{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:59:19Z","timestamp":1791341959735,"version":"4.3.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016642","name":"Japan Chemical Industry Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.abb.2010.06.015","type":"journal-article","created":{"date-parts":[[2010,6,18]],"date-time":"2010-06-18T04:30:34Z","timestamp":1276835434000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Biopersistent fiber-induced inflammation and carcinogenesis: Lessons learned from asbestos toward safety of fibrous nanomaterials"],"prefix":"10.1016","volume":"502","author":[{"given":"Hirotaka","family":"Nagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Toyokuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2010.06.015_bib1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1056\/NEJMra050152","volume":"353","author":"Robinson","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.abb.2010.06.015_bib2","series-title":"Pathology of Asbestos-associated Diseases","year":"2004"},{"key":"10.1016\/j.abb.2010.06.015_bib3","first-page":"965","volume":"67","author":"Stanton","year":"1981","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.abb.2010.06.015_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfj130","volume":"92","author":"Donaldson","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.abb.2010.06.015_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/354056a0","volume":"354","author":"Iijima","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.abb.2010.06.015_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2131\/jts.33.105","volume":"33","author":"Takagi","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.abb.2010.06.015_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2131\/jts.34.65","volume":"34","author":"Sakamoto","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.abb.2010.06.015_bib8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nnano.2008.111","volume":"3","author":"Poland","year":"2008","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.abb.2010.06.015_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1743-8977-6-16","volume":"6","author":"Jaurand","year":"2009","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.abb.2010.06.015_bib10","year":"2006"},{"key":"10.1016\/j.abb.2010.06.015_bib11","first-page":"159","volume":"34","author":"Addison","year":"1990","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.abb.2010.06.015_bib12","series-title":"Epidemiology of Work Related Diseases","author":"McDonald","year":"2000"},{"key":"10.1016\/j.abb.2010.06.015_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0891-5849(92)90117-Y","volume":"12","author":"Kamp","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.abb.2010.06.015_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1349-7006.2008.01001.x","volume":"100","author":"Toyokuni","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.abb.2010.06.015_bib15","first-page":"417","volume":"26","author":"McDonald","year":"1982","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.abb.2010.06.015_bib16","first-page":"343","volume":"126","author":"Wang","year":"1987","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.abb.2010.06.015_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1042\/bj2500589","volume":"250","author":"Ozaki","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.abb.2010.06.015_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2005.02.013","volume":"7","author":"Balkwill","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.abb.2010.06.015_bib19","doi-asserted-by":"crossref","first-page":"10397","DOI":"10.1073\/pnas.0604008103","volume":"103","author":"Yang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.abb.2010.06.015_bib20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1023\/A:1007934229968","volume":"11","author":"Toyokuni","year":"1998","journal-title":"Biotherapy"},{"key":"10.1016\/j.abb.2010.06.015_bib21","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/labinvest.2009.140","volume":"90","author":"Hu","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.abb.2010.06.015_bib22","first-page":"511","volume":"11","author":"Xio","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.abb.2010.06.015_bib23","first-page":"1","volume":"71","author":"Toyokuni","year":"2009","journal-title":"Nagoya J. Med. Sci."},{"key":"10.1016\/j.abb.2010.06.015_bib24","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1103\/PhysRevLett.86.1118","volume":"86","author":"Jorio","year":"2001","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.abb.2010.06.015_bib25","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1021\/j100196a017","volume":"96","author":"Endo","year":"1992","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.abb.2010.06.015_bib26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nnano.2009.305","volume":"4","author":"Ryman-Rasmussen","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.abb.2010.06.015_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/rtph.2001.1467","volume":"33","author":"Maxim","year":"2001","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.abb.2010.06.015_bib28","first-page":"271","volume":"46","author":"Donaldson","year":"1989","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.abb.2010.06.015_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.toxlet.2006.11.001","volume":"168","author":"Pulskamp","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.abb.2010.06.015_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.toxlet.2005.08.011","volume":"161","author":"Sayes","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.abb.2010.06.015_bib31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.toxlet.2006.08.019","volume":"168","author":"Wick","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.abb.2010.06.015_bib32","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1021\/tx800101p","volume":"21","author":"Muller","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.abb.2010.06.015_bib33","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1164\/ajrccm\/141.5_Pt_1.1266","volume":"141","author":"Mossman","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.abb.2010.06.015_bib34","series-title":"Tumors of the Serosal Membranes","author":"Churg","year":"2006"},{"key":"10.1016\/j.abb.2010.06.015_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1743-8977-7-5","volume":"7","author":"Donaldson","year":"2010","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.abb.2010.06.015_bib36","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.abb.2010.06.015_bib37","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/j.1462-5822.2008.01177.x","volume":"10","author":"Koo","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.abb.2010.06.015_bib38","first-page":"426","volume":"128","author":"Moalli","year":"1987","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.abb.2010.06.015_bib39","first-page":"146","volume":"35","author":"Morgan","year":"1978","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.abb.2010.06.015_bib40","first-page":"287","volume":"73","author":"Churg","year":"1992","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.abb.2010.06.015_bib41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/path.2284","volume":"214","author":"Zhang","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.abb.2010.06.015_bib42","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1111\/j.1742-4658.2008.06488.x","volume":"275","author":"Sumimoto","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.abb.2010.06.015_bib43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.taap.2005.01.008","volume":"207","author":"Muller","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.abb.2010.06.015_bib44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/toxsci\/kfm196","volume":"100","author":"Mitchell","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.abb.2010.06.015_bib45","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1021\/tx800100s","volume":"21","author":"Fenoglio","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.abb.2010.06.015_bib46","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.actbio.2008.05.018","volume":"4","author":"Fraczek","year":"2008","journal-title":"Acta Biomater."},{"key":"10.1016\/j.abb.2010.06.015_bib47","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3181\/0805-RM-179","volume":"233","author":"Inoue","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.abb.2010.06.015_bib48","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nnano.2009.151","volume":"4","author":"Mitchell","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.abb.2010.06.015_bib49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tox.2009.02.009","volume":"259","author":"Park","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.abb.2010.06.015_bib50","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.taap.2009.04.003","volume":"237","author":"Inoue","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.abb.2010.06.015_bib51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tox.2009.10.007","volume":"266","author":"Ellinger-Ziegelbauer","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.abb.2010.06.015_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfp057","volume":"109","author":"Nygaard","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.abb.2010.06.015_bib53","doi-asserted-by":"crossref","unstructured":"M.F. Cesta, J.P. Ryman-Rasmussen, D.G. Wallace, T. Masinde, G. Hurlburt, A.J. Taylor, J.C. Bonner, Am. J. Respir. Cell Mol. Biol., in press, doi:10.1165\/rcmb.2009-0113OC.","DOI":"10.1165\/rcmb.2009-0113OC"},{"key":"10.1016\/j.abb.2010.06.015_bib54","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1039\/b502429c","volume":"1","author":"Sato","year":"2005","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.abb.2010.06.015_bib55","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.taap.2008.06.016","volume":"232","author":"Hirano","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.abb.2010.06.015_bib56","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1016\/j.biomaterials.2009.04.019","volume":"30","author":"Cheng","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.abb.2010.06.015_bib57","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.taap.2009.10.015","volume":"242","author":"Haniu","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.abb.2010.06.015_bib58","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tox.2009.10.034","volume":"267","author":"Palomaki","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.abb.2010.06.015_bib59","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.toxlet.2004.11.004","volume":"155","author":"Monteiro-Riviere","year":"2005","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.abb.2010.06.015_bib60","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.nano.2006.07.005","volume":"2","author":"Witzmann","year":"2006","journal-title":"Nanomedicine"},{"key":"10.1016\/j.abb.2010.06.015_bib61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/carcin\/bgm243","volume":"29","author":"Muller","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.abb.2010.06.015_bib62","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.toxlet.2008.02.007","volume":"178","author":"Rotoli","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.abb.2010.06.015_bib63","first-page":"83","volume":"3","author":"Garza","year":"2008","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.abb.2010.06.015_bib64","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/tx800064j","volume":"21","author":"Karlsson","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.abb.2010.06.015_bib65","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tox.2008.09.007","volume":"253","author":"Simon-Deckers","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.abb.2010.06.015_bib66","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/15287390802476991","volume":"72","author":"Tabet","year":"2009","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.abb.2010.06.015_bib67","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.toxlet.2008.11.019","volume":"186","author":"Lindberg","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.abb.2010.06.015_bib68","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jbt.20296","volume":"23","author":"Ravichandran","year":"2009","journal-title":"J. Biochem. Mol. Toxicol."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986110002341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986110002341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:00:39Z","timestamp":1757743239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986110002341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0003986110002341"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2010.06.015","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biopersistent fiber-induced inflammation and carcinogenesis: Lessons learned from asbestos toward safety of fibrous nanomaterials","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2010.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}