{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:00:59Z","timestamp":1773658859041,"version":"3.50.1"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytical Biochemistry"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.ab.2014.04.018","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T03:58:32Z","timestamp":1398311912000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Liquid chromatography\/electrospray ionisation\u2013tandem mass spectrometry quantification of GM2 gangliosides in human peripheral cells and plasma"],"prefix":"10.1016","volume":"458","author":[{"given":"Maria","family":"Fuller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Duplock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne K.","family":"Hein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte A.","family":"Rigat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don J.","family":"Mahuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ab.2014.04.018_b0005","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1098\/rstb.2003.1265","article-title":"Biosynthesis and degradation of mammalian glycosphingolipids","volume":"358","author":"Sandhoff","year":"2003","journal-title":"Philos. Trans. R. Soc. Lond. B"},{"key":"10.1016\/j.ab.2014.04.018_b0010","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1007\/s11064-012-0744-y","article-title":"Functional roles of gangliosides in neurodevelopment: an overview of recent advances","volume":"37","author":"Yu","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ab.2014.04.018_b0015","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"3827","article-title":"The GM2 gangliosidoses","author":"Gravel","year":"2001"},{"key":"10.1016\/j.ab.2014.04.018_b0020","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF00219337","article-title":"Quantitative correlation between the residual activity of beta-hexosaminidase A and arylsulfatase A and the severity of the resulting lysosomal storage disease","volume":"88","author":"Leinekugel","year":"1992","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ab.2014.04.018_b0025","doi-asserted-by":"crossref","first-page":"9150","DOI":"10.1074\/jbc.M609304200","article-title":"Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis","volume":"282","author":"Maegawa","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ab.2014.04.018_b0030","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/mt.2011.27","article-title":"Therapeutic potential of intracerebroventricular replacement of modified human \u03b2-hexosaminidase B for GM2 gangliosidosis","volume":"19","author":"Matsuoka","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ab.2014.04.018_b0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0003-2697(90)90519-F","article-title":"Immunochemical detection of glycosphingolipids on thin-layer chromatograms","volume":"188","author":"Kniep","year":"1990","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ab.2014.04.018_b0040","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0022-2275(20)34366-2","article-title":"Quantitative analysis of brain gangliosides by high performance liquid chromatography of their perbenzoyl derivatives","volume":"26","author":"Ullman","year":"1985","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ab.2014.04.018_b0045","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cca.2006.10.010","article-title":"Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies","volume":"378","author":"Tsuji","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ab.2014.04.018_b0050","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/rcm.4716","volume":"24","author":"Ikeda","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.ab.2014.04.018_b0055","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1194\/jlr.D800038-JLR200","article-title":"Targeted analysis of ganglioside and sulphatide molecular species by LC\/ESI\u2013MS\/MS with theoretically expanded multiple reaction monitoring","volume":"49","author":"Ikeda","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ab.2014.04.018_b0060","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ymgme.2010.09.004","article-title":"An open-label phase I\/II clinical trial of pyrimethamine for the treatment of patients affected with chronic GM2 gangliosidosis (Tay-Sachs or Sandhoff variants)","volume":"102","author":"Clarke","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ab.2014.04.018_b0065","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ab.2014.04.018_b0070","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ab.2014.04.018_b0075","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ymeth.2005.01.009","article-title":"Sphingolipidomics: high-throughput, structure specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry","volume":"36","author":"Merrill","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.ab.2014.04.018_b0080","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1172\/JCI109341","article-title":"Excretion-reuptake route of beta-hexosaminidase in normal and I-cell disease cultured fibroblasts","volume":"63","author":"Vladutiu","year":"1979","journal-title":"J. Clin. Invest."}],"container-title":["Analytical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269714001675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269714001675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T21:11:47Z","timestamp":1757711507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269714001675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":16,"alternative-id":["S0003269714001675"],"URL":"https:\/\/doi.org\/10.1016\/j.ab.2014.04.018","relation":{},"ISSN":["0003-2697"],"issn-type":[{"value":"0003-2697","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquid chromatography\/electrospray ionisation\u2013tandem mass spectrometry quantification of GM2 gangliosides in human peripheral cells and plasma","name":"articletitle","label":"Article Title"},{"value":"Analytical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ab.2014.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}