROSCI.0402-13.2013","article-title":"Klotho regulates retinal pigment epithelial functions and protects against oxidative stress","volume":"33","author":"Kokkinaki","year":"2013","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.004_bb0205","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/MNH.0b013e32835422ad","article-title":"Klotho in health and disease","volume":"21","author":"Kuro-o","year":"2012","journal-title":"Current Opinion in Nephrology and Hypertension"},{"issue":"6655","key":"10.1016\/bs.vh.2016.02.004_bb0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"issue":"10","key":"10.1016\/bs.vh.2016.02.004_bb0215","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1074\/jbc.C500457200","article-title":"Regulation of fibroblast growth factor-23 signaling by klotho","volume":"281","author":"Kurosu","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"issue":"5742","key":"10.1016\/bs.vh.2016.02.004_bb0220","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1126\/science.1112766","article-title":"Suppression of aging in mice by the hormone Klotho","volume":"309","author":"Kurosu","year":"2005","journal-title":"Science"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.004_bb0225","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00424-010-0809-1","article-title":"Glutamate receptors, neurotoxicity and neurodegeneration","volume":"460","author":"Lau","year":"2010","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.004_bb0230","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1247\/csf.29.91","article-title":"Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice","volume":"29","author":"Li","year":"2004","journal-title":"Cell Structure and Function"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0235","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1525-139X.2007.00384.x","article-title":"Cognitive function in chronic kidney disease","volume":"21","author":"Madero","year":"2008","journal-title":"Seminars in Dialysis"},{"issue":"10","key":"10.1016\/bs.vh.2016.02.004_bb0240","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.neurobiolaging.2006.07.005","article-title":"Frontal connections and cognitive changes in normal aging rhesus monkeys: A DTI study","volume":"28","author":"Makris","year":"2007","journal-title":"Neurobiology of Aging"},{"issue":"12","key":"10.1016\/bs.vh.2016.02.004_bb0245","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0166-2236(93)90197-T","article-title":"NMDA-receptor-dependent synaptic plasticity: Multiple forms and mechanisms","volume":"16","author":"Malenka","year":"1993","journal-title":"Trends in Neurosciences"},{"issue":"11","key":"10.1016\/bs.vh.2016.02.004_bb7005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143623","article-title":"Secreted and transmembrane \u03b1klotho isoforms have different spatio-temporal profiles in the brain during aging and Alzheimer's disease progression","volume":"10","author":"Mass\u00f3","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.004_bb0250","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1681\/ASN.2010101073","article-title":"The inflammatory cytokines TWEAK and TNF\u03b1 reduce renal klotho expression through NF\u03baB","volume":"22","author":"Moreno","year":"2011","journal-title":"Journal of the American Society of Nephrology"},{"issue":"6056","key":"10.1016\/bs.vh.2016.02.004_bb0255","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/319774a0","article-title":"Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5","volume":"319","author":"Morris","year":"1986","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0260","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1096\/fj.02-0448fje","article-title":"Cognition impairment in the genetic model of aging klotho gene mutant mice: A role of oxidative stress","volume":"17","author":"Nagai","year":"2003","journal-title":"FASEB Journal"},{"issue":"8","key":"10.1016\/bs.vh.2016.02.004_bb0265","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/npp.2013.39","article-title":"Inactivation of JAK2\/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging","volume":"38","author":"Park","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0270","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/(SICI)1096-9861(19960715)371:1<153::AID-CNE9>3.0.CO;2-2","article-title":"Age-related changes in oligodendrocytes in monkey cerebral cortex","volume":"371","author":"Peters","year":"1996","journal-title":"The Journal of Comparative Neurology"},{"issue":"6","key":"10.1016\/bs.vh.2016.02.004_bb0275","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/cercor\/4.6.621","article-title":"The effects of aging on area 46 of the frontal cortex of the rhesus monkey","volume":"4","author":"Peters","year":"1994","journal-title":"Cerebral Cortex"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0280","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0197-4580(96)00208-4","article-title":"A further evaluation of the effect of age on striate cortex of the rhesus monkey","volume":"18","author":"Peters","year":"1997","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/bs.vh.2016.02.004_bb0285","doi-asserted-by":"crossref","first-page":"963520","DOI":"10.1155\/2013\/963520","article-title":"ROS and brain diseases: The good, the bad, and the ugly","volume":"2013","author":"Popa-Wagner","year":"2013","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"10","key":"10.1016\/bs.vh.2016.02.004_bb0290","doi-asserted-by":"crossref","first-page":"6675","DOI":"10.1167\/iovs.13-12550","article-title":"The age-regulating protein klotho is vital to sustain retinal function","volume":"54","author":"Reish","year":"2013","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"Suppl. 1","key":"10.1016\/bs.vh.2016.02.004_bb0295","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.freeradbiomed.2014.10.588","article-title":"Induction of antioxidant genes by sulforaphane and klotho in human aortic smooth muscle cells","volume":"75","author":"Rizzo","year":"2014","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/bs.vh.2016.02.004_bb0300","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.neuro.051508.135620","article-title":"The influence of stress hormones on fear circuitry","volume":"32","author":"Rodrigues","year":"2009","journal-title":"Annual Review of Neuroscience"},{"issue":"6","key":"10.1016\/bs.vh.2016.02.004_bb0305","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1073\/pnas.041620798","article-title":"CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task","volume":"98","author":"Rondi-Reig","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.004_bb0310","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1210\/en.2015-1109","article-title":"Hippocampal gene expression is highly responsive to estradiol replacement in middle-aged female rats","volume":"156","author":"Sarvari","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/bs.vh.2016.02.004_bb0315","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1176\/jnp.12.1.103-a","article-title":"Loss of recent memory after bilateral hippocampal lesions. 1957","volume":"12","author":"Scoville","year":"2000","journal-title":"The Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"10.1016\/bs.vh.2016.02.004_bb0320","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neulet.2013.10.058","article-title":"Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease","volume":"558","author":"Semba","year":"2014","journal-title":"Neuroscience Letters"},{"issue":"3","key":"10.1016\/bs.vh.2016.02.004_bb7020","doi-asserted-by":"crossref","first-page":"E326","DOI":"10.1152\/ajpendo.00090.2014","article-title":"The aging suppressor klotho: a potential regulator of growth hormone secretion","volume":"307","author":"Shahmoon","year":"2014","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.004_bb0325","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.neuroscience.2008.01.032","article-title":"Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice","volume":"152","author":"Shiozaki","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/bs.vh.2016.02.004_bb0330","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0079-6123(04)48029-7","article-title":"Don't get too excited: Mechanisms of glutamate-mediated Purkinje cell death","volume":"148","author":"Slemmer","year":"2005","journal-title":"Progress in Brain Research"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.004_bb0335","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0197-4580(99)00066-4","article-title":"Increased microglial activation and protein nitration in white matter of the aging monkey","volume":"20","author":"Sloane","year":"1999","journal-title":"Neurobiology of Aging"},{"issue":"1\u20132","key":"10.1016\/bs.vh.2016.02.004_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(00)02059-X","article-title":"Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey","volume":"862","author":"Sloane","year":"2000","journal-title":"Brain Research"},{"issue":"33","key":"10.1016\/bs.vh.2016.02.004_bb0345","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1523\/JNEUROSCI.5279-05.2006","article-title":"Estradiol-induced increase in the magnitude of long-term potentiation is prevented by blocking NR2B-containing receptors","volume":"26","author":"Smith","year":"2006","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0350","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/hipo.22495","article-title":"17beta estradiol recruits GluN2B-containing NMDARs and ERK during induction of long-term potentiation at temporoammonic-CA1 synapses","volume":"26","author":"Smith","year":"2015","journal-title":"Hippocampus"},{"issue":"3","key":"10.1016\/bs.vh.2016.02.004_bb0355","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.conb.2004.04.001","article-title":"Mitogen-activated protein kinases in synaptic plasticity and memory","volume":"14","author":"Sweatt","year":"2004","journal-title":"Current Opinion in Neurobiology"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.004_bb0360","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.nlm.2008.04.002","article-title":"Higher levels of estradiol replacement correlate with better spatial memory in surgically menopausal young and middle-aged rats","volume":"90","author":"Talboom","year":"2008","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/bs.vh.2016.02.004_bb0365","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1742-2094-10-53","article-title":"Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients","volume":"10","author":"Teocchi","year":"2013","journal-title":"Journal of Neuroinflammation"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.004_bb0370","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1053\/j.gastro.2009.12.002","article-title":"Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis","volume":"138","author":"Thurston","year":"2010","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/bs.vh.2016.02.004_bb0375","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.1074\/jbc.M312392200","article-title":"Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides","volume":"279","author":"Tohyama","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/bs.vh.2016.02.004_bb0380","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1523\/JNEUROSCI.17-03-01064.1997","article-title":"Selective degeneration fo Purkinje cells with Lewy body-like inclusions in aged NFHLACZ transgenic mice","volume":"17","author":"Tu","year":"1997","journal-title":"The Journal of Neuroscience"},{"issue":"51","key":"10.1016\/bs.vh.2016.02.004_bb0385","doi-asserted-by":"crossref","first-page":"36302","DOI":"10.1074\/jbc.M113.490052","article-title":"Biochemical and functional characterization of the Klotho-VS polymorphism implicated in aging and disease risk","volume":"288","author":"Tucker Zhou","year":"2013","journal-title":"The Journal of Biological Chemistry"},{"issue":"7120","key":"10.1016\/bs.vh.2016.02.004_bb0390","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nature05315","article-title":"Klotho converts canonical FGF receptor into a specific receptor for FGF23","volume":"444","author":"Urakawa","year":"2006","journal-title":"Nature"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.004_bb0395","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0197-4580(93)90113-P","article-title":"Regionally specific loss of neurons in the aging human hippocampus","volume":"14","author":"West","year":"1993","journal-title":"Neurobiology of Aging"},{"issue":"5","key":"10.1016\/bs.vh.2016.02.004_bb0400","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1523\/JNEUROSCI.17-05-01848.1997","article-title":"Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: Correlation with dendritic spine density","volume":"17","author":"Woolley","year":"1997","journal-title":"The Journal of Neuroscience"},{"issue":"45","key":"10.1016\/bs.vh.2016.02.004_bb0405","doi-asserted-by":"crossref","first-page":"38029","DOI":"10.1074\/jbc.M509039200","article-title":"Regulation of oxidative stress by the anti-aging hormone klotho","volume":"280","author":"Yamamoto","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"issue":"12","key":"10.1016\/bs.vh.2016.02.004_bb0410","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/hipo.20357","article-title":"Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice","volume":"17","author":"Yun","year":"2007","journal-title":"Hippocampus"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.004_bb0415","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12031-015-0598-2","article-title":"The anti-aging protein Klotho enhances remyelination following cuprizone-induced demyelination","volume":"57","author":"Zeldich","year":"2015","journal-title":"Journal of Molecular Neuroscience"},{"key":"10.1016\/bs.vh.2016.02.004_bb0420","doi-asserted-by":"crossref","first-page":"24700","DOI":"10.1074\/jbc.M114.567321","article-title":"The neuroprotective effect of Klotho is mediated via regulation of members of the redox system","volume":"289","author":"Zeldich","year":"2014","journal-title":"The Journal of Biological Chemistry"}],"container-title":["Vitamins &amp; Hormones","Klotho"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0083672916000182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0083672916000182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T18:03:57Z","timestamp":1567706637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0083672916000182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9780128048191"],"references-count":89,"URL":"https:\/\/doi.org\/10.1016\/bs.vh.2016.02.004","relation":{},"ISSN":["0083-6729"],"issn-type":[{"value":"0083-6729","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}