{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:12:56Z","timestamp":1787875976515,"version":"build-2784847793"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"the National Institute of Environmental Health and Safety","award":["R42-ES016728"],"award-info":[{"award-number":["R42-ES016728"]}]},{"name":"the National Institute of Environmental Health and Safety","award":["R41-ES018021"],"award-info":[{"award-number":["R41-ES018021"]}]},{"name":"the National Institute of Occupational Health and Safety"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytical Biochemistry"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.ab.2010.01.037","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T04:36:46Z","timestamp":1265085406000},"page":"251-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate"],"prefix":"10.1016","volume":"400","author":[{"given":"Adam V.","family":"Wisnewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Redlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ab.2010.01.037_bib1","series-title":"Polyisocyanates","author":"Wisnewski","year":"2006"},{"key":"10.1016\/j.ab.2010.01.037_bib2","series-title":"Environmental and Occupational Medicine","first-page":"502","article-title":"Health effects of isocyanates","author":"Redlich","year":"2007"},{"key":"10.1016\/j.ab.2010.01.037_bib3","doi-asserted-by":"crossref","first-page":"D82","DOI":"10.1080\/15459620903256427","article-title":"Measurements of airborne methylene diphenyl diisocyanate concentration in the US workplace [comment]","volume":"6","author":"Redlich","year":"2009","journal-title":"J. Occup. Environ. Hyg."},{"key":"10.1016\/j.ab.2010.01.037_bib4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00420-006-0150-3","article-title":"Biological monitoring of workers exposed to 4,4\u2032-methylenediphenyl diisocyanate (MDI) in 19 French polyurethane industries","volume":"80","author":"Robert","year":"2007","journal-title":"Intl. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.ab.2010.01.037_bib5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/13547500701395636","article-title":"Determination of isocyanate biomarkers in construction site workers","volume":"12","author":"Sabbioni","year":"2007","journal-title":"Biomarkers"},{"key":"10.1016\/j.ab.2010.01.037_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/15459620601133779","article-title":"Airborne methylene diphenyl diisocyanate (MDI) concentrations associated with the application of polyurethane spray foam in residential construction","volume":"4","author":"Lesage","year":"2007","journal-title":"J. Occup. Environ. Hyg."},{"key":"10.1016\/j.ab.2010.01.037_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1081-1206(10)61647-X","article-title":"Recent developments in diisocyanate asthma","volume":"90","author":"Liu","year":"2003","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.ab.2010.01.037_bib8","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1164\/ajrccm.162.6.2002086","article-title":"Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo","volume":"162","author":"Wisnewski","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ab.2010.01.037_bib9","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jaci.2004.03.009","article-title":"Isocyanate vapor-induced antigenicity of human albumin","volume":"113","author":"Wisnewski","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ab.2010.01.037_bib10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/ACI.0b013e3280895d22","article-title":"Developments in laboratory diagnostics for isocyanate asthma","volume":"7","author":"Wisnewski","year":"2007","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.ab.2010.01.037_bib11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jaci.2006.06.026","article-title":"Biophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma","volume":"118","author":"Ye","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ab.2010.01.037_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0091-6749(97)70104-0","article-title":"T-cell receptor V beta gene segment expression in diisocyanate-induced occupational asthma","volume":"99","author":"Bernstein","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ab.2010.01.037_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1567-5769(01)00174-6","article-title":"Diisocyanate asthma: clinical aspects and immunopathogenesis","volume":"2","author":"Redlich","year":"2002","journal-title":"Intl. Immunopharmacol."},{"key":"10.1016\/j.ab.2010.01.037_bib14","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1365-2222.2008.02982.x","article-title":"Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI\u2013albumin conjugates","volume":"38","author":"Wisnewski","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ab.2010.01.037_bib15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0091-6749(89)90487-9","article-title":"Immunologic specificity of isocyanate-induced IgE antibodies in serum from 10 sensitized workers","volume":"83","author":"Wass","year":"1989","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ab.2010.01.037_bib16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000237325","article-title":"EAST and CAP specificity for the evaluation of IgE and IgG antibodies to diisocyanate\u2013HSA conjugates","volume":"110","author":"Baur","year":"1996","journal-title":"Intl. Arch. Allergy Immunol."},{"key":"10.1016\/j.ab.2010.01.037_bib17","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/00003246-200104000-00043","article-title":"New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome","volume":"29","author":"Ishizaka","year":"2001","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ab.2010.01.037_bib18","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1021\/bi9625509","article-title":"Identification of N(G)-methylarginine residues in human heterogeneous RNP protein A1: Phe\/Gly-Gly-Gly-Arg-Gly-Gly-Gly\/Phe is a preferred recognition motif","volume":"36","author":"Kim","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.ab.2010.01.037_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02752260","article-title":"Enzymatic cleavage and HPLC peptide mapping of proteins","volume":"8","author":"Williams","year":"1997","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.ab.2010.01.037_bib20","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1164\/rccm.200702-215OC","article-title":"Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates","volume":"176","author":"Pronk","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ab.2010.01.037_bib21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ajim.1058","article-title":"Subclinical immunologic and physiologic responses in hexamethylene diisocyanate-exposed auto body shop workers","volume":"39","author":"Redlich","year":"2001","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.ab.2010.01.037_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0091-6749(83)90100-8","article-title":"Immunologic cross-reactivity between different albumin-bound isocyanates","volume":"71","author":"Baur","year":"1983","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ab.2010.01.037_bib23","series-title":"Chemistry and Technology of Isocyanates","author":"Urlich","year":"1996"},{"key":"10.1016\/j.ab.2010.01.037_bib24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tiv.2007.01.008","article-title":"Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein","volume":"21","author":"Aleksic","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ab.2010.01.037_bib25","first-page":"22","article-title":"Serum albumin: structure and characterization of its ligand binding sites","volume":"1","author":"Brown","year":"1982"},{"key":"10.1016\/j.ab.2010.01.037_bib26","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1074\/jbc.M410973200","article-title":"Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity","volume":"280","author":"Ahmed","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ab.2010.01.037_bib27","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1126\/science.8128252","article-title":"Coatomer interaction with di-lysine endoplasmic reticulum retention motifs","volume":"263","author":"Cosson","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ab.2010.01.037_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-5793(88)80924-4","article-title":"Identification of lysine residue 199 of human serum albumin as a binding site for benzylpenicilloyl groups","volume":"239","author":"Yvon","year":"1988","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ab.2010.01.037_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0005-2795(78)90002-8","article-title":"Reactions of 2,6-dinitro-4-trifluoromethylbenzenesulfonate with human serum albumin","volume":"534","author":"Gerig","year":"1978","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ab.2010.01.037_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0014-5793(76)80496-6","article-title":"Lysine residue 199 of human serum albumin is modified by acetylsalicyclic acid","volume":"66","author":"Walker","year":"1976","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ab.2010.01.037_bib31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0305-0491(88)90141-1","article-title":"The reactivity of p-nitrophenyl acetate with serum albumins","volume":"91","author":"Awad-Elkarim","year":"1988","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.ab.2010.01.037_bib32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0003-2697(02)00462-1","article-title":"Identification of the amino acids of human serum albumin involved in the reaction with the naproxen acyl coenzyme A thioester using liquid chromatography combined with fluorescence and mass spectrometric detection","volume":"312","author":"Olsen","year":"2003","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ab.2010.01.037_bib33","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1023\/A:1012138604016","article-title":"Species differences of serum albumins: I. Drug binding sites","volume":"14","author":"Kosa","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ab.2010.01.037_bib34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1042\/BJ20041624","article-title":"Probing conformational changes of human serum albumin due to unsaturated fatty acid binding by chemical cross-linking and mass spectrometry","volume":"387","author":"Huang","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.ab.2010.01.037_bib35","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jasms.2004.05.004","article-title":"Probing three-dimensional structure of bovine serum albumin by chemical cross-linking and mass spectrometry","volume":"15","author":"Huang","year":"2004","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.ab.2010.01.037_bib36","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.jasms.2009.04.016","article-title":"Structural elucidation of isocyanate\u2013peptide adducts using tandem mass spectrometry","volume":"20","author":"Hettick","year":"2009","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.ab.2010.01.037_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/tx00005a005","article-title":"Intra- and intermolecular reactions of 4,4\u2032-diisocyanatodiphenylmethane with human serum albumin","volume":"1","author":"Jin","year":"1988","journal-title":"Chem. Res. Toxicol."}],"container-title":["Analytical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269710000680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269710000680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T20:57:21Z","timestamp":1757710641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269710000680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0003269710000680"],"URL":"https:\/\/doi.org\/10.1016\/j.ab.2010.01.037","relation":{},"ISSN":["0003-2697"],"issn-type":[{"value":"0003-2697","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate","name":"articletitle","label":"Article Title"},{"value":"Analytical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ab.2010.01.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}