{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:48:17Z","timestamp":1792673297450,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytical Biochemistry"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ab.2021.114541","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T20:29:34Z","timestamp":1640723374000},"page":"114541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Fluorescent and colorimetric RT-LAMP as a rapid and specific qualitative method for chronic myeloid leukemia diagnosis"],"prefix":"10.1016","volume":"641","author":[{"given":"Anelis Maria","family":"Marin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila Luciola","family":"Zanette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine Marie","family":"Nardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Cili\u00e3o","family":"Munhoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Blanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8010-5077","authenticated-orcid":false,"given":"Heloisa Bruna","family":"Soligo Sanchuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francielle","family":"Bo\u00e7on de Ara\u00fajo Munhoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-161X","authenticated-orcid":false,"given":"Bruna","family":"de Oliveira Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-2897","authenticated-orcid":false,"given":"Mateus N\u00f3brega","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ab.2021.114541_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3324\/haematol.2015.139337","article-title":"Chronic myeloid leukemia: reminiscences and dreams","volume":"101","author":"Mughal","year":"2016","journal-title":"Haematologica"},{"issue":"9584","key":"10.1016\/j.ab.2021.114541_bib2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0140-6736(07)61165-9","article-title":"Chronic myeloid leukaemia","volume":"370","author":"Hehlmann","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib3","doi-asserted-by":"crossref","DOI":"10.1007\/s12185-015-1893-y","article-title":"Geographic and income variations in age at diagnosis and incidence of chronic myeloid leukemia","volume":"103","author":"Mendizabal","year":"2016","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.ab.2021.114541_bib4","unstructured":"Society AC. Key Statistics for Chronic Myeloid Leukemia."},{"key":"10.1016\/j.ab.2021.114541_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdx219","article-title":"Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","author":"Hochhaus","year":"2017","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ab.2021.114541_bib7","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.2147\/CMAR.S232752","article-title":"Monitoring of minimal residual disease (MRD) in chronic myeloid leukemia: recent advances","volume":"12","author":"Cumbo","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"9","key":"10.1016\/j.ab.2021.114541_bib8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/jclinpath-2015-203538","article-title":"BCR-ABL1 expression, RT-qPCR and treatment decisions in chronic myeloid leukaemia","volume":"69","author":"Latham","year":"2016","journal-title":"J.\u00a0Clin. Pathol."},{"issue":"3","key":"10.1016\/j.ab.2021.114541_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214305","article-title":"Diagnostic performance of the molecular BCR-ABL1 monitoring system may impact on inclusion of CML patients in stopping trials","volume":"14","author":"Spiess","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/10428194.2016.1190974","article-title":"Measurement of BCR-ABL1 transcripts on the International Scale in the United States: current status and best practices","volume":"58","author":"Arora","year":"2017","journal-title":"Leuk. Lymphoma"},{"issue":"11","key":"10.1016\/j.ab.2021.114541_bib11","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.3390\/cancers12113287","article-title":"Standardization of BCR-ABL1 p210 monitoring: from nested to digital PCR","volume":"12","author":"Jovanovski","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.ab.2021.114541_bib12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.7883\/yoken.JJID.2015.519","article-title":"Accuracy of LAMP-TB method for diagnosing tuberculosis in Haiti","volume":"69","author":"Kaku","year":"2016","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.ab.2021.114541_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2018.01.005","article-title":"Performance of the TB-LAMP diagnostic assay in reference laboratories: results from a multicentre study","author":"Pham","year":"2018","journal-title":"Int. J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/s12879-020-05250-w","article-title":"A\u00a0pooled analysis of the LAMP assay for the detection of Neisseria meningitidis","volume":"20","author":"Fan","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.ab.2021.114541_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2020.113972","article-title":"Optimization and clinical validation of dual-target RT-LAMP for SARS-CoV-2","author":"Mohon","year":"2020","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.ab.2021.114541_bib16","doi-asserted-by":"crossref","first-page":"114015","DOI":"10.1016\/j.jviromet.2020.114015","article-title":"Detection of swine influenza virus in nasal specimens by reverse transcription-loop-mediated isothermal amplification (RT-LAMP)","volume":"288","author":"Bakre","year":"2021","journal-title":"J.\u00a0Virol. Methods"},{"issue":"3","key":"10.1016\/j.ab.2021.114541_bib17","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/jam.13647","article-title":"Loop-mediated isothermal amplification (LAMP): a versatile technique for detection of micro-organisms","volume":"124","author":"Wong","year":"2018","journal-title":"J.\u00a0Appl. Microbiol."},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/v12010019","article-title":"Loop-mediated isothermal amplification (LAMP) for the diagnosis of Zika virus: a review","volume":"12","author":"Silva","year":"2019","journal-title":"Viruses"},{"issue":"10","key":"10.1016\/j.ab.2021.114541_bib19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/1348-0421.12734","article-title":"Detecting amplicons of loop-mediated isothermal amplification","volume":"63","author":"Shirato","year":"2019","journal-title":"Microbiol. Immunol."},{"issue":"13","key":"10.1016\/j.ab.2021.114541_bib20","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.7150\/thno.33980","article-title":"One-step colorimetric genotyping of single nucleotide polymorphism using probe-enhanced loop-mediated isothermal amplification (PE-LAMP)","volume":"9","author":"Ding","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/jcar.JCar_6_20","article-title":"Detection of epidermal growth factor receptor T790M mutation by allele-specific loop mediated isothermal amplification","volume":"19","author":"Arjuna","year":"2020","journal-title":"J.\u00a0Carcinog."},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib22","first-page":"2","article-title":"AS-LAMP: a new and alternative method for genotyping","volume":"12","author":"Gill","year":"2020","journal-title":"Avicenna J. Med. Biotechnol. (AJMB)"},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib23","first-page":"7","article-title":"Molecular measurement of BCR-ABL transcript variations in chronic myeloid leukemia patients in cytogenetic remission","volume":"10","author":"Serpa","year":"2010","journal-title":"BMC Blood Disord."},{"issue":"7","key":"10.1016\/j.ab.2021.114541_bib24","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/ajh.23212","article-title":"Fast-mode duplex qPCR for BCR-ABL1 molecular monitoring: innovation, automation, and harmonization","volume":"87","author":"Gerrard","year":"2012","journal-title":"Am. J. Hematol."},{"issue":"6","key":"10.1016\/j.ab.2021.114541_bib25","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1373\/clinchem.2012.196477","article-title":"Establishment and validation of analytical reference panels for the standardization of quantitative BCR-ABL1 measurements on the international scale","volume":"59","author":"White","year":"2013","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ab.2021.114541_bib26","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4939-0733-5_11","article-title":"Real-time quantification assay to monitor BCR-ABL1 transcripts in chronic myeloid leukemia","author":"Foskett","year":"2014"},{"issue":"3","key":"10.1016\/j.ab.2021.114541_bib27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s12185-015-1839-4","article-title":"Evaluation of a novel multiplex RT-qPCR assay for the quantification of leukemia-associated BCR-ABL1 translocation","volume":"102","author":"Kottwitz","year":"2015","journal-title":"Int. J. Hematol."},{"issue":"3","key":"10.1016\/j.ab.2021.114541_bib28","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/bjh.14557","article-title":"Measurement of BCR-ABL1 by RT-qPCR in chronic myeloid leukaemia: findings from an International EQA Programme","volume":"177","author":"Scott","year":"2017","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ab.2021.114541_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.leukres.2018.04.001","article-title":"New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time","volume":"69","author":"Tong","year":"2018","journal-title":"Leuk. Res."},{"issue":"4","key":"10.1016\/j.ab.2021.114541_bib30","article-title":"Detection of EGFR gene mutation by mutation-oriented LAMP method","volume":"38","author":"Matsumoto","year":"2018","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ab.2021.114541_bib31","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2020.4961","article-title":"A\u00a0novel loop-mediated isothermal amplification method for efficient and robust detection of EGFR mutations","author":"Horiuchi","year":"2020","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib32","doi-asserted-by":"crossref","first-page":"17559","DOI":"10.1038\/s41598-020-74689-3","article-title":"Non-invasive detection of EGFR mutations by cell-free loop-mediated isothermal amplification (CF-LAMP)","volume":"10","author":"Arjuna","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib33","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1038\/s41598-019-42542-x","article-title":"Detection of KRAS mutation via ligation-initiated LAMP reaction","volume":"9","author":"Fu","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ab.2021.114541_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151654","article-title":"Novel methodology for rapid detection of KRAS mutation using PNA-LNA mediated loop-mediated isothermal amplification","volume":"11","author":"Itonaga","year":"2016","journal-title":"PLoS One"},{"issue":"24","key":"10.1016\/j.ab.2021.114541_bib35","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.3390\/ijms20246106","article-title":"The Q-LAMP method represents a valid and rapid alternative for the detection of the BCR-ABL1 rearrangement in philadelphia-positive leukemias","volume":"20","author":"Stella","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.ab.2021.114541_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/sj.leu.2401592","article-title":"Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease","volume":"13","author":"van Dongen","year":"1999","journal-title":"Leukemia"},{"issue":"39","key":"10.1016\/j.ab.2021.114541_bib37","doi-asserted-by":"crossref","first-page":"24450","DOI":"10.1073\/pnas.2011221117","article-title":"SARS-CoV-2 detection using isothermal amplification and a rapid, inexpensive protocol for sample inactivation and purification","volume":"117","author":"Rabe","year":"2020","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"2","key":"10.1016\/j.ab.2021.114541_bib38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1039\/D0AY01658F","article-title":"Colorimetric loop-mediated isothermal amplification (LAMP) for cost-effective and quantitative detection of SARS-CoV-2: the change in color in LAMP-based assays quantitatively correlates with viral copy number","volume":"13","author":"Gonz\u00e1lez-Gonz\u00e1lez","year":"2021","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib39","doi-asserted-by":"crossref","first-page":"16193","DOI":"10.1038\/s41598-021-95607-1","article-title":"Clinical validation of optimised RT-LAMP for the diagnosis of SARS-CoV-2 infection","volume":"11","author":"Lim","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ab.2021.114541_bib40","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1039\/D0AN01775B","article-title":"Colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) as a visual diagnostic platform for the detection of the emerging coronavirus SARS-CoV-2","volume":"146","author":"Nawattanapaiboon","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.ab.2021.114541_bib41","doi-asserted-by":"crossref","first-page":"130411","DOI":"10.1016\/j.snb.2021.130411","article-title":"Sensitive and rapid on-site detection of SARS-CoV-2 using a gold nanoparticle-based high-throughput platform coupled with CRISPR\/Cas12-assisted RT-LAMP","volume":"345","author":"Zhang","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib42","doi-asserted-by":"crossref","first-page":"9026","DOI":"10.1038\/s41598-021-88506-y","article-title":"Colorimetric RT-LAMP SARS-CoV-2 diagnostic sensitivity relies on color interpretation and viral load","volume":"11","author":"Aoki","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ab.2021.114541_bib43","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s10020-021-00289-0","article-title":"Essential properties and pitfalls of colorimetric Reverse Transcription Loop-mediated Isothermal Amplification as a point-of-care test for SARS-CoV-2 diagnosis","volume":"27","author":"de Oliveira Coelho","year":"2021","journal-title":"Mol Med"},{"issue":"10","key":"10.1016\/j.ab.2021.114541_bib44","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1128\/JCM.00930-11","article-title":"Visual detection of high-risk human papillomavirus genotypes 16, 18, 45, 52, and 58 by loop-mediated isothermal amplification with hydroxynaphthol blue dye","volume":"49","author":"Luo","year":"2011","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.ab.2021.114541_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2016.04.008","article-title":"High sensitivity, loop-mediated isothermal amplification combined with colorimetric gold-nanoparticle probes for visual detection of high risk human papillomavirus genotypes 16 and 18","author":"Kumvongpin","year":"2016","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.ab.2021.114541_bib46","doi-asserted-by":"crossref","DOI":"10.7754\/Clin.Lab.2016.160906","article-title":"Colorimetric detection of 23 human papillomavirus genotypes by loop-mediated isothermal amplification","author":"Lin","year":"2017","journal-title":"Clin. Lab."},{"key":"10.1016\/j.ab.2021.114541_bib47","doi-asserted-by":"crossref","first-page":"101760","DOI":"10.1016\/j.mcp.2021.101760","article-title":"Facile and direct detection of human papillomavirus (HPV) DNA in cells using loop-mediated isothermal amplification (LAMP)","volume":"59","author":"Vo","year":"2021","journal-title":"Mol. Cell. Probes"},{"issue":"9","key":"10.1016\/j.ab.2021.114541_bib48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00604-021-04979-8","article-title":"Dual-modality loop-mediated isothermal amplification for pretreatment-free detection of Septin9 methylated DNA in colorectal cancer","volume":"188","author":"Lin","year":"2021","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.ab.2021.114541_bib49","doi-asserted-by":"crossref","first-page":"120407","DOI":"10.1016\/j.talanta.2019.120407","article-title":"On-chip RT-LAMP and colorimetric detection of the prostate cancer 3 biomarker with an integrated thermal and imaging box","volume":"208","author":"Wang","year":"2020","journal-title":"Talanta"}],"container-title":["Analytical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269721004425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269721004425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T21:34:44Z","timestamp":1757712884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269721004425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":48,"alternative-id":["S0003269721004425"],"URL":"https:\/\/doi.org\/10.1016\/j.ab.2021.114541","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-712437\/v1","asserted-by":"object"}]},"ISSN":["0003-2697"],"issn-type":[{"value":"0003-2697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluorescent and colorimetric RT-LAMP as a rapid and specific qualitative method for chronic myeloid leukemia diagnosis","name":"articletitle","label":"Article Title"},{"value":"Analytical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ab.2021.114541","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114541"}}