{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:15:54Z","timestamp":1760782554927},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1016\/j.abb.2003.09.001","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T15:38:36Z","timestamp":1066232316000},"page":"234-243","source":"Crossref","is-referenced-by-count":14,"title":["Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis"],"prefix":"10.1016","volume":"419","author":[{"given":"Jason S","family":"Chapman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin L","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Robert W","family":"Curley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A","family":"Highland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Clagett-Dame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2003.09.001_BIB1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1359-6101(00)00002-2","volume":"11","author":"McCaffery","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.abb.2003.09.001_BIB2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.nutr.22.010402.102745E","volume":"22","author":"Clagett-Dame","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.abb.2003.09.001_BIB3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0076-6879(90)90026-W","volume":"190","author":"Amos","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.abb.2003.09.001_BIB4","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1358\/dof.1998.023.06.858360","volume":"23","author":"Sun","year":"1998","journal-title":"Drugs Future"},{"key":"10.1016\/j.abb.2003.09.001_BIB5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.leu.2402414","volume":"16","author":"Fontana","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.abb.2003.09.001_BIB6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1753-4887.2000.tb01856.x","volume":"58","author":"Prakash","year":"2000","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.abb.2003.09.001_BIB7","series-title":"The Retinoids: Biology, Chemistry and Medicine","first-page":"597","author":"Hong","year":"1994"},{"key":"10.1016\/j.abb.2003.09.001_BIB8","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/carcin\/21.7.1271","volume":"21","author":"Hansen","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.abb.2003.09.001_BIB9","series-title":"The Retinoids: Biology, Chemistry and Medicine","first-page":"545","author":"Armstrong","year":"1994"},{"key":"10.1016\/j.abb.2003.09.001_BIB10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pharmtox.39.1.399","volume":"39","author":"Collins","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.abb.2003.09.001_BIB11","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1067\/mjd.2001.113721","volume":"45","author":"DiGiovanna","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.abb.2003.09.001_BIB12","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1067\/mjd.2001.113717","volume":"45","author":"Ellis","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.abb.2003.09.001_BIB13","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1067\/mjd.2001.113720","volume":"45","author":"Nau","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.abb.2003.09.001_BIB14","series-title":"Vitamin A and Retinoids: an Update of Biological Aspects and Clinical Applications","first-page":"241","author":"Formelli","year":"2000"},{"key":"10.1016\/j.abb.2003.09.001_BIB15","first-page":"6036","volume":"53","author":"Delia","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.abb.2003.09.001_BIB16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ijc.2910590322","volume":"59","author":"Di Vinci","year":"1994","journal-title":"Int. J Cancer"},{"key":"10.1016\/j.abb.2003.09.001_BIB17","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/jnci\/86.16.1245","volume":"86","author":"Mariotti","year":"1994","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.abb.2003.09.001_BIB18","first-page":"1213","volume":"7","author":"Avignolo","year":"1995","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.abb.2003.09.001_BIB19","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/jnci\/87.22.1674","volume":"87","author":"Kalemkerian","year":"1995","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.abb.2003.09.001_BIB20","first-page":"853","volume":"55","author":"Ponzoni","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.abb.2003.09.001_BIB21","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1093\/carcin\/16.10.2477","volume":"16","author":"Sheikh","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.abb.2003.09.001_BIB22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/(SICI)1097-0215(19960208)65:4<491::AID-IJC17>3.0.CO;2-D","volume":"65","author":"Supino","year":"1996","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.abb.2003.09.001_BIB23","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/jnci\/89.16.1191","volume":"89","author":"Oridate","year":"1997","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.abb.2003.09.001_BIB24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/(SICI)1098-2744(199903)24:3<160::AID-MC2>3.0.CO;2-M","volume":"24","author":"Shen","year":"1999","journal-title":"Mol. Carcinogen."},{"key":"10.1016\/j.abb.2003.09.001_BIB25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1081\/CNV-100000149","volume":"19","author":"Ulukaya","year":"2001","journal-title":"Cancer Invest."},{"key":"10.1016\/j.abb.2003.09.001_BIB26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1023\/A:1011342220621","volume":"6","author":"Wu","year":"2001","journal-title":"Apoptosis"},{"key":"10.1016\/j.abb.2003.09.001_BIB27","first-page":"3839","volume":"21","author":"Abou-Issa","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.abb.2003.09.001_BIB28","first-page":"337","volume":"16","author":"Shih","year":"1988","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.abb.2003.09.001_BIB29","first-page":"632","volume":"219","author":"Swanson","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.abb.2003.09.001_BIB30","first-page":"714","volume":"14","author":"Hultin","year":"1986","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.abb.2003.09.001_BIB31","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1042\/bj2560579","volume":"256","author":"Mehta","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.abb.2003.09.001_BIB32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0277-5379(91)90471-O","volume":"27","author":"Mehta","year":"1991","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.abb.2003.09.001_BIB33","doi-asserted-by":"crossref","first-page":"22441","DOI":"10.1074\/jbc.271.37.22441","volume":"271","author":"Fanjul","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2003.09.001_BIB34","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0959-8049(98)00032-X","volume":"34","author":"Mehta","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.abb.2003.09.001_BIB35","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0960-894X(01)00230-X","volume":"11","author":"Weiss","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.abb.2003.09.001_BIB36","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/00304940109356615","volume":"33","author":"Adamczyk","year":"2001","journal-title":"Org. Prep. Proc. Int."},{"key":"10.1016\/j.abb.2003.09.001_BIB37","unstructured":"K.L. Weiss, Ph.D. Dissertation, The Ohio State University, Columbus, OH, 2001"},{"key":"10.1016\/j.abb.2003.09.001_BIB38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1242\/dev.116.1.55","volume":"116","author":"Wagner","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.abb.2003.09.001_BIB39","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/jn\/100.9.1049","volume":"100","author":"Suda","year":"1970","journal-title":"J. Nutr."},{"key":"10.1016\/j.abb.2003.09.001_BIB40","series-title":"Nutrient Requirements of Laboratory Animals","author":"Council","year":"1995"},{"key":"10.1016\/j.abb.2003.09.001_BIB41","doi-asserted-by":"crossref","first-page":"13459","DOI":"10.1073\/pnas.95.23.13459","volume":"95","author":"White","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.abb.2003.09.001_BIB42","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.abb.2003.09.001_BIB43","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.abb.2003.09.001_BIB44","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1006\/abbi.1993.1095","volume":"300","author":"Clagett-Dame","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2003.09.001_BIB45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/clinchem\/40.1.48","volume":"40","author":"Meyer","year":"1994","journal-title":"Clin. Chem."},{"key":"10.1016\/j.abb.2003.09.001_BIB46","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.abb.2003.09.001_BIB47","doi-asserted-by":"crossref","first-page":"29922","DOI":"10.1074\/jbc.271.47.29922","volume":"271","author":"White","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2003.09.001_BIB48","doi-asserted-by":"crossref","first-page":"18702","DOI":"10.1074\/jbc.272.30.18702","volume":"272","author":"Ray","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2003.09.001_BIB49","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1210\/mend.14.9.0518","volume":"14","author":"Loudig","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.abb.2003.09.001_BIB50","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1073\/pnas.120161397","volume":"97","author":"White","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.abb.2003.09.001_BIB51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0925-4773(01)00463-4","volume":"107","author":"MacLean","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.abb.2003.09.001_BIB52","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fasebj.10.9.8801176","volume":"10","author":"Chambon","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.abb.2003.09.001_BIB53","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","volume":"68","author":"Wyllie","year":"1980","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.abb.2003.09.001_BIB54","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.abb.2003.09.001_BIB55","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.182.5.1545","volume":"182","author":"Martin","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.abb.2003.09.001_BIB56","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/01635588509513845","volume":"7","author":"Bunk","year":"1985","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.abb.2003.09.001_BIB57","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/0006-2952(91)90563-K","volume":"41","author":"Bhatnagar","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.abb.2003.09.001_BIB58","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/jn\/94.3.302","volume":"94","author":"Zile","year":"1968","journal-title":"J. Nutr."},{"key":"10.1016\/j.abb.2003.09.001_BIB59","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/excr.2002.5582","volume":"279","author":"Poot","year":"2002","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.abb.2003.09.001_BIB60","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/sj.leu.2402485","volume":"16","author":"O\u2019Donnell","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.abb.2003.09.001_BIB61","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1667\/0033-7587(2000)153[0725:CVAGIA]2.0.CO;2","volume":"153","author":"Loberg","year":"2000","journal-title":"Radiat. Res."},{"key":"10.1016\/j.abb.2003.09.001_BIB62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1010620600473","volume":"66","author":"Dietze","year":"2001","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.abb.2003.09.001_BIB63","first-page":"1345","volume":"4","author":"Zou","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.abb.2003.09.001_BIB64","first-page":"863","volume":"6","author":"Pellegrini","year":"1995","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.abb.2003.09.001_BIB65","first-page":"1056","volume":"56","author":"Kazmi","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.abb.2003.09.001_BIB66","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/excr.1997.3589","volume":"234","author":"Zhu","year":"1997","journal-title":"Exp. Cell Res."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986103004715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986103004715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T01:42:50Z","timestamp":1623462170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986103004715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["S0003986103004715"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2003.09.001","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}