{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:08:52Z","timestamp":1772640532293,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Anatomy - Anatomischer Anzeiger"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.aanat.2015.02.005","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T18:05:18Z","timestamp":1426010718000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Inhalative IL-10 treatment after bilateral femoral fractures affect pulmonary inflammation in mice"],"prefix":"10.1016","volume":"200","author":[{"given":"Philipp","family":"Lichte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Pfeifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Kobbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mersedeh","family":"Tohidnezhad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pufe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Almahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Christoph","family":"Pape","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.aanat.2015.02.005_bib0005","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1124\/pr.55.2.4","article-title":"Interleukin-10 therapy\u2014review of a new approach","volume":"55","author":"Asadullah","year":"2003","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"10.1016\/j.aanat.2015.02.005_bib0010","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/00000542-200509000-00019","article-title":"Pulmonary aspiration: new therapeutic approaches in the experimental model","volume":"103","author":"Beck-Schimmer","year":"2005","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.aanat.2015.02.005_bib0002","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejpb.2005.04.009","article-title":"Non-invasive pulmonary aerosol delivery in mice by the endotracheal route","volume":"61","author":"Bivas-Benita","year":"2005","journal-title":"Eur J Pharm Biopharm."},{"issue":"3","key":"10.1016\/j.aanat.2015.02.005_bib0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.7326\/0003-4819-125-3-199608010-00005","article-title":"The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome","volume":"125","author":"Donnelly","year":"1996","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.aanat.2015.02.005_bib0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/jsre.1998.5372","article-title":"Interleukin-10 reduces morbidity and mortality in murine multiple organ dysfunction syndrome (MODS)","volume":"77","author":"Ferrer","year":"1998","journal-title":"J. Surg. Res."},{"issue":"11","key":"10.1016\/j.aanat.2015.02.005_bib0025","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL-10 inhibits cytokine production by activated macrophages","volume":"147","author":"Fiorentino","year":"1991","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.aanat.2015.02.005_bib0030","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1183\/09031936.06.00046405","article-title":"Interleukin-10 polymorphism in position\u20141082 and acute respiratory distress syndrome","volume":"27","author":"Gong","year":"2006","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.aanat.2015.02.005_bib0035","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0741-5214(97)70154-X","article-title":"Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a tumor necrosis factor-dependent murine model of acute visceral ischemia","volume":"26","author":"Hess","year":"1997","journal-title":"J. Vasc. Surg."},{"issue":"6","key":"10.1016\/j.aanat.2015.02.005_bib0040","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1097\/TA.0000000000000236","article-title":"Animal models to assess the local and systemic effects of nailing: review of the literature and considerations for future studies","volume":"76","author":"Hildebrand","year":"2014","journal-title":"J. Trauma Acute Care Surg."},{"issue":"4\u20135","key":"10.1016\/j.aanat.2015.02.005_bib0045","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.etp.2004.09.004","article-title":"Role of adhesion molecule ICAM in the pathogenesis of polymicrobial sepsis","volume":"56","author":"Hildebrand","year":"2005","journal-title":"Exp. Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.aanat.2015.02.005_bib0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s101560050050","article-title":"Effect of interleukin-10 (IL-10) on experimental LPS-induced acute lung injury","volume":"6","author":"Inoue","year":"2000","journal-title":"J. Infect. Chemother."},{"issue":"9","key":"10.1016\/j.aanat.2015.02.005_bib0055","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1182\/blood.V90.9.3356","article-title":"Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis","volume":"90","author":"Keel","year":"1997","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.aanat.2015.02.005_bib0060","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/01.shk.0000136095.96306.08","article-title":"Impaired induction of IL-10 expression in the lung following hemorrhagic shock","volume":"22","author":"Khadaroo","year":"2004","journal-title":"Shock"},{"issue":"7","key":"10.1016\/j.aanat.2015.02.005_bib0065","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0305-4179(01)00028-6","article-title":"Susceptibility of thermally injured mice to cytomegalovirus infection","volume":"27","author":"Kobayashi","year":"2001","journal-title":"Burns"},{"issue":"6","key":"10.1016\/j.aanat.2015.02.005_bib0070","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/SHK.0b013e31816f257e","article-title":"Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury","volume":"30","author":"Kobbe","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.aanat.2015.02.005_bib0075","doi-asserted-by":"crossref","first-page":"512974","DOI":"10.1155\/2012\/512974","article-title":"Inhalative IL-10 attenuates pulmonary inflammation following hemorrhagic shock without major alterations of the systemic inflammatory response","volume":"2012","author":"Kobbe","year":"2012","journal-title":"Mediators Inflamm."},{"issue":"2","key":"10.1016\/j.aanat.2015.02.005_bib0080","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.injury.2012.09.011","article-title":"Increased morbidity and mortality after bilateral femoral shaft fractures: myth or reality in the era of damage control?","volume":"44","author":"Kobbe","year":"2013","journal-title":"Injury"},{"issue":"3","key":"10.1016\/j.aanat.2015.02.005_bib0085","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00011-009-8116-z","article-title":"IL-10 administration attenuates pulmonary neutrophil infiltration and alters pulmonary iNOS activation following hemorrhagic shock","volume":"58","author":"Kobbe","year":"2009","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.aanat.2015.02.005_bib0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/SHK.0b013e31815d190b","article-title":"Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture","volume":"30","author":"Kobbe","year":"2008","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.aanat.2015.02.005_bib0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/10623320213631","article-title":"Endothelial cells at inflammatory sites as target for therapeutic intervention","volume":"9","author":"Koning","year":"2002","journal-title":"Endothelium"},{"issue":"Suppl. 4","key":"10.1016\/j.aanat.2015.02.005_bib0100","first-page":"S19L 24","article-title":"Fat embolism: special situations bilateral femoral fractures and pathologic femoral fractures","volume":"37","author":"Kontakis","year":"2006","journal-title":"Injury"},{"issue":"1-2","key":"10.1016\/j.aanat.2015.02.005_bib0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-2478(94)00226-H","article-title":"IL-10 inhibits the adhesion of leukocytic cells to IL-1-activated human endothelial cells","volume":"45","author":"Krakauer","year":"1995","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.aanat.2015.02.005_bib0110","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2047-783X-19-27","article-title":"Dehydroepiandrosterone modulates the inflammatory response in a bilateral femoral shaft fracture model","volume":"19","author":"Lichte","year":"2014","journal-title":"Eur. J. Med. Res."},{"issue":"2","key":"10.1016\/j.aanat.2015.02.005_bib0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cyto.2007.11.003","article-title":"Absence of endogenous interleukin-10 enhanced organ dysfunction and mortality associated to zymosan-induced multiple organ dysfunction syndrome","volume":"41","author":"Malleo","year":"2008","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.aanat.2015.02.005_bib0120","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1016\/j.jss.2010.11.914","article-title":"Models of lower extremity damage in mice: time course of organ damage and immune response","volume":"166","author":"Menzel","year":"2011","journal-title":"J. Surg. Res."},{"issue":"10","key":"10.1016\/j.aanat.2015.02.005_bib0125","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.4049\/jimmunol.151.10.5666","article-title":"Protective effects of IL-4 and IL-10 against immune complex-induced lung injury","volume":"151","author":"Mulligan","year":"1993","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.aanat.2015.02.005_bib0130","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","article-title":"Anti-inflammatory cytokines","volume":"117","author":"Opal","year":"2000","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.aanat.2015.02.005_bib0135","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cyto.2012.05.028","article-title":"Inhalative vs. systemic IL-10 administration: differences in the systemic inflammatory response and end-organ inflammation following hemorrhagic shock","volume":"60","author":"Pfeifer","year":"2012","journal-title":"Cytokine"},{"issue":"7","key":"10.1016\/j.aanat.2015.02.005_bib0140","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"issue":"8","key":"10.1016\/j.aanat.2015.02.005_bib0145","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1365-3156.2011.02801.x","article-title":"Murine cerebral malaria: histopathology and ICAM 1 immunohistochemistry of the inner ear","volume":"16","author":"Schmutzhard","year":"2011","journal-title":"Trop. Med. Int. Health"},{"issue":"4","key":"10.1016\/j.aanat.2015.02.005_bib0150","doi-asserted-by":"crossref","first-page":"C1180","DOI":"10.1152\/ajpcell.2001.281.4.C1180","article-title":"Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury","volume":"281","author":"Schwacha","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.aanat.2015.02.005_bib0155","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/00005373-199805000-00022","article-title":"Cytokines and adhesion molecules in elective and accidental trauma-related ischemia\/reperfusion","volume":"44","author":"Seekamp","year":"1998","journal-title":"J. Trauma"},{"issue":"3","key":"10.1016\/j.aanat.2015.02.005_bib0160","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1189\/jlb.0910538","article-title":"The paradox of the neutrophil's role in tissue injury","volume":"89","author":"Segel","year":"2011","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.aanat.2015.02.005_bib0165","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0039-6060(99)70180-7","article-title":"What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant?","volume":"126","author":"Song","year":"1999","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.aanat.2015.02.005_bib0170","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00005373-199908000-00025","article-title":"Early biochemical characterization of soft-tissue trauma and fracture trauma","volume":"47","author":"Strecker","year":"1999","journal-title":"J. Trauma"},{"issue":"3","key":"10.1016\/j.aanat.2015.02.005_bib0175","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/01.shk.0000196497.49683.13","article-title":"Leukocyte\u2013endothelial interactions via ICAM-1 are detrimental in polymicrobial sepsis","volume":"25","author":"van Griensven","year":"2006","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.aanat.2015.02.005_bib0180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/01.SHK.0000071062.67193.b6","article-title":"Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion","volume":"20","author":"Welborn","year":"2003","journal-title":"Shock"}],"container-title":["Annals of Anatomy - Anatomischer Anzeiger"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940960215000308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940960215000308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T17:24:24Z","timestamp":1691515464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940960215000308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":37,"alternative-id":["S0940960215000308"],"URL":"https:\/\/doi.org\/10.1016\/j.aanat.2015.02.005","relation":{},"ISSN":["0940-9602"],"issn-type":[{"value":"0940-9602","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhalative IL-10 treatment after bilateral femoral fractures affect pulmonary inflammation in mice","name":"articletitle","label":"Article Title"},{"value":"Annals of Anatomy - Anatomischer Anzeiger","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aanat.2015.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}