{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:42:58Z","timestamp":1786120978606,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016971","name":"Lomonosov Moscow State University","doi-asserted-by":"publisher","award":["121041500039-8"],"award-info":[{"award-number":["121041500039-8"]}],"id":[{"id":"10.13039\/501100016971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytical Biochemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ab.2026.116210","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:34:56Z","timestamp":1785252896000},"page":"116210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Improving chemiluminescence in heterogeneous HRP-catalyzed enhanced chemiluminescence reaction by replacement of luminol with 5-(4-hydroxy-1,3-dioxoisoindolin-2-yl)-2,3-dihydrophthalazine-1,4-dione (HDDD)"],"prefix":"10.1016","volume":"718","author":[{"given":"Oleg L.","family":"Bodulev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgy L.","family":"Karetnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-6934","authenticated-orcid":false,"given":"Alexey V.","family":"Medved'ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-8599","authenticated-orcid":false,"given":"Ivan Yu","family":"Sakharov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ab.2026.116210_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlumin.2025.121668","article-title":"Chemiluminescent sensors based on nucleic acid amplification techniques and functional nucleic acids","author":"Huang","year":"2026","journal-title":"J. Lumin."},{"key":"10.1016\/j.ab.2026.116210_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113805","article-title":"Recent advancements in optical biosensors for cancer detection","volume":"197","author":"Kaur","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ab.2026.116210_bib3","article-title":"Phenylamine-1,2-Dioxetanes: promising class of chemiluminescent luminophores for aqueous sensing and bacterial detection","author":"David","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ab.2026.116210_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2025.118494","article-title":"Strategies for enhancing the signal-to-noise ratio in optical lateral flow immunoassay: a review","volume":"194","author":"Yuan","year":"2026","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.ab.2026.116210_bib5","article-title":"Conjugated oligomer-based NIR-II chemiluminescence nanosensor for in vivo imaging","author":"Li","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ab.2026.116210_bib6","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s44222-023-00074-0","article-title":"Chemiluminescent probes in cancer biology","volume":"1","author":"Blau","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.ab.2026.116210_bib7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1039\/D5ME00065C","article-title":"Re-engineering luminol: new frontiers in chemiluminescence chemistry","volume":"10","author":"Alsharabasy","year":"2025","journal-title":"Mol. Syst. Des. Eng."},{"key":"10.1016\/j.ab.2026.116210_bib8","article-title":"Signal enhancement of luminol-based electrochemiluminescence systems and their applications","volume":"31","author":"Liu","year":"2025","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ab.2026.116210_bib9","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.4155\/bio.09.69","article-title":"Chemiluminescent enzyme immunoassays: a review of bioanalytical applications","volume":"1","author":"Marquette","year":"2009","journal-title":"Bioanalysis"},{"key":"10.1016\/j.ab.2026.116210_bib10","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1023\/B:BIRY.0000040213.91951.bc","article-title":"Palm tree peroxidases","volume":"69","author":"Sakharov","year":"2004","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.ab.2026.116210_bib11","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1021\/jf0506075","article-title":"Soybean peroxidase-catalyzed oxidation of luminol by hydrogen peroxide","volume":"53","author":"Alpeeva","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ab.2026.116210_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/bio.931","article-title":"Luminol-hydrogen peroxide chemiluminescence produced by sweet potato peroxidase","volume":"22","author":"Alpeeva","year":"2007","journal-title":"Luminescence"},{"key":"10.1016\/j.ab.2026.116210_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0003-2697(85)90332-X","article-title":"Enhancement of the horseradish peroxidase-catalyzed chemiluminescent oxidation of cyclic diacyl hydrazides by 6-Hydroxybenzothiazoles","volume":"145","author":"Thorpe","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ab.2026.116210_bib14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1134\/S1068162013020155","article-title":"Phenothiazine derivatives as enhancers of peroxidase-dependent chemiluminescence","volume":"39","author":"Vdovenko","year":"2013","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.ab.2026.116210_bib15","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.talanta.2013.05.074","article-title":"3-(10'-Phenothiazinyl)propionic acid is a potent primary enhancer of peroxidase-induced chemiluminescence and its application in sensitive ELISA of methylglyoxal-modified low density lipoprotein","volume":"115","author":"Sakharov","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.ab.2026.116210_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.talanta.2012.03.025","article-title":"Optimization of horseradish peroxidase-catalyzed enhanced chemiluminescence reaction by full factorial design","volume":"94","author":"Vdovenko","year":"2012","journal-title":"Talanta"},{"key":"10.1016\/j.ab.2026.116210_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ab.2012.10.030","article-title":"Mechanism of action of 4-dialkylaminopyridines as secondary enhancers in enhanced chemiluminescence reaction","volume":"434","author":"Sakharov","year":"2013","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ab.2026.116210_bib18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.foodchem.2013.04.060","article-title":"Quantification of 2,4-dichlorophenoxyacetic acid in oranges and mandarins by chemiluminescent ELISA","volume":"141","author":"Vdovenko","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.ab.2026.116210_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2019.115780","article-title":"Research progress on chemiluminescence immunoassay combined with novel technologies","volume":"124","author":"Xiao","year":"2020","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.ab.2026.116210_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jim.2010.09.016","article-title":"Development of ultra-sensitive soybean peroxidase-based CL-ELISA for the determination of human thyroglobulin","volume":"362","author":"Vdovenko","year":"2010","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ab.2026.116210_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117213","article-title":"Recent development of chemiluminescence for bioanalysis","volume":"166","author":"Zhao","year":"2023","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.ab.2026.116210_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.120895","article-title":"Sakharov Chemiluminescent microplate-based assay of DNA based on isothermal circular strand-displacement polymerization reaction (ICSDPR)","volume":"215","author":"Solovjev","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.ab.2026.116210_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125525","article-title":"Chemiluminescent plate assay of microRNA-155 coupled with catalytic hairpin assembly with oligonucleotide release (CHAOR)","volume":"270","author":"Bodulev","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.ab.2026.116210_bib24","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.3390\/molecules29235782","article-title":"A chemiluminescence signal amplification method for MicroRNA detection: the combination of molecular aptamer beacons with enzyme-free hybridization chain reaction","volume":"29","author":"Han","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.ab.2026.116210_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlumin.2025.121668","article-title":"Chemiluminescent sensors based on nucleic acid amplification techniques and functional nucleic acids","volume":"289","author":"Huang","year":"2026","journal-title":"J. Lumin."},{"key":"10.1016\/j.ab.2026.116210_bib26","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1021\/acs.analchem.3c00073","article-title":"A green-emitting luminol analogue as the next-generation chemiluminescent substrate in biochemical analysis","volume":"95","author":"Chen","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ab.2026.116210_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.339161","article-title":"Next generation luminol derivative as powerful benchmark probe for chemiluminescence assays","volume":"1188","author":"Rink","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ab.2026.116210_bib28","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1039\/D4NJ04283B","article-title":"A novel luminol-related hydroxyphenyl benzothiazole analogue chemiluminescence probe with ultrahigh sensitivity for bloodstain detection","volume":"49","author":"Zhang","year":"2025","journal-title":"New J. Chem."},{"key":"10.1016\/j.ab.2026.116210_bib29","article-title":"Enhanced chemiluminescence of a superior luminol derivative provides sensitive smartphone-based point-of-care testing with enzymatic \u03bcPAD","volume":"3","author":"Rink","year":"2023","journal-title":"Anal. Sens."},{"key":"10.1016\/j.ab.2026.116210_bib30","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.1002\/chem.201500798","article-title":"Steric enhancement of the chemiluminescence of luminols","volume":"21","author":"Griesbeck","year":"2015","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ab.2026.116210_bib31","article-title":"Discovering ester and ether derivatives of luminol as advanced chemiluminescence probes","volume":"34","author":"Chen","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ab.2026.116210_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128790","article-title":"5-(4-Hydroxy-1,3-dioxoisoindolin-2-yl)-2,3-dihydrophthalazine-1,4-dione (HDDD) as effective substrate in HRP-catalyzed enhanced chemiluminescence reaction","volume":"297","author":"Bodulev","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.ab.2026.116210_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0003-9861(86)90003-2","article-title":"Prostaglandin H synthase and hydroperoxides: peroxidase reaction and inactivation kinetics","volume":"249","author":"Kulmacz","year":"1986","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ab.2026.116210_bib34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/hlca.200890067","article-title":"Colorimetric fluoride-anion sensor based on intramolecular hydrogen bonding and enol-keto tautomerization of a phenothiazine derivative","volume":"91","author":"Han","year":"2008","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.ab.2026.116210_bib35","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1021\/jf904338f","article-title":"Advantages of soybean peroxidase over horseradish peroxidase as the enzyme label in chemiluminescent enzyme-linked immunosorbent assay of sulfamethoxypyridazine","volume":"58","author":"Sakharov","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ab.2026.116210_bib36","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jenvman.2016.12.051","article-title":"Composting technology in waste stabilization: on the methods, challenges and future prospects","volume":"190","author":"Onwosi","year":"2017","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.ab.2026.116210_bib37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijhydene.2008.10.008","article-title":"Experimental design methods for fermentative hydrogen production: a review","volume":"34","author":"Wang","year":"2009","journal-title":"Int. J. Hydrogen Energy"},{"key":"10.1016\/j.ab.2026.116210_bib38","article-title":"Using response surface methodology (RSM) to optimize 2G bioethanol production: a review","volume":"151","author":"Soares Pereira","year":"2021","journal-title":"Biomass Bioenergy"},{"key":"10.1016\/j.ab.2026.116210_bib39","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1039\/D4RA00202D","article-title":"A novel ultrasensitive chemiluminescence enzyme immunoassay by employment of a signal enhancement of horseradish peroxidase-luminol-hydrogen peroxide reaction for the quantitation of atezolizumab, a monoclonal antibody used for cancer immunotherapy","volume":"14","author":"Darwish","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.ab.2026.116210_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2020.105183","article-title":"Chemiluminescence strategy induced by HRP-sandwich structure based on strand displacement for sensitive detection of DNA methyltransferase","volume":"158","author":"Yan","year":"2020","journal-title":"Microchem. J."},{"key":"10.1016\/j.ab.2026.116210_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2026.117101","article-title":"AuNPs-cascaded amplification of enzymatic chemiluminescence microfluidic system for p24 detection","volume":"222","author":"Liu","year":"2026","journal-title":"Microchem. J."},{"key":"10.1016\/j.ab.2026.116210_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111379","article-title":"Challenges of using microRNAs as potential disease biomarkers. A review","volume":"206","author":"Zinovkin","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.ab.2026.116210_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201902989","article-title":"Applications of catalytic hairpin assembly reaction in biosensing","volume":"15","author":"Liu","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.ab.2026.116210_bib44","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1134\/S0006297922050042","article-title":"Modern methods for assessment of microRNAs","volume":"87","author":"Bodulev","year":"2022","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.ab.2026.116210_bib45","doi-asserted-by":"crossref","first-page":"15275","DOI":"10.1073\/pnas.0407024101","article-title":"Triggered amplification by hybridization chain reaction","volume":"101","author":"Dirks","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Analytical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269726001661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269726001661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T02:15:19Z","timestamp":1786068919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269726001661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":45,"alternative-id":["S0003269726001661"],"URL":"https:\/\/doi.org\/10.1016\/j.ab.2026.116210","relation":{},"ISSN":["0003-2697"],"issn-type":[{"value":"0003-2697","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improving chemiluminescence in heterogeneous HRP-catalyzed enhanced chemiluminescence reaction by replacement of luminol with 5-(4-hydroxy-1,3-dioxoisoindolin-2-yl)-2,3-dihydrophthalazine-1,4-dione (HDDD)","name":"articletitle","label":"Article Title"},{"value":"Analytical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ab.2026.116210","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116210"}}