{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:25:51Z","timestamp":1771662351328,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytical Biochemistry"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ab.2022.114636","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T02:07:25Z","timestamp":1646878045000},"page":"114636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["LC-MS\/MS method for quantifying aescinate A and B and assessing their relationship with phlebitis"],"prefix":"10.1016","volume":"646","author":[{"given":"Cailian","family":"Fei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wansheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-4637","authenticated-orcid":false,"given":"Shouhong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ab.2022.114636_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2019.01.018","article-title":"Seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo","volume":"164","author":"Salinas","year":"2019","journal-title":"Antivir. Res."},{"issue":"1","key":"10.1016\/j.ab.2022.114636_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3390\/molecules23010197","article-title":"\u03b2-Escin effectively modulates HUVECS proliferation and tube formation","volume":"23","author":"Varinsk\u00e1","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ab.2022.114636_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jep.2014.08.032","article-title":"Pharmacokinetics of escin Ia in rats after intravenous administration","volume":"156","author":"Wu","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ab.2022.114636_bib4","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.2147\/DDDT.S207720","article-title":"Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties","volume":"13","author":"Gallelli","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"issue":"1","key":"10.1016\/j.ab.2022.114636_bib5","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jep.2013.11.016","article-title":"Effects of aescin on cytochrome P450 enzymes in rats","volume":"151","author":"Huang","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.ab.2022.114636_bib6","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/sj.bjp.0703461","article-title":"Effect of venotropic drugs on the respiratory activity of isolated mitochondria and in endothelial cells","volume":"130","author":"Janssens","year":"2000","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.ab.2022.114636_bib7","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/jphp.13002","article-title":"Virucidal, antiviral and immunomodulatory activities of \u03b2-escin and Aesculus hippocastanum extract","volume":"70","author":"Michelini","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"issue":"4","key":"10.1016\/j.ab.2022.114636_bib8","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1159\/000430320","article-title":"Escin increases the survival rate of LPS-induced septic mice through inhibition of HMGB1 release from macrophages","volume":"36","author":"Cheng","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.ab.2022.114636_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-2999(96)00645-0","article-title":"Effect of aescine on hypoxia-induced acti vation of human endothelial cells","volume":"315","author":"Arnould","year":"1996","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.ab.2022.114636_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/phrs.2001.0847","article-title":"Aescin: pharmacology, pharmacokinetics and therapeutic profile","volume":"44","author":"Sirtori","year":"2001","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.ab.2022.114636_bib11","first-page":"720","article-title":"Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency","volume":"328","author":"Facino","year":"1995","journal-title":"ArchPham(Weinheim)"},{"issue":"1","key":"10.1016\/j.ab.2022.114636_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0014-2999(97)01616-6","article-title":"Effect of aescine on hypoxia-induced neutrophil adherence to umbilica vein endothelium","volume":"345","author":"Bougelet","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.ab.2022.114636_bib13","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/1129729819877323","article-title":"The incidence and risk of infusion phlebitis with peripheral intravenous catheters: a meta-analysis","volume":"21","author":"Lv","year":"2020","journal-title":"J. Vasc. Access"},{"issue":"9","key":"10.1016\/j.ab.2022.114636_bib14","doi-asserted-by":"crossref","first-page":"10267","DOI":"10.3390\/molecules170910267","article-title":"Evaluation of in vivo antioxidant and immunity enhancing activities of sodium aescinate injection liquid","volume":"17","author":"Wang","year":"2012","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.ab.2022.114636_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4067\/s0716-10182017000400319","volume":"34","author":"Vergara","year":"2017","journal-title":"Rev. Chil. Infectol."},{"issue":"13","key":"10.1016\/j.ab.2022.114636_bib16","first-page":"2449","article-title":"[Application of high performance liquid-ion trap mass spectrometry in analyzing saponins in sodium aescinate]","volume":"41","author":"Song","year":"2016","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"1\u20132","key":"10.1016\/j.ab.2022.114636_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.chroma.2005.10.069","article-title":"Densitometric thin-layer chromatographic determination of aescin in a herbal medicinal product containing Aesculus and Vitis dry extracts","volume":"1112","author":"Apers","year":"2006","journal-title":"J. Chromatogr. A"},{"issue":"2","key":"10.1016\/j.ab.2022.114636_bib18","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jep.2013.11.039","article-title":"Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats","volume":"151","author":"Wu","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.ab.2022.114636_bib19","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/bmc.1441","article-title":"A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin Ib in human plasma: application to a pharmacokinetic study after intravenous administration","volume":"24","author":"Liu","year":"2010","journal-title":"Biomed. Chromatogr."},{"issue":"1","key":"10.1016\/j.ab.2022.114636_bib20","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4037\/ccn2019381","article-title":"Phlebitis in intravenous amiodarone administration: incidence and contributing factors","volume":"39","author":"Oragano","year":"2019","journal-title":"Crit. Care Nurse"},{"issue":"6","key":"10.1016\/j.ab.2022.114636_bib21","doi-asserted-by":"crossref","first-page":"498","DOI":"10.4037\/ajcc2013460","article-title":"Phlebitis in amiodarone administration: incidence, contributing factors, and clinical implications","volume":"22","author":"Norton","year":"2013","journal-title":"Am. J. Crit. Care"},{"issue":"7","key":"10.1016\/j.ab.2022.114636_bib23","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.02.013","article-title":"Reduction of nicardipine-related phlebitis in patients with acute stroke by diluting its concentration","volume":"27","author":"Kawada","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"10","key":"10.1016\/j.ab.2022.114636_bib24","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.06.028","article-title":"Risk factors of nicardipine-related phlebitis in acute stroke patients","volume":"25","author":"Kawada","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."}],"container-title":["Analytical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269722000926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269722000926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T21:35:30Z","timestamp":1757712930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269722000926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":23,"alternative-id":["S0003269722000926"],"URL":"https:\/\/doi.org\/10.1016\/j.ab.2022.114636","relation":{},"ISSN":["0003-2697"],"issn-type":[{"value":"0003-2697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LC-MS\/MS method for quantifying aescinate A and B and assessing their relationship with phlebitis","name":"articletitle","label":"Article Title"},{"value":"Analytical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ab.2022.114636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114636"}}