{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:01:50Z","timestamp":1783742510759,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H04052"],"award-info":[{"award-number":["19H04052"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.abb.2021.109044","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T12:04:02Z","timestamp":1632830642000},"page":"109044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest"],"prefix":"10.1016","volume":"712","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-4408","authenticated-orcid":false,"given":"Wenxi","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-543X","authenticated-orcid":false,"given":"Takuya","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2021.109044_bib1","author":"Compare"},{"issue":"6","key":"10.1016\/j.abb.2021.109044_bib2","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/ndt\/gfu287","article-title":"Alterations of intestinal barrier and microbiota in chronic kidney disease","volume":"30","author":"Sabatino","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"issue":"7","key":"10.1016\/j.abb.2021.109044_bib3","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1136\/gut.32.7.754","article-title":"Impaired intestinal barrier function measured by differently sized polyethylene glycols in patients with chronic renal failure","volume":"32","author":"Magnusson","year":"1991","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.abb.2021.109044_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2215\/CJN.04610510","article-title":"Circulating endotoxemia: a novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease","volume":"6","author":"McIntyre","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.abb.2021.109044_bib5","series-title":"Molecular Medical Microbiology","author":"Tang","year":"2014"},{"issue":"1","key":"10.1016\/j.abb.2021.109044_bib6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.phrs.2012.10.007","article-title":"Modulation of intestinal barrier by intestinal microbiota: pathological and therapeutic implications","volume":"69","author":"Natividad","year":"2013","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.abb.2021.109044_bib7","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1373208","article-title":"Intestinal barrier and gut microbiota: Shaping our immune responses throughout life","volume":"5","author":"Takiishi","year":"2017","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.abb.2021.109044_bib8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jff.2018.11.005","article-title":"Exopolysaccharides from Leuconostoc mesenteroides attenuate chronic kidney disease in mice by protecting the intestinal barrier","volume":"52","author":"Hung","year":"2019","journal-title":"Journal of Functional Foods"},{"issue":"1","key":"10.1016\/j.abb.2021.109044_bib9","first-page":"1","article-title":"Alteration of the gut microbiota in Chinese population with chronic kidney disease","volume":"7","author":"Jiang","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.abb.2021.109044_bib10","doi-asserted-by":"crossref","first-page":"F857","DOI":"10.1152\/ajprenal.00513.2015","article-title":"Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats","volume":"310","author":"Kieffer","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"5","key":"10.1016\/j.abb.2021.109044_bib11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1089\/ars.2013.5312","article-title":"Hydrogen sulfide signaling in the gastrointestinal tract","volume":"20","author":"Linden","year":"2014","journal-title":"Antioxidants Redox Signal."},{"issue":"5","key":"10.1016\/j.abb.2021.109044_bib12","first-page":"427","article-title":"Plasma concentrations of hydrogen sulfide in patients with hemodialysis","volume":"44","author":"Mitsuhashi","year":"2011","journal-title":"Journal of Japanese Society for Dialysis Therapy"},{"issue":"10","key":"10.1016\/j.abb.2021.109044_bib13","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1096\/fj.02-0883fje","article-title":"Hydrogen sulfide induces serum\u2010independent cell cycle entry in nontransformed rat intestinal epithelial cells","volume":"17","author":"Deplancke","year":"2003","journal-title":"The Journal of the Federation of American Societies for Experimental Biology"},{"issue":"5","key":"10.1016\/j.abb.2021.109044_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037572","article-title":"Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells","volume":"7","author":"Wu","year":"2012","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.abb.2021.109044_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00380-003-0743-7","article-title":"The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells","volume":"19","author":"Du","year":"2004","journal-title":"Heart Ves."},{"issue":"1","key":"10.1016\/j.abb.2021.109044_bib16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1600-0765.2007.00999.x","article-title":"Hydrogen sulfide inhibits cell proliferation and induces cell cycle arrest via an elevated p21Cip1 level in Ca9\u201022 cells","volume":"43","author":"Takeuchi","year":"2008","journal-title":"J. Periodontal. Res."},{"issue":"2","key":"10.1016\/j.abb.2021.109044_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/bjs.6454","article-title":"Sulphate\u2010reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis","volume":"96","author":"Rowan","year":"2009","journal-title":"Br. J. Surg."},{"issue":"18","key":"10.1016\/j.abb.2021.109044_bib18","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.abb.2021.109044_bib19","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/onc.2014.133","article-title":"Less understood issues: p21Cip1 in mitosis and its therapeutic potential","volume":"34","author":"Kreis","year":"2015","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.abb.2021.109044_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jcp.10140","article-title":"GADD45b and GADD45g are cdc2\/cyclinB1 kinase inhibitors with a role in S and G2\/M cell cycle checkpoints induced by genotoxic stress","volume":"192","author":"Vairapandi","year":"2002","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.abb.2021.109044_bib21","first-page":"326","article-title":"14-3-3\u03c3, the double-edged sword of human cancers","volume":"1","author":"Li","year":"2009","journal-title":"Am. J. Tourism Res."},{"issue":"6","key":"10.1016\/j.abb.2021.109044_bib22","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3109\/10799893.2015.1030412","article-title":"Signaling pathway of MAPK\/ERK in cell proliferation, differentiation, migration, senescence and apoptosis","volume":"35","author":"Sun","year":"2015","journal-title":"Journal of Receptors Signal Transduction"},{"issue":"5","key":"10.1016\/j.abb.2021.109044_bib23","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3945\/jn.108.100867","article-title":"Quercetin enhances intestinal barrier function through the assembly of zonnula occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells","volume":"139","author":"Suzuki","year":"2009","journal-title":"J. Nutr."},{"issue":"10","key":"10.1016\/j.abb.2021.109044_bib24","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1210\/en.2017-00391","article-title":"Hydrogen sulfide and sulfate prebiotic stimulates the secretion of GLP-1 and improves glycemia in male mice","volume":"158","author":"Pichette","year":"2017","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.abb.2021.109044_bib25","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3892\/or.2020.7896","article-title":"Effects of an elemental diet, Elental\u00ae, may differ between healthy oral cells and oral cancer cells","volume":"45","author":"Harada","year":"2021","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.abb.2021.109044_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-01443-w","article-title":"Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling","volume":"3","author":"Kohno","year":"2020","journal-title":"Communications Biology"},{"issue":"6","key":"10.1016\/j.abb.2021.109044_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021077","article-title":"The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo","volume":"6","author":"Lee","year":"2011","journal-title":"PloS One"},{"issue":"9","key":"10.1016\/j.abb.2021.109044_bib28","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3390\/cells8090948","article-title":"Fisetin suppresses the proliferation and metastasis of renal cell carcinoma through upregulation of MEK\/ERK-targeting CTSS and ADAM9","volume":"8","author":"Hsieh","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.abb.2021.109044_bib29","doi-asserted-by":"crossref","first-page":"G736","DOI":"10.1152\/ajpgi.00453.2003","article-title":"Dual role of MEK\/ERK signaling in senescence and transformation of intestinal epithelial cells","volume":"286","author":"Boucher","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"8","key":"10.1016\/j.abb.2021.109044_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02244","article-title":"Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death","volume":"5","author":"Sakuma","year":"2019","journal-title":"Heliyon"},{"issue":"7165","key":"10.1016\/j.abb.2021.109044_bib31","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.abb.2021.109044_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1574-6968.1991.tb04799.x","article-title":"Growth and activities of sulphate-reducing bacteria in gut contents of healthy subjects and patients with ulcerative colitis","volume":"86","author":"Gibson","year":"1991","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett."},{"issue":"10","key":"10.1016\/j.abb.2021.109044_bib33","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/ars.2017.7096","article-title":"Beyond a gasotransmitter: hydrogen sulfide and polysulfide in cardiovascular health and immune response","volume":"27","author":"Yuan","year":"2017","journal-title":"Antioxidants Redox Signal."},{"issue":"2","key":"10.1016\/j.abb.2021.109044_bib34","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ijrobp.2009.12.013","article-title":"Depletion of securin induces senescence after irradiation and enhances radiosensitivity in human cancer cells regardless of functional p53 expression","volume":"77","author":"Chen","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"2","key":"10.1016\/j.abb.2021.109044_bib35","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.toxlet.2006.08.018","article-title":"Opposing securin and p53 protein expression in the oxaliplatin-induced cytotoxicity of human colorectal cancer cells","volume":"167","author":"Chiu","year":"2006","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.abb.2021.109044_bib36","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1074\/jbc.M203793200","article-title":"DNA damage-induced inhibition of securin expression is mediated by p53","volume":"278","author":"Zhou","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"28","key":"10.1016\/j.abb.2021.109044_bib37","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1038\/onc.2016.502","article-title":"Census and evaluation of p53 target genes","volume":"36","author":"Fischer","year":"2017","journal-title":"Oncogene"}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121002939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121002939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:20:51Z","timestamp":1757744451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986121002939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":37,"alternative-id":["S0003986121002939"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2021.109044","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2021.109044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109044"}}