{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:43:41Z","timestamp":1792691021310,"version":"4.5.0"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K01888"],"award-info":[{"award-number":["JP17K01888"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H04136"],"award-info":[{"award-number":["JP20H04136"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K11525"],"award-info":[{"award-number":["JP20K11525"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.abb.2020.108668","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T20:10:35Z","timestamp":1605125435000},"page":"108668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Mitochondrial stress and GDF15 in the pathophysiology of sepsis"],"prefix":"10.1016","volume":"696","author":[{"given":"Yasunori","family":"Fujita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuroh","family":"Ohsawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2020.108668_bib1","doi-asserted-by":"crossref","first-page":"16080","DOI":"10.1038\/nrdp.2016.80","article-title":"Mitochondrial diseases","volume":"2","author":"Gorman","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"7","key":"10.1016\/j.abb.2020.108668_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41556-018-0133-0","article-title":"Mitochondrial dynamics in adaptive and maladaptive cellular stress responses","volume":"20","author":"Eisner","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2016.23","article-title":"Mitonuclear communication in homeostasis and stress","volume":"17","author":"Quiros","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.abb.2020.108668_bib4","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41574-020-0386-0","article-title":"The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic","volume":"16","author":"Geng","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.abb.2020.108668_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mito.2014.10.006","article-title":"GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases","volume":"20","author":"Fujita","year":"2015","journal-title":"Mitochondrion"},{"issue":"Suppl 1","key":"10.1016\/j.abb.2020.108668_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/ggi.12724","article-title":"Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders","volume":"16","author":"Fujita","year":"2016","journal-title":"Geriatr. Gerontol. Int."},{"issue":"8","key":"10.1016\/j.abb.2020.108668_bib7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"J. Am. Med. Assoc."},{"issue":"10141","key":"10.1016\/j.abb.2020.108668_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: a roadmap for future research","volume":"15","author":"Cohen","year":"2015","journal-title":"Lancet Infect. Dis."},{"issue":"9","key":"10.1016\/j.abb.2020.108668_bib10","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1097\/01.CCM.0000138558.16257.3F","article-title":"Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock","volume":"32","author":"Sakr","year":"2004","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/SHK.0000000000000463","article-title":"Mitochondrial function in sepsis","volume":"45","author":"Arulkumaran","year":"2016","journal-title":"Shock"},{"issue":"21","key":"10.1016\/j.abb.2020.108668_bib12","doi-asserted-by":"crossref","first-page":"11514","DOI":"10.1073\/pnas.94.21.11514","article-title":"MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily","volume":"94","author":"Bootcov","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib13","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1124\/mol.59.4.901","article-title":"Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities","volume":"59","author":"Baek","year":"2001","journal-title":"Mol. Pharmacol."},{"issue":"22","key":"10.1016\/j.abb.2020.108668_bib14","doi-asserted-by":"crossref","first-page":"13760","DOI":"10.1074\/jbc.273.22.13760","article-title":"Cloning and characterization of a novel member of the transforming growth factor-beta\/bone morphogenetic protein family","volume":"273","author":"Paralkar","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0167-4781(97)00122-X","article-title":"PLAB, a novel placental bone morphogenetic protein","volume":"1354","author":"Hromas","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-1119(97)00485-X","article-title":"Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta","volume":"203","author":"Lawton","year":"1997","journal-title":"Gene"},{"issue":"21","key":"10.1016\/j.abb.2020.108668_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00249-18","article-title":"Growth differentiation factor 15 maturation requires proteolytic cleavage by PCSK3, -5, and -6","volume":"38","author":"Li","year":"2018","journal-title":"Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.abb.2020.108668_bib18","doi-asserted-by":"crossref","first-page":"E2277","DOI":"10.1210\/jc.2014-1598","article-title":"Maturation of growth differentiation factor 15 in human placental trophoblast cells depends on the interaction with Matrix Metalloproteinase-26","volume":"99","author":"Li","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"24","key":"10.1016\/j.abb.2020.108668_bib19","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1158\/0008-5472.CAN-17-1397","article-title":"PACE4 undergoes an oncogenic alternative splicing switch in cancer","volume":"77","author":"Couture","year":"2017","journal-title":"Canc. Res."},{"issue":"10","key":"10.1016\/j.abb.2020.108668_bib20","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1093\/emboj\/19.10.2212","article-title":"The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1","volume":"19","author":"Bauskin","year":"2000","journal-title":"EMBO J."},{"issue":"4948","key":"10.1016\/j.abb.2020.108668_bib21","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.2315700","article-title":"Requirement for activin A and transforming growth factor--beta 1 pro-regions in homodimer assembly","volume":"247","author":"Gray","year":"1990","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/08977199209046403","article-title":"Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells","volume":"7","author":"Israel","year":"1992","journal-title":"Growth Factors"},{"issue":"570","key":"10.1016\/j.abb.2020.108668_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aav5183","article-title":"Specificity, versatility, and control of TGF-beta family signaling","volume":"12","author":"Derynck","year":"2019","journal-title":"Sci. Signal."},{"issue":"6","key":"10.1016\/j.abb.2020.108668_bib24","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1158\/0008-5472.CAN-04-3827","article-title":"The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome","volume":"65","author":"Bauskin","year":"2005","journal-title":"Canc. Res."},{"issue":"6","key":"10.1016\/j.abb.2020.108668_bib25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/jir.2009.0052","article-title":"The TGF-beta superfamily cytokine MIC-1\/GDF15: secretory mechanisms facilitate creation of latent stromal stores","volume":"30","author":"Bauskin","year":"2010","journal-title":"J. Interferon Cytokine Res."},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/onc.2015.95","article-title":"NAG-1\/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway","volume":"35","author":"Min","year":"2016","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s004410051337","article-title":"Expression of a novel member of the TGF-beta superfamily, growth\/differentiation factor-15\/macrophage-inhibiting cytokine-1 (GDF-15\/MIC-1) in adult rat tissues","volume":"297","author":"Bottner","year":"1999","journal-title":"Cell Tissue Res."},{"issue":"7493","key":"10.1016\/j.abb.2020.108668_bib28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature12787","article-title":"An atlas of active enhancers across human cell types and tissues","volume":"507","author":"Andersson","year":"2014","journal-title":"Nature"},{"issue":"7493","key":"10.1016\/j.abb.2020.108668_bib29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature13182","article-title":"A promoter-level mammalian expression atlas","volume":"507","author":"Consortium","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/cne.1333","article-title":"Expression of growth differentiation factor-15\/macrophage inhibitory cytokine-1 (GDF-15\/MIC-1) in the perinatal, adult, and injured rat brain","volume":"439","author":"Schober","year":"2001","journal-title":"J. Comp. Neurol."},{"issue":"10","key":"10.1016\/j.abb.2020.108668_bib31","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/MCB.20.10.3742-3751.2000","article-title":"Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury","volume":"20","author":"Hsiao","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/01.RES.0000202805.73038.48","article-title":"The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia\/reperfusion injury","volume":"98","author":"Kempf","year":"2006","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.abb.2020.108668_bib33","first-page":"543","article-title":"Growth differentiation factor-15\/macrophage inhibitory cytokine-1 induction after kidney and lung injury","volume":"23","author":"Zimmers","year":"2005","journal-title":"Shock"},{"issue":"9","key":"10.1016\/j.abb.2020.108668_bib34","doi-asserted-by":"crossref","first-page":"F1249","DOI":"10.1152\/ajprenal.00387.2013","article-title":"Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes","volume":"305","author":"Mazagova","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib35","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1681\/ASN.2019090876","article-title":"Renoprotective and immunomodulatory effects of GDF15 following AKI invoked by ischemia-reperfusion injury","volume":"31","author":"Liu","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.abb.2020.108668_bib36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.taap.2017.07.016","article-title":"Sex-specific differences in the modulation of growth differentiation factor 15 (GDF15) by hyperoxia in vivo and in vitro: role of hif-1alpha","volume":"332","author":"Zhang","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-013-1634-6","article-title":"Regulation and effects of GDF-15 in the retina following optic nerve crush","volume":"353","author":"Charalambous","year":"2013","journal-title":"Cell Tissue Res."},{"issue":"7795","key":"10.1016\/j.abb.2020.108668_bib38","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41586-019-1911-y","article-title":"GDF15 mediates the effects of metformin on body weight and energy balance","volume":"578","author":"Coll","year":"2020","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.abb.2020.108668_bib39","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1681\/ASN.2016080919","article-title":"Growth differentiation factor-15 and risk of CKD progression","volume":"28","author":"Nair","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.abb.2020.108668_bib40","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2164-15-91","article-title":"Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies","volume":"15","author":"Kalko","year":"2014","journal-title":"BMC Genom."},{"issue":"16","key":"10.1016\/j.abb.2020.108668_bib41","first-page":"5974","article-title":"Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer","volume":"61","author":"Welsh","year":"2001","journal-title":"Canc. Res."},{"issue":"7","key":"10.1016\/j.abb.2020.108668_bib42","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1158\/1078-0432.CCR-03-0165","article-title":"Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers","volume":"10","author":"Koopmann","year":"2004","journal-title":"Clin. Canc. Res."},{"issue":"24","key":"10.1016\/j.abb.2020.108668_bib43","doi-asserted-by":"crossref","first-page":"13562","DOI":"10.1073\/pnas.2002630117","article-title":"Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta","volume":"117","author":"Meinhardt","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5 Pt A","key":"10.1016\/j.abb.2020.108668_bib44","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.bbadis.2018.02.020","article-title":"YAP promotes breast cancer metastasis by repressing growth differentiation factor-15","volume":"1864","author":"Wang","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"26","key":"10.1016\/j.abb.2020.108668_bib45","doi-asserted-by":"crossref","first-page":"20127","DOI":"10.1074\/jbc.M909580199","article-title":"Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression","volume":"275","author":"Li","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1073\/pnas.97.1.109","article-title":"PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway","volume":"97","author":"Tan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.abb.2020.108668_bib47","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1074\/jbc.M305295200","article-title":"Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1","volume":"279","author":"Baek","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"48","key":"10.1016\/j.abb.2020.108668_bib48","doi-asserted-by":"crossref","first-page":"33129","DOI":"10.1074\/jbc.M805248200","article-title":"Nonsteroidal anti-inflammatory drug-activated gene (NAG-1\/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A","volume":"283","author":"Yoshioka","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib49","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/carcin\/bgq016","article-title":"NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C\/EBPbeta and ATF3","volume":"31","author":"Lee","year":"2010","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib50","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.bbrc.2017.08.096","article-title":"Hepatic GDF15 is regulated by CHOP of the unfolded protein response and alleviates NAFLD progression in obese mice","volume":"498","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib51","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cmet.2018.12.016","article-title":"GDF15 provides an endocrine signal of nutritional stress in mice and humans","volume":"29","author":"Patel","year":"2019","journal-title":"Cell Metabol."},{"issue":"36","key":"10.1016\/j.abb.2020.108668_bib52","doi-asserted-by":"crossref","first-page":"33384","DOI":"10.1074\/jbc.M101814200","article-title":"Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3","volume":"276","author":"Baek","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib53","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.kint.2019.02.014","article-title":"The motor protein Myo1c regulates transforming growth factor-beta-signaling and fibrosis in podocytes","volume":"96","author":"Arif","year":"2019","journal-title":"Kidney Int."},{"issue":"10","key":"10.1016\/j.abb.2020.108668_bib54","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1172\/JCI91561","article-title":"NF-kappaB regulates GDF-15 to suppress macrophage surveillance during early tumor development","volume":"127","author":"Ratnam","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"35","key":"10.1016\/j.abb.2020.108668_bib55","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1038\/s41388-018-0298-9","article-title":"C5a induces A549 cell proliferation of non-small cell lung cancer via GDF15 gene activation mediated by GCN5-dependent KLF5 acetylation","volume":"37","author":"Zhao","year":"2018","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.abb.2020.108668_bib56","first-page":"4781","article-title":"The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women","volume":"85","author":"Moore","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.abb.2020.108668_bib57","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1093\/humrep\/deq264","article-title":"Growth\/differentiation factor-15 is an abundant cytokine in human seminal plasma","volume":"25","author":"Soucek","year":"2010","journal-title":"Hum. Reprod."},{"issue":"23","key":"10.1016\/j.abb.2020.108668_bib58","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1523\/JNEUROSCI.20-23-08597.2000","article-title":"Growth\/differentiation factor-15\/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo","volume":"20","author":"Strelau","year":"2000","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib59","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/gerona\/gly153","article-title":"Human aging and longevity are characterized by high levels of mitokines","volume":"74","author":"Conte","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib60","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1373\/clinchem.2006.076828","article-title":"Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay","volume":"53","author":"Kempf","year":"2007","journal-title":"Clin. Chem."},{"issue":"12","key":"10.1016\/j.abb.2020.108668_bib61","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/s41591-019-0673-2","article-title":"Undulating changes in human plasma proteome profiles across the lifespan","volume":"25","author":"Lehallier","year":"2019","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib62","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12799","article-title":"Plasma proteomic signature of age in healthy humans","volume":"17","author":"Tanaka","year":"2018","journal-title":"Aging Cell"},{"issue":"6","key":"10.1016\/j.abb.2020.108668_bib63","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1474-9726.2010.00629.x","article-title":"Macrophage inhibitory cytokine-1 (MIC-1\/GDF15): a new marker of all-cause mortality","volume":"9","author":"Wiklund","year":"2010","journal-title":"Aging Cell"},{"issue":"19","key":"10.1016\/j.abb.2020.108668_bib64","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1161\/CIRCULATIONAHA.110.979740","article-title":"Growth-differentiation factor-15 is a robust, independent predictor of 11-year mortality risk in community-dwelling older adults: the Rancho Bernardo Study","volume":"123","author":"Daniels","year":"2011","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.abb.2020.108668_bib65","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1373\/clinchem.2012.201210","article-title":"Change in growth differentiation factor 15 concentrations over time independently predicts mortality in community-dwelling elderly individuals","volume":"59","author":"Eggers","year":"2013","journal-title":"Clin. Chem."},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib66","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cmet.2018.07.018","article-title":"The MIC-1\/GDF15-GFRAL pathway in energy homeostasis: implications for obesity, cachexia, and other associated diseases","volume":"28","author":"Tsai","year":"2018","journal-title":"Cell Metabol."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib67","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1210\/endrev\/bnaa007","article-title":"GDF15: a hormone conveying somatic distress to the brain","volume":"41","author":"Lockhart","year":"2020","journal-title":"Endocr. Rev."},{"issue":"10","key":"10.1016\/j.abb.2020.108668_bib68","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/nm.4394","article-title":"GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand","volume":"23","author":"Yang","year":"2017","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.abb.2020.108668_bib69","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/nm.4392","article-title":"GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates","volume":"23","author":"Mullican","year":"2017","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.abb.2020.108668_bib70","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nm.4393","article-title":"The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL","volume":"23","author":"Emmerson","year":"2017","journal-title":"Nat. Med."},{"issue":"7675","key":"10.1016\/j.abb.2020.108668_bib71","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature24042","article-title":"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15","volume":"550","author":"Hsu","year":"2017","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.abb.2020.108668_bib72","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nm1677","article-title":"Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1","volume":"13","author":"Johnen","year":"2007","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034868","article-title":"Macrophage inhibitory cytokine 1 (MIC-1\/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets","volume":"7","author":"Macia","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055174","article-title":"TGF-b superfamily cytokine MIC-1\/GDF15 is a physiological appetite and body weight regulator","volume":"8","author":"Tsai","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.abb.2020.108668_bib75","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1038\/s41366-019-0365-5","article-title":"GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP\/NTS","volume":"43","author":"Tsai","year":"2019","journal-title":"Int. J. Obes."},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib76","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1053\/j.gastro.2006.09.015","article-title":"Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia","volume":"131","author":"Baek","year":"2006","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.abb.2020.108668_bib77","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/ijo.2014.27","article-title":"NAG-1\/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism","volume":"38","author":"Chrysovergis","year":"2014","journal-title":"Int. J. Obes."},{"issue":"8","key":"10.1016\/j.abb.2020.108668_bib78","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41591-020-0945-x","article-title":"Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice","volume":"26","author":"Suriben","year":"2020","journal-title":"Nat. Med."},{"issue":"6489","key":"10.1016\/j.abb.2020.108668_bib79","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: from mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"issue":"6716","key":"10.1016\/j.abb.2020.108668_bib80","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.abb.2020.108668_bib81","first-page":"7920","article-title":"Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA","volume":"14","author":"Vazquez de Aldana","year":"1994","journal-title":"Mol. Cell Biol."},{"issue":"15","key":"10.1016\/j.abb.2020.108668_bib82","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0960-9822(02)01037-0","article-title":"Activation of GCN2 in UV-irradiated cells inhibits translation","volume":"12","author":"Deng","year":"2002","journal-title":"Curr. Biol."},{"issue":"6\u20137","key":"10.1016\/j.abb.2020.108668_bib83","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.biochi.2007.03.001","article-title":"The dsRNA protein kinase PKR: virus and cell control","volume":"89","author":"Garcia","year":"2007","journal-title":"Biochimie"},{"issue":"20","key":"10.1016\/j.abb.2020.108668_bib84","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1182\/blood.2019001915","article-title":"Heme-regulated eIF2alpha kinase in erythropoiesis and hemoglobinopathies","volume":"134","author":"Chen","year":"2019","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.abb.2020.108668_bib85","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tem.2017.07.003","article-title":"Surviving stress: modulation of ATF4-mediated stress responses in normal and malignant cells","volume":"28","author":"Wortel","year":"2017","journal-title":"Trends Endocrinol. Metabol."},{"issue":"1\u20132","key":"10.1016\/j.abb.2020.108668_bib86","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mito.2006.11.003","article-title":"CHOP (C\/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations","volume":"7","author":"Fujita","year":"2007","journal-title":"Mitochondrion"},{"issue":"10","key":"10.1016\/j.abb.2020.108668_bib87","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.89.10.4221","article-title":"MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts","volume":"89","author":"Chomyn","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6 Pt 1","key":"10.1016\/j.abb.2020.108668_bib88","first-page":"534","article-title":"Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria","volume":"9","author":"Tanaka","year":"2002","journal-title":"J. Biomed. Sci."},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib89","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cmet.2017.07.007","article-title":"mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression","volume":"26","author":"Khan","year":"2017","journal-title":"Cell Metabol."},{"issue":"6","key":"10.1016\/j.abb.2020.108668_bib90","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.cmet.2019.08.019","article-title":"Fibroblast growth factor 21 drives dynamics of local and systemic stress responses in mitochondrial myopathy with mtDNA deletions","volume":"30","author":"Forsstrom","year":"2019","journal-title":"Cell Metabol."},{"issue":"7","key":"10.1016\/j.abb.2020.108668_bib91","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1083\/jcb.201702058","article-title":"Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals","volume":"216","author":"Quiros","year":"2017","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib92","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.nbd.2009.02.005","article-title":"Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia","volume":"34","author":"Silva","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.abb.2020.108668_bib93","doi-asserted-by":"crossref","first-page":"e1222","DOI":"10.1038\/cddis.2014.166","article-title":"Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+)","volume":"5","author":"Krug","year":"2014","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib94","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00330.2013","article-title":"Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine","volume":"306","author":"Keipert","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib95","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbrc.2013.09.026","article-title":"Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation","volume":"440","author":"Kim","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib96","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrm.2017.110","article-title":"The mitochondrial UPR: mechanisms, physiological functions and implications in ageing","volume":"19","author":"Shpilka","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"17","key":"10.1016\/j.abb.2020.108668_bib97","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1093\/emboj\/cdf445","article-title":"A mitochondrial specific stress response in mammalian cells","volume":"21","author":"Zhao","year":"2002","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.abb.2020.108668_bib98","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/gutjnl-2011-300767","article-title":"Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation","volume":"61","author":"Rath","year":"2012","journal-title":"Gut"},{"issue":"15","key":"10.1016\/j.abb.2020.108668_bib99","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.cub.2016.06.002","article-title":"The transcription factor ATF5 mediates a mammalian mitochondrial UPR","volume":"26","author":"Fiorese","year":"2016","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib100","doi-asserted-by":"crossref","first-page":"H472","DOI":"10.1152\/ajpheart.00244.2019","article-title":"Cardioprotection by the mitochondrial unfolded protein response requires ATF5","volume":"317","author":"Wang","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.abb.2020.108668_bib101","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/2211-5463.12863","article-title":"HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response","volume":"10","author":"Katiyar","year":"2020","journal-title":"FEBS. Open Bio."},{"issue":"Pt 9","key":"10.1016\/j.abb.2020.108668_bib102","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1242\/jcs.078220","article-title":"Estrogen receptor mediates a distinct mitochondrial unfolded protein response","volume":"124","author":"Papa","year":"2011","journal-title":"J. Cell Sci."},{"issue":"7799","key":"10.1016\/j.abb.2020.108668_bib103","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41586-020-2076-4","article-title":"A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol","volume":"579","author":"Fessler","year":"2020","journal-title":"Nature"},{"issue":"7799","key":"10.1016\/j.abb.2020.108668_bib104","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41586-020-2078-2","article-title":"Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway","volume":"579","author":"Guo","year":"2020","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.abb.2020.108668_bib105","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/embj.201386474","article-title":"Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics","volume":"33","author":"Baker","year":"2014","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib106","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cmet.2020.02.017","article-title":"Serine catabolism feeds NADH when respiration is impaired","volume":"31","author":"Yang","year":"2020","journal-title":"Cell Metabol."},{"issue":"6","key":"10.1016\/j.abb.2020.108668_bib107","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.mito.2012.07.113","article-title":"Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations","volume":"12","author":"Kami","year":"2012","journal-title":"Mitochondrion"},{"key":"10.1016\/j.abb.2020.108668_bib108","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49178","article-title":"Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell","volume":"9","author":"Mick","year":"2020","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.abb.2020.108668_bib109","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S1474-4422(11)70155-7","article-title":"FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study","volume":"10","author":"Suomalainen","year":"2011","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib110","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1517\/17530059.2013.812070","article-title":"Fibroblast growth factor 21: a novel biomarker for human muscle-manifesting mitochondrial disorders","volume":"7","author":"Suomalainen","year":"2013","journal-title":"Expert Opin. Med. Diagn."},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib111","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/ana.24506","article-title":"Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders","volume":"78","author":"Yatsuga","year":"2015","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib112","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1083\/jcb.201607110","article-title":"Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis","volume":"216","author":"Chung","year":"2017","journal-title":"J. Cell Biol."},{"issue":"12","key":"10.1016\/j.abb.2020.108668_bib113","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/s42255-019-0146-4","article-title":"Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss","volume":"1","author":"Day","year":"2019","journal-title":"Nat. Metab."},{"issue":"15","key":"10.1016\/j.abb.2020.108668_bib114","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1158\/1078-0432.CCR-10-0705","article-title":"GDF-15 contributes to proliferation and immune escape of malignant gliomas","volume":"16","author":"Roth","year":"2010","journal-title":"Clin. Canc. Res."},{"issue":"11","key":"10.1016\/j.abb.2020.108668_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078618","article-title":"Growth differentiation factor-15 suppresses maturation and function of dendritic cells and inhibits tumor-specific immune response","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib116","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib117","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nm.2354","article-title":"GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice","volume":"17","author":"Kempf","year":"2011","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib118","doi-asserted-by":"crossref","first-page":"17238","DOI":"10.1038\/s41598-017-17574-w","article-title":"GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury","volume":"7","author":"Chung","year":"2017","journal-title":"Sci. Rep."},{"issue":"24","key":"10.1016\/j.abb.2020.108668_bib119","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1089\/neu.2019.6421","article-title":"MIC-1\/GDF15 overexpression is associated with increased functional recovery in traumatic spinal cord injury","volume":"36","author":"Hassanpour Golakani","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"8","key":"10.1016\/j.abb.2020.108668_bib120","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13195","article-title":"Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice","volume":"19","author":"Moon","year":"2020","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib121","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00003246-200202000-00002","article-title":"Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity","volume":"30","author":"Crouser","year":"2002","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.abb.2020.108668_bib122","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s13105-013-0280-5","article-title":"Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria","volume":"70","author":"Eyenga","year":"2014","journal-title":"J. Physiol. Biochem."},{"issue":"9328","key":"10.1016\/j.abb.2020.108668_bib123","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(02)09459-X","article-title":"Association between mitochondrial dysfunction and severity and outcome of septic shock","volume":"360","author":"Brealey","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib124","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/infdis\/jir764","article-title":"The effects of sepsis on mitochondria","volume":"205","author":"Garrabou","year":"2012","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib125","doi-asserted-by":"crossref","first-page":"R491","DOI":"10.1152\/ajpregu.00432.2003","article-title":"Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure","volume":"286","author":"Brealey","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib126","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/labinvest.3700691","article-title":"A novel endotoxin-induced pathway: upregulation of heme oxygenase 1, accumulation of free iron, and free iron-mediated mitochondrial dysfunction","volume":"88","author":"Duvigneau","year":"2008","journal-title":"Lab. Invest."},{"key":"10.1016\/j.abb.2020.108668_bib127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2014.08.009","article-title":"Cardiac mitochondrial biogenesis in endotoxemia is not accompanied by mitochondrial function recovery","volume":"77","author":"Vanasco","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib128","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00395-019-0745-y","article-title":"Mitochondrial bioenergetics links inflammation and cardiac contractility in endotoxemia","volume":"114","author":"Vico","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.abb.2020.108668_bib129","doi-asserted-by":"crossref","first-page":"5271203","DOI":"10.1155\/2017\/5271203","article-title":"Growth differentiation factor-15 is a predictor of mortality in critically ill patients with sepsis","volume":"2017","author":"Buendgens","year":"2017","journal-title":"Dis. Markers"},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib130","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2019.07.033","article-title":"GDF15 is an inflammation-induced central mediator of tissue tolerance","volume":"178","author":"Luan","year":"2019","journal-title":"Cell"},{"issue":"22","key":"10.1016\/j.abb.2020.108668_bib131","doi-asserted-by":"crossref","first-page":"12281","DOI":"10.1073\/pnas.1918508117","article-title":"CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis","volume":"117","author":"Santos","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.abb.2020.108668_bib132","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tcb.2020.01.006","article-title":"Mitochondrial functions in infection and immunity","volume":"30","author":"Tiku","year":"2020","journal-title":"Trends Cell Biol."},{"issue":"5","key":"10.1016\/j.abb.2020.108668_bib133","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019967","article-title":"Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes","volume":"6","author":"Si","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.abb.2020.108668_bib134","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bcp.2018.07.011","article-title":"HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis","volume":"155","author":"Benkheil","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.abb.2020.108668_bib135","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41598-017-00902-5","article-title":"Growth differentiation factor-15 deficiency augments inflammatory response and exacerbates septic heart and renal injury induced by lipopolysaccharide","volume":"7","author":"Abulizi","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.abb.2020.108668_bib136","first-page":"1756","article-title":"GDF15 prevents LPS and D-galactosamine-induced inflammation and acute liver injury in mice","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"9","key":"10.1016\/j.abb.2020.108668_bib137","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"7816","key":"10.1016\/j.abb.2020.108668_bib138","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-020-2286-9","article-title":"A SARS-CoV-2 protein interaction map reveals targets for drug repurposing","volume":"583","author":"Gordon","year":"2020","journal-title":"Nature"}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986120306779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986120306779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T18:48:11Z","timestamp":1733251691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986120306779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":138,"alternative-id":["S0003986120306779"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2020.108668","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial stress and GDF15 in the pathophysiology of sepsis","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2020.108668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108668"}}