{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:36:41Z","timestamp":1771623401832,"version":"3.50.1"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.abb.2021.108763","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T21:06:26Z","timestamp":1610831186000},"page":"108763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Roles of microRNAs in chronic pediatric diseases and their use as potential biomarkers: A review"],"prefix":"10.1016","volume":"699","author":[{"given":"Sujay","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M.","family":"Ruiz-Manriquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Janin","family":"Ledesma-Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier A.","family":"Benavides-Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Torres-Copado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan I.","family":"Morales-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"De Donato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aashish","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2021.108763_bib1","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1001\/jama.297.24.2755","article-title":"The increase of childhood chronic conditions in the United States","volume":"297","author":"Perrin","year":"2007","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.abb.2021.108763_bib2","series-title":"Noncommunicable Diseases","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.abb.2021.108763_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89656","article-title":"Profiling of circulating microRNAs in children with recent onset of type 1 diabetes","volume":"2","author":"Erener","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.abb.2021.108763_bib4","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/hep.30156","article-title":"MicroRNA sequencing identifies a serum MicroRNA panel, which combined with aspartate aminotransferase to platelet ratio index can detect and monitor liver disease in pediatric cystic fibrosis","volume":"68","author":"Calvopina","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.abb.2021.108763_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0191067","article-title":"Serum miRNA levels are related to glucose homeostasis and islet autoantibodies in children with high risk for type 1 diabetes","volume":"13","author":"\u00c5kerman","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.abb.2021.108763_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9071698","article-title":"Current status of microRNA-based therapeutic approaches in neurodegenerative disorders","volume":"9","author":"Paul","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.abb.2021.108763_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s13205-020-02298-y","article-title":"Characterization of miRNAs from sardine (Sardina pilchardus Walbaum, 1792) and their tissue-specific expression analysis in brain and liver","volume":"10","author":"de la Fuente Jim\u00e9nez","year":"2020","journal-title":"3 Biotech"},{"key":"10.1016\/j.abb.2021.108763_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4321\/S1889-836X2016000100007","article-title":"\u00bfQu\u00e9 son los microARNs?: posibles biomarcadores y dianas terap\u00e9uticas en la enfermedad osteopor\u00f3tica","volume":"8","author":"Giner","year":"2016","journal-title":"Rev Osteoporos Metab. Min."},{"key":"10.1016\/j.abb.2021.108763_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.abb.2014.07.022","article-title":"The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma","volume":"563","author":"Aftab","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2021.108763_bib10","first-page":"1","article-title":"MicroRNA dysregulation in cystic fibrosis","author":"Mckiernan","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.abb.2021.108763_bib11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/15476286.2019.1593094","article-title":"Small molecules with big roles in microRNA chemical biology and microRNA-targeted therapeutics","volume":"16","author":"Fan","year":"2019","journal-title":"RNA Biol."},{"key":"10.1016\/j.abb.2021.108763_bib12","series-title":"Cyst. Fibros. Light","first-page":"233","article-title":"Emerging roles of microRNAs in cystic fibrosis-from pathogenesis to development of new therapies","author":"Noel","year":"2015"},{"key":"10.1016\/j.abb.2021.108763_bib13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/CBI20100664","article-title":"MicroRNAs and cystic fibrosis \u2013 an epigenetic perspective","volume":"35","author":"Xu","year":"2011","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.abb.2021.108763_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ppedcard.2018.02.008","article-title":"Circulating microRNAs as biomarkers in pediatric heart diseases","volume":"49","author":"Sucharov","year":"2018","journal-title":"Prog. Pediatr. Cardiol."},{"key":"10.1016\/j.abb.2021.108763_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/cells9020276","article-title":"miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis","volume":"9","author":"Condrat","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.abb.2021.108763_bib16","article-title":"MicroRNAs: peque\u00f1os reguladores con un gran impacto en nuestro sistema inmune","author":"Gonz\u00e1lez Mart\u00edn","year":"2019","journal-title":"SEBBM Divulg"},{"key":"10.1016\/j.abb.2021.108763_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-018-1411-0","article-title":"Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children","volume":"16","author":"Song","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.abb.2021.108763_bib18","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2217\/bmm.11.96","article-title":"Development of biomarkers to optimize pediatric patient management: what makes children different?","volume":"5","author":"Goldman","year":"2011","journal-title":"Biomarkers Med."},{"key":"10.1016\/j.abb.2021.108763_bib19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00246-017-1607-8","article-title":"MicroRNAs association in the cardiac hypertrophy secondary to complex congenital heart disease in children","volume":"38","author":"S\u00e1nchez-G\u00f3mez","year":"2017","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.abb.2021.108763_bib20","series-title":"Pocket Book of Hospital Care for Children","author":"World Health Organization","year":"2013"},{"key":"10.1016\/j.abb.2021.108763_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-018-0368-8","article-title":"Nanotechnology based approaches for detection and delivery of microRNA in healthcare and crop protection","volume":"16","author":"Chaudhary","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.abb.2021.108763_bib22","doi-asserted-by":"crossref","first-page":"108583","DOI":"10.1016\/j.abb.2020.108583","article-title":"Roles of circulating microRNA(s) in human breast cancer","volume":"695","author":"Chong","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2021.108763_bib23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.abb.2003.08.006","article-title":"Peroxisome proliferator-activated receptor \u03b3 ligands attenuate immunological symptoms of experimental allergic asthma","volume":"418","author":"Mueller","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2021.108763_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.15585\/mmwr.mm6705e1","article-title":"Vital Signs\u00a0: asthma in children \u2014 United States, 2001\u20132016","volume":"67","author":"Zahran","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.abb.2021.108763_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fped.2018.00301","article-title":"MicroRNA 27b-3p modulates SYK in pediatric asthma induced by dust mites","volume":"6","author":"Dong","year":"2018","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.abb.2021.108763_bib27","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jaci.2007.05.005","article-title":"Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals","volume":"120","author":"Lay","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.abb.2021.108763_bib28","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1164\/rccm.201011-1813OC","article-title":"Lung function and inflammatory responses in healthy young adults exposed to 0.06 ppm ozone for 6.6 hours","volume":"183","author":"Kim","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.abb.2021.108763_bib29","first-page":"103","article-title":"Health effects of tropospheric ozone: review of recent research findings and their implications to ambient air quality standards","volume":"3","author":"Lippmann","year":"1993","journal-title":"J. Expo. Anal. Environ. Epidemiol."},{"key":"10.1016\/j.abb.2021.108763_bib30","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1152\/ajplung.00348.2013","article-title":"Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects","volume":"306","author":"Fry","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.abb.2021.108763_bib31","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.jaci.2020.01.032","article-title":"The potential of microRNAs as noninvasive biomarkers in acute pediatric asthma","volume":"145","author":"Trifunovic","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.abb.2021.108763_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molimm.2015.12.015","article-title":"MicroRNA \u2013 21 as a novel biomarker in diagnosis and response to therapy in asthmatic children","volume":"71","author":"Elbehidy","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.abb.2021.108763_bib33","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaci.2008.01.031","article-title":"Immunologic and inflammatory mechanisms that drive asthma progression to remodeling","volume":"121","author":"Broide","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.abb.2021.108763_bib34","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jaci.2012.01.060","article-title":"MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers","volume":"129","author":"Lu","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.abb.2021.108763_bib35","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3892\/mmr.2012.1030","article-title":"Profiling of miRNAs in pediatric asthma: upregulation of miRNA-221 and miRNA-485-3p","volume":"6","author":"Liu","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.abb.2021.108763_bib36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1084\/jem.20040616","article-title":"Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness","volume":"201","author":"Inoue","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.abb.2021.108763_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0224983","article-title":"Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children","volume":"14","author":"Mendes","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.abb.2021.108763_bib38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/1753425918763521","article-title":"Plasma microRNA-21, microRNA-146a and IL-13 expression in asthmatic children","volume":"24","author":"Hammad Mahmoud Hammad","year":"2018","journal-title":"Innate Immun."},{"key":"10.1016\/j.abb.2021.108763_bib39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.clinbiochem.2019.04.007","article-title":"Differential expression of miR-155 and Let-7a in the plasma of childhood asthma: potential biomarkers for diagnosis and severity","volume":"68","author":"Karam","year":"2019","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.abb.2021.108763_bib40","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.alit.2016.04.018","article-title":"Overexpression of microRNA-155 suppresses chemokine expression induced by Interleukin-13 in BEAS-2B human bronchial epithelial cells","volume":"65","author":"Matsukura","year":"2016","journal-title":"Allergol. Int."},{"key":"10.1016\/j.abb.2021.108763_bib41","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/13102818.2019.1591932","article-title":"MicroRNA profiling of patients with sporadic atrial septal defect","volume":"33","author":"Han","year":"2019","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"10.1016\/j.abb.2021.108763_bib42","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.biopha.2018.10.110","article-title":"Expression profile of maternal circulating microRNAs as non-invasive biomarkers for prenatal diagnosis of congenital heart defects","volume":"109","author":"Gu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.abb.2021.108763_bib43","first-page":"165","article-title":"The role of microRNAs in congenital heart disease, Electron","volume":"30","author":"Nagy","year":"2019","journal-title":"J. Int. Fed. Clin. Chem. Lab. Med."},{"key":"10.1016\/j.abb.2021.108763_bib44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.recesp.2018.06.020","article-title":"MicroRNAs and congenital heart disease: where are we now?","volume":"72","author":"Pulignani","year":"2019","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.abb.2021.108763_bib45","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/pd.2443","article-title":"Identification of circulating placental mRNA in maternal blood of pregnancies affected with fetal congenital heart diseases at the second trimester of pregnancy: implications for early molecular screening","volume":"30","author":"Arcelli","year":"2010","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.abb.2021.108763_bib46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.biochem.75.103004.142622","article-title":"Signaling pathways in skeletal muscle remodeling","volume":"75","author":"Bassel-Duby","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.abb.2021.108763_bib47","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1017\/S1047951101000932","article-title":"Living morphogenesis of the ventricles and congenital pathology of their component parts","volume":"11","author":"De la Cruz","year":"2001","journal-title":"Cardiol. Young"},{"key":"10.1016\/j.abb.2021.108763_bib48","first-page":"237","article-title":"Paradigms and paradoxes of left ventricular hypertrophy: from the research laboratory to the clinical consultation","volume":"77","author":"Escudero","year":"2007","journal-title":"Arch. Cardiol. Mex."},{"key":"10.1016\/j.abb.2021.108763_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40348-014-0012-0","article-title":"miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6","volume":"2","author":"Oglesby","year":"2015","journal-title":"Mol. Cell. Pediatr."},{"key":"10.1016\/j.abb.2021.108763_bib50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0003-9861(02)00427-7","article-title":"Nitric oxide and protein nitration in the cystic fibrosis airway","volume":"406","author":"Morrissey","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2021.108763_bib51","series-title":"Scientists Find New Approach that Shows Promise for Treating Cystic Fibrosis","author":"National Heart - Lung","year":"2019"},{"key":"10.1016\/j.abb.2021.108763_bib52","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/MPG.0000000000001676","article-title":"Cystic fibrosis-related liver disease: research challenges and future perspectives","volume":"65","author":"Debray","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.abb.2021.108763_bib53","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S1665-2681(19)31836-8","article-title":"AST to platelet ratio index (APRI) for the noninvasive evaluation of liver fibrosis","volume":"7","author":"Loaeza-Del-Castillo","year":"2008","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.abb.2021.108763_bib54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ccr.2011.01.001","article-title":"Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a\/b-3p as therapeutic target for hepatocellular carcinoma","volume":"19","author":"Hou","year":"2011","journal-title":"Canc. Cell"},{"key":"10.1016\/j.abb.2021.108763_bib55","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.ajpath.2017.06.014","article-title":"Epigenetic silencing of miRNA-34a in human cholangiocarcinoma via EZH2 and DNA methylation: impact on regulation of Notch pathway","volume":"187","author":"Kwon","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.abb.2021.108763_bib56","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1016\/j.ajpath.2017.08.027","article-title":"Regulation of cellular senescence by miR-34a in alcoholic liver injury","volume":"187","author":"Wan","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.abb.2021.108763_bib57","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jhep.2009.12.025","article-title":"Let-7g targets collagen type I \u03b12 and inhibits cell migration in hepatocellular carcinoma","volume":"52","author":"Ji","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.abb.2021.108763_bib58","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ijc.25336","article-title":"Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16INK4A","volume":"128","author":"Lan","year":"2010","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.abb.2021.108763_bib59","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.lfs.2017.08.017","article-title":"MiR-142-3p blocks TGF-\u03b2-induced activation of hepatic stellate cells through targeting TGF\u03b2RI","volume":"187","author":"Yang","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.abb.2021.108763_bib60","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1752-0509-7-104","article-title":"Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia","volume":"7","author":"Bessho","year":"2013","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.abb.2021.108763_bib61","article-title":"Differential plasma MicroRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B","volume":"8","author":"Winther","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.abb.2021.108763_bib62","first-page":"791045","article-title":"Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes","author":"Winther","year":"2014","journal-title":"Int. J. Hepatol."},{"key":"10.1016\/j.abb.2021.108763_bib63","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41598-020-57964-1","article-title":"Plasma microRNA levels in male and female children with cystic fibrosis","volume":"10","author":"Mooney","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.abb.2021.108763_bib64","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/jir.2012.0074","article-title":"Differential regulation of inflammation by inflammatory mediators in cystic fibrosis lung epithelial cells","volume":"33","author":"Tsuchiya","year":"2013","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.abb.2021.108763_bib65","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbrc.2013.03.025","article-title":"Regulation of miR-155 biogenesis in cystic fibrosis lung epithelial cells: antagonistic role of two mRNA-destabilizing proteins, KSRP and TTP","volume":"433","author":"Bhattacharyya","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2021.108763_bib66","doi-asserted-by":"crossref","first-page":"11604","DOI":"10.1074\/jbc.M110.198390","article-title":"Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8","volume":"286","author":"Bhattacharyya","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2021.108763_bib67","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1203\/00006450-199308000-00010","article-title":"Interleukin-8 concentrations are elevated in bronchoalveolar lavage, sputum, and sera of children with cystic fibrosis","volume":"34","author":"Dean","year":"1993","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.abb.2021.108763_bib68","first-page":"1075","article-title":"Early pulmonary inflammation in infants with cystic fibrosis","volume":"151","author":"Khan","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.abb.2021.108763_bib70","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S2213-2600(18)30460-0","article-title":"Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2\u20135 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study","volume":"7","author":"McNamara","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.abb.2021.108763_bib71","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"Haze","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.abb.2021.108763_bib72","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/path.5095","article-title":"Small RNA and transcriptome sequencing reveal the role of miR-199a-3p in inflammatory processes in cystic fibrosis airways","volume":"245","author":"Bardin","year":"2018","journal-title":"J. Pathol."},{"key":"10.1016\/j.abb.2021.108763_bib73","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/(SICI)1099-0496(199605)21:5<267::AID-PPUL1>3.0.CO;2-K","article-title":"Bronchoalveolar lavage or oropharyngeal cultures to identify lower respiratory pathogens in infants with cystic fibrosis","volume":"21","author":"Armstrong","year":"1996","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.abb.2021.108763_bib74","series-title":"PATIENT REGISTRY ANNUAL DATA REPORT","year":"2018"},{"key":"10.1016\/j.abb.2021.108763_bib75","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1165\/rcmb.2013-0160OC","article-title":"Expression of microRNA-93 and interleukin-8 during Pseudomonas aeruginosa-mediated induction of proinflammatory responses","volume":"50","author":"Fabbri","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.abb.2021.108763_bib76","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-\u03baB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.abb.2021.108763_bib77","doi-asserted-by":"crossref","first-page":"16259","DOI":"10.1038\/s41598-019-52770-w","article-title":"MiR-146a is over-expressed and controls IL-6 production in cystic fibrosis macrophages","volume":"9","author":"Luly","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.abb.2021.108763_bib78","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1517\/14728220802515293","article-title":"Toll-like receptors as therapeutic targets in cystic fibrosis","volume":"12","author":"Greene","year":"2008","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.abb.2021.108763_bib79","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.4049\/jimmunol.0902669","article-title":"miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression","volume":"184","author":"Oglesby","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.abb.2021.108763_bib80","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.4049\/jimmunol.1202960","article-title":"Regulation of cystic fibrosis transmembrane conductance regulator by MicroRNA-145, -223, and -494 is altered in \u0394F508 cystic fibrosis airway epithelium","volume":"190","author":"Oglesby","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.abb.2021.108763_bib81","doi-asserted-by":"crossref","first-page":"931","DOI":"10.4049\/jimmunol.171.2.931","article-title":"Inactivation of human \u03b2-defensins 2 and 3 by elastolytic cathepsins","volume":"171","author":"Taggart","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.abb.2021.108763_bib82","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1086\/423821","article-title":"Loss of microbial activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis","volume":"190","author":"Rogan","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.abb.2021.108763_bib83","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/ppul.21274","article-title":"Association of airway cathepsin B and S with inflammation in cystic fibrosis","volume":"45","author":"Martin","year":"2010","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.abb.2021.108763_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025577","article-title":"Human cysteine cathepsins are not reliable markers of infection by pseudomonas aeruginosa in cystic fibrosis","volume":"6","author":"Naudin","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.abb.2021.108763_bib85","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00424-012-1138-3","article-title":"Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S","volume":"464","author":"Haerteis","year":"2012","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.abb.2021.108763_bib86","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.biocel.2013.05.018","article-title":"Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties","volume":"45","author":"Lecaille","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.abb.2021.108763_bib87","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1164\/rccm.201311-1986OC","article-title":"MiR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production","volume":"190","author":"Weldon","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.abb.2021.108763_bib88","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pupt.2008.11.002","article-title":"Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation","volume":"22","author":"Williams","year":"2009","journal-title":"Pulm. Pharmacol. Therapeut."},{"key":"10.1016\/j.abb.2021.108763_bib89","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.abb.2015.08.011","article-title":"Modeling strategies to study metabolic pathways in progression to type 1 diabetes - challenges and opportunities","volume":"589","author":"Marinkovi\u0107","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2021.108763_bib90","series-title":"Diabetes: Key Facts","author":"World Health Organization","year":"2020"},{"key":"10.1016\/j.abb.2021.108763_bib91","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1038\/nrdp.2017.16","article-title":"Type 1 diabetes mellitus","volume":"3","author":"Katsarou","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.abb.2021.108763_bib92","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ecl.2010.05.011","article-title":"Epidemiology of type 1 diabetes","volume":"39","author":"Maahs","year":"2010","journal-title":"Endocrinol Metab. Clin. N. Am."},{"key":"10.1016\/j.abb.2021.108763_bib93","series-title":"IDF Diabetes Atlas","year":"2019"},{"key":"10.1016\/j.abb.2021.108763_bib94","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1530\/EC-17-0248","article-title":"MicroRNA expression profiles and type 1 diabetes mellitus: systematic review and bioinformatic analysis","volume":"6","author":"Assmann","year":"2017","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.abb.2021.108763_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/1869082","article-title":"MiRNA-375 a sensor of glucotoxicity is altered in the serum of children with newly diagnosed type 1 diabetes","author":"Marchand","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.abb.2021.108763_bib96","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00109-015-1296-9","article-title":"miR-375 gene dosage in pancreatic \u03b2-cells: implications for regulation of \u03b2-cell mass and biomarker development","volume":"93","author":"Latreille","year":"2015","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.abb.2021.108763_bib97","first-page":"1","article-title":"Circulating levels of MicroRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression","author":"Nielsen","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.abb.2021.108763_bib98","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2147\/DMSO.S247062","article-title":"Micrornas and risk factors for diabetic nephropathy in egyptian children and adolescents with type 1 diabetes","volume":"13","author":"Abdelghaffar","year":"2020","journal-title":"Diabetes, Metab. Syndrome Obes. Targets Ther."},{"key":"10.1016\/j.abb.2021.108763_bib99","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1096\/fj.08-112326","article-title":"MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy","volume":"22","author":"Wang","year":"2008","journal-title":"Faseb. J."},{"key":"10.1016\/j.abb.2021.108763_bib100","first-page":"8719060","article-title":"The role of MicroRNAs in the pathogenesis of diabetic nephropathy","volume":"2019","author":"Tang","year":"2019","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.abb.2021.108763_bib101","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jphs.2017.12.010","article-title":"Up-regulation of microRNA-93 inhibits TGF-\u03b21-induced EMT and renal fibrogenesis by down-regulation of Orai1","volume":"136","author":"Ma","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.abb.2021.108763_bib102","doi-asserted-by":"crossref","first-page":"23457","DOI":"10.1074\/jbc.M110.136168","article-title":"Identification of MicroRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions","volume":"285","author":"Long","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2021.108763_bib103","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.2337\/db11-0082","article-title":"Diabetes complications: the microRNA perspective","volume":"60","author":"Kantharidis","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.abb.2021.108763_bib104","doi-asserted-by":"crossref","first-page":"E1661","DOI":"10.1210\/jc.2013-3868","article-title":"Diabetes-associated MicroRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study","volume":"99","author":"Osipova","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.abb.2021.108763_bib105","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00125-017-4237-z","article-title":"MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells","volume":"60","author":"Sims","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.abb.2021.108763_bib106","doi-asserted-by":"crossref","first-page":"D89","DOI":"10.1093\/nar\/gky985","article-title":"EVmiRNA: a database of miRNA profiling in extracellular vesicles","volume":"47","author":"Liu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.abb.2021.108763_bib107","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1007\/s00125-018-4559-5","article-title":"Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes","volume":"61","author":"Lakhter","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.abb.2021.108763_bib108","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1210\/en.2012-1744","article-title":"Circulating miR-375 as a biomarker of \u03b2-cell death and diabetes in mice","volume":"154","author":"Erener","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.abb.2021.108763_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0186480","article-title":"Circulating microRNA-375 as biomarker of pancreatic beta cell death and protection of beta cell mass by cytoprotective compounds","volume":"12","author":"Song","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.abb.2021.108763_bib110","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1007\/s00125-015-3672-y","article-title":"Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes","volume":"58","author":"Giannopoulou","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.abb.2021.108763_bib111","article-title":"Human leukocyte antigen (HLA) system - immunology; allergic disorders - merck manuals professional edition","author":"Delves","year":"2020","journal-title":"Merck Man. Prof. Version"},{"key":"10.1016\/j.abb.2021.108763_bib112","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s11064-019-02917-y","article-title":"MicroRNAs and child neuropsychiatric disorders: a brief review","volume":"45","author":"Paul","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.abb.2021.108763_bib113","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s00415-017-8394-2","article-title":"Recent advances in epilepsy","volume":"264","author":"Manford","year":"2017","journal-title":"J. Neurol."},{"key":"10.1016\/j.abb.2021.108763_bib114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4238\/gmr.15017798","article-title":"Silencing miR-181a produces neuroprotection against hippocampus neuron cell apoptosis post-status epilepticus in a rat model and in children with temporal lobe epilepsy","volume":"15","author":"Ren","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.abb.2021.108763_bib115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/1570159X15666170703102410","article-title":"The challenge of microRNA as a biomarker of epilepsy","volume":"16","author":"Ma","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.abb.2021.108763_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13000-020-00944-w","article-title":"MicroRNA-15a-5p serves as a potential biomarker and regulates the viability and apoptosis of hippocampus neuron in children with temporal lobe epilepsy","volume":"15","author":"Li","year":"2020","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.abb.2021.108763_bib117","doi-asserted-by":"crossref","first-page":"71","DOI":"10.31083\/j.jin.2019.01.13","article-title":"Molecular expression and functional analysis of genes in children with temporal lobe epilepsy","volume":"18","author":"Wu","year":"2019","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.abb.2021.108763_bib118","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.brainres.2013.09.049","article-title":"MicroRNAs dysregulation in epilepsy","volume":"1584","author":"Li","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.abb.2021.108763_bib119","first-page":"1","article-title":"Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy","volume":"4","author":"Li","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.abb.2021.108763_bib120","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12031-013-9953-3","article-title":"Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy","volume":"50","author":"Peng","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.abb.2021.108763_bib121","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2011.09.039","article-title":"Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus","volume":"1424","author":"Risbud","year":"2011","journal-title":"Brain Res."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121000138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121000138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:17:26Z","timestamp":1757744246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986121000138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":119,"alternative-id":["S0003986121000138"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2021.108763","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of microRNAs in chronic pediatric diseases and their use as potential biomarkers: A review","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2021.108763","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108763"}}