{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:31:03Z","timestamp":1791307863612,"version":"4.3.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.abb.2009.07.016","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T13:08:36Z","timestamp":1248872916000},"page":"96-102","source":"Crossref","is-referenced-by-count":33,"title":["Flavin-dependent thymidylate synthase: A novel pathway towards thymine"],"prefix":"10.1016","volume":"493","author":[{"given":"Eric M.","family":"Koehn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amnon","family":"Kohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2009.07.016_bib1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1146\/annurev.bi.64.070195.003445","volume":"64","author":"Carreras","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.abb.2009.07.016_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1021\/bi020599a","volume":"42","author":"Finer-Moore","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.abb.2009.07.016_bib3","doi-asserted-by":"crossref","first-page":"11664","DOI":"10.1073\/pnas.142413399","volume":"99","author":"Lesley","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.abb.2009.07.016_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1072113","volume":"297","author":"Myllykallio","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.abb.2009.07.016_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1126\/science.1073910","volume":"297","author":"Murzin","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.abb.2009.07.016_bib6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/458840a","volume":"458","author":"Costi","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.abb.2009.07.016_bib7","doi-asserted-by":"crossref","first-page":"9948","DOI":"10.1073\/pnas.0801356105","volume":"105","author":"Escartin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.abb.2009.07.016_bib8","doi-asserted-by":"crossref","first-page":"8537","DOI":"10.1128\/JB.01380-07","volume":"189","author":"Leduc","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.abb.2009.07.016_bib9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0966-842X(03)00101-X","volume":"11","author":"Myllykallio","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.abb.2009.07.016_bib10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0969-2126(03)00097-2","volume":"11","author":"Mathews","year":"2003","journal-title":"Structure"},{"key":"10.1016\/j.abb.2009.07.016_bib11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/prot.10202","volume":"49","author":"Kuhn","year":"2002","journal-title":"Proteins: Struct. Funct. Genet."},{"key":"10.1016\/j.abb.2009.07.016_bib12","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1128\/JB.01094-07","volume":"190","author":"Ulmer","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.abb.2009.07.016_bib13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1021\/ja973210t","volume":"120","author":"Barrett","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.abb.2009.07.016_bib14","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1021\/bi962936j","volume":"36","author":"Hyatt","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.abb.2009.07.016_bib15","doi-asserted-by":"crossref","first-page":"43126","DOI":"10.1074\/jbc.M206523200","volume":"277","author":"Johnson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2009.07.016_bib16","doi-asserted-by":"crossref","first-page":"18314","DOI":"10.1074\/jbc.M400009200","volume":"279","author":"Atreya","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2009.07.016_bib17","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jlcr.993","volume":"48","author":"Hong","year":"2005","journal-title":"J. Labelled Comp. Radiopharm."},{"key":"10.1016\/j.abb.2009.07.016_bib18","doi-asserted-by":"crossref","first-page":"10295","DOI":"10.1021\/bi0490439","volume":"43","author":"Agrawal","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.abb.2009.07.016_bib19","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1021\/bi701363s","volume":"46","author":"Hong","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.abb.2009.07.016_bib20","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1016\/S0021-9258(19)85498-4","volume":"255","author":"Delk","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2009.07.016_bib21","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0006-291X(79)90858-1","volume":"86","author":"Delk","year":"1979","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2009.07.016_bib22","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nature07973","volume":"458","author":"Koehn","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.abb.2009.07.016_bib23","doi-asserted-by":"crossref","first-page":"24048","DOI":"10.1074\/jbc.M600745200","volume":"281","author":"Graziani","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2009.07.016_bib24","doi-asserted-by":"crossref","first-page":"54340","DOI":"10.1074\/jbc.M409121200","volume":"279","author":"Graziani","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2009.07.016_bib25","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1039\/b700977a","author":"Chernyshev","year":"2007","journal-title":"Chem. Commun."},{"key":"10.1016\/j.abb.2009.07.016_bib26","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1021\/ja0432214","volume":"127","author":"Gattis","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.abb.2009.07.016_bib27","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1074\/jbc.M412415200","volume":"280","author":"Griffin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2009.07.016_bib28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/bst0320231","volume":"32","author":"Leduc","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.abb.2009.07.016_bib29","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/0006-291X(75)90886-4","volume":"67","author":"Wataya","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2009.07.016_bib30","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1111\/j.1742-4658.2009.07003.x","volume":"276","author":"Wang","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.abb.2009.07.016_bib31","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1073\/pnas.0401365101","volume":"101","author":"Leduc","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.abb.2009.07.016_bib32","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jmb.2005.07.071","volume":"352","author":"Sampathkumar","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.abb.2009.07.016_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2006.04.061","volume":"360","author":"Sampathkumar","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.abb.2009.07.016_bib34","doi-asserted-by":"crossref","first-page":"32753","DOI":"10.1074\/jbc.273.49.32753","volume":"273","author":"Brown","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2009.07.016_bib35","doi-asserted-by":"crossref","first-page":"14926","DOI":"10.1021\/bi060919g","volume":"45","author":"Fagan","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.abb.2009.07.016_bib36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF00903105","volume":"104","author":"Klotzer","year":"1973","journal-title":"Monatsh. Chem."},{"key":"10.1016\/j.abb.2009.07.016_bib37","series-title":"Advanced Organic Chemistry, Part A","author":"Carey","year":"2000"},{"key":"10.1016\/j.abb.2009.07.016_bib38","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00253-006-0763-1","volume":"74","author":"Chernyshev","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.abb.2009.07.016_bib39","doi-asserted-by":"crossref","first-page":"e2237","DOI":"10.1371\/journal.pone.0002237","volume":"3","author":"Hunter","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.abb.2009.07.016_bib40","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1039\/b517881a","author":"Mason","year":"2006","journal-title":"Chem. Commun."},{"key":"10.1016\/j.abb.2009.07.016_bib41","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tibs.2006.03.003","volume":"31","author":"Mattevi","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.abb.2009.07.016_bib42","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1016\/j.bmcl.2008.04.080","volume":"18","author":"Esra \u00d6nen","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986109002392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986109002392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T05:10:43Z","timestamp":1633756243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986109002392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0003986109002392"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2009.07.016","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}