{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:31:09Z","timestamp":1767918669822,"version":"3.49.0"},"reference-count":74,"publisher":"Elsevier","isbn-type":[{"value":"9780443158186","type":"print"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/bs.vh.2022.11.002","type":"book-chapter","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T20:21:00Z","timestamp":1671222060000},"page":"147-169","source":"Crossref","is-referenced-by-count":13,"title":["DNA methylation in the pathogenesis of type 2 diabetes"],"prefix":"10.1016","author":[{"given":"Suneesh","family":"Kaimala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suraiya Anjum","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bright Starling","family":"Emerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/bs.vh.2022.11.002_bb0010","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.2337\/db17-1539","article-title":"Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity-associated type 2 diabetes","volume":"67","author":"Abderrahmani","year":"2018","journal-title":"Diabetes"},{"issue":"Suppl 1","key":"10.1016\/bs.vh.2022.11.002_bb0015","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc09-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"32","author":"American Diabetes Association","year":"2009","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/bs.vh.2022.11.002_bb0020","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1186\/gb-2013-14-3-r21","article-title":"DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes","volume":"14","author":"Aran","year":"2013","journal-title":"Genome Biology"},{"issue":"3","key":"10.1016\/bs.vh.2022.11.002_bb366","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.drudis.2015.12.001","article-title":"Are epigenetic drugs for diabetes and obesity at our door step?","volume":"21","author":"Arguelles","year":"2016","journal-title":"Drug Discovery Today"},{"issue":"4","key":"10.1016\/bs.vh.2022.11.002_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018284","article-title":"Genetic predisposition for type 2 diabetes, but not for overweight\/obesity, is associated with a restricted adipogenesis","volume":"6","author":"Arner","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/bs.vh.2022.11.002_bb0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cmet.2009.07.011","article-title":"Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density","volume":"10","author":"Barres","year":"2009","journal-title":"Cell Metabolism"},{"issue":"1","key":"10.1016\/bs.vh.2022.11.002_bb0035","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009191","article-title":"Insulin receptor signaling in normal and insulin-resistant states","volume":"6","author":"Boucher","year":"2014","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"6496","key":"10.1016\/bs.vh.2022.11.002_bb0040","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/371435a0","article-title":"Sp1 elements protect a CpG island from de novo methylation","volume":"371","author":"Brandeis","year":"1994","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.vh.2022.11.002_bb0045","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0006-291X(02)02633-5","article-title":"Regulation of the pdx1 gene promoter in pancreatic beta-cells","volume":"299","author":"Campbell","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"11","key":"10.1016\/bs.vh.2022.11.002_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202004507","article-title":"Hypermethylation of hepatic mitochondrial","volume":"8","author":"Cao","year":"2021","journal-title":"Advanced Science"},{"key":"10.1016\/bs.vh.2022.11.002_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fendo.2013.00037","article-title":"Beta cell dysfunction and insulin resistance","volume":"4","author":"Cerf","year":"2013","journal-title":"Frontiers in Endocrinology"},{"issue":"7\u201312","key":"10.1016\/bs.vh.2022.11.002_bb0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2119\/2005-00029.Saltiel","article-title":"Insulin signaling and the regulation of glucose transport","volume":"10","author":"Chang","year":"2004","journal-title":"Molecular Medicine"},{"issue":"9","key":"10.1016\/bs.vh.2022.11.002_bb0065","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/jhg.2014.63","article-title":"Alterations to DNA methylation and expression of CXCL14 are associated with suboptimal birth outcomes","volume":"59","author":"Cheong","year":"2014","journal-title":"Journal of Human Genetics"},{"key":"10.1016\/bs.vh.2022.11.002_bb0070","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12916-017-0792-x","article-title":"Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects","volume":"15","author":"Davegardh","year":"2017","journal-title":"BMC Medicine"},{"issue":"5","key":"10.1016\/bs.vh.2022.11.002_bb0075","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1139\/bcb-2015-0057","article-title":"Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?","volume":"93","author":"Dayeh","year":"2015","journal-title":"Biochemistry and Cell Biology"},{"issue":"4","key":"10.1016\/bs.vh.2022.11.002_bb0080","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.mcna.2004.04.013","article-title":"Pathogenesis of type 2 diabetes mellitus","volume":"88","author":"DeFronzo","year":"2004","journal-title":"The Medical Clinics of North America"},{"issue":"9548","key":"10.1016\/bs.vh.2022.11.002_bb0085","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/S0140-6736(06)69705-5","article-title":"The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes","volume":"368","author":"Drucker","year":"2006","journal-title":"The Lancet"},{"issue":"9","key":"10.1016\/bs.vh.2022.11.002_bb0090","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm4043","article-title":"DNA methylation pathways and their crosstalk with histone methylation","volume":"16","author":"Du","year":"2015","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/bs.vh.2022.11.002_bb0095","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1186\/1471-2164-12-509","article-title":"Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range","volume":"12","author":"Emerald","year":"2011","journal-title":"BMC Genomics"},{"issue":"2","key":"10.1016\/bs.vh.2022.11.002_bb0100","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jcb.10286","article-title":"Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together?","volume":"87","author":"Geiman","year":"2002","journal-title":"Journal of Cellular Biochemistry"},{"issue":"3","key":"10.1016\/bs.vh.2022.11.002_bb367","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41397-019-0138-5","article-title":"Cancer's epigenetic drugs: Where are they in the cancer medicines?","volume":"20","author":"Ghasemi","year":"2020","journal-title":"The Pharmacogenomics Journal"},{"issue":"1","key":"10.1016\/bs.vh.2022.11.002_bb0105","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41467-021-27934-w","article-title":"The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage","volume":"13","author":"Girard","year":"2022","journal-title":"Nature Communications"},{"issue":"3","key":"10.1016\/bs.vh.2022.11.002_bb0110","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1740-8709.2005.00020.x","article-title":"The developmental origins of adult disease","volume":"1","author":"Gluckman","year":"2005","journal-title":"Maternal & Child Nutrition"},{"key":"10.1016\/bs.vh.2022.11.002_bb0115","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2337\/db10-0979","article-title":"Epigenetic gene promoter methylation at birth is associated with child's later adiposity","volume":"60","author":"Godfrey","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/bs.vh.2022.11.002_bb0120","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.molmet.2017.05.015","article-title":"Epigenetics in formation, function, and failure of the endocrine pancreas","volume":"6","author":"Golson","year":"2017","journal-title":"Molecular Metabolism"},{"issue":"10","key":"10.1016\/bs.vh.2022.11.002_bb0125","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","article-title":"The diverse roles of DNA methylation in mammalian development and disease","volume":"20","author":"Greenberg","year":"2019","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"12","key":"10.1016\/bs.vh.2022.11.002_bb0130","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1463-1326.2010.01299.x","article-title":"The role of peroxisome proliferator-activated receptor \u03b3 in pancreatic \u03b2 cell function and survival: Therapeutic implications for the treatment of type 2 diabetes mellitus","volume":"12","author":"Gupta","year":"2010","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"1","key":"10.1016\/bs.vh.2022.11.002_bb0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1242\/dev.121.1.11","article-title":"Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny","volume":"121","author":"Guz","year":"1995","journal-title":"Development"},{"key":"10.1016\/bs.vh.2022.11.002_bb0140","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2350-14-76","article-title":"DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets","volume":"14","author":"Hall","year":"2013","journal-title":"BMC Medical Genetics"},{"issue":"2","key":"10.1016\/bs.vh.2022.11.002_bb0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/MED.0b013e3283514e13","article-title":"What causes the insulin resistance underlying obesity?","volume":"19","author":"Hardy","year":"2012","journal-title":"Current Opinion in Endocrinology, Diabetes, and Obesity"},{"issue":"1","key":"10.1016\/bs.vh.2022.11.002_bb0150","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13435","article-title":"Insulin regulation of gluconeogenesis","volume":"1411","author":"Hatting","year":"2018","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"4173","key":"10.1016\/bs.vh.2022.11.002_bb0155","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1126\/science.187.4173.226","article-title":"DNA modification mechanisms and gene activity during development","volume":"187","author":"Holliday","year":"1975","journal-title":"Science"},{"issue":"5","key":"10.1016\/bs.vh.2022.11.002_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097510","article-title":"DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver","volume":"9","author":"Howard","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/bs.vh.2022.11.002_bb0165","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008946","article-title":"The insulin receptor: Both a prototypical and atypical receptor tyrosine kinase","volume":"5","author":"Hubbard","year":"2013","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"9","key":"10.1016\/bs.vh.2022.11.002_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001134","article-title":"Orphan CpG islands identify numerous conserved promoters in the mammalian genome","volume":"6","author":"Illingworth","year":"2010","journal-title":"PLoS Genetics"},{"key":"10.1016\/bs.vh.2022.11.002_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.649255","article-title":"Evolution of the insulin gene: Changes in gene number, sequence, and processing","volume":"12","author":"Irwin","year":"2021","journal-title":"Frontiers in Endocrinology"},{"issue":"18","key":"10.1016\/bs.vh.2022.11.002_bb0180","doi-asserted-by":"crossref","first-page":"8556","DOI":"10.1093\/nar\/gkw723","article-title":"Allosteric control of mammalian DNA methyltransferases\u2014A new regulatory paradigm","volume":"44","author":"Jeltsch","year":"2016","journal-title":"Nucleic Acids Research"},{"issue":"7","key":"10.1016\/bs.vh.2022.11.002_bb0185","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: Islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nature Reviews. Genetics"},{"issue":"6498","key":"10.1016\/bs.vh.2022.11.002_bb0190","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/371606a0","article-title":"Insulin-promoter-factor 1 is required for pancreas development in mice","volume":"371","author":"Jonsson","year":"1994","journal-title":"Nature"},{"issue":"4","key":"10.1016\/bs.vh.2022.11.002_bb0195","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/hmj.hmj_15_21","article-title":"Risk factors which influence DNA methylation in childhood obesity","volume":"14","author":"Kaimala","year":"2021","journal-title":"Hamdan Medical Journal"},{"issue":"3","key":"10.1016\/bs.vh.2022.11.002_bb0200","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/med.21878","article-title":"Epigenetic modifications in pancreas development, diabetes, and therapeutics","volume":"42","author":"Kaimala","year":"2022","journal-title":"Medicinal Research Reviews"},{"issue":"3","key":"10.1016\/bs.vh.2022.11.002_bb0205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molmet.2015.12.004","article-title":"Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients","volume":"5","author":"Kirchner","year":"2016","journal-title":"Molecular Metabolism"},{"issue":"6","key":"10.1016\/bs.vh.2022.11.002_bb0210","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/jdi.12094","article-title":"Glucose-stimulated insulin secretion: A newer perspective","volume":"4","author":"Komatsu","year":"2013","journal-title":"Journal of Diabetes Investigation"},{"issue":"10","key":"10.1016\/bs.vh.2022.11.002_bb0215","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1007\/s00125-020-05212-6","article-title":"Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes","volume":"63","author":"Krause","year":"2020","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/bs.vh.2022.11.002_bb0220","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tig.2015.03.002","article-title":"The alternative role of DNA methylation in splicing regulation","volume":"31","author":"Lev Maor","year":"2015","journal-title":"Trends in Genetics"},{"key":"10.1016\/bs.vh.2022.11.002_bb0225","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12967-016-0834-8","article-title":"Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease","volume":"14","author":"Li","year":"2016","journal-title":"Journal of Translational Medicine"},{"issue":"11","key":"10.1016\/bs.vh.2022.11.002_bb0230","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ng.946","article-title":"Identification of genetic elements that autonomously determine DNA methylation states","volume":"43","author":"Lienert","year":"2011","journal-title":"Nature Genetics"},{"key":"10.1016\/bs.vh.2022.11.002_bb0235","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00125-007-0916-5","article-title":"Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion","volume":"51","author":"Ling","year":"2008","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/bs.vh.2022.11.002_bb0240","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1530\/JME-18-0018","article-title":"De-silencing","volume":"60","author":"Luo","year":"2018","journal-title":"Journal of Molecular Endocrinology"},{"issue":"19","key":"10.1016\/bs.vh.2022.11.002_bb0245","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1101\/gad.8.19.2282","article-title":"Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island","volume":"8","author":"Macleod","year":"1994","journal-title":"Genes & Development"},{"issue":"Suppl 3","key":"10.1016\/bs.vh.2022.11.002_bb0250","doi-asserted-by":"crossref","first-page":"S320","DOI":"10.2337\/diabetes.51.2007.S320","article-title":"Regulation of pdx-1 gene expression","volume":"51","author":"Melloul","year":"2002","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/bs.vh.2022.11.002_bb0255","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1101\/gad.1412806","article-title":"Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation","volume":"20","author":"Miyatsuka","year":"2006","journal-title":"Genes & Development"},{"issue":"1","key":"10.1016\/bs.vh.2022.11.002_bb0260","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/bs.vh.2022.11.002_bb0265","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.2337\/db13-1459","article-title":"Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes","volume":"63","author":"Nilsson","year":"2014","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/bs.vh.2022.11.002_bb0270","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.2337\/db11-1653","article-title":"Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes","volume":"61","author":"Nitert","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/bs.vh.2022.11.002_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155142","article-title":"Insulin: The master regulator of glucose metabolism","volume":"129","author":"Norton","year":"2022","journal-title":"Metabolism"},{"issue":"11","key":"10.1016\/bs.vh.2022.11.002_bb0280","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1002\/j.1460-2075.1993.tb06109.x","article-title":"IPF1, a homeodomain-containing transactivator of the insulin gene","volume":"12","author":"Ohlsson","year":"1993","journal-title":"The EMBO Journal"},{"key":"10.1016\/bs.vh.2022.11.002_bb0285","first-page":"2316","article-title":"Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1","volume":"118","author":"Park","year":"2008","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.vh.2022.11.002_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.651258","article-title":"DNA methylation patterning and the regulation of beta cell homeostasis","volume":"12","author":"Parveen","year":"2021","journal-title":"Frontiers in Endocrinology"},{"key":"10.1016\/bs.vh.2022.11.002_bb0295","article-title":"Identification of early indicators of altered metabolism in normal development using a rodent model system","volume":"11","author":"Prabakaran","year":"2018","journal-title":"Disease Models & Mechanisms"},{"issue":"Pt 2","key":"10.1016\/bs.vh.2022.11.002_bb0300","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1042\/bj3410315","article-title":"Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic beta-cells","volume":"341","author":"Qian","year":"1999","journal-title":"The Biochemical Journal"},{"issue":"1","key":"10.1016\/bs.vh.2022.11.002_bb0305","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cphy.c130024","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Comprehensive Physiology"},{"key":"10.1016\/bs.vh.2022.11.002_bb0310","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mam.2015.09.003","article-title":"Molecular pathophysiology of hepatic glucose production","volume":"46","author":"Sharabi","year":"2015","journal-title":"Molecular Aspects of Medicine"},{"issue":"5","key":"10.1016\/bs.vh.2022.11.002_bb0315","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/joim.12540","article-title":"Adipose tissue regulates insulin sensitivity: Role of adipogenesis, de novo lipogenesis and novel lipids","volume":"280","author":"Smith","year":"2016","journal-title":"Journal of Internal Medicine"},{"issue":"6","key":"10.1016\/bs.vh.2022.11.002_bb0320","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/hep.23927","article-title":"Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor \u03b3 coactivator 1\u03b1 promoter","volume":"52","author":"Sookoian","year":"2010","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/bs.vh.2022.11.002_bb0325","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2337\/diabetes.54.3.591","article-title":"A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome","volume":"54","author":"Summers","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/bs.vh.2022.11.002_bb0330","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fendo.2017.00329","article-title":"Promoting glucose transporter-4 vesicle trafficking along cytoskeletal tracks: PAK-Ing them out","volume":"8","author":"Tunduguru","year":"2017","journal-title":"Frontiers in Endocrinology"},{"issue":"6","key":"10.1016\/bs.vh.2022.11.002_bb0335","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/emboj.2011.503","article-title":"DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients","volume":"31","author":"Volkmar","year":"2012","journal-title":"The EMBO Journal"},{"key":"10.1016\/bs.vh.2022.11.002_bb0340","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2337\/db16-0996","article-title":"Whole-genome bisulfite sequencing of human pancreatic islets reveals novel differentially methylated regions in type 2 diabetes pathogenesis","volume":"66","author":"Volkov","year":"2017","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/bs.vh.2022.11.002_bb0345","first-page":"19","article-title":"Insulin and insulin resistance","volume":"26","author":"Wilcox","year":"2005","journal-title":"Clinical Biochemist Reviews"},{"issue":"2","key":"10.1016\/bs.vh.2022.11.002_bb0350","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00125-010-1967-6","article-title":"Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets","volume":"54","author":"Yang","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/bs.vh.2022.11.002_bb0355","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1210\/me.2012-1004","article-title":"Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes","volume":"26","author":"Yang","year":"2012","journal-title":"Molecular Endocrinology"},{"issue":"2","key":"10.1016\/bs.vh.2022.11.002_bb0360","first-page":"248","article-title":"The mammal-specific Pdx1 area II enhancer has multiple essential functions in early endocrine cell specification and postnatal \u03b2-cell maturation","volume":"144","author":"Yang","year":"2017","journal-title":"Development"},{"issue":"4","key":"10.1016\/bs.vh.2022.11.002_bb0365","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00125-020-05090-y","article-title":"Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation","volume":"63","author":"Zhang","year":"2020","journal-title":"Diabetologia"}],"container-title":["Vitamins and Hormones","Hormones and Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0083672922000851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0083672922000851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T13:43:35Z","timestamp":1678283015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0083672922000851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780443158186"],"references-count":74,"URL":"https:\/\/doi.org\/10.1016\/bs.vh.2022.11.002","relation":{},"ISSN":["0083-6729"],"issn-type":[{"value":"0083-6729","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}