{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:32:52Z","timestamp":1793251972900,"version":"4.5.0"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21AG062378"],"award-info":[{"award-number":["R21AG062378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["IIRG-10-173180"],"award-info":[{"award-number":["IIRG-10-173180"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["250969"],"award-info":[{"award-number":["250969"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["310475"],"award-info":[{"award-number":["310475"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["727565"],"award-info":[{"award-number":["727565"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013279","name":"Joint Programming Initiative A Healthy Diet for a Healthy Life","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytical Biochemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ab.2025.116008","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:47:54Z","timestamp":1762328874000},"page":"116008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Sulfur amino acids, metabolic health and beyond: Recent advances, translational implications, and future research considerations"],"prefix":"10.1016","volume":"709","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1805-5221","authenticated-orcid":false,"given":"Thomas","family":"Olsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8624-860X","authenticated-orcid":false,"given":"Amany","family":"Elshorbagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay E.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5969-3572","authenticated-orcid":false,"given":"Sailendra N.","family":"Nichenametla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-9214","authenticated-orcid":false,"given":"Kumar","family":"Sambamurti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-2850","authenticated-orcid":false,"suffix":"Jr.","given":"John P.","family":"Richie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-5042","authenticated-orcid":false,"given":"Kathrine J.","family":"Vinknes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ab.2025.116008_bib1","doi-asserted-by":"crossref","first-page":"1636S","DOI":"10.1093\/jn\/136.6.1636S","article-title":"The sulfur-containing amino acids: an overview","volume":"136","author":"Brosnan","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1743-7075-4-24","article-title":"Are we getting enough sulfur in our diet?","volume":"4","author":"Nimni","year":"2007","journal-title":"Nutr. Metabol."},{"key":"10.1016\/j.ab.2025.116008_bib3","first-page":"1","article-title":"Joint WHO\/FAO\/UNU expert consultation: protein and amino acid requirements in human nutrition","year":"2007","journal-title":"World Health Organ Tech Rep Ser"},{"key":"10.1016\/j.ab.2025.116008_bib4","series-title":"Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients)","year":"2005"},{"key":"10.1016\/j.ab.2025.116008_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/nu17152495","article-title":"The shuttling of methyl groups between folate and choline pathways","volume":"17","author":"Bortz","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.ab.2025.116008_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10545-009-9006-9","article-title":"Dealing with methionine\/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur","volume":"34","author":"Stipanuk","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ab.2025.116008_bib7","first-page":"219","volume":"vol. 26","author":"Finkelstein","year":"2000"},{"key":"10.1016\/j.ab.2025.116008_bib8","doi-asserted-by":"crossref","first-page":"2494S","DOI":"10.1093\/jn\/nxaa094","article-title":"Metabolism of sulfur-containing amino acids: how the body copes with excess methionine, cysteine, and sulfide","volume":"150","author":"Stipanuk","year":"2020","journal-title":"J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jn\/123.2.269","article-title":"Low methionine ingestion by rats extends life span","volume":"123","author":"Orentreich","year":"1993","journal-title":"J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1474-9726.2005.00152.x","article-title":"Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance","volume":"4","author":"Miller","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.ab.2025.116008_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11357-006-9018-4","article-title":"Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet","volume":"29","author":"Troen","year":"2007","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.ab.2025.116008_bib12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2013.02.035","article-title":"Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism","volume":"153","author":"Cabreiro","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ab.2025.116008_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097729","article-title":"Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells","volume":"9","author":"Johnson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ab.2025.116008_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1207\/s15327914nc5402_6","article-title":"Methionine restriction inhibits Colon carcinogenesis","volume":"54","author":"Komninou","year":"2006","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.ab.2025.116008_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11357-019-00129-4","article-title":"Methionine restriction delays aging-related urogenital diseases in Male fischer 344 rats","volume":"42","author":"Komninou","year":"2020","journal-title":"Geroscience"},{"key":"10.1016\/j.ab.2025.116008_bib16","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/pros.22884","article-title":"Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice","volume":"74","author":"Sinha","year":"2014","journal-title":"Prostate"},{"key":"10.1016\/j.ab.2025.116008_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1474-9726.2006.00220.x","article-title":"Methionine restriction decreases visceral fat mass and preserves insulin action in aging Male fischer 344 rats independent of energy restriction","volume":"5","author":"Malloy","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.ab.2025.116008_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/biof.1111","article-title":"Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging","volume":"40","author":"Wanders","year":"2014","journal-title":"Biofactors"},{"key":"10.1016\/j.ab.2025.116008_bib19","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bbabio.2006.01.009","article-title":"Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection","volume":"1757","author":"Pamplona","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ab.2025.116008_bib20","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.2337\/db14-0464","article-title":"Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice","volume":"63","author":"Stone","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.ab.2025.116008_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/nyas.13584","article-title":"Disease prevention and delayed aging by dietary sulfur amino acid restriction: translational implications","volume":"1418","author":"Dong","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ab.2025.116008_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.exger.2017.01.012","article-title":"Pleiotropic responses to methionine restriction","volume":"94","author":"Ables","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ab.2025.116008_bib23","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/acel.12269","article-title":"Growth hormone signaling is necessary for lifespan extension by dietary methionine","volume":"13","author":"Brown-Borg","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.ab.2025.116008_bib24","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/joim.13279","article-title":"Homocysteine - from disease biomarker to disease prevention","volume":"290","author":"Smith","year":"2021","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ab.2025.116008_bib25","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/ajcn\/70.6.1016","article-title":"Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the hordaland homocysteine study","volume":"70","author":"El-Khairy","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1373\/49.1.113","article-title":"Predictors of change in plasma total cysteine: longitudinal findings from the Hordaland homocysteine study","volume":"49","author":"El-Khairy","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ab.2025.116008_bib27","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/ajcn\/88.3.738","article-title":"Homocysteine, cysteine, and body composition in the Hordaland homocysteine study: does cysteine link amino acid and lipid metabolism?","volume":"88","author":"Elshorbagy","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib28","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1017\/S0007114511000201","article-title":"Effect of bariatric surgery on sulphur amino acids and glutamate","volume":"106","author":"Aasheim","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib29","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1007\/s00394-017-1533-9","article-title":"Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain?","volume":"57","author":"Hanvold","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.metabol.2012.10.005","article-title":"Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance","volume":"62","author":"Elshorbagy","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/j.ab.2025.116008_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1194\/jlr.M010215","article-title":"Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme a desaturase","volume":"52","author":"Elshorbagy","year":"2011","journal-title":"JLR (J. Lipid Res.)"},{"key":"10.1016\/j.ab.2025.116008_bib32","series-title":"Nutrient Requirements of Laboratory Animals","year":"1995"},{"key":"10.1016\/j.ab.2025.116008_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13177","article-title":"Age\u2010at\u2010onset\u2010dependent effects of sulfur amino acid restriction on markers of growth and stress in Male F344 rats","volume":"19","author":"Nichenametla","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.ab.2025.116008_bib34","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/oby.22763","article-title":"Weight loss and concomitant adipose autophagy in methionine-restricted Obese mice is not dependent on adiponectin or FGF21","volume":"28","author":"Cooke","year":"2020","journal-title":"Obesity"},{"key":"10.1016\/j.ab.2025.116008_bib35","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/oby.22146","article-title":"The components of age-dependent effects of dietary methionine restriction on energy balance in rats","volume":"26","author":"Wanders","year":"2018","journal-title":"Obesity"},{"key":"10.1016\/j.ab.2025.116008_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051357","article-title":"Methionine-restricted C57BL\/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density","volume":"7","author":"Ables","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ab.2025.116008_bib37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/gerona\/glp051","article-title":"Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age","volume":"64","author":"Sun","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.ab.2025.116008_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2016.12.003","article-title":"Short term methionine restriction increases hepatic global DNA methylation in adult but not young Male C57BL\/6J mice","volume":"88","author":"Mattocks","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ab.2025.116008_bib39","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3389\/fendo.2021.773975","article-title":"Nutritional regulation of hepatic FGF21 by dietary restriction of methionine","volume":"12","author":"Fang","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ab.2025.116008_bib40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10522-012-9384-5","article-title":"Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria","volume":"13","author":"Sanchez-Roman","year":"2012","journal-title":"Biogerontology"},{"key":"10.1016\/j.ab.2025.116008_bib41","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1096\/fj.05-5568com","article-title":"Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins","volume":"20","author":"Sanz","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.ab.2025.116008_bib42","doi-asserted-by":"crossref","first-page":"13582","DOI":"10.1073\/pnas.1312524110","article-title":"Metabolic niche of a prominent sulfate-reducing human gut bacterium","volume":"110","author":"Rey","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ab.2025.116008_bib43","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00305-20","article-title":"Genetic influences of the microbiota on the life span of Drosophila melanogaster","volume":"86","author":"Matthews","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ab.2025.116008_bib44","first-page":"118","article-title":"A genetic model of methionine restriction extends Drosophila health- and lifespan","author":"Parkhitko","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ab.2025.116008_bib45","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/j.celrep.2018.07.089","article-title":"Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism","volume":"24","author":"B\u00e1rcena","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ab.2025.116008_bib46","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1093\/gerona\/glaa270","article-title":"Differential effects of sulfur amino acid-restricted and low-calorie diets on gut Microbiome profile and bile acid composition in Male C57BL6\/J mice","volume":"76","author":"Nichenametla","year":"2021","journal-title":"The journals of gerontology. Series A, Biological sciences and medical sciences"},{"key":"10.1016\/j.ab.2025.116008_bib47","doi-asserted-by":"crossref","first-page":"7745","DOI":"10.1021\/acs.jafc.0c02965","article-title":"Dietary methionine restriction ameliorated fat accumulation, systemic inflammation, and increased energy metabolism by altering gut microbiota in middle-aged mice administered different fat diets","volume":"68","author":"Wu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ab.2025.116008_bib48","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1039\/C9FO00766K","article-title":"Dietary methionine restriction improves the gut microbiota and reduces intestinal permeability and inflammation in high-fat-fed mice","volume":"10","author":"Yang","year":"2019","journal-title":"Food Funct."},{"issue":"Suppl","key":"10.1016\/j.ab.2025.116008_bib49","article-title":"Cultivable and pyrosequenced fecal microflora in centenarians and young subjects","volume":"46","author":"Drago","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.ab.2025.116008_bib50","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.canlet.2019.11.019","article-title":"Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating wnt signaling and gut microbiota","volume":"469","author":"Chen","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ab.2025.116008_bib51","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.bbi.2020.10.014","article-title":"Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota-GLP-1 pathway","volume":"91","author":"Sun","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ab.2025.116008_bib52","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.bbi.2023.11.016","article-title":"Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis","volume":"115","author":"Zheng","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ab.2025.116008_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/nu12030781","article-title":"Sex-specific effects of dietary methionine restriction on the intestinal microbiome","volume":"12","author":"Wallis","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.ab.2025.116008_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.017400","article-title":"How informative is the mouse for human gut microbiota research?","volume":"8","author":"Nguyen","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ab.2025.116008_bib55","first-page":"960","article-title":"Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet","volume":"17","author":"Ommi","year":"2025","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ab.2025.116008_bib56","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s11357-024-01326-6","article-title":"An antireductant approach ameliorates misfolded proinsulin-induced hyperglycemia and glucose intolerance in Male Akita mice","volume":"47","author":"Mattocks","year":"2025","journal-title":"Geroscience"},{"key":"10.1016\/j.ab.2025.116008_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101940","article-title":"Methionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21","volume":"41","author":"Ren","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ab.2025.116008_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000190","article-title":"Methionine restriction regulates cognitive function in high-fat diet-fed mice: roles of diurnal rhythms of SCFAs Producing- and inflammation-related microbes","volume":"64","author":"Wang","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ab.2025.116008_bib59","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/oby.22919","article-title":"Dietary methionine restriction signals to the brain through fibroblast growth factor 21 to regulate energy balance and remodeling of adipose tissue","volume":"28","author":"Forney","year":"2020","journal-title":"Obesity"},{"key":"10.1016\/j.ab.2025.116008_bib60","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1039\/C8FO01922C","article-title":"Dietary methionine restriction ameliorates the impairment of learning and memory function induced by obesity in mice","volume":"10","author":"Xu","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.ab.2025.116008_bib61","doi-asserted-by":"crossref","first-page":"12896","DOI":"10.1039\/D2FO03366F","article-title":"Dietary methionine restriction improves gut microbiota composition and prevents cognitive impairment in D-galactose-induced aging mice","volume":"13","author":"Xu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.ab.2025.116008_bib62","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.nbd.2006.01.005","article-title":"Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels","volume":"22","author":"Pacheco-Quinto","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ab.2025.116008_bib63","doi-asserted-by":"crossref","first-page":"P838","DOI":"10.1016\/j.jalz.2015.06.1863","article-title":"P4-156: methionine restriction leads to A\u03b2 reduction and neuroprotection: implications in Alzheimer's disease pathogenesis and prevention","volume":"11","author":"Sambamurti","year":"2015","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.ab.2025.116008_bib64","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1021\/acs.jafc.4c09878","article-title":"Dietary methionine restriction alleviates cognitive impairment in Alzheimer's disease mice via sex-dependent modulation on gut microbiota and tryptophan metabolism: a multiomics analysis","volume":"73","author":"Zhang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ab.2025.116008_bib65","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads1532","article-title":"Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner","volume":"11","author":"Hernandez-Arciga","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ab.2025.116008_bib66","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic diet reduces midlife mortality and improves memory in aging mice cell metabolism ketogenic diet reduces midlife mortality and improves memory in aging mice","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.ab.2025.116008_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/j.1467-789X.2011.00873.x","article-title":"Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss?","volume":"12","author":"Varady","year":"2011","journal-title":"Obes. Rev. : an official journal of the International Association for the Study of Obesity"},{"key":"10.1016\/j.ab.2025.116008_bib68","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/ajcn\/86.1.7","article-title":"Alternate-day fasting and chronic disease prevention: a review of human and animal trials","volume":"86","author":"Varady","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib69","article-title":"Intermittent methionine restriction reduces IGF-1 levels and produces similar healthspan benefits to continuous methionine restriction","volume":"00","author":"Plummer","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.ab.2025.116008_bib70","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62483","article-title":"Selenium supplementation inhibits igf-1 signaling and confers methionine restriction-like healthspan benefits to mice","volume":"10","author":"Plummer","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.ab.2025.116008_bib71","first-page":"63","article-title":"Associations of common variants in methionine metabolism pathway genes with plasma homocysteine and the risk of type 2 diabetes in Han Chinese","volume":"7","author":"Huang","year":"2014","journal-title":"J. Nutrigenet. Nutrigenom."},{"key":"10.1016\/j.ab.2025.116008_bib72","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jcb.25604","article-title":"Methionine-restricted diet increases miRNAs that can target RUNX2 expression and alters bone structure in young mice","volume":"118","author":"Plummer","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ab.2025.116008_bib73","article-title":"Intermittent methionine restriction reduces marrow fat accumulation and preserves more bone mass than continuous methionine restriction","volume":"2","author":"Plummer","year":"2024","journal-title":"Aging Biol"},{"key":"10.1016\/j.ab.2025.116008_bib74","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12950-025-00451-z","article-title":"Intermittent methionine restriction and selenium supplementation protect against inflammation and the development of dermatitis","volume":"22","author":"Plummer","year":"2025","journal-title":"J. Inflamm."},{"key":"10.1016\/j.ab.2025.116008_bib75","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/oby.2008.671","article-title":"The association of plasma cysteine and gamma-glutamyltransferase with BMI and obesity","volume":"17","author":"Elshorbagy","year":"2009","journal-title":"Obesity"},{"key":"10.1016\/j.ab.2025.116008_bib76","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.numecd.2011.01.008","article-title":"The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins","volume":"22","author":"Elshorbagy","year":"2012","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"key":"10.1016\/j.ab.2025.116008_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044166","article-title":"The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents","volume":"7","author":"Elshorbagy","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ab.2025.116008_bib78","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.3945\/jn.113.179192","article-title":"S-adenosylmethionine is associated with fat mass and truncal adiposity in older adults","volume":"143","author":"Elshorbagy","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib79","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jacl.2024.11.005","article-title":"Estimated stearoyl-CoA desaturase activity mediates the associations of total cysteine with adiposity: the maastricht study","volume":"19","author":"Tore","year":"2025","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.ab.2025.116008_bib80","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/nyas.13021","article-title":"Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice","volume":"1363","author":"Niewiadomski","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ab.2025.116008_bib81","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00726-021-03071-y","article-title":"Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults","volume":"53","author":"Elkafrawy","year":"2021","journal-title":"Amino Acids"},{"key":"10.1016\/j.ab.2025.116008_bib82","article-title":"The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression","author":"Elshorbagy","year":"2022","journal-title":"Amino Acids"},{"key":"10.1016\/j.ab.2025.116008_bib83","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbalip.2017.02.009","article-title":"Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells","volume":"1862","author":"Haj-Yasein","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ab.2025.116008_bib84","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1111\/dom.15210","article-title":"Cysteine-lowering treatment with mesna against obesity: proof of concept and results from a human phase I, dose-finding study","volume":"25","author":"Vinknes","year":"2023","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.ab.2025.116008_bib85","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00726-024-03398-2","article-title":"Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study","volume":"56","author":"Olsen","year":"2024","journal-title":"Amino Acids"},{"key":"10.1016\/j.ab.2025.116008_bib86","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.biochi.2020.03.001","article-title":"Body mass index determines the response of plasma sulfur amino acids to methionine loading","volume":"173","author":"Elshorbagy","year":"2020","journal-title":"Biochimie"},{"key":"10.1016\/j.ab.2025.116008_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-020-00653-x","article-title":"Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis","volume":"20","author":"Long","year":"2020","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.ab.2025.116008_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14974-w","article-title":"Plasma amino acid profile associated with fatty liver disease and co-occurrence of metabolic risk factors","volume":"7","author":"Yamakado","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ab.2025.116008_bib89","doi-asserted-by":"crossref","DOI":"10.1007\/s00394-022-03041-4","article-title":"Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and the maastricht study","author":"Tore","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib90","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.3390\/nu12123890","article-title":"Mendelian randomization study on amino acid metabolism suggests tyrosine as causal trait for type 2 diabetes","volume":"12","author":"J\u00e4ger","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.ab.2025.116008_bib91","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00125-018-4599-x","article-title":"Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose","volume":"61","author":"Merino","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.ab.2025.116008_bib92","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijcard.2018.04.083","article-title":"Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: results from two independent cohorts","volume":"266","author":"Dhar","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ab.2025.116008_bib93","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008824","article-title":"Plasma cystathionine and risk of incident stroke in patients with suspected stable angina pectoris","volume":"7","author":"Dhar","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ab.2025.116008_bib94","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/ajcn\/nqy391","article-title":"Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease","volume":"109","author":"Dhar","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib95","first-page":"1","article-title":"The association of serum sulfur amino acids and related metabolites with incident diabetes: a prospective cohort study","author":"Elshorbagy","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjnut.2023.05.008","article-title":"The associations of habitual intake of sulfur amino acids, proteins and diet quality with plasma sulfur amino acid concentrations: the maastricht study","author":"Tore","year":"2023","journal-title":"J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43586-021-00092-5","article-title":"Mendelian randomization","volume":"2","author":"Sanderson","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.ab.2025.116008_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2019.100248","article-title":"Association of sulfur amino acid consumption with cardiometabolic risk factors: cross-Sectional findings from NHANES III","volume":"19","author":"Dong","year":"2020","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.ab.2025.116008_bib99","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00394-021-02641-w","article-title":"Association of dietary sulfur amino acid intake with mortality from diabetes and other causes","volume":"61","author":"Dong","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib100","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/nxac172","article-title":"Cumulative consumption of sulfur amino acids and risk of diabetes: a prospective cohort study","author":"Dong","year":"2022","journal-title":"J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib101","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1017\/jns.2019.1","article-title":"Association between vegetarian diets and cardiovascular risk factors in Non-Hispanic white participants of the adventist health Study-2","volume":"8","author":"Matsumoto","year":"2019","journal-title":"J. Nutr. Sci."},{"key":"10.1016\/j.ab.2025.116008_bib102","doi-asserted-by":"crossref","first-page":"S284","DOI":"10.1093\/advances\/nmy109","article-title":"Vegetarian epidemiology: review and discussion of findings from geographically diverse cohorts","volume":"10","author":"Orlich","year":"2019","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib103","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1016\/j.clnu.2020.02.037","article-title":"Health outcomes associated with vegetarian diets: an umbrella review of systematic reviews and meta-analyses","volume":"39","author":"Oussalah","year":"2020","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib104","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41430-018-0310-z","article-title":"Health and sustainability outcomes of vegetarian dietary patterns: a revisit of the EPIC-oxford and the adventist health Study-2 cohorts","volume":"72","author":"Segovia-Siapco","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib105","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1210\/jc.2010-2493","article-title":"Dietary methionine restriction increases fat oxidation in Obese adults with metabolic syndrome","volume":"96","author":"Plaisance","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ab.2025.116008_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/nu10121822","article-title":"Combining dietary sulfur amino acid restriction with polyunsaturated fatty acid intake in humans: a randomized controlled pilot trial","volume":"10","author":"Olsen","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.ab.2025.116008_bib107","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12967-020-02288-x","article-title":"Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study","volume":"18","author":"Olsen","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ab.2025.116008_bib108","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41586-019-1437-3","article-title":"Dietary methionine influences therapy in mouse cancer models and alters human metabolism","volume":"572","author":"Gao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ab.2025.116008_bib109","doi-asserted-by":"crossref","DOI":"10.1007\/s12603-023-1883-3","article-title":"Dietary methionine and total sulfur amino acid restriction in healthy adults","volume":"27","author":"Richie","year":"2023","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.ab.2025.116008_bib110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12967-021-02824-3","article-title":"Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements","volume":"19","author":"Stolt","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ab.2025.116008_bib111","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12967-023-04833-w","article-title":"Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial","volume":"22","author":"Olsen","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ab.2025.116008_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103192","article-title":"Dietary sulfur amino acid restriction in humans with overweight and obesity: evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass and adipose tissue gene expression","volume":"73","author":"Olsen","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ab.2025.116008_bib113","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s00394-021-02790-y","article-title":"Amino acid intake and plasma concentrations and their interplay with gut microbiota in vegans and omnivores in Germany","volume":"61","author":"Dietrich","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib114","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ejcn.2015.144","article-title":"Plasma concentrations and intakes of amino acids in Male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort","volume":"70","author":"Schmidt","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjnut.2023.01.012","article-title":"Amino acid intake and conformance with the dietary reference intakes in the United States: analysis of the national health and nutrition examination survey, 2001\u20132018","author":"Berryman","year":"2023","journal-title":"J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib116","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/138.10.1996S","article-title":"An approach to defining the upper safe limits of amino acid intake","volume":"138","author":"Pencharz","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib117","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.3390\/nu13082609","article-title":"The role of reduced methionine in mediating the metabolic responses to protein restriction using different sources of protein","volume":"13","author":"Fang","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ab.2025.116008_bib118","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1194\/jlr.M010215","article-title":"Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase","volume":"52","author":"Elshorbagy","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ab.2025.116008_bib119","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000339347","article-title":"Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle","volume":"5","author":"Perrone","year":"2012","journal-title":"Lifestyle Genom."},{"key":"10.1016\/j.ab.2025.116008_bib120","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/s42255-025-01297-8","article-title":"Cysteine depletion triggers adipose tissue thermogenesis and weight loss","volume":"7","author":"Lee","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.ab.2025.116008_bib121","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13739","article-title":"Cysteine restriction\u2010specific effects of sulfur amino acid restriction on lipid metabolism","author":"Nichenametla","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.ab.2025.116008_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102470","article-title":"Implementation of dietary methionine restriction using casein after selective, oxidative deletion of methionine","volume":"24","author":"Fang","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.ab.2025.116008_bib123","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jamda.2013.05.021","article-title":"Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE study group","volume":"14","author":"Bauer","year":"2013","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.ab.2025.116008_bib124","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.clnu.2014.04.007","article-title":"Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN expert group","volume":"33","author":"Deutz","year":"2014","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib125","doi-asserted-by":"crossref","DOI":"10.1093\/advances\/nmaa047","article-title":"Optimizing adult protein intake during catabolic health conditions","volume":"11","author":"Phillips","year":"2020","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib126","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ajcnut.2023.06.015","article-title":"The dietary requirement for total sulfur amino acids in adults aged >\/=60 years appears to be higher in males than in females","volume":"118","author":"Paoletti","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ab.2025.116008_bib127","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1207\/S15327914NC422_2","article-title":"Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction","volume":"42","author":"Epner","year":"2002","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.ab.2025.116008_bib128","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1349-7006.1995.tb03082.x","article-title":"Synergistic effect of methionine\u2010depleting total parenteral nutrition with 5\u2010Fluorouracil on human gastric cancer: a randomized, prospective clinical trial","volume":"86","author":"Goseki","year":"1995","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.ab.2025.116008_bib129","first-page":"5235","article-title":"Phase II trial of the association of a methionine-free diet with cystemustine therapy in melanoma and glioma","volume":"29","author":"Thivat","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ab.2025.116008_bib130","article-title":"The effect of methionine in experimental wound healing a morphologic study","author":"Perez-Tamayo","year":"1953","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ab.2025.116008_bib131","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.metabol.2013.06.012","article-title":"Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient Obese mice","volume":"62","author":"Malloy","year":"2013","journal-title":"Metabolism: clinical and experimental"},{"key":"10.1016\/j.ab.2025.116008_bib132","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2019.00301","article-title":"Extension of cellular lifespan by methionine restriction involves alterations in central carbon metabolism and is mitophagy-dependent","volume":"7","author":"Plummer","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ab.2025.116008_bib133","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/oby.22534","article-title":"Dietary methionine restriction reduces inflammation independent of FGF21 action","volume":"27","author":"Sharma","year":"2019","journal-title":"Obesity"},{"key":"10.1016\/j.ab.2025.116008_bib134","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2337\/db16-1212","article-title":"FGF21 mediates the thermogenic and insulin-sensitizing effects of dietary methionine restriction but not its effects on hepatic lipid metabolism","volume":"66","author":"Wanders","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.ab.2025.116008_bib135","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/nyas.13687","article-title":"Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation","volume":"1418","author":"Brown-Borg","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ab.2025.116008_bib136","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrendo.2013.67","article-title":"The GH\/IGF-1 axis in ageing and longevity","volume":"9","author":"Junnila","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ab.2025.116008_bib137","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001845","article-title":"Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans","volume":"3","author":"Guevara-Aguirre","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ab.2025.116008_bib138","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.exger.2006.06.061","article-title":"Stress resistance in long-lived mouse models","volume":"41","author":"Murakami","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ab.2025.116008_bib139","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tibs.2014.02.003","article-title":"FOXO transcription factors: key regulators of cellular quality control","volume":"39","author":"Webb","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ab.2025.116008_bib140","doi-asserted-by":"crossref","first-page":"403","DOI":"10.7326\/0003-4819-142-6-200503150-00006","article-title":"Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in Obese patients with type 2 diabetes","volume":"142","author":"Boden","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ab.2025.116008_bib141","doi-asserted-by":"crossref","DOI":"10.1093\/geronj\/46.5.B180","article-title":"Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins","volume":"46","author":"Breese","year":"1991","journal-title":"J. Gerontol."},{"key":"10.1016\/j.ab.2025.116008_bib142","first-page":"4667","article-title":"Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice","volume":"57","author":"Dunn","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.ab.2025.116008_bib143","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1474-9726.2008.00417.x","article-title":"Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans","volume":"7","author":"Fontana","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.ab.2025.116008_bib144","first-page":"209","article-title":"Reduction in serum leptin and IGF-1 but preserved T-lymphocyte numbers and activation after a ketogenic diet in rheumatoid arthritis patients","volume":"18","author":"Fraser","year":"2000","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.ab.2025.116008_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100910","article-title":"The influence of fasting and energy restricting diets on IGF-1 levels in humans: a systematic review and meta-analysis","volume":"53","author":"Rahmani","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ab.2025.116008_bib146","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/00498250600621627","volume":"36","author":"Scarth","year":"2006","journal-title":"Xenobiotica"}],"container-title":["Analytical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269725002477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269725002477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:01:30Z","timestamp":1793250090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269725002477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":146,"alternative-id":["S0003269725002477"],"URL":"https:\/\/doi.org\/10.1016\/j.ab.2025.116008","relation":{},"ISSN":["0003-2697"],"issn-type":[{"value":"0003-2697","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulfur amino acids, metabolic health and beyond: Recent advances, translational implications, and future research considerations","name":"articletitle","label":"Article Title"},{"value":"Analytical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ab.2025.116008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116008"}}