{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:26:32Z","timestamp":1784823992547,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.abb.2021.108895","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T23:42:17Z","timestamp":1619739737000},"page":"108895","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Adipose-derived stem cell induced-tissue repair or wound healing is mediated by the concomitant upregulation of miR-21 and miR-29b expression and activation of the AKT signaling pathway"],"prefix":"10.1016","volume":"705","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9730-1798","authenticated-orcid":false,"given":"Shao-Cheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-0408","authenticated-orcid":false,"given":"Oluwaseun Adebayo","family":"Bamodu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Tai","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iat-Hang","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Cheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-9755","authenticated-orcid":false,"given":"Chi-Tai","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyi-Gen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.abb.2021.108895_bib1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13287-020-01755-y","article-title":"Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization","volume":"11","author":"Xiao","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"6","key":"10.1016\/j.abb.2021.108895_bib2","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1002\/jcb.28376","article-title":"Adipose mesenchymal stem cell-derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt\/beta-catenin signaling in cutaneous wound healing","volume":"120","author":"Ma","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"9","key":"10.1016\/j.abb.2021.108895_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/wound.2017.0775","article-title":"Human adipose-derived stem cell conditioned media and exosomes containing MALAT1 promote human dermal fibroblast migration and ischemic wound healing","volume":"7","author":"Cooper","year":"2018","journal-title":"Adv. Wound Care"},{"issue":"2","key":"10.1016\/j.abb.2021.108895_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.yexcr.2018.06.035","article-title":"Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K\/Akt signaling pathway","volume":"370","author":"Zhang","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.abb.2021.108895_bib5","article-title":"Creation and transplantation of an adipose-derived stem cell (ASC) sheet in a diabetic wound-healing model","volume":"126","author":"Kato","year":"2017","journal-title":"JoVE"},{"issue":"4","key":"10.1016\/j.abb.2021.108895_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10735-020-09887-4","article-title":"Adipose mesenchymal stem cell exosomes promote wound healing through accelerated keratinocyte migration and proliferation by activating the AKT\/HIF-1alpha axis","volume":"51","author":"Zhang","year":"2020","journal-title":"J. Mol. Histol."},{"issue":"1\u20132","key":"10.1016\/j.abb.2021.108895_bib7","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bbrc.2015.10.083","article-title":"Sphere formation of adipose stem cell engineered by poly-2-hydroxyethyl methacrylate induces in vitro angiogenesis through fibroblast growth factor 2","volume":"468","author":"Kim","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.abb.2021.108895_bib8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/molehr\/gaz008","article-title":"Adipose tissue-derived stem cells boost vascularization in grafted ovarian tissue by growth factor secretion and differentiation into endothelial cell lineages","volume":"25","author":"Manavella","year":"2019","journal-title":"Mol. Hum. Reprod."},{"issue":"6","key":"10.1016\/j.abb.2021.108895_bib9","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/wrr.12838","article-title":"A review of epigenetic regulation in wound healing - implications for the future of wound care","volume":"28","author":"Lewis","year":"2020","journal-title":"Wound Repair Regen."},{"issue":"11","key":"10.1016\/j.abb.2021.108895_bib10","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.2174\/1389203721666200210102751","article-title":"Review of MiRNA-disease association prediction","volume":"21","author":"Jiang","year":"2020","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.abb.2021.108895_bib11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-3-319-22671-2_15","article-title":"microRNA and wound healing","volume":"888","author":"Banerjee","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"10.1016\/j.abb.2021.108895_bib12","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.ajpath.2012.08.022","article-title":"miR-21 regulates skin wound healing by targeting multiple aspects of the healing process","volume":"181","author":"Wang","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.abb.2021.108895_bib13","doi-asserted-by":"crossref","first-page":"105570","DOI":"10.1016\/j.biocel.2019.105570","article-title":"Human keratinocyte-derived microvesicle miRNA-21 promotes skin wound healing in diabetic rats through facilitating fibroblast function and angiogenesis","volume":"114","author":"Li","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.abb.2021.108895_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.trsl.2016.07.001","article-title":"Overexpression of miR-29b reduces collagen biosynthesis by inhibiting heat shock protein 47 during skin wound healing","volume":"178","author":"Zhu","year":"2016","journal-title":"Transl. Res."},{"issue":"10","key":"10.1016\/j.abb.2021.108895_bib15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1152\/physiolgenomics.00090.2016","article-title":"Mesenchymal stem cells correct impaired diabetic wound healing by decreasing ECM proteolysis","volume":"49","author":"Xu","year":"2017","journal-title":"Physiol. Genom."},{"issue":"5","key":"10.1016\/j.abb.2021.108895_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1600-0625.2010.01221.x","article-title":"Adipose-derived stem cells as a new therapeutic modality for ageing skin","volume":"20","author":"Kim","year":"2011","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.abb.2021.108895_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/15476278.2015.1126018","article-title":"Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds","volume":"11","author":"Marfia","year":"2015","journal-title":"Organogenesis"},{"issue":"4","key":"10.1016\/j.abb.2021.108895_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1089\/wound.2012.0361","article-title":"The role of mesenchymal stem cells in the regenerative wound healing phenotype","volume":"1","author":"Balaji","year":"2012","journal-title":"Adv. Wound Care"},{"issue":"2","key":"10.1016\/j.abb.2021.108895_bib19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00441-011-1306-3","article-title":"Comparative investigation of the differentiation capability of bone-marrow- and adipose-derived mesenchymal stem cells by qualitative and quantitative analysis","volume":"347","author":"Vishnubalaji","year":"2012","journal-title":"Cell Tissue Res."},{"issue":"Suppl 3","key":"10.1016\/j.abb.2021.108895_bib20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1590\/S0102-86502014001700001","article-title":"Adipose-derived stem cells (ADSC) in the viability of a random pattern dorsal skin flap in rats","volume":"29","author":"Suartz","year":"2014","journal-title":"Acta Cir. Bras."},{"issue":"1","key":"10.1016\/j.abb.2021.108895_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055640","article-title":"Topically delivered adipose derived stem cells show an activated-fibroblast phenotype and enhance granulation tissue formation in skin wounds","volume":"8","author":"Hong","year":"2013","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.abb.2021.108895_bib22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbrc.2017.01.103","article-title":"Wound healing potential of adipose tissue stem cell extract","volume":"485","author":"Na","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.abb.2021.108895_bib23","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/bjd.17984","article-title":"Adipose stem cell-derived exosomes in combination with hyaluronic acid accelerate wound healing through enhancing re-epithelialization and vascularization","volume":"181","author":"Liu","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.abb.2021.108895_bib24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1742-481X.2011.00890.x","article-title":"MicroRNA signature in diabetic wound healing: promotive role of miR-21 in fibroblast migration","volume":"9","author":"Madhyastha","year":"2012","journal-title":"Int. Wound J."},{"issue":"5","key":"10.1016\/j.abb.2021.108895_bib25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.7150\/ijbs.7.685","article-title":"miR-21 promotes keratinocyte migration and re-epithelialization during wound healing","volume":"7","author":"Yang","year":"2011","journal-title":"Int. J. Biol. Sci."},{"issue":"10","key":"10.1016\/j.abb.2021.108895_bib26","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1002\/jcb.26026","article-title":"MiR-21\/PTEN Axis promotes skin wound healing by dendritic cells enhancement","volume":"118","author":"Han","year":"2017","journal-title":"J. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.abb.2021.108895_bib27","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1152\/physiolgenomics.00146.2010","article-title":"Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?","volume":"43","author":"Albinsson","year":"2011","journal-title":"Physiol. Genom."},{"issue":"7","key":"10.1016\/j.abb.2021.108895_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068543","article-title":"Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21","volume":"8","author":"Roy","year":"2013","journal-title":"PloS One"},{"issue":"12","key":"10.1016\/j.abb.2021.108895_bib29","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1177\/1947601911407325","article-title":"PTEN tumor suppressor network in PI3K-Akt pathway control","volume":"1","author":"Georgescu","year":"2010","journal-title":"Genes Canc."},{"issue":"8","key":"10.1016\/j.abb.2021.108895_bib30","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1038\/jid.2008.39","article-title":"Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts","volume":"128","author":"Bujor","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.abb.2021.108895_bib31","doi-asserted-by":"crossref","first-page":"3909102","DOI":"10.1155\/2019\/3909102","article-title":"VEGF induce vasculogenic mimicry of choroidal melanoma through the PI3k signal pathway","volume":"2019","author":"Xu","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.abb.2021.108895_bib32","doi-asserted-by":"crossref","first-page":"109357","DOI":"10.1016\/j.biopha.2019.109357","article-title":"Ricolinostat (ACY-1215) inhibits VEGF expression via PI3K\/AKT pathway and promotes apoptosis in osteoarthritic osteoblasts","volume":"118","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.abb.2021.108895_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13148-020-00981-8","article-title":"Epigenetic modification mechanisms involved in keloid: current status and prospect","volume":"12","author":"Lv","year":"2020","journal-title":"Clin. Epigenet."},{"issue":"5","key":"10.1016\/j.abb.2021.108895_bib34","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jid.2018.11.007","article-title":"A MicroRNA-29 Mimic (Remlarsen) represses extracellular matrix expression and fibroplasia in the skin","volume":"139","author":"Gallant-Behm","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.abb.2021.108895_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1139\/cjpp-2016-0248","article-title":"miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of the TGF-\u03b21\/Smad\/CTGF signaling pathway","volume":"95","author":"Guo","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.abb.2021.108895_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.addr.2018.08.009","article-title":"Current and upcoming therapies to modulate skin scarring and fibrosis","volume":"146","author":"Coentro","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7","key":"10.1016\/j.abb.2021.108895_bib37","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.bbadis.2015.04.013","article-title":"Opposing roles of miR-21 and miR-29 in the progression of fibrosis in Duchenne muscular dystrophy","volume":"1852","author":"Zanotti","year":"2015","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121001454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121001454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:18:17Z","timestamp":1757744297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986121001454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":37,"alternative-id":["S0003986121001454"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2021.108895","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipose-derived stem cell induced-tissue repair or wound healing is mediated by the concomitant upregulation of miR-21 and miR-29b expression and activation of the AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2021.108895","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108895"}}