{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:24:23Z","timestamp":1780395863794,"version":"3.54.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aaceclinicalcasereports.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AACE Clinical Case Reports"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.aace.2020.11.028","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T07:39:14Z","timestamp":1610264354000},"page":"127-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Alpelisib-Induced Diabetic Ketoacidosis: A Case Report and Review of Literature"],"prefix":"10.1016","volume":"7","author":[{"given":"Maritza","family":"Carrillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renil M.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Mcgarvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aace.2020.11.028_bib1","unstructured":"Novartis Pharmaceuticals Corporation. PIQRAY (alpelisib) tablets prescribing information. https:\/\/www.hcp.novartis.com\/products\/piqray\/metastatic-breast-cancer\/. Accessed May 15, 2019."},{"issue":"20","key":"10.1016\/j.aace.2020.11.028_bib2","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1056\/NEJMoa1813904","article-title":"Alpelisib for PIK3CA- mutated, hormone receptor-positive advanced breast cancer","volume":"380","author":"Andre","year":"2019","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1016\/j.aace.2020.11.028_bib3","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/cncr.31921","article-title":"Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities","volume":"125","author":"Millis","year":"2019","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/j.aace.2020.11.028_bib4","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.7150\/ijbs.27173","article-title":"The PI3K\/AKT pathway in obesity and type 2 diabetes","volume":"14","author":"Huang","year":"2018","journal-title":"Intl J Biol Sci"},{"issue":"3","key":"10.1016\/j.aace.2020.11.028_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB Signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"issue":"27","key":"10.1016\/j.aace.2020.11.028_bib6","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1038\/onc.2011.495","article-title":"Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of\u00a0insulin resistance and hyperinsulinemia","volume":"31","author":"Gallagher","year":"2012","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.aace.2020.11.028_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2007.03.006","article-title":"The GLUT4 glucose transporter","volume":"5","author":"Huang","year":"2007","journal-title":"Cell Metab"},{"issue":"41","key":"10.1016\/j.aace.2020.11.028_bib8","doi-asserted-by":"crossref","first-page":"39337","DOI":"10.1074\/jbc.M305689200","article-title":"Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface","volume":"278","author":"Bentley","year":"2003","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"10.1016\/j.aace.2020.11.028_bib9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cmet.2010.02.002","article-title":"Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation","volume":"11","author":"Sopasakis","year":"2010","journal-title":"Cell Metab"},{"issue":"5","key":"10.1016\/j.aace.2020.11.028_bib10","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1158\/1535-7163.MCT-13-0865","article-title":"Characterization of the novel and specific PI3K\u03b1 inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials","volume":"13","author":"Fritsch","year":"2014","journal-title":"Mol Cancer Ther"},{"issue":"7719","key":"10.1016\/j.aace.2020.11.028_bib11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-018-0343-4","article-title":"Suppression of insulin feedback enhances the efficacy of PI3K inhibitors","volume":"560","author":"Hopkins","year":"2018","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.aace.2020.11.028_bib12","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K pathway in human disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.aace.2020.11.028_bib13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3390\/biom9090402","article-title":"For better or worse: the potential for dose limiting the on-target toxicity of PI3-kinase inhibitors","volume":"9","author":"Buchanan","year":"2019","journal-title":"Biomolecules"}],"container-title":["AACE Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2376060520310294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2376060520310294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:31:29Z","timestamp":1762497089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2376060520310294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S2376060520310294"],"URL":"https:\/\/doi.org\/10.1016\/j.aace.2020.11.028","relation":{},"ISSN":["2376-0605"],"issn-type":[{"value":"2376-0605","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alpelisib-Induced Diabetic Ketoacidosis: A Case Report and Review of Literature","name":"articletitle","label":"Article Title"},{"value":"AACE Clinical Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aace.2020.11.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 AACE. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}