{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:18:35Z","timestamp":1790839115712,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.abb.2024.110201","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:51:21Z","timestamp":1730422281000},"page":"110201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The cGAS-STING mediated crosstalk between innate immunity and autophagy in leishmaniasis using mathematical modeling: Uncovering new therapeutic avenues"],"prefix":"10.1016","volume":"762","author":[{"given":"Anil","family":"Tambekar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrushali","family":"Guhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3817-8819","authenticated-orcid":false,"given":"Shailza","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.abb.2024.110201_bib1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.it.2017.05.005","article-title":"Type I interferon in chronic virus infection and cancer","volume":"38","author":"Snell","year":"2017","journal-title":"Trends Immunol."},{"issue":"February","key":"10.1016\/j.abb.2024.110201_bib2","article-title":"Type I interferons in infectious disease","volume":"15","author":"Mcnab","year":"2015","journal-title":"Nature Publishing Group"},{"key":"10.1016\/j.abb.2024.110201_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.coviro.2016.01.001","article-title":"Type i interferons in viral control and immune regulation","volume":"16","author":"Teijaro","year":"2016","journal-title":"Current Opinion in Virology"},{"issue":"2","key":"10.1016\/j.abb.2024.110201_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nri3133","article-title":"Immunomodulatory functions of type i interferons","volume":"12","author":"Gonz\u00e1lez-Navajas","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.abb.2024.110201_bib5","first-page":"33","volume":"vol. 202","author":"Bogdan","year":"2004"},{"issue":"24","key":"10.1016\/j.abb.2024.110201_bib6","doi-asserted-by":"crossref","first-page":"11232","DOI":"10.1111\/jcmm.17046","article-title":"Increased UBE2L6 regulated by type 1 interferon as potential marker in TB","volume":"25","author":"Gao","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"5","key":"10.1016\/j.abb.2024.110201_bib7","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1128\/IAI.01176-10","article-title":"Type I interferons increase host susceptibility to trypanosoma cruzi infection","volume":"79","author":"Chessler","year":"2011","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.abb.2024.110201_bib8","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1016\/j.celrep.2020.01.099","article-title":"Type I interferons suppress anti-parasitic immunity and can Be targeted to improve treatment of visceral leishmaniasis article type I interferons suppress anti-parasitic immunity and can Be targeted to improve treatment of visceral leishmaniasis","volume":"30","author":"Kumar","year":"2020","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.abb.2024.110201_bib9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2012.03.013","article-title":"The JAK-STAT pathway at twenty","volume":"36","author":"Stark","year":"2012","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.abb.2024.110201_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type i interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.abb.2024.110201_bib11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nri3210","article-title":"Interferon-inducible effector mechanisms in cell-autonomous immunity","volume":"12","author":"MacMicking","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.abb.2024.110201_bib12","article-title":"Type I interferon antiviral response","volume":"1","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.abb.2024.110201_bib13","series-title":"Positive Feedback Regulation of Type I Interferon by the Interferon-Stimulated Gene STING","first-page":"1","author":"Ma","year":"2015"},{"issue":"6227","key":"10.1016\/j.abb.2024.110201_bib14","article-title":"Phosphorylation of innate immune adaptor proteins MAVS","volume":"347","author":"Liu","year":"2015","journal-title":"STING, and TRIF induces IRF3 activation"},{"issue":"1","key":"10.1016\/j.abb.2024.110201_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.immuni.2020.06.009","article-title":"Article interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion ll ll article interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion","volume":"53","author":"Wu","year":"2020","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.abb.2024.110201_bib16","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.celrep.2019.03.098","article-title":"Modular architecture of the STING C-terminal tail allows interferon and NF- k B signaling adaptation article modular architecture of the STING C-terminal tail allows interferon and NF- k B signaling adaptation","volume":"27","author":"Mann","year":"2019","journal-title":"Cell Rep."},{"issue":"7689","key":"10.1016\/j.abb.2024.110201_bib17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature25432","article-title":"Chromosomal instability drives metastasis through a cytosolic DNA response","volume":"553","author":"Bakhoum","year":"2018","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.abb.2024.110201_bib18","first-page":"866","article-title":"MINIREVIEWS toll-like receptors and leishmaniasis \u1c14","volume":"76","author":"Tuon","year":"2008"},{"issue":"21","key":"10.1016\/j.abb.2024.110201_bib19","doi-asserted-by":"crossref","first-page":"15595","DOI":"10.1016\/S0021-9258(18)82298-0","article-title":"The glycoinositol Phospholipids of Leishmania mexicana promastigotes","volume":"268","author":"Biosynthesis","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2024.110201_bib20","author":"Hawn"},{"key":"10.1016\/j.abb.2024.110201_bib21","first-page":"1","article-title":"Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages","author":"Yilmaz","year":"2022","journal-title":"Critical role of the cGAS-STING- TBK1 signaling pathway in macrophage parasitemia"},{"issue":"7747","key":"10.1016\/j.abb.2024.110201_bib22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41586-019-1006-9","article-title":"Autophagy induction via STING trafficking is a primordial function of the cGAS pathway","volume":"567","author":"Gui","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.abb.2024.110201_bib23","series-title":"Attenuation of cGAS-STING Signaling Is Mediated by a P 62\/SQSTM 1 -dependent Autophagy Pathway Activated by TBK 1","author":"Prabakaran","year":"2018"},{"key":"10.1016\/j.abb.2024.110201_bib24","unstructured":"Aging and Health, vol. 40."},{"key":"10.1016\/j.abb.2024.110201_bib25","first-page":"1","article-title":"Meta-analysis of host response networks identi fi es a common core in tuberculosis","author":"Sambarey","year":"2016","journal-title":"npj Systems Biology and Applications"},{"issue":"25","key":"10.1016\/j.abb.2024.110201_bib26","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1038\/onc.2014.291","article-title":"Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies","volume":"34","author":"Du","year":"2015","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.abb.2024.110201_bib27","article-title":"Mathematical modeling of intracellular signaling pathways","volume":"7","author":"Klipp","year":"2006","journal-title":"BMC Neurosci."},{"issue":"5","key":"10.1016\/j.abb.2024.110201_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000086","article-title":"Dynamic analysis of integrated signaling, metabolic, and regulatory networks","volume":"4","author":"Min Lee","year":"2008","journal-title":"PLoS Comput. Biol."},{"issue":"7","key":"10.1016\/j.abb.2024.110201_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2010.06.019","article-title":"SnapShot: key numbers in biology","volume":"141","author":"Moran","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.abb.2024.110201_bib30","article-title":"Decoding systems immunological model of sphingolipids with IL-6\/IL-17\/IL-23 axes in L. major infection","volume":"1868","author":"Jawale","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"11","key":"10.1016\/j.abb.2024.110201_bib31","first-page":"1827","article-title":"cellular biochemistry, Gulhane - MicroRNA\u2010520c\u20103p impacts sphingolipid metabolism mediating PI3K AKT","volume":"123","author":"of","year":"2022","journal-title":"signaling.pdf"},{"issue":"Jan","key":"10.1016\/j.abb.2024.110201_bib32","article-title":"Computational system level approaches for discerning reciprocal regulation of IL10 and IL12 in leishmaniasis","volume":"12","author":"Khandibharad","year":"2022","journal-title":"Front. Genet."},{"issue":"4","key":"10.1016\/j.abb.2024.110201_bib33","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/cbdd.12692","article-title":"Novel quinazoline derivatives bearing various 4-aniline moieties as potent EGFR inhibitors with enhanced activity against NSCLC cell lines","volume":"87","author":"Wang","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"issue":"2","key":"10.1016\/j.abb.2024.110201_bib34","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2019.05.036","article-title":"Article STING polymer structure reveals mechanisms","volume":"178","author":"Ergun","year":"2019","journal-title":"Cell"}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986124003230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986124003230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T14:03:15Z","timestamp":1733407395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986124003230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":34,"alternative-id":["S0003986124003230"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2024.110201","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cGAS-STING mediated crosstalk between innate immunity and autophagy in leishmaniasis using mathematical modeling: Uncovering new therapeutic avenues","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2024.110201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110201"}}