{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:46:08Z","timestamp":1781725568458,"version":"3.54.5"},"reference-count":199,"publisher":"Elsevier","isbn-type":[{"value":"9780323992251","type":"print"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-15-1-0723"],"award-info":[{"award-number":["W81XWH-15-1-0723"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP142287"],"award-info":[{"award-number":["MOP142287"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/bs.vh.2022.03.002","type":"book-chapter","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T20:05:10Z","timestamp":1658779510000},"page":"133-177","source":"Crossref","is-referenced-by-count":23,"title":["Parathyroid hormone-related protein (PTHrP) and malignancy"],"prefix":"10.1016","member":"78","reference":[{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4161\/cbt.7.1.5163","article-title":"Biology of breast cancer bone metastasis","volume":"7","author":"Akhtari","year":"2008","journal-title":"Cancer Biology & Therapy"},{"key":"10.1016\/bs.vh.2022.03.002_bb0015","first-page":"789","article-title":"Case records of the Massachusetts General Hospital (Case 27461)","volume":"225","author":"Albright","year":"1941","journal-title":"The New England Journal of Medicine"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0020","doi-asserted-by":"crossref","first-page":"pkz063","DOI":"10.1093\/jncics\/pkz063","article-title":"PTHrP, a biomarker for CNS metastasis in triple-negative breast cancer and selection for adjuvant chemotherapy in node-negative disease","volume":"4","author":"Assaker","year":"2019","journal-title":"JNCI Cancer Spectrum"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0025","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bone.2012.09.016","article-title":"Effects of PTH on osteocyte function","volume":"54","author":"Bellido","year":"2013","journal-title":"Bone"},{"issue":"10","key":"10.1016\/bs.vh.2022.03.002_bb0030","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12032-019-1315-8","article-title":"Outcomes of hypercalcemia of malignancy in patients with solid cancer: A national inpatient analysis","volume":"36","author":"Bhandari","year":"2019","journal-title":"Medical Oncology (Northwood, London, England)"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action, and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chemistry & Biology"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0040","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1210\/endo-128-6-2999","article-title":"Calcium-stimulated parathyroid hormone-like protein secretion: potentiation through a protein kinase-C pathway","volume":"128","author":"Brandt","year":"1991","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-100-1-1","article-title":"Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma","volume":"100","author":"Breslau","year":"1984","journal-title":"Annals of Internal Medicine"},{"issue":"10","key":"10.1016\/bs.vh.2022.03.002_bb0050","doi-asserted-by":"crossref","first-page":"807","DOI":"10.7326\/0003-4819-111-10-807","article-title":"Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia","volume":"111","author":"Budayr","year":"1989","journal-title":"Annals of Internal Medicine"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0055","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/clinchem\/38.11.2171","article-title":"Parathyroid hormone-related protein: structure, function, and measurement","volume":"38","author":"Burtis","year":"1992","journal-title":"Clinical Chemistry"},{"issue":"16","key":"10.1016\/bs.vh.2022.03.002_bb0060","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199004193221603","article-title":"Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer","volume":"322","author":"Burtis","year":"1990","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0065","first-page":"317","article-title":"A high abundance midregion species of parathyroid hormone-related protein: Immunological and chromatographic characterization in plasma","volume":"78","author":"Burtis","year":"1994","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"15","key":"10.1016\/bs.vh.2022.03.002_bb0070","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1016\/S0021-9258(18)48217-8","article-title":"Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy","volume":"262","author":"Burtis","year":"1987","journal-title":"The Journal of Biological Chemistry"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0075","first-page":"500","article-title":"Enhancement of taxol, doxorubicin and zoledronate anti-proliferation action on triple-negative breast cancer cells by a PTHrP blocking monoclonal antibody","volume":"3","author":"Camirand","year":"2013","journal-title":"American Journal of Cancer Research"},{"issue":"12","key":"10.1016\/bs.vh.2022.03.002_bb0080","first-page":"1656","article-title":"Differential expression of RNA transcripts encoding unique carboxy-terminal sequences of human parathyroid hormone-related peptide","volume":"8","author":"Campos","year":"1994","journal-title":"Molecular Endocrinology (Baltimore, Md.)"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0085","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1113\/expphysiol.1990.sp003437","article-title":"Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein","volume":"75","author":"Care","year":"1990","journal-title":"Experimental Physiology"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0090","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/bjc.1997.433","article-title":"Induction of cachexia in mice by a product isolated from the urine of cachectic cancer patients","volume":"76","author":"Cariuk","year":"1997","journal-title":"British Journal of Cancer"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/00005792-198803000-00002","article-title":"The syndrome of distal (type 1) renal tubular acidosis. Clinical and laboratory findings in 58 cases","volume":"67","author":"Caruana","year":"1988","journal-title":"Medicine"},{"issue":"44","key":"10.1016\/bs.vh.2022.03.002_bb0100","doi-asserted-by":"crossref","first-page":"16084","DOI":"10.1073\/pnas.0503942102","article-title":"Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism","volume":"102","author":"Castro","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"23","key":"10.1016\/bs.vh.2022.03.002_bb0105","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.2174\/092986711796642607","article-title":"Imaging studies in hypercalcemia","volume":"18","author":"Cecchin","year":"2011","journal-title":"Current Medicinal Chemistry"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0110","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1210\/mend-4-4-638","article-title":"Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells","volume":"4","author":"Chan","year":"1990","journal-title":"Molecular Endocrinology (Baltimore, Md.)"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/bcr2781","article-title":"Breast cancer metastasis to the bone: Mechanisms of bone loss","volume":"12","author":"Chen","year":"2010","journal-title":"Breast Cancer Research: BCR"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0120","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1359\/jbmr.1999.14.6.915","article-title":"Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone-related protein","volume":"14","author":"Cornish","year":"1999","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0125","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1210\/endo.138.3.4990","article-title":"Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo","volume":"138","author":"Cornish","year":"1997","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/bs.vh.2022.03.002_bb0130","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/BF01212816","article-title":"Hypercalcemia in patients with breast cancer: A survival study","volume":"120","author":"de Wit","year":"1994","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0135","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1210\/me.2007-0274","article-title":"Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH\/PTHrP receptor","volume":"22","author":"Dean","year":"2008","journal-title":"Molecular Endocrinology (Baltimore, Md.)"},{"issue":"12 Suppl","key":"10.1016\/bs.vh.2022.03.002_bb0140","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1002\/1097-0142(20000615)88:12+<3002::AID-CNCR16>3.0.CO;2-1","article-title":"Prostate carcinoma: Production of bioactive factors","volume":"88","author":"Deftos","year":"2000","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0145","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1210\/mend-3-3-503","article-title":"The parathyroid hormone-related protein associated with malignancy is secreted by neuroendocrine tumors","volume":"3","author":"Deftos","year":"1989","journal-title":"Molecular Endocrinology (Baltimore, Md.)"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0150","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1210\/endo-125-1-563","article-title":"PTHrP secretion is stimulated by CT and inhibited by CgA peptides","volume":"125","author":"Deftos","year":"1989","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0155","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jemermed.2004.04.006","article-title":"Electrocardiographic manifestations: Electrolyte abnormalities","volume":"27","author":"Diercks","year":"2004","journal-title":"The Journal of Emergency Medicine"},{"issue":"12","key":"10.1016\/bs.vh.2022.03.002_bb0160","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/0277-5379(91)90431-C","article-title":"Parathyroid hormone-related protein(50-69) and response to pamidronate therapy for tumour-induced hypercalcaemia","volume":"27","author":"Dodwell","year":"1991","journal-title":"European Journal of Cancer (Oxford, England: 1990)"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0165","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1210\/jc.2014-4250","article-title":"PTHrP-mediated hypercalcemia: causes and survival in 138 patients","volume":"100","author":"Donovan","year":"2015","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"23","key":"10.1016\/bs.vh.2022.03.002_bb0170","first-page":"6015","article-title":"Parathyroid hormone-related protein as a growth regulator of prostate carcinoma","volume":"59","author":"Dougherty","year":"1999","journal-title":"Cancer Research"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0175","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.canlet.2011.02.027","article-title":"PTHrP stimulates prostate cancer cell growth and upregulates aldo-keto reductase 1C3","volume":"306","author":"Downs","year":"2011","journal-title":"Cancer Letters"},{"key":"10.1016\/bs.vh.2022.03.002_bb0180","series-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","first-page":"760","article-title":"Myeloma bone disease and other hematological malignancies","author":"Edwards","year":"2018"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0185","doi-asserted-by":"crossref","first-page":"C1230","DOI":"10.1152\/ajpcell.2000.279.4.C1230","article-title":"Expression and regulation of parathyroid hormone-related peptide in normal and malignant melanocytes","volume":"279","author":"El Abdaimi","year":"2000","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"10.1016\/bs.vh.2022.03.002_bb0190","series-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","first-page":"173","article-title":"Regulation of calcium and magnesium","author":"Favus","year":"2013"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0195","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1210\/endo-129-6-3424","article-title":"A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]","volume":"129","author":"Fenton","year":"1991","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/bs.vh.2022.03.002_bb0200","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nchembio.206","article-title":"Sustained cyclic AMP production by parathyroid hormone receptor endocytosis","volume":"5","author":"Ferrandon","year":"2009","journal-title":"Nature Chemical Biology"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0205","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jbmr.5650090508","article-title":"Effects of epidermal growth factor on parathyroid hormone-related protein production by mammary epithelial cells","volume":"9","author":"Ferrari","year":"1994","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0210","first-page":"417","article-title":"A comparison of the in vivo biochemical responses to exogenous parathyroid hormone-(1-34) [PTH-(1-34)] and PTH-related peptide-(1-34) in man","volume":"75","author":"Fraher","year":"1992","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"22","key":"10.1016\/bs.vh.2022.03.002_bb0215","doi-asserted-by":"crossref","first-page":"10182","DOI":"10.1073\/pnas.92.22.10182","article-title":"Signaling by N- and C-terminal sequences of parathyroid hormone-related protein in hippocampal neurons","volume":"92","author":"Fukayama","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.vh.2022.03.002_bb0220","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/bonekey.2012.135","article-title":"Mechanisms of multiple myeloma bone disease","volume":"1","author":"Galson","year":"2012","journal-title":"BoneKEy Reports"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0225","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1210\/endo.135.3.8070362","article-title":"Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor","volume":"135","author":"Gardella","year":"1994","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/bs.vh.2022.03.002_bb0230","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1002\/cam4.749","article-title":"Prevalence of hypercalcemia among cancer patients in the United States","volume":"5","author":"Gastanaga","year":"2016","journal-title":"Cancer Medicine"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0235","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng.1049","article-title":"Genome-wide association analysis identifies three new breast cancer susceptibility loci","volume":"44","author":"Ghoussaini","year":"2012","journal-title":"Nature Genetics"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0240","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/1043-2760(89)90029-5","article-title":"Parathyroid hormone-like peptide: Molecular characterization and biological properties","volume":"1","author":"Goltzman","year":"1989","journal-title":"Trends in Endocrinology and Metabolism: TEM"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0245","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1210\/jcem-53-5-899","article-title":"Malignancy-associated hypercalcemia: Evaluation with a cytochemical bioassay for parathyroid hormone","volume":"53","author":"Goltzman","year":"1981","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0250","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1210\/jcem-73-6-1309","article-title":"Parathyroid hormone-related protein: Elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer","volume":"73","author":"Grill","year":"1991","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0255","first-page":"1468","article-title":"Circulating PTH and PTHrP levels before and after treatment of tumor induced hypercalcemia with Pamidronate Disodium (APD)","volume":"74","author":"Grill","year":"1992","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"7","key":"10.1016\/bs.vh.2022.03.002_bb0260","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI118947","article-title":"Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis","volume":"98","author":"Guise","year":"1996","journal-title":"The Journal of Clinical Investigation"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0265","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S8756-3282(02)00685-3","article-title":"Parathyroid hormone-related protein (PTHrP)-(1-139) isoform is efficiently secreted in vitro and enhances breast cancer metastasis to bone in vivo","volume":"30","author":"Guise","year":"2002","journal-title":"Bone"},{"issue":"8861","key":"10.1016\/bs.vh.2022.03.002_bb0270","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/0140-6736(93)90756-7","article-title":"Parathyroid hormone-related protein and response to pamidronate in tumour-induced hypercalcaemia","volume":"341","author":"Gurney","year":"1993","journal-title":"Lancet (London, England)"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0275","first-page":"954","article-title":"Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease","volume":"12","author":"Guy","year":"1992","journal-title":"Molecular and Cellular Biology"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0280","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260066","article-title":"Diagnosis of bone metastases in breast cancer: Lesion-based sensitivity of dual-time-point FDG-PET\/CT compared to low-dose CT and bone scintigraphy","volume":"16","author":"Hansen","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0290","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1158\/1078-0432.CCR-06-1487","article-title":"Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides","volume":"13","author":"Hashimoto","year":"2007","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"8","key":"10.1016\/bs.vh.2022.03.002_bb0295","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1128\/MCB.15.8.4064","article-title":"Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death","volume":"15","author":"Henderson","year":"1995","journal-title":"Molecular and Cellular Biology"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0300","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1210\/endo-127-3-1310","article-title":"Effects of passive immunization against parathyroid hormone (PTH)-like peptide and PTH in hypercalcemic tumor-bearing rats and normocalcemic controls","volume":"127","author":"Henderson","year":"1990","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0305","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/jnci\/93.3.234","article-title":"Parathyroid hormone-related protein production by breast cancers, improved survival, and reduced bone metastases","volume":"93","author":"Henderson","year":"2001","journal-title":"Journal of the National Cancer Institute"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0310","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1158\/0008-5472.CAN-05-2814","article-title":"Parathyroid hormone-related protein localization in breast cancers predict improved prognosis","volume":"66","author":"Henderson","year":"2006","journal-title":"Cancer Research"},{"issue":"8","key":"10.1016\/bs.vh.2022.03.002_bb0315","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/MPA.0000000000001124","article-title":"Pancreatic cancer-induced cachexia and relevant mouse models","volume":"47","author":"Henderson","year":"2018","journal-title":"Pancreas"},{"issue":"24","key":"10.1016\/bs.vh.2022.03.002_bb0320","first-page":"6521","article-title":"Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression","volume":"51","author":"Henderson","year":"1991","journal-title":"Cancer Research"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0325","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jbmr.5650050203","article-title":"Circulating concentrations of parathyroid hormone-like peptide in malignancy and in hyperparathyroidism","volume":"5","author":"Henderson","year":"1990","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"1-2","key":"10.1016\/bs.vh.2022.03.002_bb0330","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3835(97)00503-X","article-title":"Establishment of two human small cell lung cancer cell lines: the evidence of accelerated production of parathyroid hormone-related protein with tumor progression","volume":"125","author":"Hidaka","year":"1998","journal-title":"Cancer Letters"},{"issue":"8","key":"10.1016\/bs.vh.2022.03.002_bb0335","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/cncr.10828","article-title":"Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia","volume":"95","author":"Hiraki","year":"2002","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0340","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2174\/138161210791034012","article-title":"The CXCR4\/SDF-1 chemokine axis: A potential therapeutic target for bone metastases?","volume":"16","author":"Hirbe","year":"2010","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/bs.vh.2022.03.002_bb0345","series-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","first-page":"92","article-title":"Vitamin D: Photobiology, metabolism, machanism of action and clinical applications","author":"Holick","year":"1999"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0350","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1210\/jc.2015-3785","article-title":"Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden","volume":"101","author":"Hong","year":"2016","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0355","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1172\/JCI115505","article-title":"Abundant expression of parathyroid hormone-related protein in primary rat aortic smooth muscle cells accompanies serum-induced proliferation","volume":"88","author":"Hongo","year":"1991","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.vh.2022.03.002_bb0360","series-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","first-page":"639","article-title":"Non-parathyroid hypercalcemia","author":"Horwitz","year":"2018"},{"key":"10.1016\/bs.vh.2022.03.002_bb0365","series-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","first-page":"246","article-title":"Humoral hypercalcemia of malignancy","author":"Horwitz","year":"2003"},{"issue":"10","key":"10.1016\/bs.vh.2022.03.002_bb0370","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1359\/JBMR.050602","article-title":"Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D","volume":"20","author":"Horwitz","year":"2005","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"10","key":"10.1016\/bs.vh.2022.03.002_bb0375","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1210\/en.2013-1803","article-title":"Parathyroid hormone-related protein: Potential therapeutic target for melanoma invasion and metastasis","volume":"155","author":"Huang","year":"2014","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb1001","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/ijc.1425","article-title":"Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen","volume":"94","author":"Iguchi","year":"2001","journal-title":"International Journal of Cancer"},{"issue":"17","key":"10.1016\/bs.vh.2022.03.002_bb0380","first-page":"4040","article-title":"An experimental model of bone metastasis by human lung cancer cells: The role of parathyroid hormone-related protein in bone metastasis","volume":"56","author":"Iguchi","year":"1996","journal-title":"Cancer Research"},{"issue":"1-3","key":"10.1016\/bs.vh.2022.03.002_bb0385","first-page":"166","article-title":"Parathyroid hormone-related peptide in hypercalcemia associated with adult T cell leukemia\/lymphoma: Molecular and cellular mechanism of parathyroid hormone-related peptide overexpression in HTLV-I-infected T cells","volume":"21","author":"Ikeda","year":"1995","journal-title":"Mineral and Electrolyte Metabolism"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0390","first-page":"1322","article-title":"Development of a sensitive two-site immunoradiometric assay for parathyroid et al., hormone-related peptide: evidence for elevated levels in plasma from patients with adult T-cell leukemia\/lymphoma and B-cell lymphoma","volume":"79","author":"Ikeda","year":"1994","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0395","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jbmr.5650060113","article-title":"Urinary excretion of parathyroid hormone-related protein fragments in patients with humoral hypercalcemia of malignancy and hypercalcemic tumor-bearing nude mice","volume":"6","author":"Imamura","year":"1991","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0400","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3810\/pgm.2004.04.1486","article-title":"Understanding hypercalcemia. Its metabolic basis, signs, and symptoms","volume":"115","author":"Inzucchi","year":"2004","journal-title":"Postgraduate Medicine"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0405","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/(SICI)1097-0142(19990915)86:6<1028::AID-CNCR19>3.0.CO;2-G","article-title":"Parathyroid hormone-related protein is an independent prognostic factor for renal cell carcinoma","volume":"86","author":"Iwamura","year":"1999","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0410","first-page":"917","article-title":"Humoral hypercalcemia in Hodgkin's disease","volume":"63","author":"Jacobson","year":"1989","journal-title":"Clinical and Laboratory Evaluation. Cancer"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0415","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1158\/0008-5472.CAN-10-2993","article-title":"TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling","volume":"71","author":"Johnson","year":"2011","journal-title":"Cancer Research"},{"issue":"5034","key":"10.1016\/bs.vh.2022.03.002_bb0420","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.1658941","article-title":"A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide","volume":"254","author":"J\u00fcppner","year":"1991","journal-title":"Science (New York, N.Y.)"},{"issue":"27","key":"10.1016\/bs.vh.2022.03.002_bb0425","doi-asserted-by":"crossref","first-page":"24571","DOI":"10.1074\/jbc.M202561200","article-title":"Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways","volume":"277","author":"Kakonen","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0430","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0025-6196(12)62163-6","article-title":"Parathyroid hormone-related peptide in plasma of patients with hypercalcemia and malignant lesions","volume":"65","author":"Kao","year":"1990","journal-title":"Mayo Clinic Proceedings"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0435","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1046\/j.1523-1755.1998.00115.x","article-title":"Parathyroid hormone and dietary phosphate provoke a lysosomal routing of the proximal tubular Na\/Pi-cotransporter type II","volume":"54","author":"Keusch","year":"1998","journal-title":"Kidney International"},{"issue":"18","key":"10.1016\/bs.vh.2022.03.002_bb0440","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1158\/0008-5472.CAN-15-2614","article-title":"Calcium-sensing receptor promotes breast cancer by stimulating intracrine actions of parathyroid hormone-related protein","volume":"76","author":"Kim","year":"2016","journal-title":"Cancer Research"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0445","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0303-7207(93)90074-T","article-title":"Transforming growth factor beta stimulation of parathyroid hormone-related protein (PTHrP): A paracrine regulator?","volume":"92","author":"Kiriyama","year":"1993","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"26","key":"10.1016\/bs.vh.2022.03.002_bb0450","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1073\/pnas.93.26.15233","article-title":"Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH\/PTHrP receptor","volume":"93","author":"Kovacs","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0455","first-page":"855","article-title":"ras Activation of human prostate epithelial cells induces overexpression of parathyroid hormone-related peptide","volume":"3","author":"Kremer","year":"1997","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0460","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1172\/JCI115094","article-title":"Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes. Effect of growth factors and 1,25 dihydroxyvitamin D3 on gene expression and secretion","volume":"87","author":"Kremer","year":"1991","journal-title":"The Journal of Clinical Investigation"},{"issue":"27","key":"10.1016\/bs.vh.2022.03.002_bb0465","doi-asserted-by":"crossref","first-page":"16310","DOI":"10.1074\/jbc.271.27.16310","article-title":"Identification and characterization of 1,25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene","volume":"271","author":"Kremer","year":"1996","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0470","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0002-9343(97)89515-0","article-title":"Parathyroid-hormone-related peptide in hematologic malignancies","volume":"100","author":"Kremer","year":"1996","journal-title":"The American Journal of Medicine"},{"issue":"1 Pt. 1","key":"10.1016\/bs.vh.2022.03.002_bb0475","doi-asserted-by":"crossref","first-page":"C164","DOI":"10.1152\/ajpcell.1996.271.1.C164","article-title":"Expression and action of parathyroid hormone-related peptide in human cervical epithelial cells","volume":"271","author":"Kremer","year":"1996","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/bs.vh.2022.03.002_bb0480","doi-asserted-by":"crossref","first-page":"5496710","DOI":"10.1155\/2019\/5496710","article-title":"Parathyroid hormone measurement in chronic kidney disease: from basics to clinical implications","volume":"2019","author":"Kritmetapak","year":"2019","journal-title":"International Journal of Nephrology"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0485","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1172\/JCI113794","article-title":"Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors","volume":"82","author":"Kukreja","year":"1988","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0490","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1373\/clinchem.2015.244012","article-title":"LC-MS\/MS measurement of parathyroid hormone-related peptide","volume":"62","author":"Kushnir","year":"2016","journal-title":"Clinical Chemistry"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0495","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00005792-196605000-00004","article-title":"Pseudohyperparathyroidism","volume":"45","author":"Lafferty","year":"1966","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0500","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1210\/endo.135.4.7523099","article-title":"Role of the extracellular regions of the parathyroid hormone (PTH)\/PTH-related peptide receptor in hormone binding","volume":"135","author":"Lee","year":"1994","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0505","doi-asserted-by":"crossref","first-page":"e10587","DOI":"10.1002\/jbm4.10587","article-title":"Parathyroid hormone-related protein inhibition blocks triple-negative breast cancer expansion in bone through epithelial to mesenchymal transition reversal","volume":"6","author":"Li","year":"2022","journal-title":"JBMR Plus"},{"issue":"12","key":"10.1016\/bs.vh.2022.03.002_bb0510","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1172\/JCI46134","article-title":"PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target","volume":"121","author":"Li","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0515","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/bjc.1995.304","article-title":"Analysis of survival following treatment of tumour-induced hypercalcaemia with intravenous pamidronate (APD)","volume":"72","author":"Ling","year":"1995","journal-title":"British Journal of Cancer"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0520","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.0954-6820.1978.tb14879.x","article-title":"Reversible renal failure caused by hypercalcemia. A retrospective study","volume":"203","author":"Lins","year":"1978","journal-title":"Acta Medica Scandinavica"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0525","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.2910630222","article-title":"Inhibition of processing of parathyroid hormone-related peptide by anti-sense furin: Effect in vitro and in vivo on rat Leydig (H-500) tumor cells","volume":"63","author":"Liu","year":"1995","journal-title":"International Journal of Cancer"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0530","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1210\/endo.132.4.8462465","article-title":"Regulation of parathyroid hormone-related peptide production in vitro by the rat hypercalcemic Leydig cell tumor H-500","volume":"132","author":"Liu","year":"1993","journal-title":"Endocrinology"},{"issue":"5 Pt. 1","key":"10.1016\/bs.vh.2022.03.002_bb0535","first-page":"E832","article-title":"Processing of pro-PTHRP by the prohormone convertase, furin: Effect on biological activity","volume":"268","author":"Liu","year":"1995","journal-title":"The American Journal of Physiology"},{"issue":"21","key":"10.1016\/bs.vh.2022.03.002_bb0540","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1021\/ac020182a","article-title":"Mass spectrometric immunoassay for parathyroid hormone-related protein","volume":"74","author":"Lu","year":"2002","journal-title":"Analytical Chemistry"},{"key":"10.1016\/bs.vh.2022.03.002_bb0545","article-title":"Parathyroid hormone-related peptide (PTHrP) blockade inhibits the development of bone metastasis and potentiates the effect of zoledronic acid in vitro and in vivo in a mouse model of breast tumor progression","author":"Luco","year":"2013"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0550","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00018-003-3233-2","article-title":"The complexity of parathyroid hormone-related protein signalling","volume":"61","author":"Maioli","year":"2004","journal-title":"Cellular and Molecular Life Sciences: CMLS"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0555","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019975","article-title":"PTHrP induces autocrine\/paracrine proliferation of bone tumor cells through inhibition of apoptosis","volume":"6","author":"Mak","year":"2011","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/bs.vh.2022.03.002_bb0560","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1073\/pnas.86.7.2408","article-title":"Isolation and characterization of the human parathyroid hormone-like peptide gene","volume":"86","author":"Mangin","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0565","first-page":"F665","article-title":"Receptors for PTH and PTHrP: Their biological importance and functional properties","volume":"277","author":"Mannstadt","year":"1999","journal-title":"The American Journal of Physiology"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0570","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1158\/0008-5472.CAN-03-1968","article-title":"Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene","volume":"64","author":"Massfelder","year":"2004","journal-title":"Cancer Research"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0575","first-page":"554","article-title":"Constitutive synthesis of 1,25-dihydroxyvitamin D3 by a human small cell lung cancer cell line","volume":"79","author":"Mawer","year":"1994","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"51","key":"10.1016\/bs.vh.2022.03.002_bb0580","doi-asserted-by":"crossref","first-page":"20309","DOI":"10.1073\/pnas.0805690105","article-title":"Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein","volume":"105","author":"Miao","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0585","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ijc.11586","article-title":"Parathyroid hormone-related protein (PTHrP) is responsible for production of bone metastasis, but not visceral metastasis, by human small cell lung cancer SBC-5 cells in natural killer cell-depleted SCID mice","volume":"108","author":"Miki","year":"2004","journal-title":"International Journal of Cancer"},{"issue":"14","key":"10.1016\/bs.vh.2022.03.002_bb0590","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1073\/pnas.84.14.5048","article-title":"Parathyroid hormone-related protein purified from a human lung cancer cell line","volume":"84","author":"Moseley","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0595","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.canlet.2010.06.009","article-title":"PTHrP promotes colon cancer cell migration and invasion in an integrin \u03b16\u03b24-dependent manner through activation of Rac1","volume":"298","author":"Mula","year":"2010","journal-title":"Cancer Letters"},{"issue":"8","key":"10.1016\/bs.vh.2022.03.002_bb0600","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","article-title":"Metastasis to bone: Causes, consequences and therapeutic opportunities","volume":"2","author":"Mundy","year":"2002","journal-title":"Nature Reviews. Cancer"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0605","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1006\/bbrc.2000.2314","article-title":"Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF\/TRANCE that induces osteoclast formation","volume":"269","author":"Nagai","year":"2000","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0610","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1210\/endo.142.2.7944","article-title":"Nuclear forms of parathyroid hormone-related peptide are translated from non-AUG start sites downstream from the initiator methionine","volume":"142","author":"Nguyen","year":"2001","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0615","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jelectrocard.2005.10.015","article-title":"Hypercalcemia-induced ST-segment elevation mimicking acute myocardial infarction","volume":"39","author":"Nishi","year":"2006","journal-title":"Journal of Electrocardiology"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0620","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/(SICI)1096-9896(199901)187:2<217::AID-PATH210>3.0.CO;2-0","article-title":"Clinicopathological implications of parathyroid hormone-related protein in human colorectal tumours","volume":"187","author":"Nishihara","year":"1999","journal-title":"The Journal of Pathology"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0625","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1210\/jcem-52-5-840","article-title":"Endogenous biologically active human parathyroid hormone: measurement by a guanyl nucleotide-amplified renal adenylate cyclase assay","volume":"52","author":"Nissenson","year":"1981","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"19","key":"10.1016\/bs.vh.2022.03.002_bb0630","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1056\/NEJM199011083231907","article-title":"Hypercalcemia and ectopic secretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone","volume":"323","author":"Nussbaum","year":"1990","journal-title":"The New England Journal of Medicine"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0635","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1158\/1078-0432.CCR-04-2531","article-title":"Increased renal calcium reabsorption by parathyroid hormone-related protein is a causative factor in the development of humoral hypercalcemia of malignancy refractory to osteoclastic bone resorption inhibitors","volume":"11","author":"Onuma","year":"2005","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"12","key":"10.1016\/bs.vh.2022.03.002_bb0640","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1210\/endo.137.12.8940360","article-title":"A midregion parathyroid hormone-related peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line","volume":"137","author":"Orloff","year":"1996","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0645","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1210\/endo.136.11.7588199","article-title":"The carboxy-terminus of parathyroid hormone\u2014Inert or invaluable?","volume":"136","author":"Orloff","year":"1995","journal-title":"Endocrinology"},{"issue":"18","key":"10.1016\/bs.vh.2022.03.002_bb0650","doi-asserted-by":"crossref","first-page":"9269","DOI":"10.1021\/acs.analchem.6b02637","article-title":"Cancer diagnostics via ultrasensitive multiplexed detection of parathyroid hormone-related peptides with a microfluidic immunoarray","volume":"88","author":"Otieno","year":"2016","journal-title":"Analytical Chemistry"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0655","first-page":"98","article-title":"The distribution of secondary growths in cancer of the breast","volume":"8","author":"Paget","year":"1989","journal-title":"Cancer Metastasis Reviews"},{"issue":"20","key":"10.1016\/bs.vh.2022.03.002_bb0660","doi-asserted-by":"crossref","first-page":"11581","DOI":"10.1073\/pnas.201394498","article-title":"Multiple myeloma disrupts the TRANCE\/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression","volume":"98","author":"Pearse","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0665","first-page":"1268","article-title":"Parathyroid hormone-related protein and life expectancy in hypercalcemic cancer patients","volume":"78","author":"Pecherstorfer","year":"1994","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"9","key":"10.1016\/bs.vh.2022.03.002_bb0670","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4065\/mcp.2010.0099","article-title":"Paraneoplastic syndromes: An approach to diagnosis and treatment","volume":"85","author":"Pelosof","year":"2010","journal-title":"Mayo Clinic Proceedings"},{"issue":"7","key":"10.1016\/bs.vh.2022.03.002_bb0675","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1158\/2159-8290.CD-20-1098","article-title":"PTHrP drives pancreatic cancer growth and metastasis and reveals a new therapeutic vulnerability","volume":"11","author":"Pitarresi","year":"2021","journal-title":"Cancer Discovery"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0680","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1056\/NEJM197307262890403","article-title":"Nonparathyroid humoral hypercalcemia in patients with neoplastic diseases","volume":"289","author":"Powell","year":"1973","journal-title":"The New England Journal of Medicine"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0685","first-page":"3059","article-title":"Localization of parathyroid hormone-related protein in breast cancer metastases: Increased incidence in bone compared with other sites","volume":"51","author":"Powell","year":"1991","journal-title":"Cancer Research"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0690","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<257::AID-IJC15>3.0.CO;2-3","article-title":"Over-production of parathyroid hormone-related peptide results in increased osteolytic skeletal metastasis by prostate cancer cells in vivo","volume":"80","author":"Rabbani","year":"1999","journal-title":"International Journal of Cancer"},{"issue":"12","key":"10.1016\/bs.vh.2022.03.002_bb0695","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1210\/endo.136.12.7588290","article-title":"Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide","volume":"136","author":"Rabbani","year":"1995","journal-title":"Endocrinology"},{"issue":"8 Suppl","key":"10.1016\/bs.vh.2022.03.002_bb0700","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1564::AID-CNCR6>3.0.CO;2-K","article-title":"Parathyroid hormone-related protein and hypercalcemia","volume":"80","author":"Rankin","year":"1997","journal-title":"Cancer"},{"issue":"10 Pt 1","key":"10.1016\/bs.vh.2022.03.002_bb0705","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/clinchem\/37.10.1781","article-title":"Immunoreactivity of plasma parathyrin-related peptide: three region-specific radioimmunoassays and a two-site immunoradiometric assay compared","volume":"37","author":"Ratcliffe","year":"1991","journal-title":"Clinical Chemistry"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0710","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ijc.2910560323","article-title":"Cyclic AMP increases the release of parathyroid hormone-related protein from a lung-cancer cell line","volume":"56","author":"Rizzoli","year":"1994","journal-title":"International Journal of Cancer"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0715","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/jbmr.5650040608","article-title":"High extracellular calcium increases the production of a parathyroid hormone-like activity by cultured Leydig tumor cells associated with humoral hypercalcemia","volume":"4","author":"Rizzoli","year":"1989","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0720","first-page":"912","article-title":"A thymoma as a cause of true ectopic hyperparathyroidism","volume":"79","author":"Rizzoli","year":"1994","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"10","key":"10.1016\/bs.vh.2022.03.002_bb0725","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1210\/jcem.84.10.6026","article-title":"Serum parathyroid hormone-related protein levels and response to bisphosphonate treatment in hypercalcemia of malignancy","volume":"84","author":"Rizzoli","year":"1999","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0730","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1172\/JCI111108","article-title":"Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells","volume":"72","author":"Rodan","year":"1983","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0735","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1677\/joe.0.1220219","article-title":"Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: Stimulation by phorbol esters and epidermal growth factor","volume":"122","author":"Rodan","year":"1989","journal-title":"The Journal of Endocrinology"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0740","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.suronc.2013.01.002","article-title":"Comparison of 18 FDG PET-CT and bone scintigraphy for detection of bone metastases in breast cancer patients. A meta-analysis","volume":"22","author":"Rong","year":"2013","journal-title":"Surgical Oncology"},{"issue":"8 Suppl","key":"10.1016\/bs.vh.2022.03.002_bb0745","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1557::AID-CNCR5>3.0.CO;2-H","article-title":"Mechanisms of bone lesions in multiple myeloma and lymphoma","volume":"80","author":"Roodman","year":"1997","journal-title":"Cancer"},{"issue":"16","key":"10.1016\/bs.vh.2022.03.002_bb0750","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra030831","article-title":"Mechanisms of bone metastasis","volume":"350","author":"Roodman","year":"2004","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0755","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jcb.22403","article-title":"Pathogenesis of myeloma bone disease","volume":"109","author":"Roodman","year":"2010","journal-title":"Journal of Cellular Biochemistry"},{"issue":"10","key":"10.1016\/bs.vh.2022.03.002_bb0760","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650051008","article-title":"Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones","volume":"5","author":"Rouleau","year":"1990","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0765","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2265.1994.tb02538.x","article-title":"Malignancy-associated hypercalcaemia: Resolution of controversies over vitamin D metabolism by a pathophysiological approach to the syndrome","volume":"41","author":"Schweitzer","year":"1994","journal-title":"Clinical Endocrinology"},{"issue":"3 Pt 1","key":"10.1016\/bs.vh.2022.03.002_bb0770","doi-asserted-by":"crossref","first-page":"C723","DOI":"10.1152\/ajpcell.1994.267.3.C723","article-title":"Regulation of parathyroid hormone-related peptide production in normal human mammary epithelial cells in vitro","volume":"267","author":"Sebag","year":"1994","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/bs.vh.2022.03.002_bb0775","unstructured":"Seitz, P.K., Zhang, R.W., Simmons, D.J., & Cooper, C.W. (1995). Effects of C-terminal parathyroid hormone-related peptide on osteoblasts. Mineral and Electrolyte Metabolism, 21(1-3), 180\u2013183."},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0780","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1210\/endo.143.2.8645","article-title":"Intracrine PTHrP protects against serum starvation-induced apoptosis and regulates the cell cycle in MCF-7 breast cancer cells","volume":"143","author":"Sepulveda","year":"2002","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0785","doi-asserted-by":"crossref","first-page":"IJE04","DOI":"10.2217\/ije-2017-0005","article-title":"68-Gallium DOTATATE scanning in symptomatic patients with negative anatomic imaging but suspected neuroendocrine tumor","volume":"5","author":"Shell","year":"2018","journal-title":"International Journal of Endocrine oncology"},{"issue":"1-2","key":"10.1016\/bs.vh.2022.03.002_bb0790","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0303-7207(02)00287-3","article-title":"PTH-related protein modulates PC-3 prostate cancer cell adhesion and integrin subunit profile","volume":"199","author":"Shen","year":"2003","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0795","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1056\/NEJM198308113090601","article-title":"Absence of parathyroid hormone messenger RNA in nonparathyroid tumors associated with hypercalcemia","volume":"309","author":"Simpson","year":"1983","journal-title":"The New England Journal of Medicine"},{"issue":"12","key":"10.1016\/bs.vh.2022.03.002_bb0800","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1373\/clinchem.2018.291377","article-title":"Misclassification of calcium status based on albumin-adjusted calcium: studies in a tertiary hospital setting","volume":"64","author":"Smith","year":"2018","journal-title":"Clinical Chemistry"},{"issue":"23","key":"10.1016\/bs.vh.2022.03.002_bb0805","first-page":"7710","article-title":"Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer","volume":"50","author":"Southby","year":"1990","journal-title":"Cancer Research"},{"issue":"15","key":"10.1016\/bs.vh.2022.03.002_bb0810","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.1158\/0008-5472.CAN-06-0452","article-title":"The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells","volume":"66","author":"Sterling","year":"2006","journal-title":"Cancer Research"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0815","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJMcp042806","article-title":"Clinical practice. Hypercalcemia associated with cancer","volume":"352","author":"Stewart","year":"2005","journal-title":"The New England Journal of Medicine"},{"issue":"24","key":"10.1016\/bs.vh.2022.03.002_bb0820","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJM198012113032401","article-title":"Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups","volume":"303","author":"Stewart","year":"1980","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0825","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1210\/jcem-55-2-219","article-title":"Quantitative bone histomorphometry in humoral hypercalcemia of malignancy: Uncoupling of bone cell activity","volume":"55","author":"Stewart","year":"1982","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0830","first-page":"1373","article-title":"Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient","volume":"76","author":"Strewler","year":"1993","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0835","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1172\/JCI113275","article-title":"Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone","volume":"80","author":"Strewler","year":"1987","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.vh.2022.03.002_bb0840","series-title":"Lung cancer: Principles and practice","first-page":"775","article-title":"Palliative radiotherapy for lung cancer","author":"Sullivan","year":"1996"},{"issue":"4817","key":"10.1016\/bs.vh.2022.03.002_bb0845","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.3616618","article-title":"A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression","volume":"237","author":"Suva","year":"1987","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/bs.vh.2022.03.002_bb0850","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.metabol.2017.11.012","article-title":"Biology and treatment of myeloma related bone disease","volume":"80","author":"Terpos","year":"2018","journal-title":"Metabolism, Clinical and Experimental"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0855","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrc927","article-title":"Cachexia in cancer patients","volume":"2","author":"Tisdale","year":"2002","journal-title":"Nature Reviews. Cancer"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0860","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9343(03)00310-3","article-title":"Parathyroid hormone-related peptide and survival of patients with cancer and hypercalcemia","volume":"115","author":"Truong","year":"2003","journal-title":"The American Journal of Medicine"},{"issue":"8","key":"10.1016\/bs.vh.2022.03.002_bb0865","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/jbmr.5650070814","article-title":"Localization of parathyroid hormone-related protein mRNA expression in breast cancer and metastatic lesions by in situ hybridization","volume":"7","author":"Vargas","year":"1992","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0870","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/bjc.1994.270","article-title":"Response to intravenous bisphosphonate therapy in hypercalcaemic patients with and without bone metastases: The role of parathyroid hormone-related protein","volume":"70","author":"Walls","year":"1994","journal-title":"British Journal of Cancer"},{"issue":"12","key":"10.1016\/bs.vh.2022.03.002_bb0875","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1158\/1078-0432.CCR-13-1590","article-title":"Molecular mechanisms of bone metastasis and associated muscle weakness","volume":"20","author":"Waning","year":"2014","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0880","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1158\/1055-9965.EPI-12-1318-T","article-title":"Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis","volume":"22","author":"Washam","year":"2013","journal-title":"Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"},{"key":"10.1016\/bs.vh.2022.03.002_bb0885","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.physiol.68.040104.131050","article-title":"The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases","volume":"68","author":"Weinman","year":"2006","journal-title":"Annual Review of Physiology"},{"issue":"8","key":"10.1016\/bs.vh.2022.03.002_bb0890","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/1097-0142(19940415)73:8<2223::AID-CNCR2820730831>3.0.CO;2-C","article-title":"Significance of plasma PTH-rp in patients with hypercalcemia of malignancy treated with bisphosphonate","volume":"73","author":"Wimalawansa","year":"1994","journal-title":"Cancer"},{"issue":"40","key":"10.1016\/bs.vh.2022.03.002_bb0895","doi-asserted-by":"crossref","first-page":"24371","DOI":"10.1074\/jbc.271.40.24371","article-title":"Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein","volume":"271","author":"Wu","year":"1996","journal-title":"The Journal of Biological Chemistry"},{"issue":"9","key":"10.1016\/bs.vh.2022.03.002_bb0900","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1210\/jc.2012-2142","article-title":"Parathyroid hormone-related protein: An update","volume":"97","author":"Wysolmerski","year":"2012","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0905","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1158\/1535-7163.MCT-08-0874","article-title":"Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice","volume":"8","author":"Yamada","year":"2009","journal-title":"Molecular Cancer Therapeutics"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0910","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jbmr.5650100108","article-title":"In vivo evidence for progressive activation of parathyroid hormone-related peptide gene transcription with tumor growth and stimulation of osteoblastic bone formation at an early stage of humoral hypercalcemia of cancer","volume":"10","author":"Yamato","year":"1995","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0915","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.bone.2007.02.001","article-title":"Contributions of parathyroid hormone (PTH)\/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone","volume":"40","author":"Yang","year":"2007","journal-title":"Bone"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0920","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI3523","article-title":"TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development","volume":"103","author":"Yin","year":"1999","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0925","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02967463","article-title":"Significance of the parathyroid hormone-related protein expression in breast carcinoma","volume":"7","author":"Yoshida","year":"2000","journal-title":"Breast Cancer (Tokyo, Japan)"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0930","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1210\/jcem-68-5-976","article-title":"Ectopic production of parathyroid hormone by small cell lung cancer in a patient with hypercalcemia","volume":"68","author":"Yoshimoto","year":"1989","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0935","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1359\/jbmr.090812","article-title":"Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice","volume":"25","author":"Zhang","year":"2010","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0940","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ccr.2009.05.017","article-title":"Latent bone metastasis in breast cancer tied to Src-dependent survival signals","volume":"16","author":"Zhang","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.vh.2022.03.002_bb0945","first-page":"129","article-title":"Die bedeutung der calcium-bestimmung im blute fur die diagnose der nierrenin-siffizientz","volume":"99","author":"Zondek","year":"1923","journal-title":"Z. Clin. Med."},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb0950","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0303-7207(93)90045-L","article-title":"Calcitonin increases transcription of parathyroid hormone-related protein via cAMP","volume":"94","author":"Chilco","year":"1993","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"14","key":"10.1016\/bs.vh.2022.03.002_bb0955","first-page":"3325","article-title":"Reversal of hypercalcemia with the vitamin D analogue EB1089 in a human model of squamous cancer","volume":"59","author":"El Abdaimi","year":"1999","journal-title":"Cancer Research"},{"issue":"3","key":"10.1016\/bs.vh.2022.03.002_bb0960","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1046\/j.1365-2141.1996.d01-1819.x","article-title":"Parathyroid hormone-related protein in hypercalcaemia associated with haematological malignancy","volume":"94","author":"Firkin","year":"1996","journal-title":"British Journal of Haematology"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0965","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1172\/JCI116475","article-title":"A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancy-associated hypercalcemia in vivo","volume":"91","author":"Haq","year":"1993","journal-title":"The Journal of Clinical Investigation"},{"issue":"11","key":"10.1016\/bs.vh.2022.03.002_bb0975","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/exd.12789","article-title":"Deficiency of the parathyroid hormone-related peptide nuclear localization and carboxyl terminal sequences leads to premature skin ageing partially mediated by the upregulation of p27","volume":"24","author":"Jiang","year":"2015","journal-title":"Experimental Dermatology"},{"issue":"2","key":"10.1016\/bs.vh.2022.03.002_bb0980","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1210\/endo.134.2.8299582","article-title":"The extracellular amino-terminal region of the parathyroid hormone (PTH)\/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34)","volume":"134","author":"J\u00fcppner","year":"1994","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/bs.vh.2022.03.002_bb0985","first-page":"556","article-title":"Circulating vitamin D metabolites and hypercalcaemia of malignancy","volume":"106","author":"Ralston","year":"1984","journal-title":"Acta Endocrinologica"},{"issue":"5","key":"10.1016\/bs.vh.2022.03.002_bb0990","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1182\/blood.V82.5.1383.1383","article-title":"Calcitriol: The major humoral mediator of hypercalcemia in Hodgkin's disease and non-Hodgkin's lymphomas","volume":"82","author":"Seymour","year":"1993","journal-title":"Blood"},{"issue":"6","key":"10.1016\/bs.vh.2022.03.002_bb0995","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1096\/fj.09-147033","article-title":"The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice","volume":"24","author":"Toribio","year":"2010","journal-title":"FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"issue":"1","key":"10.1016\/bs.vh.2022.03.002_bb1000","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00001813-199502000-00012","article-title":"Vitamin D analogs: New therapeutic agents for the treatment of squamous cancer and its associated hypercalcemia","volume":"6","author":"Yu","year":"1995","journal-title":"Anti-Cancer Drugs"}],"container-title":["Vitamins and Hormones","Parathyroid Hormone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0083672922000450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0083672922000450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T16:16:37Z","timestamp":1753287397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0083672922000450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9780323992251"],"references-count":199,"URL":"https:\/\/doi.org\/10.1016\/bs.vh.2022.03.002","relation":{},"ISSN":["0083-6729"],"issn-type":[{"value":"0083-6729","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}