{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:57:38Z","timestamp":1790229458395,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012834","name":"Gifu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.abb.2021.108810","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T08:22:28Z","timestamp":1613463748000},"page":"108810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Food additive-induced oxidative stress in rat male reproductive organs and hippocampus"],"prefix":"10.1016","volume":"701","author":[{"given":"Yukiko","family":"Minamiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5221-7258","authenticated-orcid":false,"given":"Shigekazu","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2021.108810_bib1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3109\/10715762.2010.510523","article-title":"Generation of reactive oxygen species in sperms of rats as an earlier marker for evaluating the toxicity of endocrine-disrupting chemicals","volume":"44","author":"Minamiyama","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.abb.2021.108810_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9030240","article-title":"Effects of bisphenol A on oixidative stress in the rat brain","volume":"9","author":"Kobayashi","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.abb.2021.108810_bib3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nrendo.2014.167","article-title":"Gut microbiota: not so sweet--artificial sweeteners can cause glucose intolerance by affecting the gut microbiota","volume":"10","author":"Greenhill","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.abb.2021.108810_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature13793","article-title":"Artificial sweeteners induce glucose intolerance by altering the gut microbiota","volume":"514","author":"Suez","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.abb.2021.108810_bib5","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3389\/fmicb.2020.00892","article-title":"Dietary emulsifier sodium stearoyl lactylate alters gut microbiota in vitro and inhibits bacterial butyrate producers","volume":"11","author":"Elmen","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.abb.2021.108810_bib6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1089\/ars.2017.7488","article-title":"Environmental stressors and their impact on health and disease with focus on oxidative stress","volume":"28","author":"Munzel","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.abb.2021.108810_bib7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.fct.2018.03.052","article-title":"Six months exposure to a real life mixture of 13 chemicals' below individual NOAELs induced non monotonic sex-dependent biochemical and redox status changes in rats","volume":"115","author":"Docea","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.abb.2021.108810_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fct.2018.12.043","article-title":"Hormetic Neurobehavioral effects of low dose toxic chemical mixtures in real-life risk simulation (RLRS) in rats","volume":"125","author":"Tsatsakis","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.abb.2021.108810_bib9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.toxlet.2019.09.004","article-title":"Genotoxic, cytotoxic, and cytopathological effects in rats exposed for 18 months to a mixture of 13 chemicals in doses below NOAEL levels","volume":"316","author":"Tsatsakis","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.abb.2021.108810_bib10","first-page":"132","article-title":"Actions of various sweeteners on rat sperm","volume":"7","author":"Minamiyama","year":"2020","journal-title":"Glycative Stress Research"},{"key":"10.1016\/j.abb.2021.108810_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9030240","article-title":"Effects of bisphenol A on oxidative stress in the rat brain","volume":"9","author":"Kobayashi","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.abb.2021.108810_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23020367","article-title":"Effects of the artificial sweetener neotame on the gut microbiome and fecal metabolites in mice","volume":"23","author":"Chi","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.abb.2021.108810_bib13","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1007\/s00394-019-02161-8","article-title":"The impact of food additives, artificial sweeteners and domestic hygiene products on the human gut microbiome and its fibre fermentation capacity","volume":"59","author":"Gerasimidis","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.abb.2021.108810_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s13105-017-0564-2","article-title":"Food additives, contaminants and other minor components: effects on human gut microbiota-a review","volume":"74","author":"Roca-Saavedra","year":"2018","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.abb.2021.108810_bib15","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1021\/jf0303619","article-title":"Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora","volume":"51","author":"Gardana","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.abb.2021.108810_bib16","article-title":"Safety in use of glucosylated steviol glycosides as a food additive in different food categories","volume":"16","author":"Younes","year":"2018","journal-title":"Efsa J"},{"key":"10.1016\/j.abb.2021.108810_bib17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1289\/ehp.1509730","article-title":"Human health effects of biphenyl: key findings and scientific issues","volume":"124","author":"Li","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.abb.2021.108810_bib18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/carcin\/20.5.851","article-title":"Oxidative damage to cellular and isolated DNA by metabolites of a fungicide ortho-phenylphenol","volume":"20","author":"Murata","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.abb.2021.108810_bib19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/20024091064318","article-title":"O-phenylphenol and its sodium and potassium salts: a toxicological assessment","volume":"32","author":"Bomhard","year":"2002","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.abb.2021.108810_bib20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.toxlet.2019.09.015","article-title":"A mixture of routinely encountered xenobiotics induces both redox adaptations and perturbations in blood and tissues of rats after a long-term low-dose exposure regimen: the time and dose issue","volume":"317","author":"Fountoucidou","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.abb.2021.108810_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(07)63001-5","article-title":"The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)","volume":"163","author":"Amaral","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.abb.2021.108810_bib22","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.neuron.2009.08.014","article-title":"NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory","volume":"63","author":"Saab","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.abb.2021.108810_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ahe.12496","article-title":"Adult neurogenesis in the mammalian dentate gyrus","volume":"49","author":"Abbott","year":"2020","journal-title":"Anat. Histol. Embryol."},{"key":"10.1016\/j.abb.2021.108810_bib24","doi-asserted-by":"crossref","first-page":"112112","DOI":"10.1016\/j.bbr.2019.112112","article-title":"Contributions of adult neurogenesis to dentate gyrus network activity and computations","volume":"374","author":"Tuncdemir","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.abb.2021.108810_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.0000000000004826","article-title":"Practice guideline update summary: mild cognitive impairment: Report of the guideline development, dissemination, and implementation subcommittee of the American academy of neurology","volume":"90","author":"Petersen","year":"2018","journal-title":"Neurology"}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121000606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121000606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:03:27Z","timestamp":1762088607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986121000606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":25,"alternative-id":["S0003986121000606"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2021.108810","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Food additive-induced oxidative stress in rat male reproductive organs and hippocampus","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2021.108810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108810"}}