{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:09:35Z","timestamp":1758046175529,"version":"3.44.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012164","name":"National High-tech Research and Development Program","doi-asserted-by":"publisher","award":["2018ZX09101001-003"],"award-info":[{"award-number":["2018ZX09101001-003"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytical Biochemistry"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ab.2021.114291","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T11:44:51Z","timestamp":1624189491000},"page":"114291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Development and validation of a reporter gene assay for bioactivity determination of Anti-CGRP monoclonal antibodies"],"prefix":"10.1016","volume":"634","author":[{"given":"Xiao","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanfei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-6069","authenticated-orcid":false,"given":"Junzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ab.2021.114291_bib1","series-title":"Neurological Disorders and Pregnancy","first-page":"13","article-title":"2 - headache in pregnancy","author":"Elliott","year":"2011"},{"author":"World Health Organization","key":"10.1016\/j.ab.2021.114291_bib2"},{"issue":"Suppl 1","key":"10.1016\/j.ab.2021.114291_bib3","first-page":"9","article-title":"The international classification of headache disorders: second ed","volume":"24","year":"2004","journal-title":"Cephalalgia"},{"key":"10.1016\/j.ab.2021.114291_bib4","first-page":"17","article-title":"Migraine headache prophylaxis","volume":"99","author":"Ha","year":"2019","journal-title":"Am. Fam. Physician"},{"issue":"Suppl 3","key":"10.1016\/j.ab.2021.114291_bib5","first-page":"S76","article-title":"Mood and anxiety disorders in chronic headache","volume":"46","author":"Baskin","year":"2006","journal-title":"Headache"},{"key":"10.1016\/j.ab.2021.114291_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/298240a0","article-title":"Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products","volume":"298","author":"Amara","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.ab.2021.114291_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1124\/pr.54.2.233","article-title":"International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors","volume":"54","author":"Poyner","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ab.2021.114291_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bph.14075","article-title":"Update on the pharmacology of calcitonin\/CGRP family of peptides: IUPHAR Review 25","volume":"175","author":"Hay","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ab.2021.114291_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: physiology and pathophysiology","volume":"94","author":"Russell","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ab.2021.114291_bib10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1152\/physrev.00037.2003","article-title":"Vascular actions of calcitonin gene-related peptide and adrenomedullin","volume":"84","author":"Brain","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ab.2021.114291_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1146\/annurev-pharmtox-010814-124701","article-title":"Calcitonin gene-related peptide (CGRP): a new target for migraine","volume":"55","author":"Russo","year":"2015","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ab.2021.114291_bib12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2165\/11534920-000000000-00000","article-title":"Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine","volume":"24","author":"Durham","year":"2010","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ab.2021.114291_bib13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","author":"McLatchie","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ab.2021.114291_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bph.14075","article-title":"Update on the pharmacology of calcitonin\/CGRP family of peptides: IUPHAR Review 25","volume":"175","author":"Hay","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ab.2021.114291_bib15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/head.13064","article-title":"CGRP and its receptors","volume":"57","author":"Hay","year":"2017","journal-title":"Headache"},{"key":"10.1016\/j.ab.2021.114291_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/head.13081","article-title":"The trigeminovascular pathway: role of CGRP and CGRP receptors in migraine","volume":"57","author":"Edvinsson","year":"2017","journal-title":"Headache"},{"key":"10.1016\/j.ab.2021.114291_bib17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies - successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ab.2021.114291_bib18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s40263-019-00630-6","article-title":"Pathophysiological mechanisms in migraine and the identification of new therapeutic targets","volume":"33","author":"Haanes","year":"2019","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ab.2021.114291_bib19","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2174\/1389450120666190131114244","article-title":"Insight into pain modulation: nociceptors sensitization and therapeutic targets","volume":"20","author":"Khan","year":"2019","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ab.2021.114291_bib20","first-page":"20","article-title":"C-fibers may modulate adjacent A delta-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system","author":"Edvinsson","year":"2019","journal-title":"J.\u00a0Headache Pain"},{"key":"10.1016\/j.ab.2021.114291_bib21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fncel.2018.00233","article-title":"Vascular Contributions to migraine: time to revisit?","volume":"12","author":"Mason","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ab.2021.114291_bib22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0166-2236(85)90050-5","article-title":"Functional-role of perivascular peptides in the control of cerebral-circulation","volume":"8","author":"Edvinsson","year":"1985","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ab.2021.114291_bib23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1113\/jphysiol.1994.sp020045","article-title":"Calcitonin gene-related peptide activated ATP-sensitive K currents in rabbit arterial smooth muscle via protein kinase A","volume":"475","author":"Quayle","year":"1994","journal-title":"Journal of Physiology-London"},{"key":"10.1016\/j.ab.2021.114291_bib24","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/head.13529","article-title":"CGRP and the trigeminal system in migraine","volume":"59","author":"Iyengar","year":"2019","journal-title":"Headache"},{"key":"10.1016\/j.ab.2021.114291_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s10194-018-0848-0","article-title":"The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system","volume":"19","author":"Messlinger","year":"2018","journal-title":"J.\u00a0Headache Pain"},{"key":"10.1016\/j.ab.2021.114291_bib26","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1177\/0333102418786261","article-title":"Current understanding of trigeminal ganglion structure and function in headache","volume":"39","author":"Messlinger","year":"2019","journal-title":"Cephalalgia"},{"key":"10.1016\/j.ab.2021.114291_bib27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/sj.bjp.0703110","article-title":"Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist","volume":"129","author":"Doods","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ab.2021.114291_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(01)01532-1","article-title":"Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells","volume":"434","author":"Edvinsson","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ab.2021.114291_bib29","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa030505","article-title":"Calcitonin gene-related peptide receptor antagonist BIBN4096BS for the acute treatment of migraine","volume":"350","author":"Olesen","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ab.2021.114291_bib30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1468-2982.2005.00869.x","article-title":"Presence and function of the calcitonin gene-related peptide receptor on rat pial arteries investigated in\u00a0vitro and in\u00a0vivo","volume":"25","author":"Petersen","year":"2005","journal-title":"Cephalalgia"},{"key":"10.1016\/j.ab.2021.114291_bib31","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1212\/WNL.0b013e3181b87942","article-title":"Randomized, controlled trial of telcagepant for the acute treatment of migraine","volume":"73","author":"Connor","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.ab.2021.114291_bib32","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1177\/0333102411398399","article-title":"Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine","volume":"31","author":"Hewitt","year":"2011","journal-title":"Cephalalgia"},{"key":"10.1016\/j.ab.2021.114291_bib33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/0333102413500727","article-title":"BMS-927711 for the acute treatment of migraine: a double-blind, randomized, placebo controlled, dose-ranging trial","volume":"34","author":"Marcus","year":"2014","journal-title":"Cephalalgia"},{"key":"10.1016\/j.ab.2021.114291_bib34","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/0333102416653233","article-title":"A\u00a0phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine","volume":"36","author":"Voss","year":"2016","journal-title":"Cephalalgia"},{"key":"10.1016\/j.ab.2021.114291_bib35","first-page":"144","article-title":"Efficacy, safety,and tolerability of orally administered Atogepant for the prevention of episodic migraine: results from a phase 2b\/3 study","volume":"38","author":"Goadsby","year":"2018","journal-title":"Cephalalgia"},{"key":"10.1016\/j.ab.2021.114291_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/17425255.2018.1416097","article-title":"Side effects associated with current and prospective antimigraine pharmacotherapies","volume":"14","author":"Gonzalez-Hernandez","year":"2018","journal-title":"Expet Opin. Drug Metabol. Toxicol."},{"key":"10.1016\/j.ab.2021.114291_bib37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10072-019-03769-8","article-title":"CGRP and headache: A brief review","volume":"40","author":"Tepper","year":"2019","journal-title":"Neurol. Sci."},{"year":"1999","series-title":"International Conference on Harmonization (ICH) Guidelines ICH Q6B, Specifications: Test Procedures and Acceptance Criteria for Biotechnological\/biological Products","key":"10.1016\/j.ab.2021.114291_bib38"},{"key":"10.1016\/j.ab.2021.114291_bib39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/molehr\/gal053","article-title":"Calcitonin gene-related peptide stimulates human villous trophoblast cell differentiation in\u00a0vitro","volume":"12","author":"Green","year":"2006","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.ab.2021.114291_bib40","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1124\/mol.108.047142","article-title":"Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function","volume":"74","author":"Qi","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ab.2021.114291_bib41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-5793(03)01250-X","article-title":"The function of conserved cysteine residues in the extracellular domain of human receptor-activity-modifying protein 1","volume":"555","author":"Steiner","year":"2003","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."},{"key":"10.1016\/j.ab.2021.114291_bib42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1124\/jpet.119.264671","article-title":"Pharmacologic characterization of ALD403, a potent neutralizing humanized monoclonal antibody against the calcitonin gene-related peptide","volume":"374","author":"Garcia-Martinez","year":"2020","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ab.2021.114291_bib43","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1124\/jpet.115.227793","article-title":"Pharmacologic characterization of AMG 334, a potent and selective human monoclonal antibody against the calcitonin gene-related peptide receptor","volume":"356","author":"Shi","year":"2016","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ab.2021.114291_bib44","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1471-4159.2004.02833.x","article-title":"Calcitonin gene-related peptide regulates gene transcription in primary afferent neurons","volume":"91","author":"Anderson","year":"2004","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.ab.2021.114291_bib45","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1210\/endo.140.6.6783","article-title":"A\u00a0receptor activity modifying protein (RAMP)2-Dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1","volume":"140","author":"Buhlmann","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ab.2021.114291_bib46","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0196-9781(01)00536-8","article-title":"Adrenomedullin signalling in cardiomyocytes is dependent upon CRLR and RAMP2 expression","volume":"22","author":"Autelitano","year":"2001","journal-title":"Peptides"},{"key":"10.1016\/j.ab.2021.114291_bib47","series-title":"Development of Reporter Gene Assays to Determine the Bioactivity of Biopharmaceuticals","first-page":"107466","author":"Wang","year":"2019"},{"key":"10.1016\/j.ab.2021.114291_bib48","doi-asserted-by":"crossref","first-page":"14294","DOI":"10.1074\/jbc.M109661200","article-title":"Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists","volume":"277","author":"Mallee","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ab.2021.114291_bib49","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1210\/en.2011-1459","article-title":"Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling","volume":"153","author":"Egea","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.ab.2021.114291_bib50","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/j.pain.0000000000000831","article-title":"The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine","volume":"158","author":"Iyengar","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.ab.2021.114291_bib51","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0022-3565(25)12267-2","article-title":"Regulation of CREB expression: in\u00a0vivo evidence for a functional role in morphine action in the nucleus accumbens","volume":"276","author":"Widnell","year":"1996","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ab.2021.114291_bib52","doi-asserted-by":"crossref","first-page":"18743","DOI":"10.1074\/jbc.M800296200","article-title":"Mechanisms mediating the enhanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons","volume":"283","author":"Simonetti","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ab.2021.114291_bib53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/164_2018_130","article-title":"CGRP receptor signalling pathways","volume":"255","author":"Cottrell","year":"2019","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ab.2021.114291_bib54","first-page":"2643","article-title":"Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture","volume":"33","author":"Biedler","year":"1973","journal-title":"Canc. Res."},{"key":"10.1016\/j.ab.2021.114291_bib55","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/ijc.2910440314","article-title":"Stability of phenotypic and genotypic traits during the establishment of a human neuro-blastoma cell-line, IGR-N-835","volume":"44","author":"Bettanrenaud","year":"1989","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.ab.2021.114291_bib56","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/sj.bjp.0704761","article-title":"Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines","volume":"136","author":"Choksi","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ab.2021.114291_bib57","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1081\/RRS-200035220","article-title":"From transcription profile to expression: the signaling repertoire of the SK-N-MC neuroepithelioma cell-line","volume":"24","author":"Bader","year":"2004","journal-title":"Journal of Receptors and Signal Transduction"},{"key":"10.1016\/j.ab.2021.114291_bib58","first-page":"4307","article-title":"Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepitheliom","volume":"48","author":"McKeon","year":"1988","journal-title":"Canc. Res."},{"key":"10.1016\/j.ab.2021.114291_bib59","doi-asserted-by":"crossref","first-page":"106647","DOI":"10.1016\/j.intimp.2020.106647","article-title":"Characterization of a reliable cell-based reporter gene assay for measuring bioactivities of therapeutic anti-interleukin-23 monoclonal antibodies","volume":"85","author":"Huang","year":"2020","journal-title":"Int. Immunopharm."}],"container-title":["Analytical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269721001925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269721001925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T21:33:38Z","timestamp":1757712818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269721001925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":59,"alternative-id":["S0003269721001925"],"URL":"https:\/\/doi.org\/10.1016\/j.ab.2021.114291","relation":{},"ISSN":["0003-2697"],"issn-type":[{"type":"print","value":"0003-2697"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a reporter gene assay for bioactivity determination of Anti-CGRP monoclonal antibodies","name":"articletitle","label":"Article Title"},{"value":"Analytical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ab.2021.114291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114291"}}