{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:54:39Z","timestamp":1791374079403,"version":"4.3.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH206"],"award-info":[{"award-number":["ZR2020MH206"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073061"],"award-info":[{"award-number":["82073061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2020YFA0803301"],"award-info":[{"award-number":["2020YFA0803301"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.abb.2023.109552","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T02:07:25Z","timestamp":1677031645000},"page":"109552","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["XBP1s acts as a transcription factor of IRE1\u03b1 and promotes proliferation of colon cancer cells"],"prefix":"10.1016","volume":"737","author":[{"given":"Shuting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2023.109552_bib1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.abb.2023.109552_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41568-020-00312-2","article-title":"Endoplasmic reticulum stress signals in the tumour and its microenvironment","volume":"21","author":"Chen","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.abb.2023.109552_bib3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nri2359","article-title":"The endoplasmic reticulum stress response in immunity and autoimmunity","volume":"8","author":"Todd","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.abb.2023.109552_bib4","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0092-8674(93)90648-A","article-title":"Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase","volume":"73","author":"Cox","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.abb.2023.109552_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The unfolded protein response and cell fate control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.abb.2023.109552_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1129631","article-title":"Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response","volume":"313","author":"Hollien","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.abb.2023.109552_bib7","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1226191","article-title":"IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2","volume":"338","author":"Upton","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.abb.2023.109552_bib8","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.abb.2023.109552_bib9","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.1146361","article-title":"IRE1 signaling affects cell fate during the unfolded protein response","volume":"318","author":"Lin","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.abb.2023.109552_bib10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s12192-009-0163-4","article-title":"IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1","volume":"15","author":"Thorpe","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.abb.2023.109552_bib11","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1073\/pnas.1701757114","article-title":"ER stress and distinct outputs of the IRE1 RNase control proliferation and senescence in response to oncogenic Ras","volume":"114","author":"Blazanin","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.abb.2023.109552_bib12","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1038\/s41467-018-05763-8","article-title":"Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy","volume":"9","author":"Logue","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2023.109552_bib13","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.1038\/onc.2017.284","article-title":"Knockdown of IRE1\u03b1 inhibits colonic tumorigenesis through decreasing \u03b2-catenin and IRE1\u03b1 targeting suppresses colon cancer cells","volume":"36","author":"Li","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.abb.2023.109552_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101503","article-title":"The UPR transducer IRE1 promotes breast cancer malignancy by degrading tumor suppressor microRNAs","volume":"23","author":"Zhang","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.abb.2023.109552_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbrc.2018.11.112","article-title":"XBP1-s promotes colorectal cancer cell proliferation by inhibiting TAp73 transcriptional activity","volume":"508","author":"Ji","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2023.109552_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbrc.2015.12.119","article-title":"Activation of IRE1\u03b1-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma","volume":"470","author":"Jin","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2023.109552_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12967-017-1147-2","article-title":"IRE1\u03b1-XBP1 pathway promotes melanoma progression by regulating IL-6\/STAT3 signaling","volume":"15","author":"Chen","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.abb.2023.109552_bib18","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.4161\/auto.7.10.16818","article-title":"Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis","volume":"7","author":"Shi","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.abb.2023.109552_bib19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nm.2121","article-title":"A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response","volume":"16","author":"Winnay","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.abb.2023.109552_bib20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hep.29871","article-title":"Dual role for inositol-requiring enzyme 1 in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice","volume":"68","author":"Wu","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.abb.2023.109552_bib21","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.3390\/cancers13194927","article-title":"The role of BiP and the IRE1\u03b1-XBP1 Axis in rhabdomyosarcoma pathology","volume":"13","author":"Aghaei","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.abb.2023.109552_bib22","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201707929","article-title":"Dual IRE1 RNase functions dictate glioblastoma development","volume":"10","author":"Lhomond","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.abb.2023.109552_bib23","doi-asserted-by":"crossref","first-page":"18270","DOI":"10.1074\/jbc.RA118.002121","article-title":"ER stress signaling has an activating transcription factor 6 (ATF6)-dependent \"off-switch","volume":"293","author":"Walter","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2023.109552_bib24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/j.gastro.2009.09.049","article-title":"Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKK\u03b2 independent of hydroxylase activity","volume":"138","author":"Xue","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.abb.2023.109552_bib25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200903014","article-title":"Regulated Ire1-dependent decay of messenger RNAs in mammalian cells","volume":"186","author":"Hollien","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.abb.2023.109552_bib26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.canlet.2020.02.007","article-title":"IRE1\u03b1-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells","volume":"476","author":"Gao","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.abb.2023.109552_bib27","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1038\/ncomms4528","article-title":"Hepatic IRE1\u03b1 regulates fasting-induced metabolic adaptive programs through the XBP1s-PPAR\u03b1 axis signalling","volume":"5","author":"Shao","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2023.109552_bib28","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1101\/gad.839400","article-title":"The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response","volume":"14","author":"Tirasophon","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.abb.2023.109552_bib29","first-page":"ra7","article-title":"A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells, Sci","volume":"3","author":"Qiu","year":"2010","journal-title":"Signal"},{"key":"10.1016\/j.abb.2023.109552_bib30","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1101\/gad.12.12.1812","article-title":"A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase\/endoribonuclease (Ire1p) in mammalian cells","volume":"12","author":"Tirasophon","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.abb.2023.109552_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2021.05.068","article-title":"The tyrosine phosphatase SHP2 promotes proliferation and oxaliplatin resistance of colon cancer cells through AKT and ERK","volume":"563","author":"Yu","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2023.109552_bib32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/jb\/mvn091","article-title":"Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds","volume":"144","author":"Yamamoto","year":"2008","journal-title":"J. Biochem."},{"key":"10.1016\/j.abb.2023.109552_bib33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200903014","article-title":"Regulated Ire1-dependent decay of messenger RNAs in mammalian cells","volume":"186","author":"Hollien","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.abb.2023.109552_bib34","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1128\/MCB.00215-15","article-title":"IRE1\u03b1-Dependent decay of CReP\/Ppp1r15b mRNA increases eukaryotic initiation factor 2\u03b1 phosphorylation and suppresses protein synthesis","volume":"35","author":"So","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.abb.2023.109552_bib35","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1128\/MCB.00013-15","article-title":"Cleavage of BLOC1S1 mRNA by IRE1 is sequence specific, temporally separate from XBP1 splicing, and dispensable for cell viability under acute endoplasmic reticulum stress","volume":"35","author":"Bright","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.abb.2023.109552_bib36","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/ncb3266","article-title":"IRE1 is an endogenous substrate of endoplasmic-reticulum-associated degradation","volume":"17","author":"Sun","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.abb.2023.109552_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/srep24217","article-title":"Novel mechanism of enhancing IRE1\u03b1-XBP1 signalling via the PERK-ATF4 pathway","volume":"6","author":"Tsuru","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.abb.2023.109552_bib38","doi-asserted-by":"crossref","first-page":"e1239","DOI":"10.1038\/cddis.2014.194","article-title":"IRE1\u03b1 constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiation","volume":"5","author":"Guo","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.abb.2023.109552_bib39","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/embor.2008.37","article-title":"Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis","volume":"9","author":"Gao","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.abb.2023.109552_bib40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2007.12.017","article-title":"How IRE1 reacts to ER stress","volume":"132","author":"Ron","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.abb.2023.109552_bib41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbrc.2015.12.119","article-title":"Activation of IRE1\u03b1-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma","volume":"470","author":"Jin","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2023.109552_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature13119","article-title":"XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway","volume":"508","author":"Chen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.abb.2023.109552_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3892\/ijmm.2022.5089","article-title":"XBP1s promotes the development of lung adenocarcinoma via the pJNK MAPK pathway","volume":"49","author":"Jiang","year":"2022","journal-title":"Int. J. Mol. Med."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986123000516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986123000516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:23:53Z","timestamp":1757744633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986123000516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":43,"alternative-id":["S0003986123000516"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2023.109552","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"XBP1s acts as a transcription factor of IRE1\u03b1 and promotes proliferation of colon cancer cells","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2023.109552","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109552"}}