{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:58:06Z","timestamp":1770289086591,"version":"3.49.0"},"reference-count":65,"publisher":"Elsevier","isbn-type":[{"value":"9780128048191","type":"print"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/bs.vh.2016.02.010","type":"book-chapter","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T23:00:22Z","timestamp":1457737222000},"page":"311-330","source":"Crossref","is-referenced-by-count":15,"title":["Deficiency of Soluble \u03b1-Klotho as an Independent Cause of Uremic Cardiomyopathy"],"prefix":"10.1016","author":[{"given":"J.","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.-L.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-L.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/bs.vh.2016.02.010_bb0005","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000584","article-title":"Fibroblast growth factor-23 and cardiac structure and function","volume":"3","author":"Agarwal","year":"2014","journal-title":"Journal of the American Heart Association"},{"issue":"3","key":"10.1016\/bs.vh.2016.02.010_bb0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1053\/j.ajkd.2009.05.011","article-title":"Effect of a carbonaceous oral adsorbent on the progression of CKD: A multicenter, randomized, controlled trial","volume":"54","author":"Akizawa","year":"2009","journal-title":"American Journal of Kidney Diseases"},{"issue":"20","key":"10.1016\/bs.vh.2016.02.010_bb0015","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.ehj.2004.07.010","article-title":"Primary hyperparathyroidism and heart disease\u2014A review","volume":"25","author":"Andersson","year":"2004","journal-title":"European Heart Journal"},{"key":"10.1016\/bs.vh.2016.02.010_bb0020","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ncb1150","article-title":"Rapid vesicular translocation and insertion of TRP channels","volume":"6","author":"Bezzerides","year":"2004","journal-title":"Nature Cell Biology"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.010_bb0025","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1053\/ajkd.1998.v31.pm9531176","article-title":"Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study","volume":"31","author":"Block","year":"1998","journal-title":"American Journal of Kidney Diseases"},{"issue":"43","key":"10.1016\/bs.vh.2016.02.010_bb0030","doi-asserted-by":"crossref","first-page":"16810","DOI":"10.1073\/pnas.0611202104","article-title":"Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals","volume":"104","author":"Bodyak","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.010_bb0035","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1172\/JCI110137","article-title":"Effect of parathyroid hormone on rat heart cells","volume":"67","author":"Bogin","year":"1981","journal-title":"The Journal of Clinical Investigation"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.010_bb0040","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1681\/ASN.2013080899","article-title":"Longitudinal changes of cardiac structure and function in CKD (CASCADE study)","volume":"25","author":"Cai","year":"2014","journal-title":"Journal of the American Society of Nephrology"},{"issue":"28","key":"10.1016\/bs.vh.2016.02.010_bb0045","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.1073\/pnas.0803223105","article-title":"Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1","volume":"105","author":"Cha","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.vh.2016.02.010_bb0050","doi-asserted-by":"crossref","first-page":"567","DOI":"10.18632\/aging.100195","article-title":"Klotho interferes with a novel FGF-signalling pathway and insulin\/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans","volume":"2","author":"Ch\u00e2teau","year":"2010","journal-title":"Aging"},{"issue":"6","key":"10.1016\/bs.vh.2016.02.010_bb0055","first-page":"861","article-title":"Italian randomized trial of hemoglobin maintenance to prevent or delay left ventricular hypertrophy in chronic kidney disease","volume":"21","author":"Cianciaruso","year":"2008","journal-title":"Journal of Nephrology"},{"issue":"3","key":"10.1016\/bs.vh.2016.02.010_bb0060","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/81664","article-title":"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23","volume":"26","year":"2000","journal-title":"Nature Genetics"},{"issue":"17","key":"10.1016\/bs.vh.2016.02.010_bb0065","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/bs.vh.2016.02.010_bb0070","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/CIRCRESAHA.110.225888","article-title":"TRPC6 channels as effectors of cardiac hypertrophy","volume":"108","author":"Eder","year":"2011","journal-title":"Circulation"},{"issue":"26","key":"10.1016\/bs.vh.2016.02.010_bb0075","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMoa1205624","article-title":"Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis","volume":"367","author":"Chertow","year":"2012","journal-title":"The New England Journal of Medicine"},{"issue":"11","key":"10.1016\/bs.vh.2016.02.010_bb0080","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"issue":"9","key":"10.1016\/bs.vh.2016.02.010_bb0085","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1681\/ASN.2006080936","article-title":"Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: The Mild to Moderate Kidney Disease (MMKD) Study","volume":"18","author":"Fliser","year":"2007","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.010_bb0090","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ki.1995.22","article-title":"Clinical and echocardiographic disease in patients starting end-stage renal disease therapy","volume":"47","author":"Foley","year":"1995","journal-title":"Kidney International"},{"issue":"12","key":"10.1016\/bs.vh.2016.02.010_bb0095","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1681\/ASN.V5122024","article-title":"The prognostic importance of left ventricular geometry in uremic cardiomyopathy","volume":"5","author":"Foley","year":"1995","journal-title":"Journal of the American Society of Nephrology"},{"issue":"3","key":"10.1016\/bs.vh.2016.02.010_bb0100","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1046\/j.1523-1755.2000.00289.x","article-title":"Effect of hemoglobin levels in hemodialysis patients with asymptomatic cardiomyopathy","volume":"58","author":"Foley","year":"2000","journal-title":"Kidney International"},{"issue":"5 Suppl. 3","key":"10.1016\/bs.vh.2016.02.010_bb0105","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1053\/ajkd.1998.v32.pm9820470","article-title":"Clinical epidemiology of cardiovascular disease in chronic renal disease","volume":"32","author":"Foley","year":"1998","journal-title":"American Journal of Kidney Diseases"},{"issue":"5","key":"10.1016\/bs.vh.2016.02.010_bb0110","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/ajh\/hpt177","article-title":"Paricalcitol downregulates myocardial renin-angiotensin and fibroblast growth factor expression and attenuates cardiac hypertrophy in uremic rats","volume":"27","author":"Freundlich","year":"2014","journal-title":"American Journal of Hypertension"},{"issue":"Suppl. 1","key":"10.1016\/bs.vh.2016.02.010_bb0115","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.2215\/CJN.04860709","article-title":"Left ventricular mass in chronic kidney disease and ESRD","volume":"4","author":"Glassock","year":"2009","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"13","key":"10.1016\/bs.vh.2016.02.010_bb0120","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.010_bb0125","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1525-139X.2008.00454.x","article-title":"Hypertrophy and fibrosis in the cardiomyopathy of uremia\u2014Beyond coronary heart disease","volume":"21","author":"Gross","year":"2008","journal-title":"Seminars in Dialysis"},{"issue":"19","key":"10.1016\/bs.vh.2016.02.010_bb0130","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1161\/CIRCULATIONAHA.108.844506","article-title":"Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease","volume":"119","author":"Gutierrez","year":"2009","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.010_bb0135","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1681\/ASN.V471486","article-title":"Risk factors for the development of left ventricular hypertrophy in a prospectively followed cohort of dialysis patients","volume":"4","author":"Harnett","year":"1994","journal-title":"Journal of the American Society of Nephrology"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.010_bb0140","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000185077","article-title":"Analysis of left-ventricular changes associated with chronic hemodialysis. A noninvasive follow-up study","volume":"49","author":"Huting","year":"1988","journal-title":"Nephron"},{"issue":"1\u20133","key":"10.1016\/bs.vh.2016.02.010_bb0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.febslet.2004.03.090","article-title":"Secreted Klotho protein in sera and CSF: Implication for post-translational cleavage in release of Klotho protein from cell membrane","volume":"565","author":"Imura","year":"2004","journal-title":"FEBS Letters"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.010_bb0150","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2215\/CJN.02020408","article-title":"Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysis","volume":"4","author":"Krane","year":"2009","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"11","key":"10.1016\/bs.vh.2016.02.010_bb0155","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nrneph.2013.111","article-title":"Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism","volume":"9","author":"Kuro-o","year":"2013","journal-title":"Nature Reviews. Nephrology"},{"issue":"6655","key":"10.1016\/bs.vh.2016.02.010_bb0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"issue":"10","key":"10.1016\/bs.vh.2016.02.010_bb0165","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1074\/jbc.C500457200","article-title":"Regulation of fibroblast growth factor-23 signaling by klotho","volume":"281","author":"Kurosu","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"issue":"5742","key":"10.1016\/bs.vh.2016.02.010_bb0170","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1126\/science.1112766","article-title":"Suppression of aging in mice by the hormone Klotho","volume":"309","author":"Kurosu","year":"2005","journal-title":"Science"},{"key":"10.1016\/bs.vh.2016.02.010_bb0175","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1172\/JCI27702","article-title":"TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling","volume":"116","author":"Kuwahara","year":"2006","journal-title":"The Journal of Clinical Investigation"},{"issue":"11","key":"10.1016\/bs.vh.2016.02.010_bb0180","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.112.278457","article-title":"Cardiorenal syndrome: The emerging role of protein-bound uremic toxins","volume":"111","author":"Lekawanvijit","year":"2012","journal-title":"Circulation Research"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.010_bb0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0272-6386(99)70118-6","article-title":"Left ventricular mass index increase in early renal disease: Impact of decline in hemoglobin","volume":"34","author":"Levin","year":"1999","journal-title":"American Journal of Kidney Diseases"},{"issue":"4","key":"10.1016\/bs.vh.2016.02.010_bb0190","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ki.1987.94","article-title":"Uremic cardiomyopathy: An inadequate left ventricular hypertrophy","volume":"31","author":"London","year":"1987","journal-title":"Kidney International"},{"issue":"10","key":"10.1016\/bs.vh.2016.02.010_bb0195","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/sj.ki.5000249","article-title":"Redefinition of uremic cardiomyopathy by contrast-enhanced cardiac magnetic resonance imaging","volume":"69","author":"Mark","year":"2006","journal-title":"Kidney International"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.010_bb0200","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0272-6386(12)80727-X","article-title":"Chronic renal failure is a state of cellular calcium toxicity","volume":"21","author":"Massry","year":"1993","journal-title":"American Journal of Kidney Diseases"},{"issue":"3","key":"10.1016\/bs.vh.2016.02.010_bb0205","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/ndt\/gfq818","article-title":"The gut-kidney axis: Indoxyl sulfate, p-cresyl sulfate and CKD progression","volume":"26","author":"Meijers","year":"2011","journal-title":"Nephrology, Dialysis, Transplantation"},{"issue":"12","key":"10.1016\/bs.vh.2016.02.010_bb0210","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1093\/jn\/131.12.3182","article-title":"The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc","volume":"131","author":"Morishita","year":"2001","journal-title":"The Journal of Nutrition"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.010_bb0215","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1096\/fj.08-114397","article-title":"In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis","volume":"23","author":"Nakatani","year":"2009","journal-title":"The FASEB Journal"},{"key":"10.1016\/bs.vh.2016.02.010_bb0220","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.00021.2006","article-title":"Transient receptor potential cation channels in disease","volume":"87","author":"Nilius","year":"2007","journal-title":"Physiological Reviews"},{"issue":"11","key":"10.1016\/bs.vh.2016.02.010_bb0225","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1093\/ndt\/gft268","article-title":"Vitamin D receptor activation, left ventricular hypertrophy and myocardial fibrosis","volume":"28","author":"Panizo","year":"2013","journal-title":"Nephrology, Dialysis, Transplantation"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.010_bb0230","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/ndt\/11.7.1277","article-title":"Outcome and risk factors for left ventricular disorders in chronic uraemia","volume":"11","author":"Parfrey","year":"1996","journal-title":"Nephrology, Dialysis, Transplantation"},{"issue":"10","key":"10.1016\/bs.vh.2016.02.010_bb0235","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1681\/ASN.2012020145","article-title":"Associations between kidney function and subclinical cardiac abnormalities in CKD","volume":"23","author":"Park","year":"2012","journal-title":"Journal of the American Society of Nephrology"},{"issue":"11","key":"10.1016\/bs.vh.2016.02.010_bb0240","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrendo.2009.196","article-title":"The FGF23-Klotho axis: Endocrine regulation of phosphate homeostasis","volume":"5","author":"Razzaque","year":"2009","journal-title":"Nature Reviews. Endocrinology"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.010_bb0245","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/01.ASN.0000102471.89084.8B","article-title":"Effects of early and late intervention with epoetin alpha on left ventricular mass among patients with chronic kidney disease (stage 3 or 4): Results of a randomized clinical trial","volume":"15","author":"Roger","year":"2004","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/bs.vh.2016.02.010_bb0250","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s12265-010-9208-4","article-title":"TRP-ing up heart and vessels: Canonical transient receptor potential channels and cardiovascular disease","volume":"3","author":"Rowell","year":"2010","journal-title":"Journal of Cardiovascular Translational Research"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.010_bb0255","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1681\/ASN.2014010042","article-title":"Randomized placebo-controlled EPPIC trials of AST-120 in CKD","volume":"26","author":"Schulman","year":"2015","journal-title":"Journal of the American Society of Nephrology"},{"issue":"6","key":"10.1016\/bs.vh.2016.02.010_bb0260","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1053\/ajkd.2002.36881","article-title":"Clinical correlates and mortality impact of left ventricular hypertrophy among new ESRD patients in the United States","volume":"40","author":"Stack","year":"2002","journal-title":"American Journal of Kidney Diseases"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.010_bb0265","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1523-1755.2005.00072.x","article-title":"Electrocardiographic abnormalities and uremic cardiomyopathy","volume":"67","author":"Stewart","year":"2005","journal-title":"Kidney International"},{"issue":"6","key":"10.1016\/bs.vh.2016.02.010_bb0270","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10741-010-9197-z","article-title":"Hypertension, left ventricular hypertrophy and chronic kidney disease","volume":"16","author":"Taddei","year":"2011","journal-title":"Heart Failure Reviews"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.010_bb0275","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jama.2012.120","article-title":"Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: The PRIMO randomized controlled trial","volume":"307","author":"Thadhani","year":"2012","journal-title":"JAMA"},{"issue":"17","key":"10.1016\/bs.vh.2016.02.010_bb0280","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1161\/CIRCULATIONAHA.105.553198","article-title":"Relation between serum phosphate level and cardiovascular event rate in people with coronary disease","volume":"112","author":"Tonelli","year":"2005","journal-title":"Circulation"},{"issue":"7120","key":"10.1016\/bs.vh.2016.02.010_bb0285","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nature05315","article-title":"Klotho converts canonical FGF receptor into a specific receptor for FGF23","volume":"444","author":"Urakawa","year":"2006","journal-title":"Nature"},{"key":"10.1016\/bs.vh.2016.02.010_bb0290","doi-asserted-by":"crossref","first-page":"36981","DOI":"10.1074\/jbc.R300023200","article-title":"Control of cardiac growth and function by calcineurin signaling","volume":"278","author":"Vega","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/bs.vh.2016.02.010_bb0295","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1681\/ASN.2013010103","article-title":"Effect of paricalcitol on left ventricular mass and function in CKD\u2014The OPERA trial","volume":"25","author":"Wang","year":"2014","journal-title":"Journal of the American Society of Nephrology"},{"issue":"7","key":"10.1016\/bs.vh.2016.02.010_bb0300","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/ki.2012.176","article-title":"Update on fibroblast growth factor 23 in chronic kidney disease","volume":"82","author":"Wolf","year":"2012","journal-title":"Kidney International"},{"issue":"2","key":"10.1016\/bs.vh.2016.02.010_bb0305","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1046\/j.1523-1755.2000.00219.x","article-title":"Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure","volume":"58","author":"Wolf","year":"2000","journal-title":"Kidney International"},{"key":"10.1016\/bs.vh.2016.02.010_bb0310","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1038\/onc.2008.292","article-title":"Klotho: A tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer","volume":"27","author":"Wolf","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/bs.vh.2016.02.010_bb0315","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ncomms2240","article-title":"Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart","volume":"3","author":"Xie","year":"2012","journal-title":"Nature Communications"},{"issue":"5","key":"10.1016\/bs.vh.2016.02.010_bb0320","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1681\/ASN.2014040325","article-title":"Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate","volume":"26","author":"Xie","year":"2015","journal-title":"Journal of the American Society of Nephrology"},{"issue":"10","key":"10.1016\/bs.vh.2016.02.010_bb0325","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1681\/ASN.2014060543","article-title":"Klotho protects against indoxyl sulphate-induced myocardial hypertrophy","volume":"26","author":"Yang","year":"2015","journal-title":"Journal of the American Society of Nephrology"}],"container-title":["Vitamins & Hormones","Klotho"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0083672916000248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0083672916000248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:53:03Z","timestamp":1655254383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0083672916000248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9780128048191"],"references-count":65,"URL":"https:\/\/doi.org\/10.1016\/bs.vh.2016.02.010","relation":{},"ISSN":["0083-6729"],"issn-type":[{"value":"0083-6729","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}