{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:56:14Z","timestamp":1793638574257,"version":"4.5.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H04052"],"award-info":[{"award-number":["19H04052"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.abb.2021.108938","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T21:37:31Z","timestamp":1622065051000},"page":"108938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells"],"prefix":"10.1016","volume":"707","author":[{"given":"Mingzu","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-4408","authenticated-orcid":false,"given":"Wenxi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-543X","authenticated-orcid":false,"given":"Takuya","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.abb.2021.108938_bib1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.abb.2021.108938_bib2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00018-012-1070-x","article-title":"Regulation of intestinal epithelial permeability by tight junctions","volume":"70","author":"Suzuki","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.abb.2021.108938_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2006.07.028","article-title":"Role of heat shock proteins (molecular chaperones) in intestinal mucosal protection","volume":"348","author":"Otaka","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.abb.2021.108938_bib4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.tibs.2013.08.001","article-title":"Hsp70 chaperone dynamics and molecular mechanism","volume":"38","author":"Mayer","year":"2013","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"10.1016\/j.abb.2021.108938_bib5","doi-asserted-by":"crossref","first-page":"G164","DOI":"10.1152\/ajpgi.00208.2017","article-title":"Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis","volume":"314","author":"Wang","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"9","key":"10.1016\/j.abb.2021.108938_bib6","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.freeradbiomed.2008.08.001","article-title":"Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity","volume":"45","author":"Virgili","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.abb.2021.108938_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1753-4887.2009.00210.x","article-title":"Dietary polyphenols can modulate the intestinal inflammatory response","volume":"67","author":"Romier","year":"2009","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.abb.2021.108938_bib8","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1080\/10408398.2016.1152230","article-title":"Regulation of the intestinal tight junction by natural polyphenols: a mechanistic perspective","volume":"57","author":"Yang","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.abb.2021.108938_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.molimm.2018.09.004","article-title":"Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1\u03b2 production","volume":"104","author":"Gong","year":"2018","journal-title":"Mol. Immunol."},{"issue":"7","key":"10.1016\/j.abb.2021.108938_bib10","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","article-title":"IL-1beta causes an increase in intestinal epithelial tight junction permeability","volume":"178","author":"Al-Sadi","year":"2007","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.abb.2021.108938_bib11","doi-asserted-by":"crossref","first-page":"G496","DOI":"10.1152\/ajpgi.00318.2005","article-title":"Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier","volume":"290","author":"Ye","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.abb.2021.108938_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1021\/acs.jafc.7b04233","article-title":"Short-chain fatty acids suppress inflammatory reactions in Caco-2 cells and mouse colons","volume":"66","author":"Hung","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"11","key":"10.1016\/j.abb.2021.108938_bib13","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/mnfr.201300045","article-title":"Naringenin enhances intestinal barrier function through the expression and cytoskeletal association of tight junction proteins in Caco-2 cells","volume":"57","author":"Noda","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.abb.2021.108938_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jff.2014.06.004","article-title":"Quercetin increases claudin-4 expression through multiple transcription factors in intestinal Caco-2 cells","volume":"10","author":"Noda","year":"2014","journal-title":"J. Funct. Foods."},{"issue":"1","key":"10.1016\/j.abb.2021.108938_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jcp.1041490105","article-title":"Caco-2 cells cultured in serum-free medium as a model for the study of enterocytic differentiation in vitro","volume":"149","author":"Jumarie","year":"1991","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.abb.2021.108938_bib16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1379\/1466-1268(2002)007<0191:THSRAC>2.0.CO;2","article-title":"The heat shock response and cytoprotection of the intestinal epithelium","volume":"7","author":"Malago","year":"2002","journal-title":"Cell Stress Chaperones"},{"issue":"9","key":"10.1016\/j.abb.2021.108938_bib17","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.4049\/jimmunol.1103114","article-title":"Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium","volume":"188","author":"Afrazi","year":"2012","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.abb.2021.108938_bib18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/biof.1522","article-title":"Modulatory effects of curcumin on heat shock proteins in cancer: a promising therapeutic approach","volume":"45","author":"Forouzanfar","year":"2019","journal-title":"Biofactors"},{"issue":"5","key":"10.1016\/j.abb.2021.108938_bib19","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s12264-012-1275-x","article-title":"Curcumin protects against staurosporine toxicity in rat neurons","volume":"28","author":"Qin","year":"2012","journal-title":"Neurosci Bull"},{"issue":"13","key":"10.1016\/j.abb.2021.108938_bib20","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3748\/wjg.v13.i13.1953","article-title":"Protective effect of curcumin against liver warm ischemia\/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes","volume":"13","author":"Shen","year":"2007","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.abb.2021.108938_bib21","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.cgh.2006.08.008","article-title":"Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial","volume":"4","author":"Hanai","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.abb.2021.108938_bib22","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.cell.2015.01.028","article-title":"MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1","volume":"160","author":"Tang","year":"2015","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.abb.2021.108938_bib23","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1242\/dev.127.7.1541","article-title":"A developmentally regulated GAGA box-binding factor and Sp1 are required for transcription of the hsp70.1 gene at the onset of mouse zygotic genome activation","volume":"127","author":"Bevilacqua","year":"2000","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.abb.2021.108938_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/10495398.2013.844161","article-title":"Characterization of hsp70 gene promoter for cis- acting elements in Indian zebu cattle of Hariana breed","volume":"25","author":"Behl","year":"2014","journal-title":"Anim. Biotechnol."},{"key":"10.1016\/j.abb.2021.108938_bib25","first-page":"1","article-title":"Interactions of dietary polyphenols with epithelial lipids: advances from membrane and cell models in the study of polyphenol absorption, transport and delivery to the epithelium","author":"Reis","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121001879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121001879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:18:50Z","timestamp":1757744330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986121001879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":25,"alternative-id":["S0003986121001879"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2021.108938","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2021.108938","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108938"}}