{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:51:37Z","timestamp":1780599097165,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.abb.2018.11.007","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T02:37:54Z","timestamp":1541990274000},"page":"56-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Interplay of N  acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs"],"prefix":"10.1016","volume":"661","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2138-1303","authenticated-orcid":false,"given":"Tahir","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Mushtaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Maryam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam","family":"Farhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Saba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-3040","authenticated-orcid":false,"given":"Muhammad Ishtiaq","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneesa","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9049-4718","authenticated-orcid":false,"given":"Mariam","family":"Anees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Duygu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Hamera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobia","family":"Tabassum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qamar","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A","family":"da Costa Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-5211","authenticated-orcid":false,"given":"Iram","family":"Murtaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2018.11.007_bib1","doi-asserted-by":"crossref","first-page":"A13","DOI":"10.1253\/circj.CJ-08-0481","article-title":"Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure","author":"Oka","year":"2008","journal-title":"Circ. J."},{"key":"10.1016\/j.abb.2018.11.007_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbrep.2017.12.001","article-title":"Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence","volume":"13","author":"Davis","year":"2018","journal-title":"Biochem. Biophys. Reports"},{"key":"10.1016\/j.abb.2018.11.007_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.abb.2018.11.007_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/S1471-4914(03)00164-3","article-title":"Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy","author":"Tarone","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.abb.2018.11.007_bib5","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/CIRCULATIONAHA.106.637124","article-title":"Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling","volume":"114","author":"Ni","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.abb.2018.11.007_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/JCI200422220","article-title":"Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex","volume":"114","author":"Li","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.abb.2018.11.007_bib7","doi-asserted-by":"crossref","first-page":"29730","DOI":"10.1074\/jbc.M805514200","article-title":"Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase","volume":"283","author":"Tan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2018.11.007_bib8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0092-8674(04)00452-0","article-title":"FoxOs at the crossroads of cellular review metabolism , differentiation , and transformation","volume":"117","author":"Accili","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.abb.2018.11.007_bib9","article-title":"Reactive oxygen species in health and disease","volume":"14","author":"Alfadda","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.abb.2018.11.007_bib10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10059-011-0276-3","article-title":"Regulation of reactive oxygen species generation in cell signaling","volume":"32","author":"Bae","year":"2011","journal-title":"Mol. Cell."},{"key":"10.1016\/j.abb.2018.11.007_bib11","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/bph.13792","article-title":"The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system","volume":"174","author":"Kietzmann","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.abb.2018.11.007_bib12","first-page":"928","article-title":"Interplay of phosphorylated apoptosis repressor with card, casein kinase-2 and reactive oxygen species in regulating endothelin-1-induced cardiomyocyte hypertrophy, Iran","volume":"16","author":"Murtaza","year":"2013","journal-title":"J. Basic Med. Sci."},{"key":"10.1016\/j.abb.2018.11.007_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/hc0402.102863","article-title":"Involvement of nuclear factor-\u03baB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy","volume":"105","author":"Hirotani","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.abb.2018.11.007_bib14","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1161\/01.CIR.0000018605.14470.DD","article-title":"Carvedilol decreases elevated oxidative stress in human failing myocardium","volume":"105","author":"Nakamura","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.abb.2018.11.007_bib15","first-page":"30","article-title":"Insulin over expression induces heart abnormalities via reactive oxygen species regulation, might be step towards cardiac hypertrophy","volume":"61","author":"Mushtaq","year":"2015","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.abb.2018.11.007_bib16","doi-asserted-by":"crossref","first-page":"H651","DOI":"10.1152\/ajpheart.00638.2014","article-title":"Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload","volume":"308","author":"Yancey","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.abb.2018.11.007_bib17","first-page":"3091","article-title":"Cardiovascular diseases\u202f: oxidative damage and antioxidant protection","volume":"18","author":"Zhang","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.abb.2018.11.007_bib18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1254\/jphs.FP0071664","article-title":"Comparison of the protective effect of N-acetylcysteine by different treatments on rat myocardial ischemia-reperfusion injury","volume":"106","author":"Abe","year":"2008","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.abb.2018.11.007_bib19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejpn.2014.12.007","article-title":"Current role of melatonin in pediatric neurology: clinical recommendations","volume":"19","author":"Bruni","year":"2015","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.abb.2018.11.007_bib20","first-page":"1","article-title":"How do microRNAs regulate gene expression\u202f?","author":"Jackson","year":"2007","journal-title":"Sci. STKE"},{"key":"10.1016\/j.abb.2018.11.007_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.abb.2017.09.001","article-title":"Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease","volume":"633","author":"Jan","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2018.11.007_bib22","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/ncb2126","article-title":"MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin\/NFAT signalling","volume":"12","author":"Da Costa Martins","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.abb.2018.11.007_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.01370-09","article-title":"Uncoupling of expression of an intronic MicroRNA and its myosin host gene by exon skipping","author":"Bell","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.abb.2018.11.007_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.carpath.2015.06.003","article-title":"Inhibiting microRNA-144 abates oxidative stress and reduces apoptosis in hearts of streptozotocin-induced diabetic mice","volume":"24","author":"Yu","year":"2015","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.abb.2018.11.007_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.24636","article-title":"MicroRNA-214 protects cardiac myocytes against H2O2-induced injury","author":"Lv","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.abb.2018.11.007_bib26","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/cdd.2011.42","article-title":"miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition","volume":"18","author":"Magenta","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.abb.2018.11.007_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006377","article-title":"Ionizing radiation-induced oxidative stress alters miRNA expression","author":"Simone","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.abb.2018.11.007_bib28","first-page":"9291","article-title":"Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer","volume":"8","author":"Dou","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.abb.2018.11.007_bib29","article-title":"Serum miR-152, miR-148a, miR-148b, and miR-21 as novel biomarkers in non-small cell lung cancer screening","author":"shan Yang","year":"2015","journal-title":"Tumor Biol."},{"key":"10.1016\/j.abb.2018.11.007_bib30","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ncomms2090","article-title":"The miRNA-212\/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy","volume":"3","author":"Ucar","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2018.11.007_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/1479-5876-11-130","article-title":"A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats","volume":"11","author":"Chowdhury","year":"2013","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.abb.2018.11.007_bib32","first-page":"101","article-title":"MORPHOLOGY and PATHOMORPHOLOGY effect of endothelin-1 and atrial natriuretic peptide-II on heart morphogenesis in albino rats","volume":"134","author":"Mel\u2019nikova","year":"2002","journal-title":"Byulleten\u2019 Eksp. Biol. i Meditsiny."},{"key":"10.1016\/j.abb.2018.11.007_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mrgentox.2007.04.006","article-title":"High-throughput spectrophotometric assay of reactive oxygen species in serum","volume":"631","author":"Hayashi","year":"2007","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.abb.2018.11.007_bib34","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3906\/sag-1308-25","article-title":"Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarction","volume":"45","author":"Mushtaq","year":"2015","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.abb.2018.11.007_bib35","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1515\/biolog-2015-0030","article-title":"Increased endogenous serotonin level in diabetic conditions may lead to cardiac valvulopathy via reactive oxygen species regulation","volume":"70","author":"Ali","year":"2015","journal-title":"Biologia"},{"key":"10.1016\/j.abb.2018.11.007_bib36","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2298\/ABS150908028A","article-title":"Serotonin-promoted elevation of ROS levels may lead to cardiac pathologies in diabetic rat","volume":"67","author":"Ali","year":"2015","journal-title":"Arch. Biol. Sci."},{"key":"10.1016\/j.abb.2018.11.007_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/256879","article-title":"Association between oxidative stress and outcome in different subtypes of acute ischemic stroke","author":"Tsai","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.abb.2018.11.007_bib38","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/emmm.201200234","article-title":"Repression of miR-142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy","volume":"4","author":"Sharma","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.abb.2018.11.007_bib39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11010-014-1977-7","article-title":"Gelsolin ( GSN ) induces cardiomyocyte hypertrophy and BNP expression via p38 signaling and GATA-4 transcriptional factor activation","volume":"390","author":"Ho","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.abb.2018.11.007_bib40","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1111\/jcmm.13076","article-title":"CD38 promotes angiotensin II-induced cardiac hypertrophy","volume":"21","author":"Guan","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.abb.2018.11.007_bib41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/jmcc.2002.1526","article-title":"Role of oxidative stress in myocardial hypertrophy and failure","volume":"388","author":"Sawyer","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.abb.2018.11.007_bib42","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.abb.2018.11.007_bib43","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1074\/jbc.M411787200","article-title":"Interleukin-18 is a pro-hypertrophic cytokine that acts through a 1-akt-GATA4 signaling pathway in cardiomyocytes *","volume":"280","author":"Chandrasekar","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2018.11.007_bib44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11130-008-0105-9","article-title":"Effect of green tea and vitamin E combination in isoproterenol induced myocardial infarction in rats","volume":"64","author":"Upaganlawar","year":"2009","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.abb.2018.11.007_bib45","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/j.fct.2010.04.046","article-title":"Protective effect of Artemisia afra Jacq. on isoproterenol-induced myocardial injury in Wistar rats","volume":"48","author":"Sunmonu","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.abb.2018.11.007_bib46","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nrcardio.2015.71","article-title":"Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure","volume":"12","author":"Greco","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.abb.2018.11.007_bib47","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.yjmcc.2015.03.014","article-title":"Non-coding RNA in control of gene regulatory programs in cardiac development and disease","volume":"89","author":"Philippen","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.abb.2018.11.007_bib48","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s12013-013-9672-y","article-title":"Relationship between downregulation of miRNAs and increase of oxidative stress in the development of diabetic cardiac dysfunction: junctin as a target protein of mir-1","volume":"67","author":"Yildirim","year":"2013","journal-title":"Cell Biochem. Biophys."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986118306076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986118306076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T07:53:59Z","timestamp":1545724439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986118306076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":48,"alternative-id":["S0003986118306076"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2018.11.007","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2018.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}