{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:40:07Z","timestamp":1772034007133,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202040466"],"award-info":[{"award-number":["202040466"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.abb.2023.109693","type":"journal-article","created":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T16:35:02Z","timestamp":1689525302000},"page":"109693","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Astragaloside reduces toxic effect of periodontal ligament fibroblasts induced by lipopolysaccharide"],"prefix":"10.1016","volume":"744","author":[{"given":"Chen","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongying","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongsheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.abb.2023.109693_bib1","doi-asserted-by":"crossref","DOI":"10.1177\/00368504211013247","article-title":"Pathologies associated with the mandibular third molar impaction","volume":"104","author":"Ye","year":"2021","journal-title":"Sci. Prog."},{"key":"10.1016\/j.abb.2023.109693_bib2","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.omtn.2021.01.030","article-title":"Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice, Molecular therapy","volume":"23","author":"Krongbaramee","year":"2021","journal-title":"Nucleic acids"},{"key":"10.1016\/j.abb.2023.109693_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720948497","article-title":"Dose-dependent effects of zoledronic acid on human periodontal ligament stem cells: an in vitro pilot study","volume":"29","author":"Di Vito","year":"2020","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/13880209.2018.1506482","article-title":"Anti-inflammatory effects of shikonin in human periodontal ligament cells","volume":"56","author":"Fan","year":"2018","journal-title":"Pharmaceut. Biol."},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib5","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1080\/21655979.2021.1987089","article-title":"Identification and validation of potential novel biomarkers for oral squamous cell carcinoma","volume":"12","author":"Zhang","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib6","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1080\/21655979.2021.1928930","article-title":"Parathyroid hormone-related protein inhibits nitrogen-containing bisphosphonate-induced apoptosis of human periodontal ligament fibroblasts by activating MKP1 phosphatase","volume":"12","author":"Liu","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/jcpe.13046","article-title":"An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis","volume":"46","author":"Bartold","year":"2019","journal-title":"J. Clin. Periodontol."},{"issue":"8","key":"10.1016\/j.abb.2023.109693_bib8","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1177\/0022034513495242","article-title":"LPS-induced inflammatory response after therapy of aggressive periodontitis","volume":"92","author":"Shaddox","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.abb.2023.109693_bib9","doi-asserted-by":"crossref","DOI":"10.1177\/09636897211002787","article-title":"Ginsenoside Rb1 alleviates lipopolysaccharide-induced inflammatory injury by downregulating miR-222 in WI-38 cells","volume":"30","author":"Wei","year":"2021","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/0963689718807680","article-title":"In vitro long-term expansion and high osteogenic potential of periodontal ligament stem cells: more than a mirage","volume":"28","author":"Di Vito","year":"2019","journal-title":"Cell Transplant."},{"issue":"6","key":"10.1016\/j.abb.2023.109693_bib11","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1142\/S0192415X1750063X","article-title":"Anti-inflammatory and immunostimulatory activities of astragalosides","volume":"45","author":"Qi","year":"2017","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.abb.2023.109693_bib12","first-page":"244","article-title":"Astragaloside IV prevents obesity-associated hypertension by improving pro-inflammatory reaction and leptin resistance","volume":"41","author":"Jiang","year":"2018","journal-title":"Mol. Cell."},{"key":"10.1016\/j.abb.2023.109693_bib13","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2019.vol33.0032","article-title":"Effects of astragaloside IV on inflammation and immunity in rats with experimental periodontitis","volume":"33","author":"Zhang","year":"2019","journal-title":"Braz. Oral Res."},{"key":"10.1016\/j.abb.2023.109693_bib14","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.omtn.2020.11.015","article-title":"SIRT1 alleviates hepatic ischemia-reperfusion injury via the miR-182-mediated XBP1\/NLRP3 pathway, Molecular therapy","volume":"23","author":"Li","year":"2021","journal-title":"Nucleic acids"},{"key":"10.1016\/j.abb.2023.109693_bib15","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720934413","article-title":"The role of interleukin-1beta in destruction of transplanted islets","volume":"29","author":"Chen","year":"2020","journal-title":"Cell Transplant."},{"issue":"12","key":"10.1016\/j.abb.2023.109693_bib16","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1172\/JCI13271","article-title":"Why there are two cyclooxygenase isozymes","volume":"107","author":"Smith","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.abb.2023.109693_bib17","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720903691","article-title":"CORM-2 pretreatment attenuates inflammation-mediated islet dysfunction","volume":"29","author":"Cai","year":"2020","journal-title":"Cell Transplant."},{"key":"10.1016\/j.abb.2023.109693_bib18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.omtn.2020.02.002","article-title":"N(6)-Methyladenosine METTL3 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract, molecular therapy","volume":"20","author":"Yang","year":"2020","journal-title":"Nucleic acids"},{"issue":"9","key":"10.1016\/j.abb.2023.109693_bib19","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0891-5849(00)00223-9","article-title":"Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades","volume":"28","author":"Hubbard","year":"2000","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.abb.2023.109693_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/108729002760070812","article-title":"Antisense-mediated inhibition of ICAM-1 expression: a therapeutic strategy against inflammation of human periodontal tissue","volume":"12","author":"Nedbal","year":"2002","journal-title":"Antisense Nucleic Acid Drug Dev."},{"key":"10.1016\/j.abb.2023.109693_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/0963689721999330","article-title":"Circulating miRNA in patients undergoing total pancreatectomy and islet autotransplantation","volume":"30","author":"Vasu","year":"2021","journal-title":"Cell Transplant."},{"key":"10.1016\/j.abb.2023.109693_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.omtn.2020.05.012","article-title":"Non-coding RNAs and exosomes: their role in the pathogenesis of sepsis, molecular therapy","volume":"21","author":"Hashemian","year":"2020","journal-title":"Nucleic acids"},{"key":"10.1016\/j.abb.2023.109693_bib23","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.omtn.2021.10.010","article-title":"Non-coding RNA basis of muscle atrophy, Molecular therapy","volume":"26","author":"Liu","year":"2021","journal-title":"Nucleic acids"},{"key":"10.1016\/j.abb.2023.109693_bib24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.omtn.2020.08.015","article-title":"ZEB1-Mediated transcriptional upregulation of circWWC3 promotes breast cancer progression through activating ras signaling pathway, molecular therapy","volume":"22","author":"Meng","year":"2020","journal-title":"Nucleic acids"},{"issue":"12","key":"10.1016\/j.abb.2023.109693_bib25","first-page":"7568","article-title":"MicroRNA-26b-3p\/ANTXR1 signaling modulates proliferation, migration, and apoptosis of glioma","volume":"11","author":"Geng","year":"2019","journal-title":"Am. J. Tourism Res."},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib26","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1080\/21655979.2021.2020396","article-title":"Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527\/caspase-5 axis","volume":"13","author":"Pan","year":"2022","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib27","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1080\/21655979.2021.1943603","article-title":"Cullin3 aggravates the inflammatory response of periodontal ligament stem cells via regulation of SHH signaling and Nrf2","volume":"12","author":"Chen","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13578-022-00745-2","article-title":"Transcriptome-scale spatial gene expression in rat arcuate nucleus during puberty","volume":"12","author":"Zhou","year":"2022","journal-title":"Cell Biosci."},{"issue":"8","key":"10.1016\/j.abb.2023.109693_bib29","doi-asserted-by":"crossref","first-page":"12273","DOI":"10.1002\/jcb.28286","article-title":"Astragaloside attenuates lipopolysaccharide-induced cell apoptosis in human gingiva cells via MAPK signaling pathway","volume":"120","author":"Shen","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.abb.2023.109693_bib30","doi-asserted-by":"crossref","DOI":"10.1177\/00368504211054985","article-title":"Inflammatory cytokines TNFalpha, IL-1beta, and IL-6 are induced in endotoxin- stimulated microglia through different signaling cascades","volume":"104","author":"Ishijima","year":"2021","journal-title":"Sci. Prog."},{"key":"10.1016\/j.abb.2023.109693_bib31","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.omtn.2021.10.030","article-title":"Ubiquitinated ligation protein NEDD4L participates in MiR-30a-5p attenuated atherosclerosis by regulating macrophage polarization and lipid metabolism, Molecular therapy","volume":"26","author":"Song","year":"2021","journal-title":"Nucleic acids"},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1600-0765.1994.tb01090.x","article-title":"Adhesion molecule expression in chronic inflammatory periodontal disease tissue","volume":"29","author":"Gemmell","year":"1994","journal-title":"J. Periodontal. Res."},{"issue":"1","key":"10.1016\/j.abb.2023.109693_bib33","first-page":"59","article-title":"Expression of ICAM-1 and E-selectin in gingival tissues of smokers and non-smokers with periodontitis","volume":"31","author":"Rezavandi","year":"2002","journal-title":"J. Oral Pathol. Med. Official publicat. Int. Associat. Oral Pathol. Am. Acad. Oral Pathol."},{"issue":"4","key":"10.1016\/j.abb.2023.109693_bib34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/0022034509359575","article-title":"COX-2 is associated with periodontitis in Europeans","volume":"89","author":"Schaefer","year":"2010","journal-title":"J. Dent. Res."},{"issue":"6","key":"10.1016\/j.abb.2023.109693_bib35","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1902\/jop.1998.69.6.670","article-title":"Induction of COX-2 expression by mechanical tension force in human periodontal ligament cells","volume":"69","author":"Shimizu","year":"1998","journal-title":"J. Periodontol."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986123001923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986123001923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:28:08Z","timestamp":1757744888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986123001923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":35,"alternative-id":["S0003986123001923"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2023.109693","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astragaloside reduces toxic effect of periodontal ligament fibroblasts induced by lipopolysaccharide","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2023.109693","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109693"}}