{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:24:28Z","timestamp":1786983868956,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Linus Pauling Institute"},{"name":"OSU College of Pharmacy, Hopsteiner, Inc., New York"},{"name":"OSU Foundation Buhler-Wang Research Fund"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10RR027878"],"award-info":[{"award-number":["S10RR027878"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AT009168"],"award-info":[{"award-number":["R01AT009168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.abb.2016.03.008","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T12:34:04Z","timestamp":1457699644000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL\/6J mice"],"prefix":"10.1016","volume":"599","author":[{"given":"Cristobal L.","family":"Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie D.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewoo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph L.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-9347","authenticated-orcid":false,"given":"Jan F.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2016.03.008_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","volume":"109","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.abb.2016.03.008_bib2","series-title":"Prevalence of Metabolic Syndrome Among Adults 20 Years of Age and over, by Sex, Age, Race and Ethnicity, and Body Mass Index: United States, 2003\u20132006","author":"Ervin","year":"2009"},{"key":"10.1016\/j.abb.2016.03.008_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/oby.2011.169","volume":"20","author":"Trogdon","year":"2012","journal-title":"Obes. (Silver Spring)"},{"key":"10.1016\/j.abb.2016.03.008_bib4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jada.2007.12.007","volume":"108","author":"Hollander","year":"2008","journal-title":"J.\u00a0Am. Diet. Assoc."},{"key":"10.1016\/j.abb.2016.03.008_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.phytochem.2012.04.018","volume":"91","author":"Legette","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.abb.2016.03.008_bib6","doi-asserted-by":"crossref","first-page":"19000","DOI":"10.1074\/jbc.M112.445452","volume":"288","author":"Kirkwood","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.abb.2016.03.008_bib7","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.fct.2010.04.030","volume":"48","author":"Dorn","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.abb.2016.03.008_bib8","first-page":"P1","volume":"50","author":"Dorn","year":"2012","journal-title":"Z.\u00a0Gastroenterol."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.abb.2016.03.008_bib9","doi-asserted-by":"crossref","first-page":"S205","DOI":"10.1002\/mnfr.200900314","volume":"54","author":"Dorn","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.abb.2016.03.008_bib10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fphys.2015.00140","volume":"6","author":"Weiskirchen","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.abb.2016.03.008_bib11","first-page":"159","volume":"63","author":"Yui","year":"2014","journal-title":"J.\u00a0Oleo Sci."},{"key":"10.1016\/j.abb.2016.03.008_bib12","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1002\/mnfr.201200794","volume":"57","author":"Doddapattar","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.abb.2016.03.008_bib13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3390\/molecules20010754","volume":"20","author":"Liu","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.abb.2016.03.008_bib14","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bbrc.2005.08.159","volume":"336","author":"Nozawa","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2016.03.008_bib15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/1573399810666140508121012","volume":"10","author":"Wang","year":"2014","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.abb.2016.03.008_bib16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pharmthera.2012.11.004","volume":"137","author":"Fellmann","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.abb.2016.03.008_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.physbeh.2004.02.006","volume":"81","author":"Collins","year":"2004","journal-title":"Physiol. Behav."},{"issue":"Suppl.\u00a03","key":"10.1016\/j.abb.2016.03.008_bib18","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.2337\/diabetes.53.suppl_3.S215","volume":"53","author":"Winzell","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.abb.2016.03.008_bib19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.atherosclerosis.2011.04.018","volume":"216","author":"Cariou","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.abb.2016.03.008_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/cpt.281","volume":"99","author":"Shantha","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.abb.2016.03.008_bib21","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.abb.2016.03.008_bib22","first-page":"s18","volume":"39","author":"Legette","year":"2013","journal-title":"Spectrosc. Springf"},{"key":"10.1016\/j.abb.2016.03.008_bib23","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1194\/jlr.M058941","volume":"56","author":"Choi","year":"2015","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.abb.2016.03.008_bib24","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.abb.2016.03.008_bib25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12020-009-9224-9","volume":"36","author":"Hoffler","year":"2009","journal-title":"Endocrine"},{"key":"10.1016\/j.abb.2016.03.008_bib26","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/oby.2007.238","volume":"15","author":"Gallou-Kabani","year":"2007","journal-title":"Obes. Silver Spring"},{"key":"10.1016\/j.abb.2016.03.008_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2014.08.045","volume":"275","author":"Zamzow","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.abb.2016.03.008_bib28","series-title":"Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers","author":"FDA","year":"2005"},{"key":"10.1016\/j.abb.2016.03.008_bib29","doi-asserted-by":"crossref","first-page":"20565","DOI":"10.1074\/jbc.M115.656975","volume":"290","author":"Miyata","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.abb.2016.03.008_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/mnfr.201300333","volume":"58","author":"Legette","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.abb.2016.03.008_bib31","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/mnfr.200500089","volume":"49","author":"Hussong","year":"2005","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.abb.2016.03.008_bib32","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/oby.2008.66","volume":"16","author":"Yang","year":"2008","journal-title":"Obes. Silver Spring"},{"key":"10.1016\/j.abb.2016.03.008_bib33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.abb.2016.03.008_bib34","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","volume":"116","author":"Kanda","year":"2006","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.abb.2016.03.008_bib35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yexmp.2012.05.003","volume":"94","author":"Dorn","year":"2013","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.abb.2016.03.008_bib36","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1055\/s-0029-1241013","volume":"76","author":"Peluso","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.abb.2016.03.008_bib37","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1021\/jf901244k","volume":"57","author":"Lupinacci","year":"2009","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.abb.2016.03.008_bib38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuint.2010.11.008","volume":"58","author":"Lee","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.abb.2016.03.008_bib39","first-page":"52","volume":"4","author":"McArdle","year":"2013","journal-title":"Front. Endocrinol. Lausanne"},{"key":"10.1016\/j.abb.2016.03.008_bib40","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1210\/en.2009-0926","volume":"151","author":"Tateya","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.abb.2016.03.008_bib41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1467-789X.2007.00410.x","volume":"9","author":"Hoene","year":"2008","journal-title":"Obes. Rev."},{"key":"10.1016\/j.abb.2016.03.008_bib42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.metabol.2014.08.004","volume":"64","author":"Park","year":"2015","journal-title":"Metabolism"},{"key":"10.1016\/j.abb.2016.03.008_bib43","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.abb.2016.03.008_bib44","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1210\/en.2004-0726","volume":"145","author":"Munzberg","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.abb.2016.03.008_bib45","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jacc.2008.05.060","volume":"52","author":"Martin","year":"2008","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.abb.2016.03.008_bib46","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1039\/C5FO00602C","volume":"6","author":"Liu","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.abb.2016.03.008_bib47","author":"Justo","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.abb.2016.03.008_bib48","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1021\/acs.jafc.5b00073","volume":"63","author":"Kuo","year":"2015","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.abb.2016.03.008_bib49","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.tips.2015.04.010","volume":"36","author":"Soyal","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.abb.2016.03.008_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10787-015-0255-y","volume":"24","author":"Ellulu","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.abb.2016.03.008_bib51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","volume":"232","author":"Brown","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.abb.2016.03.008_bib52","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/S0140-6736(14)61368-4","volume":"385","author":"Fulcher","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.abb.2016.03.008_bib53","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1373\/clinchem.2009.128645","volume":"55","author":"Chan","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.abb.2016.03.008_bib54","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1373\/clinchem.2007.099747","volume":"54","author":"Lambert","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.abb.2016.03.008_bib55","doi-asserted-by":"crossref","first-page":"40","DOI":"10.7326\/M14-2957","volume":"163","author":"Navarese","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.abb.2016.03.008_bib56","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0140-6736(13)61914-5","volume":"383","author":"Fitzgerald","year":"2014","journal-title":"Lancet"}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986116300601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986116300601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T19:37:03Z","timestamp":1718393823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986116300601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":56,"alternative-id":["S0003986116300601"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2016.03.008","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL\/6J mice","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2016.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}