{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:12:21Z","timestamp":1790136741728,"version":"4.0.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Commission of Health and Family Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.abb.2021.109049","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T02:38:20Z","timestamp":1633487900000},"page":"109049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["SPARC knockdown attenuated TGF-\u03b21-induced fibrotic effects through Smad2\/3 pathways in human pterygium fibroblasts"],"prefix":"10.1016","volume":"713","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-2553","authenticated-orcid":false,"given":"Jianwu","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2021.109049_bib1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exer.2015.01.010","article-title":"Fibroblast biology in pterygia","volume":"142","author":"Kim","year":"2016","journal-title":"Exp. Eye Res."},{"issue":"12","key":"10.1016\/j.abb.2021.109049_bib2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3109\/02713683.2013.823212","article-title":"Progress in the pathogenesis of pterygium","volume":"38","author":"Liu","year":"2013","journal-title":"Curr. Eye Res."},{"issue":"6","key":"10.1016\/j.abb.2021.109049_bib3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/s41433-020-0786-3","article-title":"Pterygium: new insights","volume":"34","author":"Chu","year":"2020","journal-title":"Eye"},{"issue":"1","key":"10.1016\/j.abb.2021.109049_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/mmr.2016.5223","article-title":"The role of ultraviolet radiation in the pathogenesis of pterygia (Review)","volume":"14","author":"Zhou","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.abb.2021.109049_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ophtha.2012.06.066","article-title":"Options and adjuvants in surgery for pterygium: a report by the American Academy of Ophthalmology","volume":"120","author":"Kaufman","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.abb.2021.109049_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/1874364102014010082","article-title":"Comparing adjuvant beta radiation, mitomycin C, and conjunctival autograft in primary pterygium treatment, a three-year follow-up study","volume":"14","author":"Al-Salem","year":"2020","journal-title":"Open Ophthalmol. J."},{"issue":"1","key":"10.1016\/j.abb.2021.109049_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10384-020-00786-5","article-title":"Pterygium excision with modified bare sclera technique combined with mitomycin C","volume":"65","author":"Aziza","year":"2021","journal-title":"Jpn. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.abb.2021.109049_bib8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/ICO.0000000000000384","article-title":"Mitomycin C-associated scleral stromalysis after pterygium surgery","volume":"34","author":"Lindquist","year":"2015","journal-title":"Cornea"},{"issue":"5","key":"10.1016\/j.abb.2021.109049_bib9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/ICO.0000000000000400","article-title":"Monitoring corneal densities following primary pterygium excision with adjuvant topical mitomycin-C application--an observational study of corneal scar changes","volume":"34","author":"Kam","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.abb.2021.109049_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ceb.2014.09.001","article-title":"Signaling pathway cooperation in TGF-beta-induced epithelial-mesenchymal transition","volume":"31","author":"Derynck","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.abb.2021.109049_bib11","series-title":"[Pterygium: Pathogenesis, Diagnosis and Treatment]","author":"Rokohl","year":"2021"},{"key":"10.1016\/j.abb.2021.109049_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.preteyeres.2017.08.001","article-title":"Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis","volume":"60","author":"Shu","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.abb.2021.109049_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/bjo.2004.050633","article-title":"Characterisation of myofibroblasts in fibrovascular tissues of primary and recurrent pterygia","volume":"89","author":"Touhami","year":"2005","journal-title":"Br. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.abb.2021.109049_bib14","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/bjo.2008.151852","article-title":"The science of pterygia","volume":"94","author":"Bradley","year":"2010","journal-title":"Br. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.abb.2021.109049_bib15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/039463201202500307","article-title":"Immunohistochemical profile of VEGF, TGF-beta and PGE(2) in human pterygium and normal conjunctiva: experimental study and review of the literature","volume":"25","author":"Bianchi","year":"2012","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"9","key":"10.1016\/j.abb.2021.109049_bib16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s004170050144","article-title":"Growth factors in cultured pterygium fibroblasts: immunohistochemical and ELISA analysis","volume":"236","author":"Kria","year":"1998","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"1","key":"10.1016\/j.abb.2021.109049_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcdb.2009.11.018","article-title":"Modulation of matrix remodeling by SPARC in neoplastic progression","volume":"21","author":"Chlenski","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"issue":"3\u20134","key":"10.1016\/j.abb.2021.109049_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12079-009-0062-6","article-title":"The role of SPARC in extracellular matrix assembly","volume":"3","author":"Bradshaw","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.abb.2021.109049_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/1874312901206010146","article-title":"The function of SPARC as a mediator of fibrosis","volume":"6","author":"Trombetta-Esilva","year":"2012","journal-title":"Open Rheumatol. J."},{"issue":"1","key":"10.1016\/j.abb.2021.109049_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bph.13653","article-title":"The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease","volume":"174","author":"Wong","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.abb.2021.109049_bib21","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1093\/rheumatology\/kez583","article-title":"Extracellular SPARC cooperates with TGF-beta signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts","volume":"59","author":"Carvalheiro","year":"2020","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.abb.2021.109049_bib22","doi-asserted-by":"crossref","first-page":"G739","DOI":"10.1152\/ajpgi.00316.2010","article-title":"SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-beta1 and PDGF","volume":"300","author":"Atorrasagasti","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.abb.2021.109049_bib23","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/ar2973","article-title":"Attenuation of fibrosis in vitro and in vivo with SPARC siRNA","volume":"12","author":"Wang","year":"2010","journal-title":"Arthritis Res. Ther."},{"issue":"7","key":"10.1016\/j.abb.2021.109049_bib24","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1167\/iovs.13-12463","article-title":"TGF-beta 2-mediated ocular hypertension is attenuated in SPARC-null mice","volume":"55","author":"Swaminathan","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.abb.2021.109049_bib25","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1172\/JCI41203","article-title":"Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF\/TGF-beta signaling in hepatic stellate cells","volume":"120","author":"Cao","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.abb.2021.109049_bib26","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1582-4934.2011.01400.x","article-title":"In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon's fibroblasts: comparisons with mitomycin C","volume":"16","author":"Seet","year":"2012","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.abb.2021.109049_bib27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1167\/iovs.11-7941","article-title":"Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium","volume":"53","author":"Seet","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.abb.2021.109049_bib28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jcb.20008","article-title":"SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells","volume":"91","author":"Francki","year":"2004","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.abb.2021.109049_bib29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1167\/iovs.18-25376","article-title":"Critical role of mTORC2-akt signaling in TGF-beta1-induced myofibroblast differentiation of human pterygium fibroblasts","volume":"60","author":"Kim","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.abb.2021.109049_bib30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1755-1536-6-6","article-title":"Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-beta and is required for TGF-beta-induced hydrogen peroxide production in fibroblasts","volume":"6","author":"Shibata","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"7","key":"10.1016\/j.abb.2021.109049_bib31","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/jop.2015.0057","article-title":"Secreted protein acidic and rich in cysteine in ocular tissue","volume":"31","author":"Scavelli","year":"2015","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"issue":"45","key":"10.1016\/j.abb.2021.109049_bib32","doi-asserted-by":"crossref","first-page":"32145","DOI":"10.1074\/jbc.274.45.32145","article-title":"SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells","volume":"274","author":"Francki","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.abb.2021.109049_bib33","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1167\/iovs.09-4921","article-title":"Effect of TIMP-1 and MMP in pterygium invasion","volume":"51","author":"Tsai","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.abb.2021.109049_bib34","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1167\/iovs.12-11474","article-title":"Regulation of SPARC by transforming growth factor beta 2 in human trabecular meshwork","volume":"54","author":"Kang","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.abb.2021.109049_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040378","article-title":"The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasion","volume":"7","author":"Fenouille","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.abb.2021.109049_bib36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.abb.2021.109049_bib37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fphar.2017.00461","article-title":"Targeting TGF-beta mediated SMAD signaling for the prevention of fibrosis","volume":"8","author":"Walton","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"14","key":"10.1016\/j.abb.2021.109049_bib38","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1167\/iovs.19-27153","article-title":"Antifibrotic effects of sakuraso-saponin in primary cultured pterygium fibroblasts in comparison with mitomycin C","volume":"60","author":"Lee","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.abb.2021.109049_bib39","first-page":"189","article-title":"Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells","volume":"11","author":"Chen","year":"2018","journal-title":"Int. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.abb.2021.109049_bib40","first-page":"2903","article-title":"SMOC1 silencing suppresses the angiotensin II-induced myocardial fibrosis of mouse myocardial fibroblasts via affecting the BMP2\/Smad pathway","volume":"16","author":"Wang","year":"2018","journal-title":"Oncol Lett"},{"issue":"3","key":"10.1016\/j.abb.2021.109049_bib41","doi-asserted-by":"crossref","first-page":"H841","DOI":"10.1152\/ajpheart.01247.2010","article-title":"SPARC regulates collagen interaction with cardiac fibroblast cell surfaces","volume":"301","author":"Harris","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"21","key":"10.1016\/j.abb.2021.109049_bib42","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1021\/ac051349d","article-title":"Identifying the SPARC binding sites on collagen I and procollagen I by atomic force microscopy","volume":"77","author":"Wang","year":"2005","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.abb.2021.109049_bib43","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.bbrc.2011.12.065","article-title":"SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells","volume":"417","author":"Chetty","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"46","key":"10.1016\/j.abb.2021.109049_bib44","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.3748\/wjg.v25.i46.6713","article-title":"Aberrant methylation of secreted protein acidic and rich in cysteine gene and its significance in gastric cancer","volume":"25","author":"Shao","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.abb.2021.109049_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173209","article-title":"SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament","volume":"12","author":"Rosset","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.abb.2021.109049_bib46","doi-asserted-by":"crossref","DOI":"10.1089\/scd.2020.0196","article-title":"The effect of secreted protein acidic and rich in cysteine on the proliferation and migration of limbal epithelial stem cells during the corneal epithelial wound healing","volume":"30","author":"Wang","year":"2021","journal-title":"Stem Cell. Dev."},{"issue":"10","key":"10.1016\/j.abb.2021.109049_bib47","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1167\/iovs.08-3147","article-title":"Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C","volume":"50","author":"Yang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.abb.2021.109049_bib48","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160107","article-title":"Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis","volume":"36","author":"Robert","year":"2016","journal-title":"Biosci. Rep."},{"issue":"1","key":"10.1016\/j.abb.2021.109049_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169675","article-title":"Inhibition of pterygium fibroblast migration and outgrowth by bevacizumab and cyclosporine A involves down-regulation of matrix metalloproteinases-3 and -13","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"issue":"22\u201324","key":"10.1016\/j.abb.2021.109049_bib50","first-page":"177","article-title":"SPARC is expressed in scars of the Tenon's capsule and mediates scarring properties of human Tenon's fibroblasts in vitro","volume":"17","author":"Fuchshofer","year":"2011","journal-title":"Mol. Vis."},{"issue":"3","key":"10.1016\/j.abb.2021.109049_bib51","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1167\/iovs.02-0412","article-title":"Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro","volume":"44","author":"Daniels","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121002988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986121002988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:03:54Z","timestamp":1762088634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986121002988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":51,"alternative-id":["S0003986121002988"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2021.109049","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SPARC knockdown attenuated TGF-\u03b21-induced fibrotic effects through Smad2\/3 pathways in human pterygium fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2021.109049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109049"}}