{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:11:51Z","timestamp":1788361911294,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.abb.2019.108095","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T11:04:54Z","timestamp":1567163094000},"page":"108095","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Regenerative effects of glycyrrhizin and\/or platelet rich plasma on type-II collagen induced arthritis: Targeting autophay machinery markers, inflammation and oxidative stress"],"prefix":"10.1016","volume":"675","author":[{"given":"Noha M.","family":"Shafik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Osama","family":"El-Esawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin A.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan A.","family":"Deghidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omnia Safwat","family":"El-Deeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.abb.2019.108095_bib1","first-page":"383","article-title":"Tofacitinib, an oral Janus kinase inhibitor: pooled efficacy and safety analyses in an Australian rheumatoid arthritis population","volume":"5","author":"Hall","year":"2018","journal-title":"RheumatolTher"},{"key":"10.1016\/j.abb.2019.108095_bib2","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.4727","article-title":"Improved quality of life and joint functions in patients with knee rheumatoid arthritis who underwent five portal arthroscopic synovectomy","volume":"6","author":"Liu","year":"2018","journal-title":"Peer J"},{"key":"10.1016\/j.abb.2019.108095_bib3","first-page":"171","article-title":"Pathogenesis of rheumatoid arthritis: the intersection of genetics and epigenetics","volume":"129","author":"Firestein","year":"2018","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"issue":"3","key":"10.1016\/j.abb.2019.108095_bib4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/14397595.2014.958274","article-title":"Chronological changes in baseline disease activity of patients with rheumatoid arthritis who received biologic DMARDs between 2003 and 2012","volume":"25","author":"Sato","year":"2015","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.abb.2019.108095_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.biomaterials.2014.12.017","article-title":"The antibody atliximab attenuates collagen-induced arthritis by neutralizing AIMP1, an inflammatory cytokine that enhances osteoclastogenesis","volume":"44","author":"Hong","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.abb.2019.108095_bib6","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.2119\/molmed.2015.00087","article-title":"High mobility group box protein 1 (HMGB1): the prototypical endogenous danger molecule","volume":"21","author":"Yang","year":"2015","journal-title":"Mol. Med."},{"issue":"10","key":"10.1016\/j.abb.2019.108095_bib7","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/rheumatology\/ket134","article-title":"The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis","volume":"52","author":"Chen","year":"2013","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"10.1016\/j.abb.2019.108095_bib8","first-page":"403","article-title":"Recent insights into the role of autophagy in the pathogenesis of rheumatoid arthritis","volume":"55","author":"Dai","year":"2016","journal-title":"Rheumatology (Oxford)"},{"issue":"9","key":"10.1016\/j.abb.2019.108095_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrrheum.2016.92","article-title":"Autophagy: controlling cell fate in rheumatic diseases","volume":"12","author":"Rockel","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.abb.2019.108095_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00011-012-0572-1","article-title":"Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis","volume":"62","author":"Xu","year":"2013","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.abb.2019.108095_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.yjmcc.2015.10.032","article-title":"Regulation of autophagy by Beclin 1 in the heart","volume":"95","author":"Maejima","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.abb.2019.108095_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/08830185.2017.1363198","article-title":"Redox-sensitive transcription factors play a significant role in the development of rheumatoid arthritis","volume":"37","author":"Le Rossignol","year":"2018","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.abb.2019.108095_bib13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ejphar.2007.08.012","article-title":"Inhibitory effect of glycyrrhizin on lipopolysaccharide and d-galactosamine-induced mouse liver injury","volume":"576","author":"Yoshida","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.abb.2019.108095_bib14","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/S0002-9270(01)02612-0","article-title":"Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C","volume":"96","author":"vanRossum","year":"2001","journal-title":"Am. J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.abb.2019.108095_bib15","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrrheum.2013.141","article-title":"Platelet-rich plasma for managing pain and inflammation in osteoarthritis","volume":"9","author":"Andia","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.abb.2019.108095_bib16","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.12659\/MSM.898218","article-title":"Advantages of pure platelet-rich plasma compared with leukocyte- and platelet-rich plasma in treating rabbit knee osteoarthritis","volume":"22","author":"Yin","year":"2016","journal-title":"Med. Sci. Monit."},{"issue":"4","key":"10.1016\/j.abb.2019.108095_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tibtech.2018.11.010","article-title":"Addressing reproducibility in stem cell and PRP therapies","volume":"37","author":"Anitua","year":"2019","journal-title":"Trends Biotechnol."},{"issue":"4","key":"10.1016\/j.abb.2019.108095_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/17453674.2017.1338417","article-title":"Effect of platelet-rich plasma on rat Achilles tendon healing is related to microbiota","volume":"88","author":"Dietrich","year":"2017","journal-title":"Acta Orthop."},{"key":"10.1016\/j.abb.2019.108095_bib19","doi-asserted-by":"crossref","first-page":"932930","DOI":"10.1155\/2014\/932930","article-title":"Effect of platelet-rich plasma on CCl4-induced chronic liver injury in male rats","volume":"2014","author":"Hesami","year":"2014","journal-title":"Int J Hepatol"},{"issue":"6","key":"10.1016\/j.abb.2019.108095_bib20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1139\/cjpp-2017-0738","article-title":"A\u00a0study on the regenerative effect of platelet-rich plasma on experimentally induced hepatic damage in albino rats","volume":"96","author":"Shoeib","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.abb.2019.108095_bib21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1084\/jem.146.3.857","article-title":"Autoimmunity to type II collagen an experimental model of arthritis","volume":"146","author":"Trentham","year":"1977","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.abb.2019.108095_bib22","first-page":"955","article-title":"Effects of diammoniumglycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism, Xenobiotica; the fate of foreign compounds in biological systems","volume":"39","author":"Chen","year":"2009"},{"issue":"6","key":"10.1016\/j.abb.2019.108095_bib23","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1159\/000491544","article-title":"Biochemical and molecular mechanisms of platelet rich plasma in ameliorating liver fibrosis induced by dimethylnitrosurea","volume":"47","author":"Salem","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.abb.2019.108095_bib24","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/S0002-9440(10)65077-8","article-title":"The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats","volume":"156","author":"Carlson","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.abb.2019.108095_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2249.2004.02499.x","article-title":"Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment","volume":"137","author":"Rioja","year":"2004","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.abb.2019.108095_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1952","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.abb.2019.108095_bib27","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J.\u00a0Investig. Dermatol."},{"issue":"2","key":"10.1016\/j.abb.2019.108095_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Sinha","year":"1972","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.abb.2019.108095_bib29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using quantitative PCR and the 2 (Delta Delta CT) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.abb.2019.108095_bib30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jmu.2016.11.001","article-title":"Serum calprotectin in rheumatoid arthritis: a promising diagnostic marker, how far is it related to activity and sonographic findings ?","volume":"25","author":"Mansour","year":"2017","journal-title":"J.\u00a0Med. Ultrasound"},{"issue":"2","key":"10.1016\/j.abb.2019.108095_bib31","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2174\/157488409788184936","article-title":"Mimicking self-antigens with synthetic peptides in systemic autoimmune rheumatic diseases","volume":"4","author":"Cai","year":"2009","journal-title":"Curr. Clin. Pharmacol."},{"issue":"5","key":"10.1016\/j.abb.2019.108095_bib32","doi-asserted-by":"crossref","first-page":"E298","DOI":"10.25011\/cim.v34i5.15673","article-title":"Correlation of synovial fluid HMGB-1 levels with radiographic severity of knee osteoarthritis","volume":"34","author":"Li","year":"2011","journal-title":"Clin. Investig. Med."},{"issue":"4","key":"10.1016\/j.abb.2019.108095_bib33","doi-asserted-by":"crossref","first-page":"17864","DOI":"10.4238\/2015.December.22.11","article-title":"PKR and HMGB1 expression and function in rheumatoid arthritis","volume":"14","author":"Wang","year":"2015","journal-title":"Genet. Mol. Res."},{"issue":"3","key":"10.1016\/j.abb.2019.108095_bib34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1365-2796.2003.01303.x","article-title":"HMGB1 is a potent trigger of arthritis","volume":"255","author":"Andersson","year":"2004","journal-title":"J.\u00a0Intern. Med."},{"issue":"1\u20132","key":"10.1016\/j.abb.2019.108095_bib35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbagrm.2009.11.003","article-title":"The role of HMGB1 in the pathogenesis of rheumatic disease","volume":"1799","author":"Andersson","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.abb.2019.108095_bib36","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1158\/0008-5472.CAN-11-2291","article-title":"p53\/HMGB1 complexes regulate autophagy and apoptosis","volume":"72","author":"Livesey","year":"2012","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.abb.2019.108095_bib37","first-page":"40","article-title":"Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts","volume":"66","author":"Kato","year":"2014","journal-title":"ArthRheumatol"},{"issue":"5","key":"10.1016\/j.abb.2019.108095_bib38","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.200911078","article-title":"Endogenous HMGB1 regulates autophagy","volume":"190","author":"Tang","year":"2010","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.abb.2019.108095_bib39","doi-asserted-by":"crossref","first-page":"7623145","DOI":"10.1155\/2017\/7623145","article-title":"The autophagy level is increased in the synovial tissues of patients with active rheumatoid arthritis and is correlated with disease severity","volume":"2017","author":"Zhu","year":"2017","journal-title":"Mediat. Inflamm."},{"issue":"3","key":"10.1016\/j.abb.2019.108095_bib40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.autrev.2013.10.007","article-title":"Recent insights on the putative role of autophagy in autoimmune diseases","volume":"13","author":"Gianchecchi","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.abb.2019.108095_bib41","first-page":"853","article-title":"Association of HMGB1 with oxidative stress markers and regulators in PDR","volume":"23","author":"Abu El-Asrar","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.abb.2019.108095_bib42","doi-asserted-by":"crossref","first-page":"6097417","DOI":"10.1155\/2016\/6097417","article-title":"Oxidative stress relevance in the pathogenesis of the rheumatoid arthritis: a systematic review","volume":"2016","author":"Qui\u00f1onez-Flores","year":"2016","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.abb.2019.108095_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.lfs.2014.09.012","article-title":"Increased levels of serum myeloperoxidase in patients with active rheumatoid arthritis","volume":"117","author":"Wang","year":"2014","journal-title":"Life Sci."},{"issue":"1\u20132","key":"10.1016\/j.abb.2019.108095_bib44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cccn.2003.08.011","article-title":"Antioxidant status in rheumatoid arthritis and role of antioxidant therapy","volume":"338","author":"Jaswal","year":"2003","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.abb.2019.108095_bib45","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3748\/wjg.v18.i7.679","article-title":"Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway","volume":"18","author":"Gwak","year":"2012","journal-title":"World J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.abb.2019.108095_bib46","article-title":"Blocking autophagy enhances the apoptotic effect of 18\u03b2-glycyrrhetinic acid on human sarcoma cells via endoplasmic reticulum stress and JNK activation","volume":"8","author":"Shen","year":"2017","journal-title":"Ku Cell Death Dis"},{"key":"10.1016\/j.abb.2019.108095_bib47","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/ijms12020905","article-title":"Antioxidant status and immune activity of glycyrrhizin in allergic rhinitis miceInt","volume":"12","author":"Li","year":"2011","journal-title":"J.\u00a0Mol. Sci."},{"issue":"11","key":"10.1016\/j.abb.2019.108095_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142901","article-title":"HMGB1 promotes mitochondrial dysfunction. triggered striatal neurodegeneration via autophagy and apoptosis activation L","volume":"10","author":"Qi","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.abb.2019.108095_bib49","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/gb-2011-12-7-226","article-title":"Atg 8: an autophagy-related ubiquitin-like protein family","volume":"12","author":"Shpilka","year":"2011","journal-title":"Genome Biol."},{"issue":"7","key":"10.1016\/j.abb.2019.108095_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102993","article-title":"Platelet-rich plasma and skeletal muscle healing: a molecular analysis of the phases of the regeneration process in an experimental animal model","volume":"9","author":"Dimauro","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.abb.2019.108095_bib51","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/cr.2013.159","article-title":"A\u00a0current perspective of autophagosome biogenesis","volume":"24","author":"Shibutani","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.abb.2019.108095_bib52","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.yexcr.2017.02.012","article-title":"Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage","volume":"352","author":"Moussa","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.abb.2019.108095_bib53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bone.2014.04.029","article-title":"Role of platelet-released growth factors in detoxification of reactive oxygen species in osteoblasts","volume":"65","author":"Tohidnezhand","year":"2014","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.abb.2019.108095_bib54","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1080\/09537104.2016.1184752","article-title":"Platelet-rich plasma reduces the oxidative damage determined by a skeletal muscle contusion in rats","volume":"27","author":"Martins","year":"2016","journal-title":"Platelets"},{"issue":"5","key":"10.1016\/j.abb.2019.108095_bib55","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2165\/00007256-200333050-00004","article-title":"The roles of growth factors in tendon and ligament healing","volume":"33","author":"Molloy","year":"2003","journal-title":"Sport. Med."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986119304667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986119304667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:11:04Z","timestamp":1757743864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986119304667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":55,"alternative-id":["S0003986119304667"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2019.108095","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regenerative effects of glycyrrhizin and\/or platelet rich plasma on type-II collagen induced arthritis: Targeting autophay machinery markers, inflammation and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2019.108095","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108095"}}