{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:02:19Z","timestamp":1792083739520,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601974"],"award-info":[{"award-number":["81601974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.abb.2020.108297","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T02:23:48Z","timestamp":1580869428000},"page":"108297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Activation of GPR43 suppresses TNF-\u03b1-induced inflammatory response in human fibroblast-like synoviocytes"],"prefix":"10.1016","volume":"684","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.abb.2020.108297_bib1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"10.1016\/j.abb.2020.108297_bib2","first-page":"30203","article-title":"Mechanistic immunological based classification of rheumatoid arthritis","volume":"S1568\u20139972","author":"McGonagle","year":"2018","journal-title":"Autoimmun. Rev."},{"issue":"5","key":"10.1016\/j.abb.2020.108297_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s11914-018-0473-5","article-title":"Mechanisms for joint pain in rheumatoid arthritis (RA): from cytokines to central sensitization","volume":"16","author":"Zhang","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.abb.2020.108297_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrrheum.2012.190","article-title":"Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors","volume":"9","author":"Bottini","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"issue":"11","key":"10.1016\/j.abb.2020.108297_bib5","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/art.1780391103","article-title":"Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?","volume":"39","author":"Firestein","year":"1996","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.abb.2020.108297_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1044-5323(02)00124-0","article-title":"Chemokines and chemokine receptors in rheumatoid arthritis","volume":"15","author":"Szekanecz","year":"2003","journal-title":"Semin. Immunol."},{"issue":"2","key":"10.1016\/j.abb.2020.108297_bib7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/rheumatology\/36.2.164","article-title":"A distinct profile of six soluble adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin, L-selectin and P-selectin) in rheumatoid arthritis","volume":"36","author":"Littler","year":"1997","journal-title":"Br. J. Rheumatol."},{"issue":"5","key":"10.1016\/j.abb.2020.108297_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18050905","article-title":"Matrix metalloproteinase gene activation resulting from disordred epigenetic mechanisms in rheumatoid arthritis","volume":"18","author":"Araki","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.abb.2020.108297_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152925","article-title":"Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis","volume":"11","author":"Mateen","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.abb.2020.108297_bib10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.freeradbiomed.2016.06.020","article-title":"Reactive oxygen and nitrogen species in patients with rheumatoid arthritis as potential biomarkers for disease activity and the role of antioxidants","volume":"97","author":"Khojah","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.abb.2020.108297_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1172\/JCI11891","article-title":"Series introduction: the transcription factor NF-\u03baB and human disease","volume":"107","author":"Baldwin","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.abb.2020.108297_bib12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive oxygen species in homeostasis and degradation of cartilage","volume":"11","author":"Henrotin","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.abb.2020.108297_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cellsig.2017.02.014","article-title":"GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model","volume":"33","author":"Nadeem","year":"2017","journal-title":"Cell. Signal."},{"key":"10.1016\/j.abb.2020.108297_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2015.12.010","article-title":"Selective novel inverse agonists for human GPR43 augment GLP-1 secretion","volume":"771","author":"Park","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.abb.2020.108297_bib15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/2211-5463.12049","article-title":"A comparative proteomics study of a synovial cell line stimulated with TNF\u2010\u03b1","volume":"6","author":"Shibasaki","year":"2016","journal-title":"FEBS Open Bio"},{"issue":"1","key":"10.1016\/j.abb.2020.108297_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jaci.2005.03.014","article-title":"Expression of functional cysteinyl leukotriene receptors by human basophils","volume":"116","author":"Gauvreau","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.abb.2020.108297_bib17","doi-asserted-by":"crossref","first-page":"105732","DOI":"10.1016\/j.intimp.2019.105732","article-title":"The protective effects of lixisenatide against inflammatory response in human rheumatoid arthritis fibroblast-like synoviocytes","volume":"75","author":"Du","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.abb.2020.108297_bib18","unstructured":"Jing W, Sun W, Zhang N, Zhao C, Yan X. The Protective Effects of the GPR39 Agonist TC-G 1008 against TNF-\u03b1-Induced Inflammation in Human Fibroblast-like Synoviocytes (FLSs).."},{"key":"10.1016\/j.abb.2020.108297_bib19","doi-asserted-by":"crossref","first-page":"109737","DOI":"10.1016\/j.biopha.2019.109737","article-title":"GPR43 regulates HBV X protein (HBx)-induced inflammatory response in human LO2 hepatocytes","volume":"123","author":"He","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.abb.2020.108297_bib20","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1038\/srep08134","article-title":"The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes","volume":"5","author":"Zhiwei","year":"2015","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.abb.2020.108297_bib21","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/eji.201444908","article-title":"HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1\u03b1 activation","volume":"45","author":"Park","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.abb.2020.108297_bib22","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10787-017-0385-5","article-title":"Protective effects of paeonol on inflammatory response in IL-1\u03b2-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-\u03baB pathway","volume":"25","author":"Zhai","year":"2017","journal-title":"Inflammopharmacology"},{"issue":"5","key":"10.1016\/j.abb.2020.108297_bib23","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s10753-012-9484-z","article-title":"Short-chain fatty acids suppress lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines through inhibition of NF-\u03baB pathway in RAW264. 7 cells","volume":"35","author":"Liu","year":"2012","journal-title":"Inflammation"},{"issue":"6","key":"10.1016\/j.abb.2020.108297_bib24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4110\/in.2014.14.6.277","article-title":"Gut microbiota-derived short-chain fatty acids, T cells, and inflammation","volume":"14","author":"Kim","year":"2014","journal-title":"Immune Netw."},{"issue":"11","key":"10.1016\/j.abb.2020.108297_bib25","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1248\/bpb.b13-00312","article-title":"\u03b2-Arrestin 2 mediates G protein-coupled receptor 43 signals to nuclear factor-\u03baB","volume":"36","author":"Lee","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.abb.2020.108297_bib26","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1038\/srep08134","article-title":"The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes","volume":"5","author":"Ang","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.abb.2020.108297_bib27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000495203","article-title":"Butyrate modulates inflammation in chondrocytes via GPR43 receptor","volume":"51","author":"Pirozzi","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.abb.2020.108297_bib28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/01.bor.0000218948.42730.39","article-title":"Role of adhesion molecules in synovial inflammation","volume":"18","author":"Agarwal","year":"2006","journal-title":"Curr. Opin. Rheumatol."},{"issue":"1","key":"10.1016\/j.abb.2020.108297_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0002-9343(99)00332-0","article-title":"Apoptosis in rheumatic diseases","volume":"108","author":"Grodzicky","year":"2000","journal-title":"Am. J. Med."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986119311014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986119311014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:13:11Z","timestamp":1757743991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986119311014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":29,"alternative-id":["S0003986119311014"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2020.108297","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of GPR43 suppresses TNF-\u03b1-induced inflammatory response in human fibroblast-like synoviocytes","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2020.108297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108297"}}