{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:37:44Z","timestamp":1780432664813,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","award":["600043"],"award-info":[{"award-number":["600043"]}],"id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Invitation Research Fund","award":["IN59326"],"award-info":[{"award-number":["IN59326"]}]},{"name":"Faculty of Medicine, Khon Kaen University, Thailand"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Anatomy - Anatomischer Anzeiger"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.aanat.2017.11.005","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T18:39:51Z","timestamp":1513795191000},"page":"82-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Carthamus tinctorius L. extract improves hemodynamic and vascular alterations in a rat model of renovascular hypertension through Ang II-AT 1 R-NADPH oxidase pathway"],"prefix":"10.1016","volume":"216","author":[{"given":"Sarawoot","family":"Bunbupha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutamas","family":"Wunpathe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putcharawipa","family":"Maneesai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thewarid","family":"Berkban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upa","family":"Kukongviriyapan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerapol","family":"Kukongviriyapan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichat","family":"Prachaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8114-5954","authenticated-orcid":false,"given":"Poungrat","family":"Pakdeechote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aanat.2017.11.005_bib0005","first-page":"386","article-title":"Antidiabetic effect of hydroalcoholic extract of Carthamus tinctorius L. in alloxan-induced diabetic rats","volume":"17","author":"Asgary","year":"2012","journal-title":"J. Res. Med. Sci."},{"key":"10.1016\/j.aanat.2017.11.005_bib0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/01.HYP.0000196728.05488.c3","article-title":"Peroxisome proliferator-activated receptor gamma regulates angiotensin II-stimulated phosphatidylinositol 3-kinase and mitogen-activated protein kinase in blood vessels in vivo","volume":"47","author":"Benkirane","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.aanat.2017.11.005_bib0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.niox.2014.09.001","article-title":"Curcumin improves endothelial dysfunction and vascular remodeling in 2K-1C hypertensive rats by raising nitric oxide availability and reducing oxidative stress","volume":"42","author":"Boonla","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.aanat.2017.11.005_bib0020","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.3390\/nu7075252","article-title":"Peptides-derived from Thai rice bran improves endothelial function in 2K-1C renovascular hypertensive rats","volume":"7","author":"Boonla","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.aanat.2017.11.005_bib0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aanat.2017.03.007","article-title":"Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47phox and iNOS in nitric oxide deficient rats","volume":"212","author":"Boonprom","year":"2017","journal-title":"Ann. Anat."},{"key":"10.1016\/j.aanat.2017.11.005_bib0030","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1515\/jbcpp-2016-0145","article-title":"Effects of peripherally and centrally applied ghrelin on the oxidative stress induced by renin angiotensin system in a rat model of renovascular hypertension","volume":"28","author":"Boshra","year":"2017","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0035","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1113\/expphysiol.2014.079855","article-title":"Mechanisms of renal sympathetic activation in renovascular hypertension","volume":"100","author":"Campos","year":"2015","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0040","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/01.RES.38.4.315","article-title":"Blood pressure and plasma angiotensin II concentration after renal artery constriction and angiotensin infusion in the dog. (5-Isoleucine)angiotensin II and its breakdown fragments in dog blood","volume":"38","author":"Caravaggi","year":"1976","journal-title":"Circ. Res."},{"key":"10.1016\/j.aanat.2017.11.005_bib0045","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.freeradbiomed.2009.02.011","article-title":"Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension","volume":"46","author":"Castro","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.aanat.2017.11.005_bib0050","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.matbio.2012.01.009","article-title":"Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension","volume":"31","author":"Ceron","year":"2012","journal-title":"Matrix Biol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.freeradbiomed.2013.06.033","article-title":"Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-beta and MMPs: and decreases vascular remodeling in renovascular hypertension","volume":"65","author":"Ceron","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.aanat.2017.11.005_bib0060","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00210-012-0798-z","article-title":"Euterpe oleracea Mart.-derived polyphenols prevent endothelial dysfunction and vascular structural changes in renovascular hypertensive rats: role of oxidative stress","volume":"385","author":"da Costa","year":"2012","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0065","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1172\/JCI79423","article-title":"Limiting reductive stress for treating in-stent stenosis: the heart of the matter?","volume":"124","author":"de Haan","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.aanat.2017.11.005_bib0070","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/ajcp\/66.2.416","article-title":"A sensitive fluorimetric assay for serum angiotensin-converting enzyme","volume":"66","author":"Friedland","year":"1976","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0075","first-page":"1368","article-title":"Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms","volume":"19","author":"Fu","year":"2016","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.aanat.2017.11.005_bib0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.phrs.2016.10.015","article-title":"NADPH oxidases and vascular remodeling in cardiovascular diseases","volume":"114","author":"Garcia-Redondo","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.aanat.2017.11.005_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.CIR.32.1.1","article-title":"Renovascular hypertension due to renal ischemia","volume":"32","author":"Goldblatt","year":"1965","journal-title":"Circulation"},{"key":"10.1016\/j.aanat.2017.11.005_bib0090","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1073\/pnas.73.5.1722","article-title":"The effect of main artery occlusion of one kidney on blood pressure of dogs","volume":"73","author":"Goldblatt","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.aanat.2017.11.005_bib0095","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.redox.2015.08.017","article-title":"Atorvastatin and sildenafil decrease vascular TGF-beta levels and MMP-2 activity and ameliorate arterial remodeling in a model of renovascular hypertension","volume":"6","author":"Guimaraes","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0100","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1056\/NEJMoa013591","article-title":"Endothelial function and oxidative stress in renovascular hypertension","volume":"346","author":"Higashi","year":"2002","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.aanat.2017.11.005_bib0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/ajh\/4.1.51","article-title":"Coronary vascular remodeling and myocardial fibrosis in the rat with renovascular hypertension. Response to captopril","volume":"4","author":"Jalil","year":"1991","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.aanat.2017.11.005_bib0110","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1161\/01.CIR.0000124223.00113.A4","article-title":"gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension","volume":"109","author":"Jung","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.aanat.2017.11.005_bib0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00004872-199109010-00003","article-title":"Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells","volume":"9","author":"Kato","year":"1991","journal-title":"J. Hypertens."},{"key":"10.1016\/j.aanat.2017.11.005_bib0120","first-page":"785","article-title":"Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin II level","volume":"27","author":"Liu","year":"1992","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.aanat.2017.11.005_bib0125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF01923359","article-title":"A simple, sensitive, non-stimulated photon counting system for detection of superoxide anion in whole blood","volume":"52","author":"Lu","year":"1996","journal-title":"Experientia"},{"key":"10.1016\/j.aanat.2017.11.005_bib0130","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2004.12.152","article-title":"Angiotensin II induces MMP-2 in a p47phox-dependent manner","volume":"328","author":"Luchtefeld","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.aanat.2017.11.005_bib0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/nu8030122","article-title":"Synergistic antihypertensive effect of Carthamus tinctorius L. extract and captopril in L-NAME-induced hypertensive rats via restoration of eNOS and AT(1)R expression","volume":"8","author":"Maneesai","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.aanat.2017.11.005_bib0140","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/hr.2016.61","article-title":"Aliskiren and l-arginine treatments restore depressed baroreflex sensitivity and decrease oxidative stress in renovascular hypertension rats","volume":"39","author":"Mengal","year":"2016","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.aanat.2017.11.005_bib0145","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.carpath.2015.11.003","article-title":"Resveratrol improves vasoprotective effects of captopril on aortic remodeling and fibrosis triggered by renovascular hypertension","volume":"25","author":"Natalin","year":"2016","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0150","first-page":"170","article-title":"Unraveling the mystery of goldblatt hypertension","volume":"13","author":"Navar","year":"1998","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.aanat.2017.11.005_bib0155","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ajh.2007.12","article-title":"Oxidative stress contributes to renovascular hypertension","volume":"21","author":"Oliveira-Sales","year":"2008","journal-title":"Am. J. Hypertens."},{"issue":"Suppl. 2","key":"10.1016\/j.aanat.2017.11.005_bib0160","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.33549\/physiolres.931396","article-title":"Contribution of captopril thiol group to the prevention of spontaneous hypertension","volume":"56","author":"Pechanova","year":"2007","journal-title":"Physiol. Res."},{"key":"10.1016\/j.aanat.2017.11.005_bib0165","first-page":"108","article-title":"Vascular hypertrophy in hypertension: role of the renin-angiotensin system","volume":"65","author":"Rosendorff","year":"1998","journal-title":"Mt. Sinai J. Med."},{"key":"10.1016\/j.aanat.2017.11.005_bib0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1590\/1414-431X20144191","article-title":"Combined aliskiren and l-arginine treatment has antihypertensive effects and prevents vascular endothelial dysfunction in a model of renovascular hypertension","volume":"48","author":"Santuzzi","year":"2015","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.aanat.2017.11.005_bib0175","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1006\/abio.1995.1079","article-title":"Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP+ when the Griess reaction is used to assay for nitrite","volume":"224","author":"Verdon","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.aanat.2017.11.005_bib0180","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0975-7406.154437","article-title":"Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats","volume":"7","author":"Visnagri","year":"2015","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.aanat.2017.11.005_bib0185","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/cvr\/cvt225","article-title":"Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension","volume":"100","author":"Wakui","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.aanat.2017.11.005_bib0190","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1172\/JCI113142","article-title":"Angiotensin-converting enzyme labeled with [3H]captopril. Tissue localizations and changes in different models of hypertension in the rat","volume":"80","author":"Wilson","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.aanat.2017.11.005_bib0195","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12012-015-9335-x","article-title":"Paraventricular nucleus infusion of epigallocatechin-3-O-gallate improves renovascular hypertension","volume":"16","author":"Yi","year":"2016","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0200","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1248\/cpb.45.1910","article-title":"Antioxidative compounds isolated from safflower (Carthamus tinctorius L.) oil cake","volume":"45","author":"Zhang","year":"1997","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.aanat.2017.11.005_bib0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jep.2013.10.050","article-title":"Towards a better understanding of medicinal uses of Carthamus tinctorius L. in traditional Chinese medicine: a phytochemical and pharmacological review","volume":"151","author":"Zhou","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.aanat.2017.11.005_bib0210","article-title":"Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats","author":"Zhu","year":"2017","journal-title":"J. Cell Biochem."}],"container-title":["Annals of Anatomy - Anatomischer Anzeiger"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940960217301516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940960217301516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T23:00:40Z","timestamp":1660172440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940960217301516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":42,"alternative-id":["S0940960217301516"],"URL":"https:\/\/doi.org\/10.1016\/j.aanat.2017.11.005","relation":{},"ISSN":["0940-9602"],"issn-type":[{"value":"0940-9602","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carthamus tinctorius L. extract improves hemodynamic and vascular alterations in a rat model of renovascular hypertension through Ang II-AT1R-NADPH oxidase pathway","name":"articletitle","label":"Article Title"},{"value":"Annals of Anatomy - Anatomischer Anzeiger","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aanat.2017.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}