{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T21:07:48Z","timestamp":1774559268745,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703528"],"award-info":[{"award-number":["81703528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.abb.2019.05.009","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T10:55:58Z","timestamp":1557572158000},"page":"42-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment"],"prefix":"10.1016","volume":"671","author":[{"given":"Lingling","family":"Si","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yachao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuheng","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Onodera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ikejima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.abb.2019.05.009_bib1","first-page":"271","article-title":"Cancer treatment and survivorship statistics, 2016","volume":"66","author":"Miller","year":"2016","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.abb.2019.05.009_bib2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2017.07.019","article-title":"Mitochondrial fusion, fission, and mitochondrial toxicity","volume":"391","author":"Meyer","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.abb.2019.05.009_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jchemneu.2017.12.004","article-title":"Reinforcing mitochondrial functions in aging brain: an insight into Parkinson's disease therapeutics","volume":"95","author":"Chandra","year":"2019","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.abb.2019.05.009_bib4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3389\/fphar.2017.00753","article-title":"Impairment of mitochondrial biogenesis and dynamics involved in isoniazid-induced apoptosis of HepG2 cells was alleviated by p38 MAPK pathway","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.abb.2019.05.009_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuint.2017.08.002","article-title":"Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease","volume":"117","author":"Chiang","year":"2018","journal-title":"Friedreich's ataxia, Neurochemistry international"},{"issue":"2","key":"10.1016\/j.abb.2019.05.009_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4196\/kjpp.2018.22.2.203","article-title":"Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation","volume":"22","author":"Kim","year":"2018","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"issue":"6","key":"10.1016\/j.abb.2019.05.009_bib7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1083\/jcb.200209124","article-title":"Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis","volume":"159","author":"Karbowski","year":"2002","journal-title":"J. Cell Biol."},{"issue":"40","key":"10.1016\/j.abb.2019.05.009_bib8","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1038\/onc.2012.494","article-title":"Mitochondrial dynamics regulates migration and invasion of breast cancer cells","volume":"32","author":"Zhao","year":"2013","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.abb.2019.05.009_bib9","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1111\/jcmm.13560","article-title":"Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission","volume":"22","author":"Han","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.abb.2019.05.009_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jphotobiol.2014.03.006","article-title":"The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells","volume":"133","author":"G\u00e1ndara","year":"2014","journal-title":"J. Photochem. Photobiol. B Biol."},{"issue":"1","key":"10.1016\/j.abb.2019.05.009_bib11","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1038\/s41598-018-21674-6","article-title":"Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats","volume":"8","author":"Tong","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.abb.2019.05.009_bib12","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1002\/jcb.26693","article-title":"Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer","volume":"119","author":"Prack Mc Cormick","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.abb.2019.05.009_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jphs.2015.05.001","article-title":"ERalpha down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells","volume":"128","author":"Zheng","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.abb.2019.05.009_bib14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-3-319-22671-2_8","article-title":"The emerging role of MitomiRs in the pathophysiology of human disease","volume":"888","author":"Duarte","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"issue":"14","key":"10.1016\/j.abb.2019.05.009_bib15","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.jmb.2017.05.023","article-title":"Connection of protein transport and organelle contact sites in mitochondria","volume":"429","author":"Ellenrieder","year":"2017","journal-title":"J. Mol. Biol."},{"issue":"9","key":"10.1016\/j.abb.2019.05.009_bib16","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1080\/15548627.2016.1193656","article-title":"FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy","volume":"12","author":"Wu","year":"2016","journal-title":"Autophagy"},{"issue":"Pt 10","key":"10.1016\/j.abb.2019.05.009_bib17","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1093\/brain\/awv182","article-title":"Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission","volume":"138","author":"Shahni","year":"2015","journal-title":"Brain : J. Neurol."},{"issue":"1","key":"10.1016\/j.abb.2019.05.009_bib18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10549-008-0217-9","article-title":"MCF-7 breast carcinoma cells do not express caspase-3","volume":"117","author":"Janicke","year":"2009","journal-title":"Breast Canc. Res. Treat."},{"issue":"21","key":"10.1016\/j.abb.2019.05.009_bib19","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V120.21.5121.5121","article-title":"Drp1 activation overcomes diffuse large B-cell lymphoma cells radioresistance","volume":"120","author":"Pang","year":"2012","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.abb.2019.05.009_bib20","first-page":"1148","article-title":"Silibinin promotes the apoptosis of gastric cancer BGC823 cells through caspase pathway","volume":"22","author":"Li","year":"2017","journal-title":"Journal of B.U.ON. : Off. J. Balkan Union of Oncol."},{"issue":"6","key":"10.1016\/j.abb.2019.05.009_bib21","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3892\/or.2015.3915","article-title":"Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells","volume":"33","author":"Jiang","year":"2015","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.abb.2019.05.009_bib22","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/jcp.26069","article-title":"Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells","volume":"233","author":"Ham","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.abb.2019.05.009_bib23","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1080\/01635581.2017.1367935","article-title":"Silibinin reduces the impact of obesity on invasive liver cancer","volume":"69","author":"Miethe","year":"2017","journal-title":"Nutr. Canc."},{"key":"10.1016\/j.abb.2019.05.009_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.abb.2016.01.002","article-title":"ERbeta up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells","volume":"591","author":"Zheng","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2019.05.009_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.lfs.2018.11.037","article-title":"Silibinin inhibits endometrial carcinoma via blocking pathways of STAT3 activation and SREBP1-mediated lipid accumulation","volume":"217","author":"Shi","year":"2019","journal-title":"Life Sci."},{"issue":"11","key":"10.1016\/j.abb.2019.05.009_bib26","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.7150\/ijbs.21300","article-title":"Overexpression of selenoprotein H prevents mitochondrial dynamic imbalance induced by glutamate exposure","volume":"13","author":"Ma","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.abb.2019.05.009_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41420-018-0042-9","article-title":"Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells","volume":"4","author":"Hoque","year":"2018","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.abb.2019.05.009_bib28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1083\/jcb.143.2.351","article-title":"A human dynamin-related protein controls the distribution of mitochondria","volume":"143","author":"Smirnova","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.abb.2019.05.009_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.toxlet.2017.12.004","article-title":"PGAM5 regulates PINK1\/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction","volume":"284","author":"Park","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.abb.2019.05.009_bib30","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.3892\/mmr.2017.7203","article-title":"Amyloid beta-42 induces neuronal apoptosis by targeting mitochondria","volume":"16","author":"Han","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.abb.2019.05.009_bib31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.201511036","article-title":"Metabolic regulation of mitochondrial dynamics","volume":"212","author":"Mishra","year":"2016","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.abb.2019.05.009_bib32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/1573406412666160307151904","article-title":"Isoliquiritigenin inhibits proliferation and induces apoptosis via alleviating hypoxia and reducing glycolysis in mouse melanoma B16F10 cells","volume":"11","author":"Wang","year":"2016","journal-title":"Recent Pat. Anti-Cancer Drug Discov."},{"issue":"3","key":"10.1016\/j.abb.2019.05.009_bib33","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.bbrc.2018.01.113","article-title":"Cyclosporin A inhibits mitochondrial biogenesis in Hep G2 cells","volume":"496","author":"Qi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2019.05.009_bib34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejpb.2019.02.016","article-title":"Hyaluronic acid functionalized nanoparticles loaded with IR780 and DOX for cancer chemo-photothermal therapy","volume":"137","author":"Alves","year":"2019","journal-title":"Eur. J. Pharm. Biopharm. : Off. J. Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"issue":"9","key":"10.1016\/j.abb.2019.05.009_bib35","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4161\/cc.24092","article-title":"Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer","volume":"12","author":"Curry","year":"2013","journal-title":"Cell Cycle"},{"issue":"2","key":"10.1016\/j.abb.2019.05.009_bib36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0092-8674(00)80564-4","article-title":"Cell death in development","volume":"96","author":"Vaux","year":"1999","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.abb.2019.05.009_bib37","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1073\/pnas.95.4.1455","article-title":"Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux","volume":"95","author":"Shimizu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.abb.2019.05.009_bib38","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/cdd.2010.135","article-title":"BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane","volume":"18","author":"Schug","year":"2011","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.abb.2019.05.009_bib39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.radonc.2017.11.019","article-title":"Fragmentation level determines mitochondrial damage response and subsequently the fate of cancer cells exposed to carbon ions, Radiotherapy and oncology","volume":"129","author":"Jin","year":"2018","journal-title":"J. Eur. Soc. Therap. Radiol. Oncol."},{"key":"10.1016\/j.abb.2019.05.009_bib40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mito.2016.06.006","article-title":"Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate","volume":"30","author":"Sehrawat","year":"2016","journal-title":"Mitochondrion"},{"issue":"3","key":"10.1016\/j.abb.2019.05.009_bib41","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1254\/jphs.08054FP","article-title":"Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochondrial apoptotic pathways in human breast cancer MCF-7 cells","volume":"107","author":"Wang","year":"2008","journal-title":"J. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.abb.2019.05.009_bib42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3109\/10715760903300717","article-title":"Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells","volume":"44","author":"Wang","year":"2010","journal-title":"Free Radic. Res."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986119300980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986119300980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:10:24Z","timestamp":1757743824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986119300980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":42,"alternative-id":["S0003986119300980"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2019.05.009","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2019.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}