{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T22:06:40Z","timestamp":1767046000106,"version":"3.44.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.abb.2019.07.009","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T19:49:18Z","timestamp":1562874558000},"page":"108044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["HDAC3 positively regulates HE4 expression to promote ovarian carcinoma progression"],"prefix":"10.1016","volume":"675","author":[{"given":"Tong","family":"Lou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyu","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongdong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.abb.2019.07.009_bib1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1469-185X.1996.tb01283.x","article-title":"Ovarian surface epithelium, ovulation and carcinogenesis","volume":"71","author":"Murdoch","year":"1996","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"issue":"3","key":"10.1016\/j.abb.2019.07.009_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/01.pgp.0000164599.26969.8a","article-title":"The impact of c-kit and ki-67 expression on patients prognosis in advanced ovarian serous carcinoma","volume":"24","author":"Khalifeh","year":"2005","journal-title":"Int. J. Gynecol. Pathol. : Off. J. Int. Soc. Gynecol. Patholog."},{"issue":"35","key":"10.1016\/j.abb.2019.07.009_bib3","doi-asserted-by":"crossref","first-page":"12519","DOI":"10.1073\/pnas.0505641102","article-title":"Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer","volume":"102","author":"Eder","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"11","key":"10.1016\/j.abb.2019.07.009_bib4","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/S1470-2045(08)70277-8","article-title":"Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer","volume":"9","author":"Singh","year":"2008","journal-title":"Lancet Oncol."},{"issue":"8","key":"10.1016\/j.abb.2019.07.009_bib5","first-page":"2396","article-title":"Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer","volume":"7","author":"Schmalfeldt","year":"2001","journal-title":"Clin. Cancer Res. :Offic. J. Am. Assoc. Canc. Res."},{"issue":"1","key":"10.1016\/j.abb.2019.07.009_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.molcel.2008.02.030","article-title":"Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control","volume":"30","author":"Bhaskara","year":"2008","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.abb.2019.07.009_bib7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ccr.2010.10.022","article-title":"Hdac3 is essential for the maintenance of chromatin structure and genome stability","volume":"18","author":"Bhaskara","year":"2010","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.abb.2019.07.009_bib8","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI77088","article-title":"FOXP3+ regulatory T cell development and function require histone\/protein deacetylase 3","volume":"125","author":"Wang","year":"2015","journal-title":"J.\u00a0Clin. Investig."},{"year":"2019","series-title":"HDAC3 Inhibition Up-Regulates PD-L1 Expression in B-Cell Lymphomas and Augments the Efficacy of Anti-PD-L1 Therapy","author":"Deng","key":"10.1016\/j.abb.2019.07.009_bib9"},{"key":"10.1016\/j.abb.2019.07.009_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.28193","article-title":"Downregulation of HDAC2 and HDAC3 via oleuropein as a potent prevention and therapeutic agent in MCF-7 breast cancer cells","author":"Bayat","year":"2019","journal-title":"J.\u00a0Cell. Biochem."},{"issue":"4","key":"10.1016\/j.abb.2019.07.009_bib11","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708478","article-title":"Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer","volume":"10","author":"Yan","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"10.1016\/j.abb.2019.07.009_bib12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0378-1119(99)00342-X","article-title":"Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas","volume":"238","author":"Schummer","year":"1999","journal-title":"Gene"},{"issue":"1\u20132","key":"10.1016\/j.abb.2019.07.009_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0378-1119(99)00035-9","article-title":"Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray","volume":"229","author":"Wang","year":"1999","journal-title":"Gene"},{"issue":"13","key":"10.1016\/j.abb.2019.07.009_bib14","first-page":"3695","article-title":"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma","volume":"63","author":"Hellstrom","year":"2003","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.abb.2019.07.009_bib15","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1515\/cclm-2011-0477","article-title":"Diagnostic value of HE4 for ovarian cancer: a meta-analysis","volume":"50","author":"Yu","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.abb.2019.07.009_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biochi.2014.06.022","article-title":"Overexpression of Lewis y antigen promotes human epididymis protein 4-mediated invasion and metastasis of ovarian cancer cells","volume":"105","author":"Zhuang","year":"2014","journal-title":"Biochimie"},{"issue":"7","key":"10.1016\/j.abb.2019.07.009_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068994","article-title":"Co-expression of Lewis y antigen with human epididymis protein 4 in ovarian epithelial carcinoma","volume":"8","author":"Zhuang","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.abb.2019.07.009_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.86.1.15","article-title":"Phosphatidylinositol 3-kinase is required for insulin-like growth factor-I-induced vascular smooth muscle cell proliferation and migration","volume":"86","author":"Duan","year":"2000","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.abb.2019.07.009_bib19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nm.4483","article-title":"A\u00a0histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration","volume":"24","author":"He","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.abb.2019.07.009_bib20","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.biopha.2016.07.049","article-title":"Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K\/Akt-related signaling pathways","volume":"83","author":"Zhang","year":"2016","journal-title":"Biomed. Pharmacother.\u00a0= Biomedecine & pharmacotherapie"},{"issue":"1","key":"10.1016\/j.abb.2019.07.009_bib21","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/jog.13181","article-title":"Role of human epididymis protein 4 in chemoresistance and prognosis of epithelial ovarian cancer","volume":"43","author":"Lee","year":"2017","journal-title":"J.\u00a0Obstet. Gynaecol. Res."},{"key":"10.1016\/j.abb.2019.07.009_bib22","first-page":"237","article-title":"N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors","volume":"274","author":"Jones","year":"2003","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"1","key":"10.1016\/j.abb.2019.07.009_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrg2485","article-title":"The many roles of histone deacetylases in development and physiology: implications for disease and therapy","volume":"10","author":"Haberland","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"5","key":"10.1016\/j.abb.2019.07.009_bib24","doi-asserted-by":"crossref","first-page":"6428","DOI":"10.1002\/jcp.27378","article-title":"Tyrosine phosphorylation of HDAC3 by Src kinase mediates proliferation of HER2-positive breast cancer cells","volume":"234","author":"Seo","year":"2019","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.abb.2019.07.009_bib25","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.12659\/MSM.906576","article-title":"Relationship between histone deacetylase 3 (HDAC3) and breast cancer","volume":"24","author":"Cui","year":"2018","journal-title":"Med. Sci. Monit. : Int. Med. J. Exp. Clin. Res."},{"issue":"6","key":"10.1016\/j.abb.2019.07.009_bib26","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1172\/JCI90077","article-title":"Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis","volume":"127","author":"Zhang","year":"2017","journal-title":"J.\u00a0Clin. Investig."},{"issue":"35","key":"10.1016\/j.abb.2019.07.009_bib27","doi-asserted-by":"crossref","first-page":"56767","DOI":"10.18632\/oncotarget.10790","article-title":"Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells","volume":"7","author":"Jeong","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.abb.2019.07.009_bib28","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbrc.2012.02.008","article-title":"Human epididymis protein 4 (HE4) plays a key role in ovarian cancer cell adhesion and motility","volume":"419","author":"Lu","year":"2012","journal-title":"BBRC (Biochem. Biophys. Res. Commun.)"},{"issue":"4","key":"10.1016\/j.abb.2019.07.009_bib29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1995-7645(13)60055-3","article-title":"Effect of WFDC 2 silencing on the proliferation, motility and invasion of human serous ovarian cancer cells in\u00a0vitro","volume":"6","author":"Zhu","year":"2013","journal-title":"Asian Pacific J. Tropic. Med."},{"issue":"1","key":"10.1016\/j.abb.2019.07.009_bib30","first-page":"4","article-title":"The PI3K\/Akt\/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges","volume":"34","author":"Cheaib","year":"2015","journal-title":"Chin. J. Canc."},{"issue":"4","key":"10.1016\/j.abb.2019.07.009_bib31","first-page":"1305","article-title":"Upregulation of AKAP12 with HDAC3 depletion suppresses the progression and migration of colorectal cancer","volume":"52","author":"He","year":"2018","journal-title":"Int. J. Oncol."},{"issue":"4","key":"10.1016\/j.abb.2019.07.009_bib32","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s13277-014-2858-0","article-title":"The human epididymis protein 4 acts as a prognostic factor and promotes progression of gastric cancer","volume":"36","author":"Guo","year":"2015","journal-title":"Tumour Biol.: J. Int. Soc. Oncodevelopmen. Biol. Med."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986119302978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986119302978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:11:35Z","timestamp":1757743895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986119302978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":32,"alternative-id":["S0003986119302978"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2019.07.009","relation":{},"ISSN":["0003-9861"],"issn-type":[{"type":"print","value":"0003-9861"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HDAC3 positively regulates HE4 expression to promote ovarian carcinoma progression","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2019.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108044"}}